Molecular mechanism of mitochondrial calcium uptake

Mitochondria as signaling organelles

(2014) Navdeep S Chandel   BMC BIOLOGY

The elusive importance of being a mitochondrial Ca2+ uniporter

(2014) Diana Pendin et al.   CELL CALCIUM

Structural and mechanistic insights into MICU1 regulation of mitochondrial calcium uptake

(2014) L. Wang et al.   EMBO JOURNAL

The gatekeepers of mitochondrial calcium influx: MICU1 and MICU2

(2014) M. Ahuja et al.   EMBO REPORTS

MICU1 and MICU2 play nonredundant roles in the regulation of the mitochondrial calcium uniporter

(2014) K. J. Kamer et al.   EMBO REPORTS

SLC25A23 augments mitochondrial Ca2+ uptake, interacts with MCU, and induces oxidative stress–mediated cell death

(2014) Nicholas E. Hoffman et al.   MOLECULAR BIOLOGY OF THE CELL

Proteomic Mapping of the Human Mitochondrial Intermembrane Space in Live Cells via Ratiometric APEX Tagging

(2014) Victoria Hung et al.   MOLECULAR CELL

MICU1 and MICU2 Finely Tune the Mitochondrial Ca2+ Uniporter by Exerting Opposite Effects on MCU Activity

(2014) Maria Patron et al.   MOLECULAR CELL

Molecular and functional identification of a mitochondrial ryanodine receptor in neurons

(2014) Regina Jakob et al.   NEUROSCIENCE LETTERS

Reconstitution of the mitochondrial calcium uniporter in yeast

(2014) E. Kovacs-Bogdan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

LETM1 in mitochondrial cation transport

(2014) Karin Nowikovsky et al.   Frontiers in Physiology

MICU1 Controls Both the Threshold and Cooperative Activation of the Mitochondrial Ca2+ Uniporter

(2013) György Csordás et al.   Cell Metabolism

The mitochondrial calcium uniporter is a multimer that can include a dominant-negative pore-forming subunit

(2013) Anna Raffaello et al.   EMBO JOURNAL

Hallmarks of a new era in mitochondrial biochemistry

(2013) D. J. Pagliarini et al.   GENES & DEVELOPMENT

Trypanosome Letm1 Protein Is Essential for Mitochondrial Potassium Homeostasis

(2013) Hassan Hashimi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Functional reconstitution of the mitochondrial Ca2+/H+antiporter Letm1

(2013) Ming-Feng Tsai et al.   JOURNAL OF GENERAL PHYSIOLOGY

Calcium signaling in cardiac mitochondria

(2013) Elena N. Dedkova et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

The mitochondrial calcium uniporter complex: molecular components, structure and physiopathological implications

(2013) Saverio Marchi et al.   JOURNAL OF PHYSIOLOGY-LONDON

Life without the mitochondrial calcium uniporter

(2013) Sébastien Herzig et al.   NATURE CELL BIOLOGY

The physiological role of mitochondrial calcium revealed by mice lacking the mitochondrial calcium uniporter

(2013) Xin Pan et al.   NATURE CELL BIOLOGY

Characterization of distinct single-channel properties of Ca2+ inward currents in mitochondria

(2013) Alexander I. Bondarenko et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

MICU2, a Paralog of MICU1, Resides within the Mitochondrial Uniporter Complex to Regulate Calcium Handling

(2013) Molly Plovanich et al.   PLoS One

Canonical transient receptor potential 3 channels regulate mitochondrial calcium uptake

(2013) S. Feng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

EMRE Is an Essential Component of the Mitochondrial Calcium Uniporter Complex

(2013) Y. Sancak et al.   SCIENCE

MICU1 Motifs Define Mitochondrial Calcium Uniporter Binding and Activity

(2013) Nicholas E. Hoffman et al.   Cell Reports

MICU1 Is an Essential Gatekeeper for MCU-Mediated Mitochondrial Ca2+ Uptake that Regulates Cell Survival

(2012) Karthik Mallilankaraman et al.   CELL

Downregulation of the Mitochondrial Calcium Uniporter by Cancer-Related miR-25

(2012) Saverio Marchi et al.   CURRENT BIOLOGY

CaMKII determines mitochondrial stress responses in heart

(2012) Mei-ling A. Joiner et al.   NATURE

Engineered ascorbate peroxidase as a genetically encoded reporter for electron microscopy

(2012) Jeffrey D Martell et al.   NATURE BIOTECHNOLOGY

MCUR1 is an essential component of mitochondrial Ca2+ uptake that regulates cellular metabolism

(2012) Karthik Mallilankaraman et al.   NATURE CELL BIOLOGY

Endoplasmic reticulum–mitochondria contacts: function of the junction

(2012) Ashley A. Rowland et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mitochondria as sensors and regulators of calcium signalling

(2012) Rosario Rizzuto et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Evolutionary Diversity of the Mitochondrial Calcium Uniporter

(2012) A. G. Bick et al.   SCIENCE

VDAC1 selectively transfers apoptotic Ca2+ signals to mitochondria

(2011) D De Stefani et al.   CELL DEATH AND DIFFERENTIATION

After half a century mitochondrial calcium in- and efflux machineries reveal themselves

(2011) Ilaria Drago et al.   EMBO JOURNAL

Single Channel Characterization of the Mitochondrial Ryanodine Receptor in Heart Mitoplasts

(2011) Shin-Young Ryu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Calcium Binding and Transport by Coenzyme Q

(2011) Ivan Bogeski et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

VDAC, a multi-functional mitochondrial protein as a pharmacological target

(2011) Varda Shoshan-Barmatz et al.   MITOCHONDRION

Mitochondrial uncoupling protein 2 structure determined by NMR molecular fragment searching

(2011) Marcelo J. Berardi et al.   NATURE

Integrative genomics identifies MCU as an essential component of the mitochondrial calcium uniporter

(2011) Joshua M. Baughman et al.   NATURE

A forty-kilodalton protein of the inner membrane is the mitochondrial calcium uniporter

(2011) Diego De Stefani et al.   NATURE

The fateful encounter of mitochondria with calcium: How did it happen?

(2010) Ernesto Carafoli   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Calcium Signalling: Fishing Out Molecules of Mitochondrial Calcium Transport

(2010) György Hajnóczky et al.   CURRENT BIOLOGY

Mitochondrial ryanodine receptors and other mitochondrial Ca2+ permeable channels

(2010) Shin-Young Ryu et al.   FEBS LETTERS

VDAC, a multi-functional mitochondrial protein regulating cell life and death

(2010) Varda Shoshan-Barmatz et al.   MOLECULAR ASPECTS OF MEDICINE

A sensor for calcium uptake

(2010) Sean Collins et al.   NATURE

MICU1 encodes a mitochondrial EF hand protein required for Ca2+ uptake

(2010) Fabiana Perocchi et al.   NATURE

TRPC channel lipid specificity and mechanisms of lipid regulation

(2009) David J. Beech et al.   CELL CALCIUM

Regulation of the Human Cardiac Mitochondrial Ca 2+ Uptake by 2 Different Voltage-Gated Ca 2+ Channels

(2009) Guido Michels et al.   CIRCULATION

The VDAC1 N-terminus is essential both for apoptosis and the protective effect of anti-apoptotic proteins

(2009) S. Abu-Hamad et al.   JOURNAL OF CELL SCIENCE

Genome-Wide RNAi Screen Identifies Letm1 as a Mitochondrial Ca2+/H+ Antiporter

(2009) D. Jiang et al.   SCIENCE

Biophysical characterization of the EF-hand and SAM domain containing Ca2+ sensory region of STIM1 and STIM2

(2008) Le Zheng et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Structure of the human voltage-dependent anion channel

(2008) M. Bayrhuber et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The crystal structure of mouse VDAC1 at 2.3 A resolution reveals mechanistic insights into metabolite gating

(2008) R. Ujwal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Solution Structure of the Integral Human Membrane Protein VDAC-1 in Detergent Micelles

(2008) S. Hiller et al.   SCIENCE

Mapping the ruthenium red-binding site of the voltage-dependent anion channel-1

(2007) Adrian Israelson et al.   CELL CALCIUM