The split protein phosphatase system

Importance of the subcellular location of protein deposits in neurodegenerative diseases

(2018) Anne Bertolotti   CURRENT OPINION IN NEUROBIOLOGY

Kinase inhibitors: the road ahead

(2018) Fleur M. Ferguson et al.   NATURE REVIEWS DRUG DISCOVERY

Target-Based Discovery of an Inhibitor of the Regulatory Phosphatase PPP1R15B

(2018) Agnieszka Krzyzosiak et al.   CELL

Decoding the selectivity of eIF2α holophosphatases and PPP1R15A inhibitors

(2017) Marta Carrara et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Genomics and evolution of protein phosphatases

(2017) Mark J. Chen et al.   Science Signaling

Decoding the selectivity of eIF2α holophosphatases and PPP1R15A inhibitors

(2017) Marta Carrara et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Genomics and evolution of protein phosphatases

(2017) Mark J. Chen et al.   Science Signaling

PP2A as a master regulator of the cell cycle

(2016) Nathan Wlodarchak et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

The Ki-67 and RepoMan mitotic phosphatases assemble via an identical, yet novel mechanism

(2016) Ganesan Senthil Kumar et al.   eLife

Assembly and quality control of the protein phosphatase 1 holoenzyme involves the Cdc48-Shp1 chaperone

(2015) Y.-L. Cheng et al.   JOURNAL OF CELL SCIENCE

Surviving protein quality control catastrophes - from cells to organisms

(2015) K. Schneider et al.   JOURNAL OF CELL SCIENCE

An eIF2α-binding motif in protein phosphatase 1 subunit GADD34 and its viral orthologs is required to promote dephosphorylation of eIF2α

(2015) Margarito Rojas et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Preventing proteostasis diseases by selective inhibition of a phosphatase regulatory subunit

(2015) I. Das et al.   SCIENCE

Structural and Functional Analysis of the GADD34:PP1 eIF2α Phosphatase

(2015) Meng S. Choy et al.   Cell Reports

G-actin provides substrate-specificity to eukaryotic initiation factor 2α holophosphatases

(2015) Ruming Chen et al.   eLife

Status of Large-scale Analysis of Post-translational Modifications by Mass Spectrometry

(2013) Jesper V. Olsen et al.   MOLECULAR & CELLULAR PROTEOMICS

Protein Ser/ Thr phosphatases - the ugly ducklings of cell signalling

(2012) David L. Brautigan   FEBS Journal

The Molecular Basis for Substrate Specificity of the Nuclear NIPP1:PP1 Holoenzyme

(2012) Nichole O'Connell et al.   STRUCTURE

Spatial expression of the genome: the signal hypothesis at forty

(2011) Karl S. Matlin   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Selective Inhibition of a Regulatory Subunit of Protein Phosphatase 1 Restores Proteostasis

(2011) P. Tsaytler et al.   SCIENCE

Spinophilin directs protein phosphatase 1 specificity by blocking substrate binding sites

(2010) Michael J Ragusa et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

An overlapping kinase and phosphatase docking site regulates activity of the retinoblastoma protein

(2010) Alexander Hirschi et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Serine/Threonine Phosphatases: Mechanism through Structure

(2009) Yigong Shi   CELL

Regulation of Translation Initiation in Eukaryotes: Mechanisms and Biological Targets

(2009) Nahum Sonenberg et al.   CELL

Docking Motif-Guided Mapping of the Interactome of Protein Phosphatase-1

(2009) Annick Hendrickx et al.   CHEMISTRY & BIOLOGY

A Conserved Docking Surface on Calcineurin Mediates Interaction with Substrates and Immunosuppressants

(2009) Antonio Rodríguez et al.   MOLECULAR CELL

From Promiscuity to Precision: Protein Phosphatases Get a Makeover

(2009) David M. Virshup et al.   MOLECULAR CELL

Ppp1r15 gene knockout reveals an essential role for translation initiation factor 2 alpha (eIF2α) dephosphorylation in mammalian development

(2009) Heather P. Harding et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA