HspB1, HspB5 and HspB4 in Human Cancers: Potent Oncogenic Role of Some of Their Client Proteins

Expression of Alpha-Crystallins in Human Sebaceous Carcinoma of the Eyelid

(2018) Panayota K. Rigas et al.   EUROPEAN JOURNAL OF OPHTHALMOLOGY

Hsp27 Regulates Epithelial Mesenchymal Transition, Metastasis, and Circulating Tumor Cells in Prostate Cancer

(2013) M. Shiota et al.   CANCER RESEARCH

Extracellular HSP27 mediates angiogenesis through Toll-like receptor 3

(2013) Dominique Thuringer et al.   FASEB JOURNAL

Human small heat shock proteins: Protein interactomes of homo- and hetero-oligomeric complexes: An update

(2013) André-Patrick Arrigo   FEBS LETTERS

Protein interactomes of three stress inducible small heat shock proteins: HspB1, HspB5 and HspB8

(2013) André-Patrick Arrigo et al.   INTERNATIONAL JOURNAL OF HYPERTHERMIA

Peptide aptamers: tools to negatively or positively modulate HSPB1(27) function

(2013) B. Gibert et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Analysis of the Dominant Effects Mediated by Wild Type or R120G Mutant of αB-crystallin (HspB5) towards Hsp27 (HspB1)

(2013) Stéphanie Simon et al.   PLoS One

Heat shock proteins and heat shock factor 1 in carcinogenesis and tumor development: an update

(2012) Daniel R. Ciocca et al.   ARCHIVES OF TOXICOLOGY

Activation of an immune-regulatory macrophage response and inhibition of lung inflammation in a mouse model of COPD using heat-shock protein alpha B-crystallin-loaded PLGA microparticles

(2012) Johannes M. van Noort et al.   BIOMATERIALS

Targeting heat shock protein 27 (HspB1) interferes with bone metastasis and tumour formation in vivo

(2012) B Gibert et al.   BRITISH JOURNAL OF CANCER

Hsp27 (HSPB1): a possible surrogate molecular marker for loss of heterozygosity (LOH) of chromosome 1p in oligodendrogliomas but not in astrocytomas

(2012) Gisela N. Castro et al.   CELL STRESS & CHAPERONES

Downregulation of Hsp27 (HSPB1) in MCF-7 human breast cancer cells induces upregulation of PTEN

(2012) Niubys Cayado-Gutiérrez et al.   CELL STRESS & CHAPERONES

Extracellular HSP27 acts as a signaling molecule to activate NF-κB in macrophages

(2012) Samira Salari et al.   CELL STRESS & CHAPERONES

Alpha-Crystallins and Tumorigenesis

(2012) P. Chen et al.   CURRENT MOLECULAR MEDICINE

Editorial [Hot Topic: Heat Shock Proteins in Cancer]

(2012) Andre-Patrick Arrigo   CURRENT MOLECULAR MEDICINE

Role of Human and Mouse HspB1 in Metastasis

(2012) G.M. Nagaraja et al.   CURRENT MOLECULAR MEDICINE

HspB1 Dynamic Phospho-Oligomeric Structure Dependent Interactome as Cancer Therapeutic Target

(2012) A.-P. Arrigo et al.   CURRENT MOLECULAR MEDICINE

αA- and αB-Crystallins Interact with Caspase-3 and Bax to Guard Mouse Lens Development

(2012) W.-F. Hu et al.   CURRENT MOLECULAR MEDICINE

HSF1, A Versatile Factor in Tumorogenesis

(2012) S.K. Calderwood   CURRENT MOLECULAR MEDICINE

HSP27 expression in primary colorectal cancers is dependent on mutation of KRAS and PI3K/AKT activation status and is independent of TP53

(2012) Anil Ghosh et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

Small heat shock proteins in redox metabolism: Implications for cardiovascular diseases

(2012) Elisabeth S. Christians et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Small heat shock proteins and the cytoskeleton: An essential interplay for cell integrity?

(2012) G. Wettstein et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Commentary on paper: Small heat shock proteins and the cytoskeleton: An essential interplay for cell integrity? (Wettstein et al.)

(2012) Alim S. Seit-Nebi et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Therapeutic Effects of Systemic Administration of Chaperone αB-Crystallin Associated with Binding Proinflammatory Plasma Proteins

(2012) Jonathan B. Rothbard et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Signal Transducer and Activator of Transcription 3 (STAT3) Protein Suppresses Adenoma-to-carcinoma Transition inApcmin/+Mice via Regulation of Snail-1 (SNAI) Protein Stability

(2012) Jongdae Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A chemical proteomics approach reveals Hsp27 as a target for proapoptotic clerodane diterpenes

(2012) Laura Faiella et al.   Molecular BioSystems

Inhibition of HSP27 alone or in combination with pAKT inhibition as therapeutic approaches to target SPARC-induced glioma cell survival

(2012) Chad R Schultz et al.   Molecular Cancer

Expression of αB-crystallin overrides the anti-apoptotic activity of XIAP

(2012) Jee Suk Lee et al.   NEURO-ONCOLOGY

Knock Down of Heat Shock Protein 27 (HspB1) Induces Degradation of Several Putative Client Proteins

(2012) Benjamin Gibert et al.   PLoS One

The Wnt/β-Catenin Pathway Cross-Talks with STAT3 Signaling to Regulate Survival of Retinal Pigment Epithelium Cells

(2012) Miryam A. Fragoso et al.   PLoS One

Suppression of heat shock protein 27 induces long-term dormancy in human breast cancer

(2012) O. Straume et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

αB-crystallin, a small heat shock protein, modulates NF-κB activity in a phosphorylation-dependent manner and protects muscle myoblasts from TNF-α induced cytotoxicity

(2011) Amit S. Adhikari et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Phosphorylation status of heat shock protein 27 plays a key role in gemcitabine-induced apoptosis of pancreatic cancer cells

(2011) Masanori Nakashima et al.   CANCER LETTERS

Silencing hsp25/hsp27 Gene Expression Augments Proteasome Activity and Increases CD8+ T-Cell-Mediated Tumor Killing and Memory Responses

(2011) G. M. Nagaraja et al.   Cancer Prevention Research

Peptides and Aptamers Targeting HSP70: A Novel Approach for Anticancer Chemotherapy

(2011) Anne-Laure Rérole et al.   CANCER RESEARCH

Deletion of the SPARC acidic domain or EGF-like module reduces SPARC-induced migration and signaling through p38 MAPK/HSP27 in glioma

(2011) H. M. McClung et al.   CARCINOGENESIS

Hsp27 silencing coordinately inhibits proliferation and promotes Fas-induced apoptosis by regulating the PEA-15 molecular switch

(2011) N Hayashi et al.   CELL DEATH AND DIFFERENTIATION

Hsp-27 induction requires POU4F2/Brn-3b TF in doxorubicin-treated breast cancer cells, whereas phosphorylation alters its cellular localisation following drug treatment

(2011) Rieko Fujita et al.   CELL STRESS & CHAPERONES

Heterooligomeric complexes of human small heat shock proteins

(2011) Evgeny V. Mymrikov et al.   CELL STRESS & CHAPERONES

Lymphovascular invasion of colorectal cancer is correlated to SPARC expression in the tumor stromal microenvironment

(2011) Tetsunori Yoshimura et al.   Epigenetics

Ubiquitination of heat shock protein 27 is mediated by its interaction with Smad ubiquitination regulatory factor 2 in A549 cells

(2011) Yong Sun et al.   EXPERIMENTAL LUNG RESEARCH

αB-Crystallin is a Novel Oncoprotein Associated with Poor Prognosis in Breast Cancer

(2011) Hae Sung Kim et al.   Journal of Breast Cancer

RP101 (brivudine) binds to heat shock protein HSP27 (HSPB1) and enhances survival in animals and pancreatic cancer patients

(2011) Jörg-Christian Heinrich et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Heat shock protein 27 as a prognostic and predictive biomarker in pancreatic ductal adenocarcinoma

(2011) Claus Schäfer et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Chaperone Hsp27 Modulates AUF1 Proteolysis and AU-Rich Element-Mediated mRNA Degradation

(2011) A. M. Knapinska et al.   MOLECULAR AND CELLULAR BIOLOGY

Toward an understanding of the protein interaction network of the human liver

(2011) J. Wang et al.   Molecular Systems Biology

Inhibition of heat shock protein 27 (HspB1) tumorigenic functions by peptide aptamers

(2011) B Gibert et al.   ONCOGENE

Large Potentials of Small Heat Shock Proteins

(2011) Evgeny V. Mymrikov et al.   PHYSIOLOGICAL REVIEWS

HSPB1, HSPB6, HSPB7 and HSPB8 Protect against RhoA GTPase-Induced Remodeling in Tachypaced Atrial Myocytes

(2011) Lei Ke et al.   PLoS One

Small heat shock proteins and α-crystallins: dynamic proteins with flexible functions

(2011) Eman Basha et al.   TRENDS IN BIOCHEMICAL SCIENCES

The small heat shock protein αA-crystallin is expressed in pancreas and acts as a negative regulator of carcinogenesis

(2010) Mi Deng et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

HSP27 controls GATA-1 protein level during erythroid cell differentiation

(2010) A. de Thonel et al.   BLOOD

 B-crystallin: a novel VEGF chaperone

(2010) B. A. Kerr et al.   BLOOD

Chemoresistance of lung cancer stemlike cells depends on activation of Hsp27

(2010) Han-Shui Hsu et al.   CANCER

Hsp27 Promotes Insulin-Like Growth Factor-I Survival Signaling in Prostate Cancer via p90Rsk-Dependent Phosphorylation and Inactivation of BAD

(2010) A. Zoubeidi et al.   CANCER RESEARCH

Extracellular heat shock proteins, cellular export vesicles, and the Stress Observation System: A form of communication during injury, infection, and cell damage

(2010) Antonio De Maio   CELL STRESS & CHAPERONES

KNK437 Downregulates Heat Shock Protein 27 of Pancreatic Cancer Cells and Enhances the Cytotoxic Effect of Gemcitabine

(2010) Kumiko Taba et al.   CHEMOTHERAPY

Repeated-dose toxicity of HSP27-binding heptapeptide in mice

(2010) Hae-June Lee et al.   DRUG AND CHEMICAL TOXICOLOGY

ATM activates the pentose phosphate pathway promoting anti-oxidant defence and DNA repair

(2010) Claudia Cosentino et al.   EMBO JOURNAL

Dynamic processes that reflect anti-apoptotic strategies set up by HspB1 (Hsp27)

(2010) Catherine Paul et al.   EXPERIMENTAL CELL RESEARCH

Low molecular weight heat shock protein HSP27 is a prognostic indicator in rectal cancer but not colon cancer

(2010) E. M. Tweedle et al.   GUT

Heat shock proteins in prostate cancer: from tumorigenesis to the clinic

(2010) Daniel R. Ciocca et al.   INTERNATIONAL JOURNAL OF HYPERTHERMIA

Serine 59 Phosphorylation of αB-Crystallin Down-regulates Its Anti-apoptotic Function by Binding and Sequestering Bcl-2 in Breast Cancer Cells

(2010) Nathalie Launay et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Interaction of Hsp27 with Native Phosphorylase Kinase under Crowding Conditions

(2010) Natalia A. Chebotareva et al.   MACROMOLECULAR BIOSCIENCE

Heat shock protein 27 confers resistance to androgen ablation and chemotherapy in prostate cancer cells through eIF4E

(2010) C Andrieu et al.   ONCOGENE

Reduced αB-crystallin staining in perineural invasion of head and neck cutaneous squamous cell carcinoma

(2010) C. Arturo Solares et al.   OTOLARYNGOLOGY-HEAD AND NECK SURGERY

Quaternary dynamics and plasticity underlie small heat shock protein chaperone function

(2010) F. Stengel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interactions between Small Heat Shock Protein α-Crystallin and Galectin-Related Interfiber Protein (GRIFIN) in the Ocular Lens

(2009) Kelly A. Barton et al.   BIOCHEMISTRY

Regulation of αB-crystallin gene expression by the transcription factor Ets1 in breast cancer

(2009) Joshua D. Bosman et al.   BREAST CANCER RESEARCH AND TREATMENT

Crystal Structures of α-Crystallin Domain Dimers of αB-Crystallin and Hsp20

(2009) C. Bagnéris et al.   JOURNAL OF MOLECULAR BIOLOGY

Down-regulation of HSP27 sensitizes TRAIL-resistant tumor cell to TRAIL-induced apoptosis

(2009) Hongqin Zhuang et al.   LUNG CANCER

Heat shock protein 27 is involved in SUMO-2/3 modification of heat shock factor 1 and thereby modulates the transcription factor activity

(2009) M Brunet Simioni et al.   ONCOGENE

Upregulated HSP27 in human breast cancer cells reduces Herceptin susceptibility by increasing Her2 protein stability

(2008) Se Hun Kang et al.   BMC CANCER

Expression of heat shock protein 27 and alpha-crystallins in human retinoblastoma after chemoreduction

(2008) S Kase et al.   BRITISH JOURNAL OF OPHTHALMOLOGY

The Cytoplasmic Deacetylase HDAC6 Is Required for Efficient Oncogenic Tumorigenesis

(2008) Y.-S. Lee et al.   CANCER RESEARCH

P-Cadherin and β-catenin are useful prognostic markers in breast cancer patients; β-catenin interacts with heat shock protein Hsp27

(2008) Mariel A. Fanelli et al.   CELL STRESS & CHAPERONES

HSP27 regulates IL-1 stimulated IKK activation through interacting with TRAF6 and affecting its ubiquitination

(2008) Y WU et al.   CELLULAR SIGNALLING

Extracellular Release of the Atheroprotective Heat Shock Protein 27 Is Mediated by Estrogen and Competitively Inhibits acLDL Binding to Scavenger Receptor-A

(2008) Katey Rayner et al.   CIRCULATION RESEARCH

Serum Heat Shock Protein 27 and Diabetes Complications in the EURODIAB Prospective Complications Study: A Novel Circulating Marker for Diabetic Neuropathy

(2008) G. Gruden et al.   DIABETES

Identification of a PTEN-regulated STAT3 brain tumor suppressor pathway

(2008) N. de la Iglesia et al.   GENES & DEVELOPMENT

HSP27 mediates SPARC-induced changes in glioma morphology, migration, and invasion

(2008) William A. Golembieski et al.   GLIA

Expression and prognostic significance of the αB-crystallin gene in human hepatocellular carcinoma

(2008) Qi Tang et al.   HUMAN PATHOLOGY

Protective Role of Hsp27 Protein Against Gamma Radiation–Induced Apoptosis and Radiosensitization Effects of Hsp27 Gene Silencing in Different Human Tumor Cells

(2008) Marie-Thérèse Aloy et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

αB-Crystallin is a Cytoplasmic Interaction Partner of the Kidney-Specific Cadherin-16

(2008) Cornelia Thedieck et al.   JOURNAL OF MOLECULAR BIOLOGY

Chaperone Hsp27, a Novel Subunit of AUF1 Protein Complexes, Functions in AU-Rich Element-Mediated mRNA Decay

(2008) K. S. Sinsimer et al.   MOLECULAR AND CELLULAR BIOLOGY

αB-crystallin: A novel marker of invasive basal-like and metaplastic breast carcinomas

(2007) Stephanie M. Sitterding et al.   Annals of Diagnostic Pathology

Interactive sequences in the molecular chaperone, human αB crystallin modulate the fibrillation of amyloidogenic proteins

(2007) Joy G. Ghosh et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY