Visions of Eye Commensals: The Known and the Unknown About How the Microbiome Affects Eye Disease

Neuroinflammation in glaucoma: A new opportunity

(2017) Pete A. Williams et al.   EXPERIMENTAL EYE RESEARCH

Homeostatic Immunity and the Microbiota

(2017) Yasmine Belkaid et al.   IMMUNITY

An Ocular Commensal Protects against Corneal Infection by Driving an Interleukin-17 Response from Mucosal γδ T Cells

(2017) Anthony J. St. Leger et al.   IMMUNITY

Two rheumatoid arthritis–specific autoantigens correlate microbial immunity with autoimmune responses in joints

(2017) Annalisa Pianta et al.   JOURNAL OF CLINICAL INVESTIGATION

Treg-recruiting microspheres prevent inflammation in a murine model of dry eye disease

(2017) Michelle L. Ratay et al.   JOURNAL OF CONTROLLED RELEASE

The Pathophysiology of Dry Eye Disease

(2017) Stephen C. Pflugfelder et al.   OPHTHALMOLOGY

Involvement of a gut–retina axis in protection against dietary glycemia-induced age-related macular degeneration

(2017) Sheldon Rowan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Oral administration of Clostridium butyricum CGMCC0313-1 inhibits β-lactoglobulin-induced intestinal anaphylaxis in a mouse model of food allergy

(2017) Juan Zhang et al.   Gut Pathogens

Short chain fatty acids ameliorate immune-mediated uveitis partially by altering migration of lymphocytes from the intestine

(2017) Yukiko K. Nakamura et al.   Scientific Reports

Distinct Microbial Communities Trigger Colitis Development upon Intestinal Barrier Damage via Innate or Adaptive Immune Cells

(2017) Urmi Roy et al.   Cell Reports

Probiotics in Asthma and Allergy Prevention

(2017) Maurizio Mennini et al.   Frontiers in Pediatrics

Temporal Stability and Composition of the Ocular Surface Microbiome

(2017) Jerome Ozkan et al.   Scientific Reports

Defining the normal core microbiome of conjunctival microbial communities

(2016) Y. Huang et al.   CLINICAL MICROBIOLOGY AND INFECTION

Emerging therapeutics for ocular surface disease

(2016) Brett P. Bielory et al.   Current Opinion in Allergy and Clinical Immunology

The interaction between host genetics and the microbiome in the pathogenesis of spondyloarthropathies

(2016) Mark Asquith et al.   CURRENT OPINION IN RHEUMATOLOGY

Microbial antigen mimics activate diabetogenic CD8 T cells in NOD mice

(2016) Ningwen Tai et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Age-related spontaneous lacrimal keratoconjunctivitis is accompanied by dysfunctional T regulatory cells

(2016) T G Coursey et al.   Mucosal Immunology

Impact of Microbiome on Ocular Health

(2016) Abirami Kugadas et al.   Ocular Surface

Changes in the Eye Microbiota Associated with Contact Lens Wearing

(2016) Hakdong Shin et al.   mBio

Impact of Microbiota on Resistance to Ocular Pseudomonas aeruginosa-Induced Keratitis

(2016) Abirami Kugadas et al.   PLoS Pathogens

Altered Mucosal Microbiome Diversity and Disease Severity in Sjögren Syndrome

(2016) Cintia S. de Paiva et al.   Scientific Reports

Microbiota-Dependent Activation of an Autoreactive T Cell Receptor Provokes Autoimmunity in an Immunologically Privileged Site

(2015) Reiko Horai et al.   IMMUNITY

Extraintestinal Manifestations of Inflammatory Bowel Disease

(2015) Stephan R. Vavricka et al.   INFLAMMATORY BOWEL DISEASES

The microbiome, HLA, and the pathogenesis of uveitis

(2015) James T. Rosenbaum et al.   JAPANESE JOURNAL OF OPHTHALMOLOGY

Randomized Trial of Peanut Consumption in Infants at Risk for Peanut Allergy

(2015) George Du Toit et al.   NEW ENGLAND JOURNAL OF MEDICINE

Identification of Torque Teno Virus in Culture-Negative Endophthalmitis by Representational Deep DNA Sequencing

(2015) Aaron Y. Lee et al.   OPHTHALMOLOGY

Considerations in Understanding the Ocular Surface Microbiome

(2014) Michael E. Zegans et al.   AMERICAN JOURNAL OF OPHTHALMOLOGY

Human Corneal Epithelial Cells Produce Antimicrobial Peptides LL-37 and β-Defensins in Response to Heat-Killed Candida albicans

(2014) Xia Hua et al.   OPHTHALMIC RESEARCH

Oral Microbiome Link to Neurodegeneration in Glaucoma

(2014) Konstantin Astafurov et al.   PLoS One

Antimicrobial compounds in tears

(2013) Alison M. McDermott   EXPERIMENTAL EYE RESEARCH

Conjunctival Inflammation in Thrombospondin-1 Deficient Mouse Model of Sjögren’s Syndrome

(2013) Laura Contreras-Ruiz et al.   PLoS One

Development, Alteration and Real Time Dynamics of Conjunctiva-Associated Lymphoid Tissue

(2013) Sebastian Siebelmann et al.   PLoS One

Sex Differences in the Gut Microbiome Drive Hormone-Dependent Regulation of Autoimmunity

(2013) J. G. M. Markle et al.   SCIENCE

Critical Role for Mast Cells in Interleukin-1β-Driven Skin Inflammation Associated with an Activating Mutation in the Nlrp3 Protein

(2012) Yuumi Nakamura et al.   IMMUNITY

Cytokeratins mediate epithelial innate defense through their antimicrobial properties

(2012) Connie Tam et al.   JOURNAL OF CLINICAL INVESTIGATION

The Genus Corynebacterium and Other Medically Relevant Coryneform-Like Bacteria

(2012) K. Bernard   JOURNAL OF CLINICAL MICROBIOLOGY

NK Cells Promote Th-17 Mediated Corneal Barrier Disruption in Dry Eye

(2012) Xiaobo Zhang et al.   PLoS One

Conjunctiva-associated lymphoid tissue in avian mucosal immunity

(2011) F.W. van Ginkel et al.   DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY

Role of IL-17 and Th17 Cells in Herpes Simplex Virus-Induced Corneal Immunopathology

(2011) A. Suryawanshi et al.   JOURNAL OF IMMUNOLOGY

Commensal microbiota and myelin autoantigen cooperate to trigger autoimmune demyelination

(2011) Kerstin Berer et al.   NATURE

Germ-free C57BL/6J mice are resistant to high-fat-diet-induced insulin resistance and have altered cholesterol metabolism

(2010) Sylvie Rabot et al.   FASEB JOURNAL

Role of Defensins in Corneal Epithelial Barrier Function againstPseudomonas aeruginosaTraversal

(2010) Danielle K. Augustin et al.   INFECTION AND IMMUNITY

The impact of the microbiota on the pathogenesis of IBD: lessons from mouse infection models

(2010) Sandra Nell et al.   NATURE REVIEWS MICROBIOLOGY

Reversible Microbial Colonization of Germ-Free Mice Reveals the Dynamics of IgA Immune Responses

(2010) S. Hapfelmeier et al.   SCIENCE

Induction of Colonic Regulatory T Cells by Indigenous Clostridium Species

(2010) K. Atarashi et al.   SCIENCE

Induction of Intestinal Th17 Cells by Segmented Filamentous Bacteria

(2009) Ivaylo I. Ivanov et al.   CELL

A Mutation in the Nlrp3 Gene Causing Inflammasome Hyperactivation Potentiates Th17 Cell-Dominant Immune Responses

(2009) Guangxun Meng et al.   IMMUNITY

Role of Th17 cells in the immunopathogenesis of dry eye disease

(2009) S K Chauhan et al.   Mucosal Immunology

Lymphoid tissue genesis induced by commensals through NOD1 regulates intestinal homeostasis

(2008) Djahida Bouskra et al.   NATURE

ATP drives lamina propria TH17 cell differentiation

(2008) Koji Atarashi et al.   NATURE