From integrative disease modeling to predictive, preventive, personalized and participatory (P4) medicine

Patient-centered medicine and patient-oriented research: improving health outcomes for individual patients

(2013) José A Sacristán   BMC Medical Informatics and Decision Making

Systems Biology and the Discovery of Diagnostic Biomarkers

(2013) Kai Wang et al.   DISEASE MARKERS

A network model of genomic hormone interactions underlying dementia and its translational validation through serendipitous off-target effect

(2013) Erfan Younesi et al.   Journal of Translational Medicine

SVM Based Descriptor Selection and Classification of Neurodegenerative Disease Drugs for Pharmacological Modeling

(2013) Mohammad Shahid et al.   Molecular Informatics

Genomic responses in mouse models poorly mimic human inflammatory diseases

(2013) Junhee Seok et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Assessment of network perturbation amplitudes by applying high-throughput data to causal biological networks

(2012) Florian Martin et al.   BMC Systems Biology

Challenges and opportunities for oncology biomarker discovery

(2012) Avisek Deyati et al.   DRUG DISCOVERY TODAY

Genes Associated with Intestinal Permeability in Ulcerative Colitis: Changes in Expression Following Infliximab Therapy

(2012) Gary Toedter et al.   INFLAMMATORY BOWEL DISEASES

An anti-diabetes agent protects the mouse brain from defective insulin signaling caused by Alzheimer’s disease–associated Aβ oligomers

(2012) Theresa R. Bomfim et al.   JOURNAL OF CLINICAL INVESTIGATION

Evolution and Functional Impact of Rare Coding Variation from Deep Sequencing of Human Exomes

(2012) J. A. Tennessen et al.   SCIENCE

General Report & Recommendations in Predictive, Preventive and Personalised Medicine 2012: White Paper of the European Association for Predictive, Preventive and Personalised Medicine

(2012) Olga Golubnitschaja et al.   EPMA Journal

Discriminating lymphomas and reactive lymphadenopathy in lymph node biopsies by gene expression profiling

(2011) To Ha Loi et al.   BMC Medical Genomics

Editorial: Computational methods for drug repurposing

(2011) P. Sanseau et al.   BRIEFINGS IN BIOINFORMATICS

The biomarker is not the end

(2011) Michael Nohaile   DRUG DISCOVERY TODAY

A Novel Knowledge-Driven Systems Biology Approach for Phenotype Prediction upon Genetic Intervention

(2011) Rui Chang et al.   IEEE-ACM Transactions on Computational Biology and Bioinformatics

The effect of rosiglitazone on LRP1 expression and amyloid β uptake in human brain microvascular endothelial cells: a possible role of a low-dose thiazolidinedione for dementia treatment

(2011) Jae Hoon Moon et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

The Diabetes Drug Liraglutide Prevents Degenerative Processes in a Mouse Model of Alzheimer's Disease

(2011) P. L. McClean et al.   JOURNAL OF NEUROSCIENCE

Accelerated clinical discovery using self-reported patient data collected online and a patient-matching algorithm

(2011) Paul Wicks et al.   NATURE BIOTECHNOLOGY

Crizotinib

(2011) Alice T. Shaw et al.   NATURE REVIEWS DRUG DISCOVERY

Personalized medicine is more than genomic medicine: confusion over terminology impedes progress towards personalized healthcare

(2011) Leigh Ann Simmons et al.   Personalized Medicine

Computationally Generated Cardiac Biomarkers for Risk Stratification After Acute Coronary Syndrome

(2011) Z. Syed et al.   Science Translational Medicine

Using Electronic Patient Records to Discover Disease Correlations and Stratify Patient Cohorts

(2011) Francisco S. Roque et al.   PLoS Computational Biology

Genome-Wide Association Studies and Beyond

(2010) John S. Witte   Annual Review of Public Health

Diabetes mellitus and Alzheimer's disease: shared pathology and treatment?

(2010) Kawser Akter et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

The promises of personalized medicine

(2010) Ingolf Cascorbi   EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

The benefits and limitations of animal models for translational research in neurodegenerative diseases

(2010) Mathias Jucker   NATURE MEDICINE

How does diabetes accelerate Alzheimer disease pathology?

(2010) Catrina Sims-Robinson et al.   Nature Reviews Neurology

Can Animal Models of Disease Reliably Inform Human Studies?

(2010) H. Bart van der Worp et al.   PLOS MEDICINE

Computational disease modeling – fact or fiction?

(2009) Jesper N Tegnér et al.   BMC Systems Biology

Progress towards personalized medicine

(2009) Stewart Bates   DRUG DISCOVERY TODAY

Variations in DNA elucidate molecular networks that cause disease

(2008) Yanqing Chen et al.   NATURE

Genetics of gene expression and its effect on disease

(2008) Valur Emilsson et al.   NATURE