How I treat infant leukemia

Trametinib inhibits RAS -mutant MLL -rearranged acute lymphoblastic leukemia at specific niche sites and reduces ERK phosphorylation in vivo

(2018) Mark Kerstjens et al.   HAEMATOLOGICA

Trametinib inhibits RAS -mutant MLL -rearranged acute lymphoblastic leukemia at specific niche sites and reduces ERK phosphorylation in vivo

(2018) Mark Kerstjens et al.   HAEMATOLOGICA

The MLL recombinome of acute leukemias in 2017

(2017) C Meyer et al.   LEUKEMIA

The HDAC inhibitor panobinostat (LBH589) exerts in vivo anti-leukaemic activity against MLL-rearranged acute lymphoblastic leukaemia and involves the RNF20/RNF40/WAC-H2B ubiquitination axis

(2017) P Garrido Castro et al.   LEUKEMIA

Acquisition of a CD19-negative myeloid phenotype allows immune escape of MLL-rearranged B-ALL from CD19 CAR-T-cell therapy

(2016) R. Gardner et al.   BLOOD

Subclonality and prenatal origin ofRASmutations inKMT2A (MLL)-rearranged infant acute lymphoblastic leukaemia

(2015) Mariana Emerenciano et al.   BRITISH JOURNAL OF HAEMATOLOGY

Clinical and molecular genetic characterization of wild-type MLL infant acute lymphoblastic leukemia identifies few recurrent abnormalities

(2015) M. H. van der Linden et al.   HAEMATOLOGICA

The landscape of somatic mutations in infant MLL-rearranged acute lymphoblastic leukemias

(2015) Anna K Andersson et al.   NATURE GENETICS

Characterization of CD22 expression in acute lymphoblastic leukemia

(2015) Nirali N. Shah et al.   PEDIATRIC BLOOD & CANCER

Clinical and molecular genetic characterization of wild-type MLL infant acute lymphoblastic leukemia identifies few recurrent abnormalities

(2015) M. H. van der Linden et al.   HAEMATOLOGICA

Plerixafor as a chemosensitizing agent in pediatric acute lymphoblastic leukemia: efficacy and potential mechanisms of resistance to CXCR4 inhibition

(2015) Edward Allan R. Sison et al.   Oncotarget

Identification of CD34+ and CD34- leukemia-initiating cells in MLL-rearranged human acute lymphoblastic leukemia

(2014) Y. Aoki et al.   BLOOD

Gemtuzumab Ozogamicin in Children and Adolescents With De Novo Acute Myeloid Leukemia Improves Event-Free Survival by Reducing Relapse Risk: Results From the Randomized Phase III Children's Oncology Group Trial AAML0531

(2014) Alan S. Gamis et al.   JOURNAL OF CLINICAL ONCOLOGY

Potent inhibition of DOT1L as treatment of MLL-fusion leukemia

(2013) S. R. Daigle et al.   BLOOD

Leukemic transformation by the MLL-AF6 fusion oncogene requires the H3K79 methyltransferase Dot1l

(2013) A. J. Deshpande et al.   BLOOD

MLL-rearranged acute lymphoblastic leukaemia stem cell interactions with bone marrow stroma promote survival and therapeutic resistance that can be overcome with CXCR4 antagonism

(2013) Edward Allan R. Sison et al.   BRITISH JOURNAL OF HAEMATOLOGY

The silent mutational landscape of infantMLL-AF4pro-B acute lymphoblastic leukemia

(2013) Sara E. Dobbins et al.   GENES CHROMOSOMES & CANCER

Frequencies and prognostic impact of RAS mutations in MLL-rearranged acute lymphoblastic leukemia in infants

(2013) E. M. C. Driessen et al.   HAEMATOLOGICA

Cytogenetics and outcome of infants with acute lymphoblastic leukemia and absence of MLL rearrangements

(2013) P De Lorenzo et al.   LEUKEMIA

Dynamic Chemotherapy-Induced Upregulation of CXCR4 Expression: A Mechanism of Therapeutic Resistance in Pediatric AML

(2013) E. A. R. Sison et al.   MOLECULAR CANCER RESEARCH

Does hematopoietic stem cell transplantation benefit infants with acute leukemia?

(2013) E. A. R. Sison et al.   Hematology-American Society of Hematology Education Program

Epigenetic reprogramming reverses the relapse-specific gene expression signature and restores chemosensitivity in childhood B-lymphoblastic leukemia

(2012) T. Bhatla et al.   BLOOD

Absence of global hypomethylation in promoter hypermethylated Mixed Lineage Leukaemia-rearranged infant acute lymphoblastic leukaemia

(2012) Dominique J.P.M. Stumpel et al.   EUROPEAN JOURNAL OF CANCER

Improved Survival for Children and Adolescents With Acute Lymphoblastic Leukemia Between 1990 and 2005: A Report From the Children's Oncology Group

(2012) Stephen P. Hunger et al.   JOURNAL OF CLINICAL ONCOLOGY

Abrogation of MLL–AF10 and CALM–AF10-mediated transformation through genetic inactivation or pharmacological inhibition of the H3K79 methyltransferase Dot1l

(2012) L Chen et al.   LEUKEMIA

Suppression of the let-7b microRNA pathway by DNA hypermethylation in infant acute lymphoblastic leukemia with MLL gene rearrangements

(2012) M Nishi et al.   LEUKEMIA

Prognostic significance of FLT3 mutational status and expression levels in MLL-AF4+ and MLL-germline acute lymphoblastic leukemia

(2012) M C Chillón et al.   LEUKEMIA

Genetic variants modify susceptibility to leukemia in infants: A Children's Oncology Group report

(2012) Julie A. Ross et al.   PEDIATRIC BLOOD & CANCER

Gene expression profiles predictive of outcome and age in infant acute lymphoblastic leukemia: a Children's Oncology Group study

(2011) H. Kang et al.   BLOOD

DOT1L, the H3K79 methyltransferase, is required for MLL-AF9-mediated leukemogenesis

(2011) A. T. Nguyen et al.   BLOOD

Results of a randomized trial in children with Acute Myeloid Leukaemia: Medical Research Council AML12 trial

(2011) Brenda E. S. Gibson et al.   BRITISH JOURNAL OF HAEMATOLOGY

Selective Killing of Mixed Lineage Leukemia Cells by a Potent Small-Molecule DOT1L Inhibitor

(2011) Scott R. Daigle et al.   CANCER CELL

MLL-Rearranged Leukemia Is Dependent on Aberrant H3K79 Methylation by DOT1L

(2011) Kathrin M. Bernt et al.   CANCER CELL

Connectivity mapping identifies HDAC inhibitors for the treatment of t(4;11)-positive infant acute lymphoblastic leukemia

(2011) D J P M Stumpel et al.   LEUKEMIA

Favorable outcome in infants with AML after intensive first- and second-line treatment: an AML-BFM study group report

(2011) U Creutzig et al.   LEUKEMIA

RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia

(2011) Johannes Zuber et al.   NATURE

Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia

(2011) Mark A. Dawson et al.   NATURE

Improved outcome with hematopoietic stem cell transplantation in a poor prognostic subgroup of infants with mixed-lineage-leukemia (MLL)-rearranged acute lymphoblastic leukemia: results from the Interfant-99 Study

(2010) G. Mann et al.   BLOOD

Promoter hypermethylation in MLL-r infant acute lymphoblastic leukemia: biology and therapeutic targeting

(2010) E. Schafer et al.   BLOOD

Cytogenetics of Childhood Acute Myeloid Leukemia: United Kingdom Medical Research Council Treatment Trials AML 10 and 12

(2010) Christine J. Harrison et al.   JOURNAL OF CLINICAL ONCOLOGY

Hypermethylation of specific microRNA genes in MLL-rearranged infant acute lymphoblastic leukemia: major matters at a micro scale

(2010) D J P M Stumpel et al.   LEUKEMIA

Implementation of array based whole-genome high-resolution technologies confirms the absence of secondary copy-number alterations in MLL-AF4-positive infant ALL patients

(2010) M Bardini et al.   LEUKEMIA

Specific promoter methylation identifies different subgroups of MLL-rearranged infant acute lymphoblastic leukemia, influences clinical outcome, and provides therapeutic options

(2009) D. J. P. M. Stumpel et al.   BLOOD

Gene expression profiling-based dissection of MLL translocated and MLL germline acute lymphoblastic leukemia in infants

(2009) R. W. Stam et al.   BLOOD

Novel prognostic subgroups in childhood 11q23/MLL-rearranged acute myeloid leukemia: results of an international retrospective study

(2009) B. V. Balgobind et al.   BLOOD

Prognostic significance of minimal residual disease in infants with acute lymphoblastic leukemia treated within the Interfant-99 protocol

(2009) V H J Van der Velden et al.   LEUKEMIA

DNA copy-number abnormalities do not occur in infant ALL with t(4;11)/MLL-AF4

(2009) M Bardini et al.   LEUKEMIA

Treating Childhood Acute Lymphoblastic Leukemia without Cranial Irradiation

(2009) Ching-Hon Pui et al.   NEW ENGLAND JOURNAL OF MEDICINE

Outcome of recurrent or refractory acute lymphoblastic leukemia in infants withMLLgene rearrangements: A report from the Japan infant leukemia study group

(2009) Daisuke Tomizawa et al.   PEDIATRIC BLOOD & CANCER

Pharmacokinetics of high-dose methotrexate in infants treated for acute lymphoblastic leukemia

(2009) Gudmar Lönnerholm et al.   PEDIATRIC BLOOD & CANCER

In Childhood Acute Lymphoblastic Leukemia, Blasts at Different Stages of Immunophenotypic Maturation Have Stem Cell Properties

(2008) Christoph le Viseur et al.   CANCER CELL