The role of metal ions in the virulence and viability of bacterial pathogens

New Insights into the Role of Zinc Acquisition and Zinc Tolerance in Group A Streptococcal Infection

(2018) Cheryl-lynn Y. Ong et al.   INFECTION AND IMMUNITY

Mechanistic insights into staphylopine-mediated metal acquisition

(2018) Liqiang Song et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A new role for Zinc limitation in bacterial pathogenicity: modulation of α-hemolysin from uropathogenic Escherichia coli

(2018) Elsa Velasco et al.   Scientific Reports

Metal homeostasis and resistance in bacteria

(2017) Pete Chandrangsu et al.   NATURE REVIEWS MICROBIOLOGY

The Metallophore Staphylopine Enables Staphylococcus aureus To Compete with the Host for Zinc and Overcome Nutritional Immunity

(2017) Kyle P. Grim et al.   mBio

A Superoxide Dismutase Capable of Functioning with Iron or Manganese Promotes the Resistance of Staphylococcus aureus to Calprotectin and Nutritional Immunity

(2017) Yuritzi M. Garcia et al.   PLoS Pathogens

Pseudomonas aeruginosa zinc uptake in chelating environment is primarily mediated by the metallophore pseudopaline

(2017) Sébastien Lhospice et al.   Scientific Reports

Hemolysin of uropathogenic Escherichia coli: A cloak or a dagger?

(2016) Laura C. Ristow et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Salmonella employs multiple mechanisms to subvert the TLR-inducible zinc-mediated antimicrobial response of human macrophages

(2016) Ronan Kapetanovic et al.   FASEB JOURNAL

Bacterial Strategies to Maintain Zinc Metallostasis at the Host-Pathogen Interface

(2016) Daiana A. Capdevila et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Biosynthesis of a broad-spectrum nicotianamine-like metallophore in Staphylococcus aureus

(2016) G. Ghssein et al.   SCIENCE

The Role of Copper and Zinc Toxicity in Innate Immune Defense against Bacterial Pathogens

(2015) Karrera Y. Djoko et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Metal binding spectrum and model structure of the Bacillus anthracis virulence determinant MntA

(2015) Elena Vigonsky et al.   Metallomics

Copper intoxication inhibits aerobic nucleotide synthesis in Streptococcus pneumoniae

(2015) Michael D. L. Johnson et al.   Metallomics

Copper tolerance and virulence in bacteria

(2015) Erik Ladomersky et al.   Metallomics

The capability of Pseudomonas aeruginosa to recruit zinc under conditions of limited metal availability is affected by inactivation of the ZnuABC transporter

(2015) Melania D'Orazio et al.   Metallomics

Human calprotectin is an iron-sequestering host-defense protein

(2015) Toshiki G Nakashige et al.   Nature Chemical Biology

Dysregulation of transition metal ion homeostasis is the molecular basis for cadmium toxicity in Streptococcus pneumoniae

(2015) Stephanie L. Begg et al.   Nature Communications

Zinc disrupts central carbon metabolism and capsule biosynthesis in Streptococcus pyogenes

(2015) Cheryl-lynn Y. Ong et al.   Scientific Reports

ZnuA and zinc homeostasis in Pseudomonas aeruginosa

(2015) Victoria G. Pederick et al.   Scientific Reports

Apo, Zn2+-bound and Mn2+-bound structures reveal ligand-binding properties of SitA from the pathogenStaphylococcus pseudintermedius

(2014) Francesca Abate et al.   BIOSCIENCE REPORTS

The Mismetallation of Enzymes during Oxidative Stress

(2014) James A. Imlay   JOURNAL OF BIOLOGICAL CHEMISTRY

Metal Preferences and Metallation

(2014) Andrew W. Foster et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Bacillithiol is a major buffer of the labile zinc pool inBacillus subtilis

(2014) Zhen Ma et al.   MOLECULAR MICROBIOLOGY

Extracellular Zinc Competitively Inhibits Manganese Uptake and Compromises Oxidative Stress Management in Streptococcus pneumoniae

(2014) Bart A. Eijkelkamp et al.   PLoS One

Escape from bacterial iron piracy through rapid evolution of transferrin

(2014) M. F. Barber et al.   SCIENCE

The Host Protein Calprotectin Modulates the Helicobacter pylori cag Type IV Secretion System via Zinc Sequestration

(2014) Jennifer A. Gaddy et al.   PLoS Pathogens

Pathogenic adaptations to host-derived antibacterial copper

(2014) Kaveri S. Chaturvedi et al.   Frontiers in Cellular and Infection Microbiology

Antimicrobial Action of Copper Is Amplified via Inhibition of Heme Biosynthesis

(2013) Karrera Y. Djoko et al.   ACS Chemical Biology

Metal ions in macrophage antimicrobial pathways: emerging roles for zinc and copper

(2013) Sian L. Stafford et al.   BIOSCIENCE REPORTS

Bacterial killing in macrophages and amoeba: do they all use a brass dagger?

(2013) Nadezhda German et al.   Future Microbiology

Porins Increase Copper Susceptibility of Mycobacterium tuberculosis

(2013) A. Speer et al.   JOURNAL OF BACTERIOLOGY

Copper Efflux Is Induced during Anaerobic Amino Acid Limitation in Escherichia coli To Protect Iron-Sulfur Cluster Enzymes and Biogenesis

(2013) D. K. C. Fung et al.   JOURNAL OF BACTERIOLOGY

A Manganese-rich Environment Supports Superoxide Dismutase Activity in a Lyme Disease Pathogen,Borrelia burgdorferi

(2013) J. Dafhne Aguirre et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

High-Affinity Manganese Coordination by Human Calprotectin Is Calcium-Dependent and Requires the Histidine-Rich Site Formed at the Dimer Interface

(2013) Joshua A. Hayden et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Imperfect coordination chemistry facilitates metal ion release in the Psa permease

(2013) Rafael M Couñago et al.   Nature Chemical Biology

Antimicrobial activity of metals: mechanisms, molecular targets and applications

(2013) Joseph A. Lemire et al.   NATURE REVIEWS MICROBIOLOGY

Molecular basis for manganese sequestration by calprotectin and roles in the innate immune response to invading bacterial pathogens

(2013) S. M. Damo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Competition for zinc binding in the host-pathogen interaction

(2013) Mauro Cerasi et al.   Frontiers in Cellular and Infection Microbiology

The roles of transition metals in the physiology and pathogenesis of Streptococcus pneumoniae

(2013) Erin S. Honsa et al.   Frontiers in Cellular and Infection Microbiology

Lactoferrin – 50 years on

(2012) Jeremy H. Brock   Biochemistry and Cell Biology

Copper in Microbial Pathogenesis: Meddling with the Metal

(2012) Marie I. Samanovic et al.   Cell Host & Microbe

Borrelia burgdorferi, a Pathogen That Lacks Iron, Encodes Manganese-dependent Superoxide Dismutase Essential for Resistance to Streptonigrin

(2012) Bryan Troxell et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nutritional immunity: transition metals at the pathogen–host interface

(2012) M. Indriati Hood et al.   NATURE REVIEWS MICROBIOLOGY

Metallobiology of host–pathogen interactions: an intoxicating new insight

(2012) Hélène Botella et al.   TRENDS IN MICROBIOLOGY

Interaction of Lipocalin 2, Transferrin, and Siderophores Determines the Replicative Niche of Klebsiella pneumoniae during Pneumonia

(2012) M. A. Bachman et al.   mBio

Identification of an Acinetobacter baumannii Zinc Acquisition System that Facilitates Resistance to Calprotectin-mediated Zinc Sequestration

(2012) M. Indriati Hood et al.   PLoS Pathogens

Mycobacterial P1-Type ATPases Mediate Resistance to Zinc Poisoning in Human Macrophages

(2011) Hélène Botella et al.   Cell Host & Microbe

Nutrient Metal Sequestration by Calprotectin Inhibits Bacterial Superoxide Defense, Enhancing Neutrophil Killing of Staphylococcus aureus

(2011) Thomas E. Kehl-Fie et al.   Cell Host & Microbe

Phenotypic Characterization of acopAMutant of Neisseria gonorrhoeae Identifies a Link between Copper and Nitrosative Stress

(2011) Karrera Y. Djoko et al.   INFECTION AND IMMUNITY

Staphylococcus lugdunensis IsdG Liberates Iron from Host Heme

(2011) K. P. Haley et al.   JOURNAL OF BACTERIOLOGY

Copper toxicity and the origin of bacterial resistance—new insights and applications

(2011) Christopher L. Dupont et al.   Metallomics

The combined actions of the copper-responsive repressor CsoR and copper-metallochaperone CopZ modulate CopA-mediated copper efflux in the intracellular pathogen Listeria monocytogenes

(2011) David Corbett et al.   MOLECULAR MICROBIOLOGY

The alternative aerobic ribonucleotide reductase of Escherichia coli, NrdEF, is a manganese-dependent enzyme that enables cell replication during periods of iron starvation

(2011) Julia E. Martin et al.   MOLECULAR MICROBIOLOGY

The cop operon is required for copper homeostasis and contributes to virulence in Streptococcus pneumoniae

(2011) Sulman Shafeeq et al.   MOLECULAR MICROBIOLOGY

Copper resistance is essential for virulence of Mycobacterium tuberculosis

(2011) F. Wolschendorf et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Molecular Mechanism for Bacterial Susceptibility to Zinc

(2011) Christopher A. McDevitt et al.   PLoS Pathogens

Molecular Mechanisms ofStaphylococcus aureusIron Acquisition

(2010) Neal D. Hammer et al.   Annual Review of Microbiology

A critical review of the roles of host lactoferrin in immunity

(2010) Dominique Legrand et al.   BIOMETALS

Staphylococcus aureus Fur Regulates the Expression of Virulence Factors That Contribute to the Pathogenesis of Pneumonia

(2010) V. J. Torres et al.   INFECTION AND IMMUNITY

The Multi-Copper-Ion Oxidase CueO of Salmonella enterica Serovar Typhimurium Is Required for Systemic Virulence

(2010) M. E. S. Achard et al.   INFECTION AND IMMUNITY

Copper Stress Affects Iron Homeostasis by Destabilizing Iron-Sulfur Cluster Formation in Bacillus subtilis

(2010) S. Chillappagari et al.   JOURNAL OF BACTERIOLOGY

Copper Homeostasis inSalmonellaIs Atypical and Copper-CueP Is a Major Periplasmic Metal Complex

(2010) Deenah Osman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A novel copper-responsive regulon in Mycobacterium tuberculosis

(2010) Richard A. Festa et al.   MOLECULAR MICROBIOLOGY

CtpV: a putative copper exporter required for full virulence of Mycobacterium tuberculosis

(2010) Sarah K. Ward et al.   MOLECULAR MICROBIOLOGY

The Battle for Iron between Bacterial Pathogens and Their Vertebrate Hosts

(2010) Eric P. Skaar   PLoS Pathogens

Nutritional immunity beyond iron: a role for manganese and zinc

(2009) Thomas E Kehl-Fie et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Physiological functions of mineral micronutrients (Cu, Zn, Mn, Fe, Ni, Mo, B, Cl)

(2009) Robert Hänsch et al.   CURRENT OPINION IN PLANT BIOLOGY

A Role for the ATP7A Copper-transporting ATPase in Macrophage Bactericidal Activity

(2009) Carine White et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Metalloproteins and metal sensing

(2009) Kevin J. Waldron et al.   NATURE

The iron-sulfur clusters of dehydratases are primary intracellular targets of copper toxicity

(2009) L. Macomber et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bacterial heme-transport proteins and their heme-coordination modes

(2008) Yong Tong et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Metal ions in biological catalysis: from enzyme databases to general principles

(2008) Claudia Andreini et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

Biosynthesis and IroC-dependent export of the siderophore salmochelin are essential for virulence of Salmonella enterica serovar Typhimurium

(2008) Marie-Laure V. Crouch et al.   MOLECULAR MICROBIOLOGY

How do bacterial cells ensure that metalloproteins get the correct metal?

(2008) Kevin J. Waldron et al.   NATURE REVIEWS MICROBIOLOGY

Metal Chelation and Inhibition of Bacterial Growth in Tissue Abscesses

(2008) Brian D. Corbin et al.   SCIENCE

Bacillus anthracis Secretes Proteins That Mediate Heme Acquisition from Hemoglobin

(2008) Anthony W. Maresso et al.   PLoS Pathogens