Magnesium lithospermate B protects the endothelium from inflammation-induced dysfunction through activation of Nrf2 pathway

The Role of Nrf2 Signaling in PPARβ/δ-Mediated Vascular Protection against Hyperglycemia-Induced Oxidative Stress

(2018) Rosario Jimenez et al.   Oxidative Medicine and Cellular Longevity

Co-Activation of PKC-δ by CRIF1 Modulates Oxidative Stress in Bone Marrow Multipotent Mesenchymal Stromal Cells after Irradiation by Phosphorylating NRF2 Ser40

(2017) Lili Chen et al.   Theranostics

The NRF2 knockout rat: a new animal model to study endothelial dysfunction, oxidant stress, and microvascular rarefaction

(2016) Jessica R. C. Priestley et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Targeting vascular (endothelial) dysfunction

(2016) Andreas Daiber et al.   BRITISH JOURNAL OF PHARMACOLOGY

Salvianolic Acid B Prevents Iodinated Contrast Media-Induced Acute Renal Injury in Rats via the PI3K/Akt/Nrf2 Pathway

(2016) Liu Tongqiang et al.   Oxidative Medicine and Cellular Longevity

The Endothelium in Sepsis

(2016) Can Ince et al.   SHOCK

Salvianolic acid B protects against paraquat-induced pulmonary injury by mediating Nrf2/Nox4 redox balance and TGF-β1/Smad3 signaling

(2016) Bin Liu et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Implementing guidelines on reporting research using animals (ARRIVE etc.): new requirements for publication in BJP

(2015) John C McGrath et al.   BRITISH JOURNAL OF PHARMACOLOGY

PKCε-CREB-Nrf2 signalling induces HO-1 in the vascular endothelium and enhances resistance to inflammation and apoptosis

(2015) Hayley Mylroie et al.   CARDIOVASCULAR RESEARCH

Nrf2 as an Endothelial Mechanosensitive Transcription Factor

(2015) Shane R. McSweeney et al.   HYPERTENSION

Salvianolic acid B protects against acetaminophen hepatotoxicity by inducing Nrf2 and phase II detoxification gene expression via activation of the PI3K and PKC signaling pathways

(2015) Musen Lin et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Endothelial protein kinase MAP4K4 promotes vascular inflammation and atherosclerosis

(2015) Rachel J. Roth Flach et al.   Nature Communications

Intravital Microscopy of Leukocyte-endothelial and Platelet-leukocyte Interactions in Mesenterial Veins in Mice

(2015) Nadine Herr et al.   Jove-Journal of Visualized Experiments

Salvianolic acid A protects RPE cells against oxidative stress through activation of Nrf2/HO-1 signaling

(2014) Hui Zhang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Sphingosine-1-phosphate protects endothelial glycocalyx by inhibiting syndecan-1 shedding

(2013) Ye Zeng et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

NF- B inhibitor targeted to activated endothelium demonstrates a critical role of endothelial NF- B in immune-mediated diseases

(2013) B. Sehnert et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nrf2 acts cell-autonomously in endothelium to regulate tip cell formation and vascular branching

(2013) Y. Wei et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pathophysiology of microcirculatory dysfunction and the pathogenesis of septic shock

(2013) Daniel De Backer et al.   Virulence

Nrf2 Redirects Glucose and Glutamine into Anabolic Pathways in Metabolic Reprogramming

(2012) Yoichiro Mitsuishi et al.   CANCER CELL

Endothelium-Selective Activation of AMP-Activated Protein Kinase Prevents Diabetes Mellitus–Induced Impairment in Vascular Function and Reendothelialization via Induction of Heme Oxygenase-1 in Mice

(2012) Francois Y.L. Li et al.   CIRCULATION

Laminar Flow Activation of ERK5 Protein in Vascular Endothelium Leads to Atheroprotective Effect via NF-E2-related Factor 2 (Nrf2) Activation

(2012) Miso Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Magnesium lithospermate B alleviates the production of endothelin-1 through an NO-dependent mechanism and reduces experimental vasospasm in rats

(2011) Chih-Zen Chang et al.   ACTA NEUROCHIRURGICA

Lithospermic acid B protects beta-cells from cytokine-induced apoptosis by alleviating apoptotic pathways and activating anti-apoptotic pathways of Nrf2–HO-1 and Sirt1

(2011) Byung-Wan Lee et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

GSK-3: Functional Insights from Cell Biology and Animal Models

(2011) Oksana Kaidanovich-Beilin et al.   Frontiers in Molecular Neuroscience

Magnesium lithospermate B dilates mesenteric arteries by activating BKCa currents and contracts arteries by inhibiting KV currents

(2010) Hai-fei Zhang et al.   ACTA PHARMACOLOGICA SINICA

Protective effects of magnesium lithospermate B against diabetic atherosclerosis via Nrf2-ARE-NQO1 transcriptional pathway

(2010) Kyu Yeon Hur et al.   ATHEROSCLEROSIS

Animal research: Reporting in vivo experiments: The ARRIVE guidelines

(2010) Carol Kilkenny et al.   BRITISH JOURNAL OF PHARMACOLOGY

Natural therapeutic magnesium lithospermate B potently protects the endothelium from hyperglycaemia-induced dysfunction

(2010) So Hun Kim et al.   CARDIOVASCULAR RESEARCH

Magnesium lithospermate B decreases [Ca2+]i in endothelial cells by inhibiting K+ currents

(2010) Haifei Zhang et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Actinonin, a Meprin a Inhibitor, Protects the Renal Microcirculation During Sepsis

(2010) Zhen Wang et al.   SHOCK

Activation of Nrf2 in Endothelial Cells Protects Arteries From Exhibiting a Proinflammatory State

(2009) Mustafa Zakkar et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Active NF-E2-related Factor (Nrf2) Contributes to Keep Endothelial NO Synthase (eNOS) in the Coupled State

(2009) Elke H. Heiss et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Occludin Phosphorylation and Ubiquitination Regulate Tight Junction Trafficking and Vascular Endothelial Growth Factor-induced Permeability

(2009) Tomoaki Murakami et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Pivotal Role of Endothelial-Specific NF- B Signaling in the Pathogenesis of Septic Shock and Septic Vascular Dysfunction

(2009) J. Ding et al.   JOURNAL OF IMMUNOLOGY

Therapeutic effect of magnesium lithospermate B on neointimal formation after balloon-induced vascular injury

(2008) Kyu Yeon Hur et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Divergent roles of endothelial NF-κB in multiple organ injury and bacterial clearance in mouse models of sepsis

(2008) Xiaobing Ye et al.   JOURNAL OF EXPERIMENTAL MEDICINE