Hedgehog Cholesterolysis: Specialized Gatekeeper to Oncogenic Signaling

Förster resonance energy transfer-based cholesterolysis assay identifies a novel hedgehog inhibitor

(2015) Timothy S. Owen et al.   ANALYTICAL BIOCHEMISTRY

Hedgehog Signaling and Steroidogenesis

(2015) Isabella Finco et al.   Annual Review of Physiology

Hedgehog signaling stimulates the conversion of cholesterol to steroids

(2015) Chao Tang et al.   CELLULAR SIGNALLING

Hedgehog signaling in prostate epithelial–mesenchymal growth regulation

(2015) Yu-Ching Peng et al.   DEVELOPMENTAL BIOLOGY

Zinc Inhibits Hedgehog Autoprocessing

(2015) Jian Xie et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hedgehog Acyltransferase as a target in estrogen receptor positive, HER2 amplified, and tamoxifen resistant breast cancer cells

(2015) Armine Matevossian et al.   Molecular Cancer

SufB intein ofMycobacterium tuberculosisas a sensor for oxidative and nitrosative stresses

(2015) Natalya I. Topilina et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Active Site Targeting of Hedgehog Precursor Protein with Phenylarsine Oxide

(2014) Timothy S. Owen et al.   CHEMBIOCHEM

Discovery and preclinical development of vismodegib

(2014) Stephen E Gould et al.   Expert Opinion on Drug Discovery

Intein Applications: From Protein Purification and Labeling to Metabolic Control Methods

(2014) David W. Wood et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hedgehog acyltransferase as a target in pancreatic ductal adenocarcinoma

(2014) E Petrova et al.   ONCOGENE

Serum and Tissue Zinc in Epithelial Malignancies: A Meta-Analysis

(2014) Jaromir Gumulec et al.   PLoS One

New chemical probes targeting cholesterylation of Sonic Hedgehog in human cells and zebrafish

(2014) Paulina Ciepla et al.   Chemical Science

Chemical Bypass of Intein-Catalyzed N-S Acyl Shift in Protein Splicing

(2013) Jens Binschik et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Internal Disulfide Bond Acts as a Switch for Intein Activity

(2013) Michael C. Nicastri et al.   BIOCHEMISTRY

The GLI1 splice variant TGLI1 promotes glioblastoma angiogenesis and growth

(2013) Hu Zhu et al.   CANCER LETTERS

TAK-441, a novel investigational smoothened antagonist, delays castration-resistant progression in prostate cancer by disrupting paracrine hedgehog signaling

(2013) Naokazu Ibuki et al.   INTERNATIONAL JOURNAL OF CANCER

Hedgehog Signaling in Prostate Cancer and Its Therapeutic Implication

(2013) Annelies Gonnissen et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Derlin2 Protein Facilitates HRD1-mediated Retro-translocation of Sonic Hedgehog at the Endoplasmic Reticulum

(2013) Chih-Hsiang Huang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Role of HERP and a HERP-related Protein in HRD1-dependent Protein Degradation at the Endoplasmic Reticulum

(2013) Chih-Hsiang Huang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Extein Residues Play an Intimate Role in the Rate-Limiting Step of Protein Trans-Splicing

(2013) Neel H. Shah et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A new role for Hedgehogs in juxtacrine signaling

(2013) Christopher A. Pettigrew et al.   MECHANISMS OF DEVELOPMENT

Inhibitors of Hedgehog acyltransferase block Sonic Hedgehog signaling

(2013) Elissaveta Petrova et al.   Nature Chemical Biology

Unraveling the therapeutic potential of the Hedgehog pathway in cancer

(2013) Dereck Amakye et al.   NATURE MEDICINE

Proteome-wide mapping of cholesterol-interacting proteins in mammalian cells

(2013) Jonathan J Hulce et al.   NATURE METHODS

The mechanisms of Hedgehog signalling and its roles in development and disease

(2013) James Briscoe et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A conserved threonine spring-loads precursor for intein splicing

(2013) Albert K. Dearden et al.   PROTEIN SCIENCE

Secretion and Signaling Activities of Lipoprotein-Associated Hedgehog and Non-Sterol-Modified Hedgehog in Flies and Mammals

(2013) Wilhelm Palm et al.   PLOS BIOLOGY

Hedgehog Signaling Regulates Bladder Cancer Growth and Tumorigenicity

(2012) D. L. Fei et al.   CANCER RESEARCH

Cholesterol and its derivatives in Sonic Hedgehog signaling and cancer

(2012) Natalia A Riobo   CURRENT OPINION IN PHARMACOLOGY

Scube/You activity mediates release of dually lipid-modified Hedgehog signal in soluble form

(2012) A. Creanga et al.   GENES & DEVELOPMENT

Hedgehog signaling in myofibroblasts directly promotes prostate tumor cell growth

(2012) Maribella Domenech et al.   Integrative Biology

Detection of Canonical Hedgehog Signaling in Breast Cancer by 131-Iodine-Labeled Derivatives of the Sonic Hedgehog Protein

(2012) Jennifer Sims-Mourtada et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Protease nexin 1 inhibits hedgehog signaling in prostate adenocarcinoma

(2012) Chad M. McKee et al.   JOURNAL OF CLINICAL INVESTIGATION

Hedgehog inhibitor gets landmark skin cancer approval, but questions remain for wider potential

(2012) Malini Guha   NATURE REVIEWS DRUG DISCOVERY

Dispatched and Scube Mediate the Efficient Secretion of the Cholesterol-Modified Hedgehog Ligand

(2012) Hanna Tukachinsky et al.   Cell Reports

Amide Bonds to the Nitrogen Atoms of Cysteine and Serine as “Weak Points” in the Backbones of Proteins

(2011) Charles A. Lewis et al.   BIOCHEMISTRY

Hedgehog Overexpression Is Associated with Stromal Interactions and Predicts for Poor Outcome in Breast Cancer

(2011) S. A. O'Toole et al.   CANCER RESEARCH

Androgenic regulation of hedgehog signaling pathway components in prostate cancer cells

(2011) Mengqian Chen et al.   CELL CYCLE

Bioorthogonal chemical tagging of protein cholesterylation in living cells

(2011) William P. Heal et al.   CHEMICAL COMMUNICATIONS

Structural and Mutational Studies of a Hyperthermophilic Intein from DNA Polymerase II ofPyrococcus abyssi

(2011) Zhenming Du et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Processing and turnover of the Hedgehog protein in the endoplasmic reticulum

(2011) Xin Chen et al.   JOURNAL OF CELL BIOLOGY

Targeting the Hedgehog Pathway: The development of Cyclopamine and the Development of Anti-Cancer Drugs Targeting the Hedgehog Pathway

(2011) A. Gould et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Abiraterone prolongs survival in metastatic prostate cancer

(2011) Oliver Sartor   Nature Reviews Clinical Oncology

Structure of catalytically competent intein caught in a redox trap with functional and evolutionary implications

(2011) Brian P Callahan et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Lipid Modifications of Sonic Hedgehog Ligand Dictate Cellular Reception and Signal Response

(2011) Vandana K. Grover et al.   PLoS One

Canonical hedgehog signaling augments tumor angiogenesis by induction of VEGF-A in stromal perivascular cells

(2011) W. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Paracrine hedgehog increases the steroidogenic potential of prostate stromal cells in a Gli-dependent manner

(2011) Elina Levina et al.   PROSTATE

Focus Issue: Fine-Tuning Hedgehog Signaling in Development and Disease

(2011) A. M. VanHook   Science Signaling

Hedgehog morphogen: from secretion to reception

(2011) Armel Gallet   TRENDS IN CELL BIOLOGY

Cyclopamine and Hedgehog Signaling: Chemistry, Biology, Medical Perspectives

(2010) Philipp Heretsch et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Activation of Hedgehog Signaling by the Environmental Toxicant Arsenic May Contribute to the Etiology of Arsenic-Induced Tumors

(2010) D. L. Fei et al.   CANCER RESEARCH

Extensive In Vivo Metabolite-Protein Interactions Revealed by Large-Scale Systematic Analyses

(2010) Xiyan Li et al.   CELL

Hedgehog Pathway Antagonist 5E1 Binds Hedgehog at the Pseudo-active Site

(2010) Henry R. Maun et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Clinical Experience With Hedgehog Pathway Inhibitors

(2010) Jennifer A. Low et al.   JOURNAL OF CLINICAL ONCOLOGY

Backbone Dynamics and Global Effects of an Activating Mutation in Minimized Mtu RecA Inteins

(2010) Zhenming Du et al.   JOURNAL OF MOLECULAR BIOLOGY

Spontaneous Proton Transfer to a Conserved Intein Residue Determines On-Pathway Protein Splicing

(2010) Brian Pereira et al.   JOURNAL OF MOLECULAR BIOLOGY

Hedgehog/Gli supports androgen signaling in androgen deprived and androgen independent prostate cancer cells

(2010) Mengqian Chen et al.   Molecular Cancer

Targeting cancer stem cells by inhibiting Wnt, Notch and Hedgehog pathways

(2010) Naoko Takebe et al.   Nature Reviews Clinical Oncology

Arsenic antagonizes the Hedgehog pathway by preventing ciliary accumulation and reducing stability of the Gli2 transcriptional effector

(2010) J. Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Semisynthesis of a Protein with Cholesterol at the C-Terminal, Targeted to the Cell Membrane of Live Cells

(2010) Kenta Teruya et al.   PROTEIN JOURNAL

Paracrine Hedgehog Signaling in Cancer

(2009) J.-W. Theunissen et al.   CANCER RESEARCH

The Full-length Unprocessed Hedgehog Protein Is an Active Signaling Molecule

(2009) Robert Tokhunts et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protein Autoproteolysis: Conformational Strain Linked to the Rate of Peptide Cleavage by the pH Dependence of the N → O Acyl Shift Reaction

(2009) Denny G. A. Johansson et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Sonic hedgehog ligand partners with caveolin-1 for intracellular transport

(2009) Hua Mao et al.   LABORATORY INVESTIGATION

Metal ions binding to recA inteins from Mycobacterium tuberculosis

(2009) Liyun Zhang et al.   Molecular BioSystems

Paracrine sonic hedgehog signalling by prostate cancer cells induces osteoblast differentiation

(2009) Samantha M Zunich et al.   Molecular Cancer

The Sonic Hedgehog pathway stimulates prostate tumor growth by paracrine signaling and recapitulates embryonic gene expression in tumor myofibroblasts

(2009) A Shaw et al.   ONCOGENE

Modulation of intein activity by its neighboring extein substrates

(2009) G. Amitai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Addition of a cholesterol group to an HIV-1 peptide fusion inhibitor dramatically increases its antiviral potency

(2009) P. Ingallinella et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The hedgehog-patched signaling pathway and function in the mammalian ovary: a novel role for hedgehog proteins in stimulating proliferation and steroidogenesis of theca cells

(2009) Leon J Spicer et al.   REPRODUCTION

Smoothened Mutation Confers Resistance to a Hedgehog Pathway Inhibitor in Medulloblastoma

(2009) R. L. Yauch et al.   SCIENCE

Mechanisms of Hedgehog pathway activation in cancer and implications for therapy

(2009) Suzie J. Scales et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

The Adventures of Sonic Hedgehog in Development and Repair. III. Hedgehog processing and biological activity

(2008) Shohreh F. Farzan et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Aberrant activation of hedgehog signaling pathway in ovarian cancers: effect on prognosis, cell invasion and differentiation

(2008) Xiaoyun Liao et al.   CARCINOGENESIS

Nanoscale Organization of Hedgehog Is Essential for Long-Range Signaling

(2008) Neha Vyas et al.   CELL

Hedgehog Signaling in Development and Cancer

(2008) Jin Jiang et al.   DEVELOPMENTAL CELL

Hhat Is a Palmitoylacyltransferase with Specificity forN-Palmitoylation of Sonic Hedgehog

(2008) John A. Buglino et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lipid Modification of Proteins through Sortase-Catalyzed Transpeptidation

(2008) John M. Antos et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A paracrine requirement for hedgehog signalling in cancer

(2008) Robert L. Yauch et al.   NATURE

Multiple roles for lipids in the Hedgehog signalling pathway

(2008) Suzanne Eaton   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Efficient Inhibition of the Alzheimer's Disease  -Secretase by Membrane Targeting

(2008) L. Rajendran et al.   SCIENCE

The Adventures of Sonic Hedgehog in Development and Repair. I. Hedgehog signaling in gastrointestinal development and disease

(2007) Caroline A. Parkin et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY