Self-maintenance of neurogenic inflammation contributes to a vicious cycle in skin

Immunomodulatory Effects of Balneotherapy with Hae-Un-Dae Thermal Water on Imiquimod-Induced Psoriasis-Like Murine Model

(2014) Young Bok Lee et al.   Annals of Dermatology

Mechanism of Race-Dependent Platelet Activation Through the Protease-Activated Receptor-4 and Gq Signaling Axis

(2014) Benjamin E. Tourdot et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Enhanced excitability of MRGPRA3- and MRGPRD-positive nociceptors in a model of inflammatory itch and pain

(2014) Lintao Qu et al.   BRAIN

Protease-Activated Receptor 4: A Critical Participator in Inflammatory Response

(2014) Qiang Fu et al.   INFLAMMATION

Cathepsin S Causes Inflammatory PainviaBiased Agonism of PAR2and TRPV4

(2014) Peishen Zhao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Transgenic kallikrein 5 mice reproduce major cutaneous and systemic hallmarks of Netherton syndrome

(2014) Laetitia Furio et al.   JOURNAL OF EXPERIMENTAL MEDICINE

TRPV1, TRPA1, and TRPM8 channels in inflammation, energy redirection, and water retention: role in chronic inflammatory diseases with an evolutionary perspective

(2014) Rainer H. Straub   JOURNAL OF MOLECULAR MEDICINE-JMM

Role of spinal bombesin-responsive neurons in nonhistaminergic itch

(2014) Tasuku Akiyama et al.   JOURNAL OF NEUROPHYSIOLOGY

Regulation of Epithelial Cell Tight Junctions by Protease-Activated Receptor 2

(2014) Shuhei ENJOJI et al.   JOURNAL OF VETERINARY MEDICAL SCIENCE

The contribution of transient receptor potential ankyrin 1 (TRPA1) to the in vivo nociceptive effects of prostaglandin E2

(2014) Marcelo C. Dall'Acqua et al.   LIFE SCIENCES

Calcium entry via TRPV1 but not ASICs induces neuropeptide release from sensory neurons

(2014) Aurélien Boillat et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

B-Type Natriuretic Peptide is Neither Itch-Specific Nor Functions Upstream of the GRP-GRPR Signaling Pathway

(2014) Xian-Yu Liu et al.   Molecular Pain

Nociceptive sensory neurons drive interleukin-23-mediated psoriasiform skin inflammation

(2014) Lorena Riol-Blanco et al.   NATURE

TRPV1 receptor inhibition decreases CCL2-induced hyperalgesia

(2014) Diana Spicarova et al.   NEUROPHARMACOLOGY

Biased Signaling of Protease-Activated Receptors

(2014) Peishen Zhao et al.   Frontiers in Endocrinology

TRPA1: A Transducer and Amplifier of Pain and Inflammation

(2013) Ari Koivisto et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

The Epithelial Cell-Derived Atopic Dermatitis Cytokine TSLP Activates Neurons to Induce Itch

(2013) Sarah R. Wilson et al.   CELL

Netherton syndrome: skin inflammation and allergy by loss of protease inhibition

(2013) Alain Hovnanian   CELL AND TISSUE RESEARCH

Epidermal keratinocyte polarity and motility require Ca2+ influx through TRPV1

(2013) D. M. Graham et al.   JOURNAL OF CELL SCIENCE

Protease-activated receptor 4 activation increases the expression of calcitonin gene-related peptide mRNA and protein in dorsal root ganglion neurons

(2013) Zhaojin Wang et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Neurogenic neuroinflammation: inflammatory CNS reactions in response to neuronal activity

(2013) Dimitris N. Xanthos et al.   NATURE REVIEWS NEUROSCIENCE

Interleukin-1β Increased the Expression of Protease-Activated Receptor 4 mRNA and Protein in Dorsal Root Ganglion Neurons

(2013) Zhaojin Wang et al.   NEUROCHEMICAL RESEARCH

Calcium Mobilization And Protein Kinase C Activation Downstream Of Protease Activated Receptor 4 (PAR4) Is Negatively Regulated By PAR3 In Mouse Platelets

(2013) Amal Arachiche et al.   PLoS One

Human Mas-Related G Protein-Coupled Receptors-X1 Induce Chemokine Receptor 2 Expression in Rat Dorsal Root Ganglia Neurons and Release of Chemokine Ligand 2 from the Human LAD-2 Mast Cell Line

(2013) Hans Jürgen Solinski et al.   PLoS One

Effects of a Skin Neuropeptide (Substance P) on Cutaneous Microflora

(2013) Lily Mijouin et al.   PLoS One

Role of neuropeptides, neurotrophins, and neurohormones in skin wound healing

(2013) Jérémy Chéret et al.   WOUND REPAIR AND REGENERATION

Capsaicin Up-Regulates Protease-Activated Receptor-4 mRNA and Protein in Primary Cultured Dorsal Root Ganglion Neurons

(2012) Dan Chen et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Keratinocyte expression of inflammatory mediators plays a crucial role in substance P-induced acute and chronic pain

(2012) Tzuping Wei et al.   Journal of Neuroinflammation

Transient Receptor Potential Vanilloid 1 — a Polymodal Nociceptive Receptor — Plays a Crucial Role in Formaldehyde-Induced Skin Inflammation in Mice

(2012) Haruki Usuda et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

A subpopulation of nociceptors specifically linked to itch

(2012) Liang Han et al.   NATURE NEUROSCIENCE

TRPA1 ion channel in the spinal dorsal horn as a therapeutic target in central pain hypersensitivity and cutaneous neurogenic inflammation

(2011) Antti Pertovaara et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

TRPA1 is required for histamine-independent, Mas-related G protein–coupled receptor–mediated itch

(2011) Sarah R Wilson et al.   NATURE NEUROSCIENCE

Proteinase-activated receptor 2 sensitizes transient receptor potential vanilloid 1, transient receptor potential vanilloid 4, and transient receptor potential ankyrin 1 in paclitaxel-induced neuropathic pain

(2011) Y. Chen et al.   NEUROSCIENCE

Development of an in vitro coculture of primary sensitive pig neurons and keratinocytes for the study of cutaneous neurogenic inflammation

(2010) Ulysse Pereira et al.   EXPERIMENTAL DERMATOLOGY

Effects of sangre de drago in an in vitro model of cutaneous neurogenic inflammation

(2010) Ulysse Pereira et al.   EXPERIMENTAL DERMATOLOGY

Par2 Inactivation Inhibits Early Production of TSLP, but Not Cutaneous Inflammation, in Netherton Syndrome Adult Mouse Model

(2010) Anaïs Briot et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Protease Activated Receptors 1 and 4 Sensitize TRPV1 in Nociceptive Neurones

(2010) Vittorio Vellani et al.   Molecular Pain

Tetracyclines Modulate Protease-Activated Receptor 2-Mediated Proinflammatory Reactions in Epidermal Keratinocytes

(2009) C. Ishikawa et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Sensory Neuron-Specific GPCR Mrgprs Are Itch Receptors Mediating Chloroquine-Induced Pruritus

(2009) Qin Liu et al.   CELL

Kallikrein 5 induces atopic dermatitis–like lesions through PAR2-mediated thymic stromal lymphopoietin expression in Netherton syndrome

(2009) Anaïs Briot et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Non-Neuronal Expression of Transient Receptor Potential Type A1 (TRPA1) in Human Skin

(2009) Ruzanna Atoyan et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Proteinase-Activated Receptor-4 (PAR4) Activation Leads to Sensitization of Rat Joint Primary Afferents Via a Bradykinin B2 Receptor-Dependent Mechanism

(2009) Fiona A. Russell et al.   JOURNAL OF NEUROPHYSIOLOGY

Activation of protease-activated receptor-4 inhibits the intrinsic excitability of colonic dorsal root ganglia neurons

(2009) r. karanjia et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Neuropeptides activate human mast cell degranulation and chemokine production

(2007) Marianna Kulka et al.   IMMUNOLOGY