Ascorbate as a Co-Factor for Fe- and 2-Oxoglutarate Dependent Dioxygenases: Physiological Activity in Tumor Growth and Progression
出版年份 2014 全文链接
标题
Ascorbate as a Co-Factor for Fe- and 2-Oxoglutarate Dependent Dioxygenases: Physiological Activity in Tumor Growth and Progression
作者
关键词
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出版物
Frontiers in Oncology
Volume 4, Issue -, Pages -
出版商
Frontiers Media SA
发表日期
2014-12-10
DOI
10.3389/fonc.2014.00359
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- FTO and Obesity: Mechanisms of Association
- (2014) Xu Zhao et al. Current Diabetes Reports
- Intracellular ascorbate enhances hypoxia-inducible factor (HIF)-hydroxylase activity and preferentially suppresses the HIF-1 transcriptional response
- (2014) Caroline Kuiper et al. FREE RADICAL BIOLOGY AND MEDICINE
- OGFOD1 catalyzes prolyl hydroxylation of RPS23 and is involved in translation control and stress granule formation
- (2014) R. S. Singleton et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- TET1-Mediated Hydroxymethylation Facilitates Hypoxic Gene Induction in Neuroblastoma
- (2014) Christopher J. Mariani et al. Cell Reports
- Increased Tumor Ascorbate is Associated with Extended Disease-Free Survival and Decreased Hypoxia-Inducible Factor-1 Activation in Human Colorectal Cancer
- (2014) Caroline Kuiper et al. Frontiers in Oncology
- Breathing-in epigenetic change with vitamin C
- (2013) Asun Monfort et al. EMBO REPORTS
- What a difference a hydroxyl makes: mutant IDH, (R)-2-hydroxyglutarate, and cancer
- (2013) J.-A. Losman et al. GENES & DEVELOPMENT
- Ascorbate Induces Ten-Eleven Translocation (Tet) Methylcytosine Dioxygenase-mediated Generation of 5-Hydroxymethylcytosine
- (2013) Emily A. Minor et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Ascorbic Acid Enhances Tet-Mediated 5-Methylcytosine Oxidation and Promotes DNA Demethylation in Mammals
- (2013) Ruichuan Yin et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Vitamin C induces Tet-dependent DNA demethylation and a blastocyst-like state in ES cells
- (2013) Kathryn Blaschke et al. NATURE
- Vitamin C modulates TET1 function during somatic cell reprogramming
- (2013) Jiekai Chen et al. NATURE GENETICS
- Sprouts of RNA epigenetics
- (2013) Guanqun Zheng et al. RNA Biology
- Kinetic analysis of FTO (fat mass and obesity-associated) reveals that it is unlikely to function as a sensor for 2-oxoglutarate
- (2012) Marcella Ma et al. BIOCHEMICAL JOURNAL
- Changes in Protein Dynamics of the DNA Repair Dioxygenase AlkB upon Binding of Fe2+ and 2-Oxoglutarate
- (2012) Boris Bleijlevens et al. BIOCHEMISTRY
- Ascorbic acid: Chemistry, biology and the treatment of cancer
- (2012) Juan Du et al. BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
- The FIH hydroxylase is a cellular peroxide sensor that modulates HIF transcriptional activity
- (2012) Norma Masson et al. EMBO REPORTS
- Autocatalysed oxidative modifications to 2-oxoglutarate dependent oxygenases
- (2012) Monica Mantri et al. FEBS Journal
- Enhanced antitumor activity of vitamin C via p53 in Cancer cells
- (2012) Jinsun Kim et al. FREE RADICAL BIOLOGY AND MEDICINE
- Ascorbate supplementation inhibits growth and metastasis of B16FO melanoma and 4T1 breast cancer cells in vitamin C-deficient mice
- (2012) JOHN CHA et al. INTERNATIONAL JOURNAL OF ONCOLOGY
- Oxygenase-catalyzed ribosome hydroxylation occurs in prokaryotes and humans
- (2012) Wei Ge et al. Nature Chemical Biology
- SVCT-2 in breast cancer acts as an indicator for L-ascorbate treatment
- (2012) S-W Hong et al. ONCOGENE
- Phase I Evaluation of Intravenous Ascorbic Acid in Combination with Gemcitabine and Erlotinib in Patients with Metastatic Pancreatic Cancer
- (2012) Daniel A. Monti et al. PLoS One
- High-resolution genome-wide mapping of HIF-binding sites by ChIP-seq
- (2011) J. Schodel et al. BLOOD
- Vitamin C is dispensable for oxygen sensing in vivo
- (2011) K. J. Nytko et al. BLOOD
- The SLC23 family of ascorbate transporters: ensuring that you get and keep your daily dose of vitamin C
- (2011) James M May BRITISH JOURNAL OF PHARMACOLOGY
- The Histone Demethylases Jhdm1a/1b Enhance Somatic Cell Reprogramming in a Vitamin-C-Dependent Manner
- (2011) Tao Wang et al. Cell Stem Cell
- Hypoxia-mediated drug resistance: Novel insights on the functional interaction of HIFs and cell death pathways
- (2011) Nadine Rohwer et al. DRUG RESISTANCE UPDATES
- Pharmacologic ascorbate synergizes with gemcitabine in preclinical models of pancreatic cancer
- (2011) Michael Graham Espey et al. FREE RADICAL BIOLOGY AND MEDICINE
- Effects of ascorbic acid on carcinogenicity and acute toxicity of nickel subsulfide, and on tumor transplants growth in gulonolactone oxidase knock-out mice and wild-type C57BL mice
- (2011) Kazimierz S. Kasprzak et al. TOXICOLOGY AND APPLIED PHARMACOLOGY
- Prostate Imaging Modalities that Can Be Used for Complementary and Alternative Medicine Clinical Studies
- (2011) Reginald W. Dusing et al. UROLOGIC CLINICS OF NORTH AMERICA
- Chelation of intracellular iron enhances endothelial barrier function: A role for vitamin C?
- (2010) James M. May et al. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
- Cellular pathways for transport and efflux of ascorbate and dehydroascorbate
- (2010) Alessandro Corti et al. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
- Investigating the dependence of the hypoxia-inducible factor hydroxylases (factor inhibiting HIF and prolyl hydroxylase domain 2) on ascorbate and other reducing agents
- (2010) Emily Flashman et al. BIOCHEMICAL JOURNAL
- Ascorbate exerts anti-proliferative effects through cell cycle inhibition and sensitizes tumor cells towards cytostatic drugs
- (2010) Anja Frömberg et al. CANCER CHEMOTHERAPY AND PHARMACOLOGY
- Low Ascorbate Levels Are Associated with Increased Hypoxia-Inducible Factor-1 Activity and an Aggressive Tumor Phenotype in Endometrial Cancer
- (2010) C. Kuiper et al. CANCER RESEARCH
- Vitamin C Enhances the Generation of Mouse and Human Induced Pluripotent Stem Cells
- (2010) Miguel Angel Esteban et al. Cell Stem Cell
- Role of Tet proteins in 5mC to 5hmC conversion, ES-cell self-renewal and inner cell mass specification
- (2010) Shinsuke Ito et al. NATURE
- Vitamin C: Intravenous Use by Complementary and Alternative Medicine Practitioners and Adverse Effects
- (2010) Sebastian J. Padayatty et al. PLoS One
- Physiological and biochemical aspects of hydroxylations and demethylations catalyzed by human 2-oxoglutarate oxygenases
- (2010) Christoph Loenarz et al. TRENDS IN BIOCHEMICAL SCIENCES
- Cobalt-induced oxidant stress in cultured endothelial cells: Prevention by ascorbate in relation to HIF-1α
- (2009) Huan Qiao et al. BIOFACTORS
- HIF-1: upstream and downstream of cancer metabolism
- (2009) Gregg L Semenza CURRENT OPINION IN GENETICS & DEVELOPMENT
- Pharmacologic concentrations of ascorbate are achieved by parenteral administration and exhibit antitumoral effects
- (2009) Julien Verrax et al. FREE RADICAL BIOLOGY AND MEDICINE
- Antiproliferative Effect of Ascorbic Acid Is Associated with the Inhibition of Genes Necessary to Cell Cycle Progression
- (2009) Sophie Belin et al. PLoS One
- CANCER: Puzzling Patterns of Predisposition
- (2009) P. J. Pollard et al. SCIENCE
- Jmjd6 Catalyses Lysyl-Hydroxylation of U2AF65, a Protein Associated with RNA Splicing
- (2009) Celia J. Webby et al. SCIENCE
- Conversion of 5-Methylcytosine to 5-Hydroxymethylcytosine in Mammalian DNA by MLL Partner TET1
- (2009) M. Tahiliani et al. SCIENCE
- Kinetic characterization and identification of a novel inhibitor of hypoxia-inducible factor prolyl hydroxylase 2 using a time-resolved fluorescence resonance energy transfer-based assay technology
- (2008) Jennifer H. Dao et al. ANALYTICAL BIOCHEMISTRY
- Phase I clinical trial of i.v. ascorbic acid in advanced malignancy
- (2008) L. J. Hoffer et al. ANNALS OF ONCOLOGY
- Increased levels of 8-hydroxydeoxyguanosine and its relationship with lipid peroxidation and antioxidant vitamins in lung cancer
- (2008) Emel Çalışkan-Can et al. CLINICAL CHEMISTRY AND LABORATORY MEDICINE
- Reactive Oxygen Species Regulate Hypoxia-Inducible Factor 1 Differentially in Cancer and Ischemia
- (2008) A. A. Qutub et al. MOLECULAR AND CELLULAR BIOLOGY
- Pharmacologic doses of ascorbate act as a prooxidant and decrease growth of aggressive tumor xenografts in mice
- (2008) Q. Chen et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Metal Ions-Stimulated Iron Oxidation in Hydroxylases Facilitates Stabilization of HIF-1α Protein
- (2008) Monika Kaczmarek et al. TOXICOLOGICAL SCIENCES
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