Hippocampal Proteomic Analysis Reveals Distinct Pathway Deregulation Profiles at Early and Late Stages in a Rat Model of Alzheimer’s-Like Amyloid Pathology

A Novel Transgenic Rat Model with a Full Alzheimer's-Like Amyloid Pathology Displays Pre-Plaque Intracellular Amyloid-β-Associated Cognitive Impairment

(2017) Wanda Carolina Leon et al.   JOURNAL OF ALZHEIMERS DISEASE

Neuroinflammation in Alzheimer's Disease and Mild Cognitive Impairment: A Field in Its Infancy

(2017) Edith G. McGeer et al.   JOURNAL OF ALZHEIMERS DISEASE

Dynamic relationships between age, amyloid-β deposition, and glucose metabolism link to the regional vulnerability to Alzheimer’s disease

(2016) Hwamee Oh et al.   BRAIN

Stereological estimation of neuron number and plaque load in the hippocampal region of a transgenic rat model of Alzheimer's disease

(2015) Ingrid Heggland et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Redox proteomics identification of specifically carbonylated proteins in the hippocampi of triple transgenic Alzheimer's disease mice at its earliest pathological stage

(2015) Liming Shen et al.   Journal of Proteomics

Development and evaluation of a multiplexed mass spectrometry based assay for measuring candidate peptide biomarkers in Alzheimer's Disease Neuroimaging Initiative (ADNI) CSF

(2015) Daniel S. Spellman et al.   Proteomics Clinical Applications

Cortical hypermetabolism in MCI subjects: a compensatory mechanism?

(2014) A. Ashraf et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Serum Calreticulin Is a Negative Biomarker in Patients with Alzheimer’s Disease

(2014) Qiao Lin et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Janus Faces of Amyloid Proteins in Neuroinflammation

(2014) Lawrence Steinman et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Quantification of the Brain Proteome in Alzheimer’s Disease Using Multiplexed Mass Spectrometry

(2014) Sravani Musunuri et al.   JOURNAL OF PROTEOME RESEARCH

Quantitative proteomics reveals that PEA15 regulates astroglial Aβ phagocytosis in an Alzheimer's disease mouse model

(2014) Junniao Lv et al.   Journal of Proteomics

Advancing research diagnostic criteria for Alzheimer's disease: the IWG-2 criteria

(2014) Bruno Dubois et al.   LANCET NEUROLOGY

Neuronal driven pre-plaque inflammation in a transgenic rat model of Alzheimer's disease

(2014) Cecilia E. Hanzel et al.   NEUROBIOLOGY OF AGING

STRING v10: protein–protein interaction networks, integrated over the tree of life

(2014) Damian Szklarczyk et al.   NUCLEIC ACIDS RESEARCH

The TRiC/CCT Chaperone Is Implicated in Alzheimer's Disease Based on Patient GWAS and an RNAi Screen in Aβ-Expressing Caenorhabditis elegans

(2014) Eleonora Khabirova et al.   PLoS One

Intracellular Aβ pathology and early cognitive impairments in a transgenic rat overexpressing human amyloid precursor protein: a multidimensional study

(2014) M Florencia Iulita et al.   Acta Neuropathologica Communications

Longitudinal testing of hippocampal plasticity reveals the onset and maintenance of endogenous human Aß-induced synaptic dysfunction in individual freely behaving pre-plaque transgenic rats: rapid reversal by anti-Aß agents

(2014) Yingjie Qi et al.   Acta Neuropathologica Communications

Metabolic Networks Underlying Cognitive Reserve in Prodromal Alzheimer Disease: A European Alzheimer Disease Consortium Project

(2013) S. Morbelli et al.   JOURNAL OF NUCLEAR MEDICINE

Tracking pathophysiological processes in Alzheimer's disease: an updated hypothetical model of dynamic biomarkers

(2013) Clifford R Jack et al.   LANCET NEUROLOGY

A mitochondrial location for haemoglobins—Dynamic distribution in ageing and Parkinson's disease

(2013) Freya Shephard et al.   MITOCHONDRION

Modeling Alzheimer’s disease in transgenic rats

(2013) Sonia Do Carmo et al.   Molecular Neurodegeneration

Differential Expression of Proteins in Brain Regions of Alzheimer’s Disease Patients

(2013) Saadia Zahid et al.   NEUROCHEMICAL RESEARCH

Characterization of Adult α- and β-Globin Elevated by Hydrogen Peroxide in Cervical Cancer Cells That Play A Cytoprotective Role Against Oxidative Insults

(2013) Xiaolei Li et al.   PLoS One

Mild Oxidative Stress Induces Redistribution of BACE1 in Non-Apoptotic Conditions and Promotes the Amyloidogenic Processing of Alzheimer’s Disease Amyloid Precursor Protein

(2013) Jiang-Li Tan et al.   PLoS One

Amyloid β-Peptide (1–42)-Induced Oxidative Stress in Alzheimer Disease: Importance in Disease Pathogenesis and Progression

(2012) D. Allan Butterfield et al.   ANTIOXIDANTS & REDOX SIGNALING

Therapeutic Effects of Systemic Administration of Chaperone αB-Crystallin Associated with Binding Proinflammatory Plasma Proteins

(2012) Jonathan B. Rothbard et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Brain imaging and fluid biomarker analysis in young adults at genetic risk for autosomal dominant Alzheimer's disease in the presenilin 1 E280A kindred: a case-control study

(2012) Eric M Reiman et al.   LANCET NEUROLOGY

Heat shock protein 90 in neurodegenerative diseases

(2012) Wenjie Luo et al.   Molecular Neurodegeneration

Quantitative Proteomic Analysis of Human Substantia Nigra in Alzheimer’s Disease, Huntington’s Disease and Multiple Sclerosis

(2012) Sheng Chen et al.   NEUROCHEMICAL RESEARCH

Proteomic analysis of the hippocampus in Alzheimer's disease model mice by using two-dimensional fluorescence difference in gel electrophoresis

(2012) Masaoki Takano et al.   NEUROSCIENCE LETTERS

Clinical and Biomarker Changes in Dominantly Inherited Alzheimer's Disease

(2012) Randall J. Bateman et al.   NEW ENGLAND JOURNAL OF MEDICINE

Analysis of a membrane-enriched proteome from postmortem human brain tissue in Alzheimer's disease

(2012) Laura E. Donovan et al.   Proteomics Clinical Applications

Alzheimer’s disease Aβ assemblies mediating rapid disruption of synaptic plasticity and memory

(2012) Igor Klyubin et al.   Molecular Brain

Toward defining the preclinical stages of Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease

(2011) Reisa A. Sperling et al.   Alzheimers & Dementia

Quantitative proteomics analysis of phosphorylated proteins in the hippocampus of Alzheimer's disease subjects

(2011) Fabio Di Domenico et al.   Journal of Proteomics

Early dysregulation of the mitochondrial proteome in a mouse model of Alzheimer's disease

(2011) Jose L. Chou et al.   Journal of Proteomics

Hemoglobin level in older persons and incident Alzheimer disease: Prospective cohort analysis

(2011) R. C. Shah et al.   NEUROLOGY

Soluble amyloid  -protein dimers isolated from Alzheimer cortex directly induce Tau hyperphosphorylation and neuritic degeneration

(2011) M. Jin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Protein levels of heat shock proteins 27, 32, 60, 70, 90 and thioredoxin-1 in amnestic mild cognitive impairment: An investigation on the role of cellular stress response in the progression of Alzheimer disease

(2010) Fabio Di Domenico et al.   BRAIN RESEARCH

Regional cerebral glucose uptake in the 3xTG model of Alzheimer's disease highlights common regional vulnerability across AD mouse models

(2010) Rachel M. Nicholson et al.   BRAIN RESEARCH

Revising the definition of Alzheimer's disease: a new lexicon

(2010) Bruno Dubois et al.   LANCET NEUROLOGY

Preclinical Alzheimer disease: Brain oxidative stress, Aβ peptide and proteomics

(2010) Christopher D. Aluise et al.   NEUROBIOLOGY OF DISEASE

Detection by voxel-wise statistical analysis of significant changes in regional cerebral glucose uptake in an APP/PS1 transgenic mouse model of Alzheimer's disease

(2010) Albertine Dubois et al.   NEUROIMAGE

Alzheimer's Disease

(2010) Henry W. Querfurth et al.   NEW ENGLAND JOURNAL OF MEDICINE

Alterations of brain and cerebellar proteomes linked to Aβ and tau pathology in a female triple-transgenic murine model of Alzheimer's disease

(2010) D Ciavardelli et al.   Cell Death & Disease

β-Secretase-1 elevation in transgenic mouse models of Alzheimer’s disease is associated with synaptic/axonal pathology and amyloidogenesis: implications for neuritic plaque development

(2009) Xue-Mei Zhang et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Neurons express hemoglobin α- and β-chains in rat and human brains

(2009) Franziska Richter et al.   JOURNAL OF COMPARATIVE NEUROLOGY

The amyloid hypothesis for Alzheimer’s disease: a critical reappraisal

(2009) John Hardy   JOURNAL OF NEUROCHEMISTRY

Basal Cerebral Metabolism May Modulate the Cognitive Effects of A  in Mild Cognitive Impairment: An Example of Brain Reserve

(2009) A. D. Cohen et al.   JOURNAL OF NEUROSCIENCE

Recovery of Afferent Function and Synaptic Strength in Hippocampal CA1 following Traumatic Brain Injury

(2009) Christopher M. Norris et al.   JOURNAL OF NEUROTRAUMA

Alzheimer's disease: synaptic dysfunction and Aβ

(2009) Ganesh M Shankar et al.   Molecular Neurodegeneration

Oxidative Stress Impairs the Heat Stress Response and Delays Unfolded Protein Recovery

(2009) Masaaki Adachi et al.   PLoS One

Unexpected expression of  - and  -globin in mesencephalic dopaminergic neurons and glial cells

(2009) M. Biagioli et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Widespread Changes in Dendritic Spines in a Model of Alzheimer's Disease

(2008) S. Knafo et al.   CEREBRAL CORTEX

Brain oxidative stress in a triple-transgenic mouse model of Alzheimer disease

(2008) Rosa Resende et al.   FREE RADICAL BIOLOGY AND MEDICINE

Phase Transfer Surfactant-Aided Trypsin Digestion for Membrane Proteome Analysis

(2008) Takeshi Masuda et al.   JOURNAL OF PROTEOME RESEARCH

Proteomics-Determined Differences in the Concanavalin-A-Fractionated Proteome of Hippocampus and Inferior Parietal Lobule in Subjects with Alzheimer’s Disease and Mild Cognitive Impairment: Implications for Progression of AD

(2008) Joshua B. Owen et al.   JOURNAL OF PROTEOME RESEARCH

Glutathione: Overview of its protective roles, measurement, and biosynthesis

(2008) Henry Jay Forman et al.   MOLECULAR ASPECTS OF MEDICINE

Amyloid-β protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory

(2008) Ganesh M Shankar et al.   NATURE MEDICINE

iTRAQ Analysis of Complex Proteome Alterations in 3xTgAD Alzheimer's Mice: Understanding the Interface between Physiology and Disease

(2008) Bronwen Martin et al.   PLoS One

ADAM-10 over-expression increases cortical synaptogenesis

(2006) Karen F.S. Bell et al.   NEUROBIOLOGY OF AGING