Inhibition of HSP27 alone or in combination with pAKT inhibition as therapeutic approaches to target SPARC-induced glioma cell survival

Autophagy as a therapeutic target in cancer

(2011) Ning Chen et al.   CANCER BIOLOGY & THERAPY

Autophagy as a target for anticancer therapy

(2011) Filip Janku et al.   Nature Reviews Clinical Oncology

Akt2 and Akt3 play a pivotal role in malignant gliomas

(2011) H. Mure et al.   NEURO-ONCOLOGY

Overall survival, prognostic factors, and repeated surgery in a consecutive series of 516 patients with glioblastoma multiforme

(2010) R. Helseth et al.   ACTA NEUROLOGICA SCANDINAVICA

Integrated Genomic Analysis Identifies Clinically Relevant Subtypes of Glioblastoma Characterized by Abnormalities in PDGFRA, IDH1, EGFR, and NF1

(2010) Roel G.W. Verhaak et al.   CANCER CELL

Distinct Biological Roles for the Akt Family in Mammary Tumor Progression: Figure 1.

(2010) Rachelle L. Dillon et al.   CANCER RESEARCH

A clinicopathological and molecular analysis of glioblastoma multiforme with long-term survival

(2010) Prasenjit Das et al.   JOURNAL OF CLINICAL NEUROSCIENCE

Effect of aberrant p53 function on temozolomide sensitivity of glioma cell lines and brain tumor initiating cells from glioblastoma

(2010) Michael D. Blough et al.   JOURNAL OF NEURO-ONCOLOGY

PTEN augments SPARC suppression of proliferation and inhibits SPARC-induced migration by suppressing SHC-RAF-ERK and AKT signaling

(2010) Stacey L. Thomas et al.   NEURO-ONCOLOGY

Secreted protein, acidic and rich in cysteine (SPARC) expression in astrocytic tumour cells negatively correlates with proliferation, while vascular SPARC expression is associated with patient survival

(2010) D. Capper et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

SPARC Is Associated with Gastric Cancer Progression and Poor Survival of Patients

(2009) Z.-S. Zhao et al.   CLINICAL CANCER RESEARCH

Caspase-7: A protease involved in apoptosis and inflammation

(2009) Mohamed Lamkanfi et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Intravesical combination treatment with antisense oligonucleotides targeting heat shock protein-27 and HTI-286 as a novel strategy for high-grade bladder cancer

(2009) Y. Matsui et al.   MOLECULAR CANCER THERAPEUTICS

Glioblastoma Subclasses Can Be Defined by Activity among Signal Transduction Pathways and Associated Genomic Alterations

(2009) Cameron Brennan et al.   PLoS One

Role of Akt isoforms in HGF-induced invasive growth of human salivary gland cancer cells

(2008) Shingo Hara et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

SPARC in cancer biology: Its role in cancer progression and potential for therapy

(2008) Isabella T. Tai et al.   DRUG RESISTANCE UPDATES

HSP27 mediates SPARC-induced changes in glioma morphology, migration, and invasion

(2008) William A. Golembieski et al.   GLIA

The Copper Binding Domain of SPARC Mediates Cell Survivalin Vitrovia Interaction with Integrin β1 and Activation of Integrin-linked Kinase

(2008) Matt S. Weaver et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Akt inhibition promotes autophagy and sensitizes PTEN-null tumors to lysosomotropic agents

(2008) Michael Degtyarev et al.   JOURNAL OF CELL BIOLOGY

Integrin-linked kinase - essential roles in physiology and cancer biology

(2008) P. C. McDonald et al.   JOURNAL OF CELL SCIENCE

Phase I/II Trial of Erlotinib and Temozolomide With Radiation Therapy in the Treatment of Newly Diagnosed Glioblastoma Multiforme: North Central Cancer Treatment Group Study N0177

(2008) Paul D. Brown et al.   JOURNAL OF CLINICAL ONCOLOGY

Comprehensive genomic characterization defines human glioblastoma genes and core pathways

(2008) Roger McLendon et al.   NATURE

Executioner caspase-3 and caspase-7 are functionally distinct proteases

(2008) J. G. Walsh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An Integrated Genomic Analysis of Human Glioblastoma Multiforme

(2008) D. W. Parsons et al.   SCIENCE

IFATS Collection: Combinatorial Peptides Identify α5β1 Integrin as a Receptor for the Matricellular Protein SPARC on Adipose Stromal Cells

(2008) Jing Nie et al.   STEM CELLS