Genomics of lipid-laden human hepatocyte cultures enables drug target screening for the treatment of non-alcoholic fatty liver disease
Published 2018 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Genomics of lipid-laden human hepatocyte cultures enables drug target screening for the treatment of non-alcoholic fatty liver disease
Authors
Keywords
Non-alcoholic fatty liver disease (NAFLD), Transcriptomics, LD-associated proteins, Drug targets; nuclear receptor/PPARs, TNFα
Journal
BMC Medical Genomics
Volume 11, Issue 1, Pages -
Publisher
Springer Nature
Online
2018-12-14
DOI
10.1186/s12920-018-0438-7
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Hypoxia-inducible lipid droplet-associated protein inhibits adipose triglyceride lipase
- (2018) Krishna M. Padmanabha Das et al. JOURNAL OF LIPID RESEARCH
- PLIN2 is a Key Regulator of the Unfolded Protein Response and Endoplasmic Reticulum Stress Resolution in Pancreatic β Cells
- (2017) Elaine Chen et al. Scientific Reports
- FoxO1 antagonist suppresses autophagy and lipid droplet growth in adipocytes
- (2016) Longhua Liu et al. CELL CYCLE
- Genomics of human fatty liver disease reveal mechanistically linked lipid droplet–associated gene regulations in bland steatosis and nonalcoholic steatohepatitis
- (2016) Nishika Sahini et al. Translational Research
- Perilipin 2 and Age-Related Metabolic Diseases: A New Perspective
- (2016) Maria Conte et al. TRENDS IN ENDOCRINOLOGY AND METABOLISM
- Metabolic aspects of adult patients with nonalcoholic fatty liver disease
- (2016) Ludovico Abenavoli et al. WORLD JOURNAL OF GASTROENTEROLOGY
- Fatty acid transport proteins: targeting FATP2 as a gatekeeper involved in the transport of exogenous fatty acids
- (2016) Paul N. Black et al. MedChemComm
- Amelioration of nonalcoholic fatty liver disease by hepatic stimulator substance via preservation of carnitine palmitoyl transferase-1 activity
- (2015) Weichun Xiao et al. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
- Fatty acid transport protein-2 inhibitor Grassofermata/CB5 protects cells against lipid accumulation and toxicity
- (2015) Nipun Saini et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Chemical inhibition of fatty acid absorption and cellular uptake limits lipotoxic cell death
- (2015) Constance Ahowesso et al. BIOCHEMICAL PHARMACOLOGY
- The role of fibroblast growth factor 21 in the pathogenesis of non-alcoholic fatty liver disease and implications for therapy
- (2015) Jia Liu et al. METABOLISM-CLINICAL AND EXPERIMENTAL
- Inducible Deletion of Protein Kinase Map4k4 in Obese Mice Improves Insulin Sensitivity in Liver and Adipose Tissues
- (2015) Laura V. Danai et al. MOLECULAR AND CELLULAR BIOLOGY
- FGF21 Revolutions: Recent Advances Illuminating FGF21 Biology and Medicinal Properties
- (2015) Alexei Kharitonenkov et al. TRENDS IN ENDOCRINOLOGY AND METABOLISM
- Vitamin D: A new player in non-alcoholic fatty liver disease?
- (2015) Myrto Eliades WORLD JOURNAL OF GASTROENTEROLOGY
- Genetic polymorphisms and oxidative stress in non-alcoholic steatohepatitis (NASH): A mini review
- (2015) Claudia P. Oliveira et al. Clinics and Research in Hepatology and Gastroenterology
- Regulation of Liver Enriched Transcription Factors in Rat Hepatocytes Cultures on Collagen and EHS Sarcoma Matrices
- (2015) Jürgen Borlak et al. PLoS One
- Characterization of Zebrafish Green Cone Photoresponse Recorded with Pressure-Polished Patch Pipettes, Yielding Efficient Intracellular Dialysis
- (2015) Marco Aquila et al. PLoS One
- FGF21 treatment ameliorates alcoholic fatty liver through activation of AMPK-SIRT1 pathway
- (2014) S. Zhu et al. ACTA BIOCHIMICA ET BIOPHYSICA SINICA
- Roles for Chemokines in Liver Disease
- (2014) Fabio Marra et al. GASTROENTEROLOGY
- Exendin-4 Improves Nonalcoholic Fatty Liver Disease by Regulating Glucose Transporter 4 Expression in ob/ob Mice
- (2014) Seok Kim et al. KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY
- Pharmacological Inhibition of TPL2/MAP3K8 Blocks Human Cytotoxic T Lymphocyte Effector Functions
- (2014) Fatema Z. Chowdhury et al. PLoS One
- Fibroblast Growth Factor 21 Improves Insulin Sensitivity and Synergizes with Insulin in Human Adipose Stem Cell-Derived (hASC) Adipocytes
- (2014) Darwin V. Lee et al. PLoS One
- Fatty acid-inducible ANGPTL4 governs lipid metabolic response to exercise
- (2014) M. Catoire et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Recent insights into the molecular pathophysiology of lipid droplet formation in hepatocytes
- (2014) Nishika Sahini et al. PROGRESS IN LIPID RESEARCH
- How useful are clinical liver function tests in in vitro human hepatotoxicity assays?
- (2014) Jürgen Borlak et al. TOXICOLOGY IN VITRO
- Nonalcoholic fatty liver disease: A comprehensive review of a growing epidemic
- (2014) Kareem Hassan WORLD JOURNAL OF GASTROENTEROLOGY
- Role of endoplasmic reticulum stress in the pathogenesis of nonalcoholic fatty liver disease
- (2014) Xue-Qun Zhang WORLD JOURNAL OF GASTROENTEROLOGY
- Cross-enhancement of ANGPTL4 transcription by HIF1 alpha and PPAR beta/delta is the result of the conformational proximity of two response elements
- (2014) Tsuyoshi Inoue et al. GENOME BIOLOGY
- Long-Chain Acyl Coenzyme A Synthetase 1 Overexpression in Primary Cultured Schwann Cells Prevents Long Chain Fatty Acid-Induced Oxidative Stress and Mitochondrial Dysfunction
- (2013) Lucy M. Hinder et al. ANTIOXIDANTS & REDOX SIGNALING
- Propranolol, a β-adrenoceptor antagonist, worsens liver injury in a model of non-alcoholic steatohepatitis
- (2013) Chad McKee et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Triacylglycerol Synthesis Enzymes Mediate Lipid Droplet Growth by Relocalizing from the ER to Lipid Droplets
- (2013) Florian Wilfling et al. DEVELOPMENTAL CELL
- Structure-guided Development of Specific Pyruvate Dehydrogenase Kinase Inhibitors Targeting the ATP-binding Pocket
- (2013) Shih-Chia Tso et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- SLC27 fatty acid transport proteins
- (2013) Courtney M. Anderson et al. MOLECULAR ASPECTS OF MEDICINE
- The Proteome of Human Liver Peroxisomes: Identification of Five New Peroxisomal Constituents by a Label-Free Quantitative Proteomics Survey
- (2013) Thomas Gronemeyer et al. PLoS One
- Plin2 Inhibits Cellular Glucose Uptake through Interactions with SNAP23, a SNARE Complex Protein
- (2013) Subramanian Senthivinayagam et al. PLoS One
- A Cross-Platform Comparison of Affymetrix and Agilent Microarrays Reveals Discordant miRNA Expression in Lung Tumors of c-Raf Transgenic Mice
- (2013) Valerio Del Vescovo et al. PLoS One
- The Lipid Droplet as a Potential Therapeutic Target in NAFLD
- (2013) Vera Goh et al. SEMINARS IN LIVER DISEASE
- Modulation of the Unfolded Protein Response During Hepatocyte and Cardiomyocyte Apoptosis In Trauma/Hemorrhagic Shock
- (2013) Stephen A. Thacker et al. Scientific Reports
- Consumption of a high-fat diet rapidly exacerbates the development of fatty liver disease that occurs with chronically elevated glucocorticoids
- (2012) Anna M. D'souza et al. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
- Lipid Droplets and Cellular Lipid Metabolism
- (2012) Tobias C. Walther et al. Annual Review of Biochemistry
- Endoplasmic Reticulum Stress in Nonalcoholic Fatty Liver Disease
- (2012) Michael J. Pagliassotti Annual Review of Nutrition
- CIDE Proteins and Lipid Metabolism
- (2012) Li Xu et al. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
- SOCS2 deletion protects against hepatic steatosis but worsens insulin resistance in high-fat-diet-fed mice
- (2012) Fahad Zadjali et al. FASEB JOURNAL
- Stress management: How the unfolded protein response impacts fatty liver disease
- (2012) Dru Imrie et al. JOURNAL OF HEPATOLOGY
- Foxa1 Reduces Lipid Accumulation in Human Hepatocytes and Is Down-Regulated in Nonalcoholic Fatty Liver
- (2012) Marta Moya et al. PLoS One
- Skin-Targeted Inhibition of PPAR β/δ by Selective Antagonists to Treat PPAR β/δ – Mediated Psoriasis-Like Skin Disease In Vivo
- (2012) Katrin Hack et al. PLoS One
- Role of cytokines and chemokines in non-alcoholic fatty liver disease
- (2012) Vincent Braunersreuther WORLD JOURNAL OF GASTROENTEROLOGY
- Meta-analysis: pioglitazone improves liver histology and fibrosis in patients with non-alcoholic steatohepatitis
- (2011) E. Boettcher et al. ALIMENTARY PHARMACOLOGY & THERAPEUTICS
- Enhancing liver mitochondrial fatty acid oxidation capacity in obese mice improves insulin sensitivity independently of hepatic steatosis
- (2011) Julia Monsénégo et al. JOURNAL OF HEPATOLOGY
- The interaction of hepatic lipid and glucose metabolism in liver diseases
- (2011) Lars P. Bechmann et al. JOURNAL OF HEPATOLOGY
- Beneficial Effects of L- and N-type Calcium Channel Blocker on Glucose and Lipid Metabolism and Renal Function in Patients with Hypertension and Type II Diabetes Mellitus
- (2010) Takashi Masuda et al. Cardiovascular Therapeutics
- Acyl-coenzyme A synthetases in metabolic control
- (2010) Jessica M Ellis et al. CURRENT OPINION IN LIPIDOLOGY
- Liver-specific suppressor of cytokine signaling-3 deletion in mice enhances hepatic insulin sensitivity and lipogenesis resulting in fatty liver and obesity1
- (2010) Nirupa Sachithanandan et al. HEPATOLOGY
- Quantitative Analysis of Lipid Droplet Fusion: Inefficient Steady State Fusion but Rapid Stimulation by Chemical Fusogens
- (2010) Samantha Murphy et al. PLoS One
- Histopathology of nonalcoholic fatty liver disease
- (2010) Elizabeth M Brunt WORLD JOURNAL OF GASTROENTEROLOGY
- Identification and characterization of small compound inhibitors of human FATP2
- (2009) Angel Sandoval et al. BIOCHEMICAL PHARMACOLOGY
- Angiopoietin-like 4 (ANGPTL4, Fasting-induced Adipose Factor) Is a Direct Glucocorticoid Receptor Target and Participates in Glucocorticoid-regulated Triglyceride Metabolism
- (2009) Suneil K. Koliwad et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Lipid droplets at a glance
- (2009) Y. Guo et al. JOURNAL OF CELL SCIENCE
- Endocytosis of flotillin-1 and flotillin-2 is regulated by Fyn kinase
- (2009) K. Riento et al. JOURNAL OF CELL SCIENCE
- Clathrin- and Dynamin-Dependent Endocytic Pathway Regulates Muramyl Dipeptide Internalization and NOD2 Activation
- (2009) N. Marina-Garcia et al. JOURNAL OF IMMUNOLOGY
- Toxicogenomics Applied to Cultures of Human Hepatocytes Enabled an Identification of Novel Petasites hybridus Extracts for the Treatment of Migraine with Improved Hepatobiliary Safety
- (2009) Nora Anderson et al. TOXICOLOGICAL SCIENCES
- Biochemical and physiological function of stearoyl-CoA desaturase
- (2008) Chad M. Paton et al. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
- Fibroblast Growth Factor 21 Corrects Obesity in Mice
- (2008) Tamer Coskun et al. ENDOCRINOLOGY
- Molecular Mechanisms and Therapeutic Targets in Steatosis and Steatohepatitis
- (2008) N. Anderson et al. PHARMACOLOGICAL REVIEWS
Add your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload NowAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started