Endoplasmic Reticulum Stress in the Diabetic Kidney, the Good, the Bad and the Ugly

Febuxostat Ameliorates Diabetic Renal Injury in a Streptozotocin-Induced Diabetic Rat Model

(2014) Hong-Joo Lee et al.   AMERICAN JOURNAL OF NEPHROLOGY

Risk of Metabolic Complications in Kidney Transplantation After Conversion to mTOR Inhibitor: A Systematic Review and Meta-Analysis

(2014) N. Murakami et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Autophagy protects renal tubular cells against cyclosporine toxicity

(2014) Nicolas Pallet et al.   Autophagy

Renal protection by low dose irbesartan in diabetic nephropathy is paralleled by a reduction of inflammation, not of endoplasmic reticulum stress

(2014) Andrea Hartner et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Spliced X-Box Binding Protein 1 Couples the Unfolded Protein Response to Hexosamine Biosynthetic Pathway

(2014) Zhao V. Wang et al.   CELL

Acetaminophen Attenuates Obesity-Related Renal Injury Through ER-Mediated Stress Mechanisms

(2014) Cuifen Wang et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Epidermal Growth Factor Receptor Inhibition Slows Progression of Diabetic Nephropathy in Association With a Decrease in Endoplasmic Reticulum Stress and an Increase in Autophagy

(2014) Ming-Zhi Zhang et al.   DIABETES

Role of endoplasmic reticulum stress in apoptosis of differentiated mouse podocytes induced by high glucose

(2014) YANPING CAO et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Inhibition of ER stress–associated IRE-1/XBP-1 pathway reduces leukemic cell survival

(2014) Chih-Hang Anthony Tang et al.   JOURNAL OF CLINICAL INVESTIGATION

Endoplasmic Reticulum Stress Regulator XBP-1 Contributes to Effector CD8+ T Cell Differentiation during Acute Infection

(2014) D. Kamimura et al.   JOURNAL OF IMMUNOLOGY

Tribbles Homolog 3 Attenuates Mammalian Target of Rapamycin Complex-2 Signaling and Inflammation in the Diabetic Kidney

(2014) E. Borsting et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Protective effects of aliskiren and valsartan in mice with diabetic nephropathy

(2014) Weidong Wang et al.   JOURNAL OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM

VEGF Signals through ATF6 and PERK to Promote Endothelial Cell Survival and Angiogenesis in the Absence of ER Stress

(2014) Evdoxia Karali et al.   MOLECULAR CELL

Liraglutide alleviates diabetic cardiomyopathy by blocking CHOP-triggered apoptosis via the inhibition of the IRE-α pathway

(2014) YUQIANG JI et al.   Molecular Medicine Reports

XBP1 promotes triple-negative breast cancer by controlling the HIF1α pathway

(2014) Xi Chen et al.   NATURE

Emerging functions of the unfolded protein response in immunity

(2014) Sophie Janssens et al.   NATURE IMMUNOLOGY

The unfolded-protein-response sensor IRE-1α regulates the function of CD8α+ dendritic cells

(2014) Fabiola Osorio et al.   NATURE IMMUNOLOGY

Endoplasmic reticulum stress and fungal pathogenesis converge

(2014) David S Askew   Virulence

Endoplasmic reticulum stress signaling: the microRNA connection

(2013) Marion Maurel et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

A mathematical model of the unfolded protein stress response reveals the decision mechanism for recovery, adaptation and apoptosis

(2013) Kamil Erguler et al.   BMC Systems Biology

XBP-1 Is a Cell-Nonautonomous Regulator of Stress Resistance and Longevity

(2013) Rebecca C. Taylor et al.   CELL

Danger signalling during cancer cell death: origins, plasticity and regulation

(2013) A D Garg et al.   CELL DEATH AND DIFFERENTIATION

Receptor for advanced glycation end-products promotes premature senescence of proximal tubular epithelial cells via activation of endoplasmic reticulum stress-dependent p21 signaling

(2013) Jun Liu et al.   CELLULAR SIGNALLING

Endoplasmic Reticulum (ER) Stress and Hypoxia Response Pathways Interact to Potentiate Hypoxia-inducible Factor 1 (HIF-1) Transcriptional Activity on Targets Like Vascular Endothelial Growth Factor (VEGF)

(2013) Ethel R. Pereira et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pleiotropic Potential of Dehydroxymethylepoxyquinomicin for NF- B Suppression via Reactive Oxygen Species and Unfolded Protein Response

(2013) S. Nakajima et al.   JOURNAL OF IMMUNOLOGY

Chronic kidney disease: global dimension and perspectives

(2013) Vivekanand Jha et al.   LANCET

ER-stress-induced transcriptional regulation increases protein synthesis leading to cell death

(2013) Jaeseok Han et al.   NATURE CELL BIOLOGY

Suppression of XBP1S Mediates High Glucose-Induced Oxidative Stress and Extracellular Matrix Synthesis in Renal Mesangial Cell and Kidney of Diabetic Rats

(2013) Decui Shao et al.   PLoS One

Autophagy Attenuates Diabetic Glomerular Damage through Protection of Hyperglycemia-Induced Podocyte Injury

(2013) Li Fang et al.   PLoS One

Involvement of Endoplasmic Reticulum Stress in Albuminuria Induced Inflammasome Activation in Renal Proximal Tubular Cells

(2013) Li Fang et al.   PLoS One

MicroRNA-1291-mediated silencing of IRE1  enhances Glypican-3 expression

(2013) M. Maurel et al.   RNA

Glucagon-Like Peptide-1 Analog Liraglutide Protects against Diabetic Cardiomyopathy by the Inhibition of the Endoplasmic Reticulum Stress Pathway

(2013) Jieyu Liu et al.   Journal of Diabetes Research

Regulation of the transcriptome by ER stress: non-canonical mechanisms and physiological consequences

(2013) Angela M. Arensdorf et al.   Frontiers in Genetics

Characterization of the R162W Kir7.1 mutation associated with snowflake vitreoretinopathy

(2012) Wei Zhang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Emerging role of autophagy in kidney function, diseases and aging

(2012) Tobias B. Huber et al.   Autophagy

Febuxostat suppressed renal ischemia–reperfusion injury via reduced oxidative stress

(2012) Hidetoshi Tsuda et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Overexpression of TCL1 activates the endoplasmic reticulum stress response: a novel mechanism of leukemic progression in mice

(2012) C. L. Kriss et al.   BLOOD

Thioredoxin-Interacting Protein Mediates ER Stress-Induced β Cell Death through Initiation of the Inflammasome

(2012) Christine M. Oslowski et al.   Cell Metabolism

IRE1α Induces Thioredoxin-Interacting Protein to Activate the NLRP3 Inflammasome and Promote Programmed Cell Death under Irremediable ER Stress

(2012) Alana G. Lerner et al.   Cell Metabolism

Central nervous system endoplasmic reticulum stress in a murine model of type 2 diabetes

(2012) C. Sims-Robinson et al.   DIABETOLOGIA

A novel pathway combining calreticulin exposure and ATP secretion in immunogenic cancer cell death

(2012) Abhishek D Garg et al.   EMBO JOURNAL

SLC33A1/AT-1 Protein Regulates the Induction of Autophagy Downstream of IRE1/XBP1 Pathway

(2012) Mariana Pehar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PI3K/Akt pathway mediates high glucose-induced lipid accumulation in human renal proximal tubular cells via spliced XBP-1

(2012) Song Zhao et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

IRE1α activation protects mice against acetaminophen-induced hepatotoxicity

(2012) Kyu Yeon Hur et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Autophagy can repair endoplasmic reticulum stress damage of the passive Heymann nephritis model as revealed by proteomics analysis

(2012) Liyuan Wang et al.   Journal of Proteomics

The intersecting roles of endoplasmic reticulum stress, ubiquitin–proteasome system, and autophagy in the pathogenesis of proteinuric kidney disease

(2012) Andrey V. Cybulsky   KIDNEY INTERNATIONAL

GLP-1 analog liraglutide protects against oxidative stress and albuminuria in streptozotocin-induced diabetic rats via protein kinase A-mediated inhibition of renal NAD(P)H oxidases

(2012) Hari Hendarto et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Toll-like receptor activation suppresses ER stress factor CHOP and translation inhibition through activation of eIF2B

(2012) Connie W. Woo et al.   NATURE CELL BIOLOGY

Extensive Translatome Remodeling during ER Stress Response in Mammalian Cells

(2012) Iván Ventoso et al.   PLoS One

Downregulation of miR-205 Modulates Cell Susceptibility to Oxidative and Endoplasmic Reticulum Stresses in Renal Tubular Cells

(2012) Shiyo Muratsu-Ikeda et al.   PLoS One

The molecular basis for selective inhibition of unconventional mRNA splicing by an IRE1-binding small molecule

(2012) B. C. S. Cross et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IRE1  Cleaves Select microRNAs During ER Stress to Derepress Translation of Proapoptotic Caspase-2

(2012) J.-P. Upton et al.   SCIENCE

Bidirectional crosstalk between endoplasmic reticulum stress and mTOR signaling

(2012) Christian Appenzeller-Herzog et al.   TRENDS IN CELL BIOLOGY

Knockout of Toll-Like Receptor-2 Attenuates Both the Proinflammatory State of Diabetes and Incipient Diabetic Nephropathy

(2011) Sridevi Devaraj et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

mTORC1 serves ER stress-triggered apoptosis via selective activation of the IRE1–JNK pathway

(2011) H Kato et al.   CELL DEATH AND DIFFERENTIATION

The human glucagon-like peptide-1 analogue liraglutide preserves pancreatic beta cells via regulation of cell kinetics and suppression of oxidative and endoplasmic reticulum stress in a mouse model of diabetes

(2011) M. Shimoda et al.   DIABETOLOGIA

Autophagy as a Therapeutic Target in Diabetic Nephropathy

(2011) Yuki Tanaka et al.   Experimental Diabetes Research

Salubrinal, an eIF2α dephosphorylation inhibitor, enhances cisplatin-induced oxidative stress and nephrotoxicity in a mouse model

(2011) Cheng Tien Wu et al.   FREE RADICAL BIOLOGY AND MEDICINE

Control of NF-κB and Inflammation by the Unfolded Protein Response

(2011) Masanori Kitamura   INTERNATIONAL REVIEWS OF IMMUNOLOGY

Potent and Selective Inhibitors of the Inositol-requiring Enzyme 1 Endoribonuclease

(2011) Kori Volkmann et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Role of mTOR in podocyte function and diabetic nephropathy in humans and mice

(2011) Markus Gödel et al.   JOURNAL OF CLINICAL INVESTIGATION

mTORC1 activation in podocytes is a critical step in the development of diabetic nephropathy in mice

(2011) Ken Inoki et al.   JOURNAL OF CLINICAL INVESTIGATION

p38 MAPK–mediated regulation of Xbp1s is crucial for glucose homeostasis

(2011) Jaemin Lee et al.   NATURE MEDICINE

Regulation of glucose homeostasis through a XBP-1–FoxO1 interaction

(2011) Yingjiang Zhou et al.   NATURE MEDICINE

Humanized mouse models to study human diseases

(2011) Michael A Brehm et al.   Current Opinion in Endocrinology Diabetes and Obesity

Metabolic stress promotes renal tubular inflammation by triggering the unfolded protein response

(2011) S Fougeray et al.   Cell Death & Disease

Induction of Diabetes in Aged C57B6 Mice Results in Severe Nephropathy

(2010) Jin Wu et al.   AMERICAN JOURNAL OF PATHOLOGY

Identification of an Ire1alpha endonuclease specific inhibitor with cytotoxic activity against human multiple myeloma

(2010) I. Papandreou et al.   BLOOD

Endoplasmic Reticulum Stress and the Inflammatory Basis of Metabolic Disease

(2010) Gökhan S. Hotamisligil   CELL

Tauroursodeoxycholic Acid May Improve Liver and Muscle but Not Adipose Tissue Insulin Sensitivity in Obese Men and Women

(2010) Marleen Kars et al.   DIABETES

Preconditioning with Endoplasmic Reticulum Stress Mitigates Retinal Endothelial Inflammation via Activation of X-box Binding Protein 1

(2010) Jingming Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Endoplasmic Reticulum Stress Response Mediated by the PERK-eIF2α-ATF4 Pathway Is Involved in Osteoblast Differentiation Induced by BMP2

(2010) Atsushi Saito et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Endoplasmic Reticulum Stress Response Factor CHOP-10 Protects against Hypoxia-induced Neuronal Death

(2010) Marc W. Halterman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of basal cellular physiology by the homeostatic unfolded protein response

(2010) D. Thomas Rutkowski et al.   JOURNAL OF CELL BIOLOGY

Cannabinoid receptor 1 mediates palmitic acid-induced apoptosis via endoplasmic reticulum stress in human renal proximal tubular cells

(2010) J.C. Lim et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Autophagy influences glomerular disease susceptibility and maintains podocyte homeostasis in aging mice

(2010) Björn Hartleben et al.   JOURNAL OF CLINICAL INVESTIGATION

Attenuation of diabetic nephropathy in diabetes rats induced by streptozotocin by regulating the endoplasmic reticulum stress inflammatory response

(2010) Wei Qi et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Transcriptional Regulation of VEGF-A by the Unfolded Protein Response Pathway

(2010) Rajarshi Ghosh et al.   PLoS One

IRE1α Disruption Causes Histological Abnormality of Exocrine Tissues, Increase of Blood Glucose Level, and Decrease of Serum Immunoglobulin Level

(2010) Takao Iwawaki et al.   PLoS One

Effects of 4-phenylbutyric acid on the process and development of diabetic nephropathy induced in rats by streptozotocin: Regulation of endoplasmic reticulum stress-oxidative activation

(2010) Zhi-Feng Luo et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

BiP Binding to the ER-Stress Sensor Ire1 Tunes the Homeostatic Behavior of the Unfolded Protein Response

(2010) David Pincus et al.   PLOS BIOLOGY

3D tomography reveals connections between the phagophore and endoplasmic reticulum

(2009) Päivi Ylä-Anttila et al.   Autophagy

The mTOR pathway is highly activated in diabetic nephropathy and rapamycin has a strong therapeutic potential

(2009) Hiroyuki Mori et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

IRE1α Kinase Activation Modes Control Alternate Endoribonuclease Outputs to Determine Divergent Cell Fates

(2009) Dan Han et al.   CELL

Preventing oxidative stress: a new role for XBP1

(2009) Y Liu et al.   CELL DEATH AND DIFFERENTIATION

Roles for Endoplasmic Reticulum–Associated Degradation and the Novel Endoplasmic Reticulum Stress Response Gene Derlin-3 in the Ischemic Heart

(2009) Peter J. Belmont et al.   CIRCULATION RESEARCH

ACE-inhibitor Suppresses the Apoptosis Induced by Endoplasmic Reticulum Stress in Renal Tubular in Experimental Diabetic Rats

(2009) H. Sun et al.   EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES

Activation of mammalian IRE1α upon ER stress depends on dissociation of BiP rather than on direct interaction with unfolded proteins

(2009) Daisuke Oikawa et al.   EXPERIMENTAL CELL RESEARCH

XBP-1 deficiency in the nervous system protects against amyotrophic lateral sclerosis by increasing autophagy

(2009) C. Hetz et al.   GENES & DEVELOPMENT

Signalling Pathways in the Unfolded Protein Response: Development from Yeast to Mammals

(2009) K. Mori   JOURNAL OF BIOCHEMISTRY

Regulated Ire1-dependent decay of messenger RNAs in mammalian cells

(2009) Julie Hollien et al.   JOURNAL OF CELL BIOLOGY

The Protective Effect of a Newly Developed Molecular Chaperone–Inducer Against Mouse Ischemic Acute Kidney Injury

(2009) Worapat Prachasilchai et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

BAX Inhibitor-1 Is a Negative Regulator of the ER Stress Sensor IRE1α

(2009) Fernanda Lisbona et al.   MOLECULAR CELL

Fine-Tuning of the Unfolded Protein Response: Assembling the IRE1α Interactome

(2009) Claudio Hetz et al.   MOLECULAR CELL

Adaptive suppression of the ATF4–CHOP branch of the unfolded protein response by toll-like receptor signalling

(2009) Connie W. Woo et al.   NATURE CELL BIOLOGY

A subdomain of the endoplasmic reticulum forms a cradle for autophagosome formation

(2009) Mitsuko Hayashi-Nishino et al.   NATURE CELL BIOLOGY

Endoplasmic reticulum stress induces autophagy in renal proximal tubular cells

(2009) T. Kawakami et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Effect of Taurine-Conjugated Ursodeoxycholic Acid on Endoplasmic Reticulum Stress and Apoptosis Induced by Advanced Glycation End Products in Cultured Mouse Podocytes

(2008) Yu Chen et al.   AMERICAN JOURNAL OF NEPHROLOGY

Dysfunction of the ER chaperone BiP accelerates the renal tubular injury

(2008) Keita Kimura et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Apoptosis induced by endoplasmic reticulum stress involved in diabetic kidney disease

(2008) Guanghui Liu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

ATF6 Is a Transcription Factor Specializing in the Regulation of Quality Control Proteins in the Endoplasmic Reticulum

(2008) Yusuke Adachi et al.   CELL STRUCTURE AND FUNCTION

A protective role of unfolded protein response in mouse ischemic acute kidney injury

(2008) Worapat Prachasilchai et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Unraveling the mysteries of protein folding and misfolding

(2008) Heath Ecroyd et al.   IUBMB LIFE

Chemical Biology Investigation of Cell Death Pathways Activated by Endoplasmic Reticulum Stress Reveals Cytoprotective Modulators of ASK1

(2008) InKi Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Proteinuria and Hyperglycemia Induce Endoplasmic Reticulum Stress

(2008) M. T. Lindenmeyer et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Preconditioning with Endoplasmic Reticulum Stress Ameliorates Mesangioproliferative Glomerulonephritis

(2008) R. Inagi et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

JNK1-Mediated Phosphorylation of Bcl-2 Regulates Starvation-Induced Autophagy

(2008) Yongjie Wei et al.   MOLECULAR CELL

From endoplasmic-reticulum stress to the inflammatory response

(2008) Kezhong Zhang et al.   NATURE

Activating transcription factor 4

(2007) Kurosh Ameri et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY