Mitotic slippage: an old tale with a new twist

Chemoresistance Evolution in Triple-Negative Breast Cancer Delineated by Single-Cell Sequencing

(2018) Charissa Kim et al.   CELL

Cep55 overexpression causes male-specific sterility in mice by suppressing Foxo1 nuclear retention through sustained activation of PI3K/Akt signaling

(2018) Debottam Sinha et al.   FASEB JOURNAL

CEP55 promotes the proliferation, migration and invasion of esophageal squamous cell carcinoma via the PI3K/Akt pathway

(2018) Yang Jia et al.   OncoTargets and Therapy

CEP55 is a determinant of cell fate during perturbed mitosis in breast cancer

(2018) Murugan Kalimutho et al.   EMBO Molecular Medicine

CEP55 Promotes Cell Motility via JAK2–STAT3–MMPs Cascade in Hepatocellular Carcinoma

(2018) Minjing Li et al.   Cells

Centrosomal protein 55 activates NF-κB signalling and promotes pancreatic cancer cells aggressiveness

(2017) Tao Peng et al.   Scientific Reports

Mechanisms and Consequences of Cancer Genome Instability: Lessons from Genome Sequencing Studies

(2016) June-Koo Lee et al.   Annual Review of Pathology-Mechanisms of Disease

Bax assembly into rings and arcs in apoptotic mitochondria is linked to membrane pores

(2016) R. Salvador-Gallego et al.   EMBO JOURNAL

Inactivation of prosurvival Bcl-2 proteins activates Bax/Bak through the outer mitochondrial membrane

(2016) Katelyn L. O'Neill et al.   GENES & DEVELOPMENT

PIM1 kinase inhibition as a targeted therapy against triple-negative breast tumors with elevated MYC expression

(2016) Dai Horiuchi et al.   NATURE MEDICINE

Centromere and kinetochore gene misexpression predicts cancer patient survival and response to radiotherapy and chemotherapy

(2016) Weiguo Zhang et al.   Nature Communications

The Role of Aneuploidy in Cancer Evolution

(2016) Laurent Sansregret et al.   Cold Spring Harbor Perspectives in Medicine

Inhibition of Bcl-xL sensitizes cells to mitotic blockers, but not mitotic drivers

(2016) Ailsa Bennett et al.   Open Biology

MYC Is a Major Determinant of Mitotic Cell Fate

(2015) Caroline Topham et al.   CANCER CELL

Lessons from gain- and loss-of-function models of pro-survival Bcl2 family proteins: implications for targeted therapy

(2015) Maja Sochalska et al.   FEBS Journal

Combined Inhibition of MEK and Plk1 Has Synergistic Antitumor Activity in NRAS Mutant Melanoma

(2015) Christian Posch et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Beyond cytokinesis: the emerging roles of CEP55 in tumorigenesis

(2015) J Jeffery et al.   ONCOGENE

The NOXA–MCL1–BIM axis defines lifespan on extended mitotic arrest

(2015) Manuel D. Haschka et al.   Nature Communications

Structural Model of Active Bax at the Membrane

(2014) Stephanie Bleicken et al.   MOLECULAR CELL

Endocycles: a recurrent evolutionary innovation for post-mitotic cell growth

(2014) Bruce A. Edgar et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Cytotoxicity of Paclitaxel in Breast Cancer Is due to Chromosome Missegregation on Multipolar Spindles

(2014) L. M. Zasadil et al.   Science Translational Medicine

Stressing Mitosis to Death

(2014) Andrew Burgess et al.   Frontiers in Oncology

NEK2 Induces Drug Resistance Mainly through Activation of Efflux Drug Pumps and Is Associated with Poor Prognosis in Myeloma and Other Cancers

(2013) Wen Zhou et al.   CANCER CELL

BimEL is phosphorylated at mitosis by Aurora A and targeted for degradation by βTrCP1

(2013) M Moustafa-Kamal et al.   CELL DEATH AND DIFFERENTIATION

Mitosis and apoptosis: how is the balance set?

(2013) Caroline H Topham et al.   CURRENT OPINION IN CELL BIOLOGY

Patterns of Recurrence and Outcome According to Breast Cancer Subtypes in Lymph Node–Negative Disease: Results From International Breast Cancer Study Group Trials VIII and IX

(2013) Otto Metzger-Filho et al.   JOURNAL OF CLINICAL ONCOLOGY

Control of apoptosis by the BCL-2 protein family: implications for physiology and therapy

(2013) Peter E. Czabotar et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The cancer biology of whole-chromosome instability

(2013) P H G Duijf et al.   ONCOGENE

Mechanisms and insights into drug resistance in cancer

(2013) Hiba Zahreddine et al.   Frontiers in Pharmacology

Inhibitors Targeting Mitosis: Tales of How Great Drugs against a Promising Target Were Brought Down by a Flawed Rationale

(2012) E. Komlodi-Pasztor et al.   CLINICAL CANCER RESEARCH

Cancer cells preferentially lose small chromosomes

(2012) Pascal H.G. Duijf et al.   INTERNATIONAL JOURNAL OF CANCER

Up-regulation of Pro-apoptotic Protein Bim and Down-regulation of Anti-apoptotic Protein Mcl-1 Cooperatively Mediate Enhanced Tumor Cell Death Induced by the Combination of ERK Kinase (MEK) Inhibitor and Microtubule Inhibitor

(2012) Takumi Kawabata et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Signaling Pathways that Regulate Cell Division

(2012) N. Rhind et al.   Cold Spring Harbor Perspectives in Biology

Mitosis-targeted anti-cancer therapies: where they stand

(2012) K-S Chan et al.   Cell Death & Disease

Cytotoxic T Lymphocytes Efficiently Recognize Human Colon Cancer Stem-Like Cells

(2011) Satoko Inoda et al.   AMERICAN JOURNAL OF PATHOLOGY

Navitoclax (ABT-263) Accelerates Apoptosis during Drug-Induced Mitotic Arrest by Antagonizing Bcl-xL

(2011) J. Shi et al.   CANCER RESEARCH

Chromosomal Instability Confers Intrinsic Multidrug Resistance

(2011) A. J. X. Lee et al.   CANCER RESEARCH

Centrosomal Protein 55 (Cep55) Stability Is Negatively Regulated by p53 Protein through Polo-like Kinase 1 (Plk1)

(2011) Yu-Chen Chang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phosphorylation of Mcl-1 by CDK1–cyclin B1 initiates its Cdc20-dependent destruction during mitotic arrest

(2010) Margaret E Harley et al.   EMBO JOURNAL

Prediction of Risk of Distant Recurrence Using the 21-Gene Recurrence Score in Node-Negative and Node-Positive Postmenopausal Patients With Breast Cancer Treated With Anastrozole or Tamoxifen: A TransATAC Study

(2010) Mitch Dowsett et al.   JOURNAL OF CLINICAL ONCOLOGY

Downstream targets of FOXM1: CEP55 and HELLS are cancer progression markers of head and neck squamous cell carcinoma

(2010) Ahmad Waseem et al.   ORAL ONCOLOGY

Cep55/c10orf3, a Tumor Antigen Derived From a Centrosome Residing Protein in Breast Carcinoma

(2009) Satoko Inoda et al.   JOURNAL OF IMMUNOTHERAPY

FOXM1 Upregulation Is an Early Event in Human Squamous Cell Carcinoma and it Is Enhanced by Nicotine during Malignant Transformation

(2009) Emilios Gemenetzidis et al.   PLoS One

Cancer Cells Display Profound Intra- and Interline Variation following Prolonged Exposure to Antimitotic Drugs

(2008) Karen E. Gascoigne et al.   CANCER CELL

The gene expression signature of genomic instability in breast cancer is an independent predictor of clinical outcome

(2008) Jens K. Habermann et al.   INTERNATIONAL JOURNAL OF CANCER

Key role for Bak activation and Bak-Bax interaction in the apoptotic response to vinblastine

(2008) M. Upreti et al.   MOLECULAR CANCER THERAPEUTICS