Retinoids Issued from Hepatic Stellate Cell Lipid Droplet Loss as Potential Signaling Molecules Orchestrating a Multicellular Liver Injury Response

Hepatic stellate cells retain retinoid-laden lipid droplets after cellular transdifferentiation into activated myofibroblasts

(2018) Loretta L Jophlin et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Cenicriviroc, a cytokine receptor antagonist, potentiates all-trans retinoic acid in reducing liver injury in cholestatic rodents

(2018) Dongke Yu et al.   LIVER INTERNATIONAL

In vitro inhibition of hepatic stellate cell activation by the autophagy-related lipid droplet protein ATG2A

(2018) Yun Hong et al.   Scientific Reports

The logic of transcriptional regulator recruitment architecture at cis -regulatory modules controlling liver functions

(2017) Julie Dubois-Chevalier et al.   GENOME RESEARCH

The PNPLA3 I148M variant modulates the fibrogenic phenotype of human hepatic stellate cells

(2017) Francesca Virginia Bruschi et al.   HEPATOLOGY

Lysosome-mediated degradation of a distinct pool of lipid droplets during hepatic stellate cell activation

(2017) Maidina Tuohetahuntila et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mechanisms of hepatic stellate cell activation

(2017) Takuma Tsuchida et al.   Nature Reviews Gastroenterology & Hepatology

Disturbed Vitamin A Metabolism in Non-Alcoholic Fatty Liver Disease (NAFLD)

(2017) Ali Saeed et al.   Nutrients

SECs (Sinusoidal Endothelial Cells), Liver Microenvironment, and Fibrosis

(2017) Vaishaali Natarajan et al.   Biomed Research International

Autophagy regulates turnover of lipid droplets via ROS-dependent Rab25 activation in hepatic stellate cell

(2017) Zili Zhang et al.   Redox Biology

Hepatic stellate cells: fibrogenic, regenerative or both? Heterogeneity and context are key

(2016) Meena B. Bansal   Hepatology International

PNPLA3 overexpression results in reduction of proteins predisposing to fibrosis

(2016) Piero Pingitore et al.   HUMAN MOLECULAR GENETICS

ATGL and DGAT1 are involved in the turnover of newly synthesized triacylglycerols in hepatic stellate cells

(2016) Maidina Tuohetahuntila et al.   JOURNAL OF LIPID RESEARCH

Microbiota and bile acid profiles in retinoic acid-primed mice that exhibit accelerated liver regeneration

(2015) Hui-Xin Liu et al.   Oncotarget

Biological functional annotation of retinoic acid alpha and beta in mouse liver based on genome-wide binding

(2014) Yuqi He et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Alcohol dehydrogenase III exacerbates liver fibrosis by enhancing stellate cell activation and suppressing natural killer cells in mice

(2014) Hyon-Seung Yi et al.   HEPATOLOGY

Retinol and retinyl esters: biochemistry and physiology

(2013) Sheila M. O'Byrne et al.   JOURNAL OF LIPID RESEARCH

Hepatic retinoid stores are required for normal liver regeneration

(2013) Igor O. Shmarakov et al.   JOURNAL OF LIPID RESEARCH

Association Between Liver Vitamin A Reserves and Severity of Nonalcoholic Fatty Liver Disease in the Class III Obese Following Bariatric Surgery

(2013) Gabriela Villaça Chaves et al.   OBESITY SURGERY

Nuclear receptor atlas of female mouse liver parenchymal, endothelial, and Kupffer cells

(2013) Zhaosha Li et al.   PHYSIOLOGICAL GENOMICS

Autophagy fuels tissue fibrogenesis

(2012) Virginia Hernández-Gea et al.   Autophagy

Deactivation of Hepatic Stellate Cells During Liver Fibrosis Resolution in Mice

(2012) Juliane S. Troeger et al.   GASTROENTEROLOGY

Vitamin A deficiency is associated with hepatitis C virus chronic infection and with unresponsiveness to interferon-based antiviral therapy

(2012) Davide Bitetto et al.   HEPATOLOGY

Retinoic acids and hepatic stellate cells in liver disease

(2012) Young-Sun Lee et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

PDX-1/Hes-1 interactions determine cholangiocyte proliferative response to injury in rodents: Possible implications for sclerosing cholangitis

(2012) Marco Marzioni et al.   JOURNAL OF HEPATOLOGY

Replacement of Retinyl Esters by Polyunsaturated Triacylglycerol Species in Lipid Droplets of Hepatic Stellate Cells during Activation

(2012) Nicole Testerink et al.   PLoS One

Myofibroblasts revert to an inactive phenotype during regression of liver fibrosis

(2012) T. Kisseleva et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Absence of hepatic stellate cell retinoid lipid droplets does not enhance hepatic fibrosis but decreases hepatic carcinogenesis

(2011) J. Kluwe et al.   GUT

Connecting liver and gut: Murine liver sinusoidal endothelium induces gut tropism of CD4+ T cells via retinoic acid

(2011) Katrin Neumann et al.   HEPATOLOGY

Hepatic Stellate Cells Function as Regulatory Bystanders

(2011) S. Ichikawa et al.   JOURNAL OF IMMUNOLOGY

Genome-Wide Profiling of Liver X Receptor, Retinoid X Receptor, and Peroxisome Proliferator-Activated Receptor   in Mouse Liver Reveals Extensive Sharing of Binding Sites

(2011) M. Boergesen et al.   MOLECULAR AND CELLULAR BIOLOGY

Therapeutic effects of vitamin A on experimental cholestatic rats with hepatic fibrosis

(2011) Ken-ichi Murakami et al.   PEDIATRIC SURGERY INTERNATIONAL

Distinct Populations of Hepatic Stellate Cells in the Mouse Liver Have Different Capacities for Retinoid and Lipid Storage

(2011) Diana N. D'Ambrosio et al.   PLoS One

All-trans-retinoic acid ameliorates carbon tetrachloride-induced liver fibrosis in mice through modulating cytokine production

(2010) Shigeo Hisamori et al.   LIVER INTERNATIONAL

Hepatic stellate cell lipid droplets: A specialized lipid droplet for retinoid storage

(2008) William S. Blaner et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Mesenchymal origin of hepatic stellate cells, submesothelial cells, and perivascular mesenchymal cells during mouse liver development

(2008) Kinji Asahina et al.   HEPATOLOGY