Anticipated Classes of New Medications and Molecular Targets for Pulmonary Arterial Hypertension

Pharmocoepigenetics: a new approach to predicting individual drug responses and targeting new drugs

(2014) Wanda Baer-Dubowska et al.   Pharmacological Reports

Expression of Mutant BMPR-II in Pulmonary Endothelial Cells Promotes Apoptosis and a Release of Factors that Stimulate Proliferation of Pulmonary Arterial Smooth Muscle Cells

(2014) Xudong Yang et al.   Pulmonary Circulation

A brief overview of mouse models of pulmonary arterial hypertension: problems and prospects

(2012) Jose Gomez-Arroyo et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Lung18F-Fluorodeoxyglucose Positron Emission Tomography for Diagnosis and Monitoring of Pulmonary Arterial Hypertension

(2012) Glenn Marsboom et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Modern Age Pathology of Pulmonary Arterial Hypertension

(2012) Elvira Stacher et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Role of Src Tyrosine Kinases in Experimental Pulmonary Hypertension

(2012) Soni Savai Pullamsetti et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Gremlin Plays a Key Role in the Pathogenesis of Pulmonary Hypertension

(2012) Edwina Cahill et al.   CIRCULATION

Pulmonary Arterial Hypertension in Patients Treated by Dasatinib

(2012) David Montani et al.   CIRCULATION

Selective Class I Histone Deacetylase Inhibition Suppresses Hypoxia-Induced Cardiopulmonary Remodeling Through an Antiproliferative Mechanism

(2012) Maria A. Cavasin et al.   CIRCULATION RESEARCH

Dynamin-Related Protein 1–Mediated Mitochondrial Mitotic Fission Permits Hyperproliferation of Vascular Smooth Muscle Cells and Offers a Novel Therapeutic Target in Pulmonary Hypertension

(2012) Glenn Marsboom et al.   CIRCULATION RESEARCH

Selexipag: an oral, selective prostacyclin receptor agonist for the treatment of pulmonary arterial hypertension

(2012) Gérald Simonneau et al.   EUROPEAN RESPIRATORY JOURNAL

Src tyrosine kinase is crucial for potassium channel function in human pulmonary arteries

(2012) C. Nagaraj et al.   EUROPEAN RESPIRATORY JOURNAL

Activin-like kinase 3 is important for kidney regeneration and reversal of fibrosis

(2012) Hikaru Sugimoto et al.   NATURE MEDICINE

Peptide-Directed Highly Selective Targeting of Pulmonary Arterial Hypertension

(2011) Takeo Urakami et al.   AMERICAN JOURNAL OF PATHOLOGY

The monocrotaline model of pulmonary hypertension in perspective

(2011) Jose G. Gomez-Arroyo et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

A Novel Murine Model of Severe Pulmonary Arterial Hypertension

(2011) Loredana Ciuclan et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Suppression of Histone Deacetylases Worsens Right Ventricular Dysfunction after Pulmonary Artery Banding in Rats

(2011) Harm J. Bogaard et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Pulmonary Lymphoid Neogenesis in Idiopathic Pulmonary Arterial Hypertension

(2011) Frédéric Perros et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Tyrosine Kinase Inhibitors Are Potent Acute Pulmonary Vasodilators in Rats

(2011) Kohtaro Abe et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Therapeutic Potential for HDAC Inhibitors in the Heart

(2011) Timothy A. McKinsey   Annual Review of Pharmacology and Toxicology

Disruption of the Apelin-APJ System Worsens Hypoxia-Induced Pulmonary Hypertension

(2011) Suparna M. Chandra et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Safety and efficacy of an oral histone deacetylase inhibitor in systemic-onset juvenile idiopathic arthritis

(2011) Jelena Vojinovic et al.   ARTHRITIS AND RHEUMATISM

Hypoxia-inducible factors in human pulmonary arterial hypertension: a link to the intrinsic myeloid abnormalities

(2011) S. Farha et al.   BLOOD

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Induction of Vascular GTP-Cyclohydrolase I and Endogenous Tetrahydrobiopterin Synthesis Protect Against Inflammation-Induced Endothelial Dysfunction in Human Atherosclerosis

(2011) Charalambos Antoniades et al.   CIRCULATION

Targeted gene delivery of BMPR2 attenuates pulmonary hypertension

(2011) A. M. Reynolds et al.   EUROPEAN RESPIRATORY JOURNAL

Riociguat for the treatment of pulmonary hypertension

(2011) Ralph T Schermuly et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Pro-apoptotic effects of imatinib on PDGF-stimulated pulmonary artery smooth muscle cells from patients with idiopathic pulmonary arterial hypertension

(2011) Kazufumi Nakamura et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Rodent models of pulmonary hypertension: harmonisation with the world health organisation’s categorisation of human PH

(2011) J. Ryan et al.   INTERNATIONAL JOURNAL OF CLINICAL PRACTICE

Disruption of PPARγ/β-catenin–mediated regulation of apelin impairs BMP-induced mouse and human pulmonary arterial EC survival

(2011) Tero-Pekka Alastalo et al.   JOURNAL OF CLINICAL INVESTIGATION

Emergence of Fibroblasts with a Proinflammatory Epigenetically Altered Phenotype in Severe Hypoxic Pulmonary Hypertension

(2011) M. Li et al.   JOURNAL OF IMMUNOLOGY

Therapeutic inhibition of fatty acid oxidation in right ventricular hypertrophy: exploiting Randle’s cycle

(2011) Yong-Hu Fang et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Unknown

(2011) Eli Lewis et al.   MOLECULAR MEDICINE

Unknown

(2011) Charles Dinarello et al.   MOLECULAR MEDICINE

Efficacy and Safety of Sirolimus in Lymphangioleiomyomatosis

(2011) Francis X. McCormack et al.   NEW ENGLAND JOURNAL OF MEDICINE

Somatic Chromosome Abnormalities in the Lungs of Patients with Pulmonary Arterial Hypertension

(2010) Micheala A. Aldred et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Imatinib in Pulmonary Arterial Hypertension Patients with Inadequate Response to Established Therapy

(2010) Hossein A. Ghofrani et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Autocrine Fibroblast Growth Factor-2 Signaling Contributes to Altered Endothelial Phenotype in Pulmonary Hypertension

(2010) Ly Tu et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Bone morphogenetic protein receptor II regulates pulmonary artery endothelial cell barrier function

(2010) V. J. Burton et al.   BLOOD

Formation of Plexiform Lesions in Experimental Severe Pulmonary Arterial Hypertension

(2010) Kohtaro Abe et al.   CIRCULATION

Epigenetic Attenuation of Mitochondrial Superoxide Dismutase 2 in Pulmonary Arterial Hypertension

(2010) Stephen L. Archer et al.   CIRCULATION

Elevated Levels of Inflammatory Cytokines Predict Survival in Idiopathic and Familial Pulmonary Arterial Hypertension

(2010) Elaine Soon et al.   CIRCULATION

Basic Science of Pulmonary Arterial Hypertension for Clinicians

(2010) Stephen L. Archer et al.   CIRCULATION

Sodium Valproate, a Histone Deacetylase Inhibitor, but Not Captopril, Prevents Right Ventricular Hypertrophy in Rats

(2010) Young Kuk Cho et al.   CIRCULATION JOURNAL

Protein Acetylation in the Cardiorenal Axis

(2010) Erik W. Bush et al.   CIRCULATION RESEARCH

Epigenetic Regulation of the Cardiovascular System

(2010) Benoit G. Bruneau   CIRCULATION RESEARCH

Prevalence of anti-endothelial cell antibodies in idiopathic pulmonary arterial hypertension

(2010) S. J. Arends et al.   EUROPEAN RESPIRATORY JOURNAL

Riociguat for chronic thromboembolic pulmonary hypertension and pulmonary arterial hypertension: a phase II study

(2010) H. A. Ghofrani et al.   EUROPEAN RESPIRATORY JOURNAL

Terguride ameliorates monocrotaline-induced pulmonary hypertension in rats

(2010) R. Dumitrascu et al.   EUROPEAN RESPIRATORY JOURNAL

Therapeutic efficacy of azaindole-1 in experimental pulmonary hypertension

(2010) B. K. Dahal et al.   EUROPEAN RESPIRATORY JOURNAL

Safety of sapropterin dihydrochloride (6r–bh4) in patients with pulmonary hypertension

(2010) Ivan M. Robbins et al.   EXPERIMENTAL LUNG RESEARCH

Acute vasodilator effects of inhaled fasudil, a specific Rho-kinase inhibitor, in patients with pulmonary arterial hypertension

(2010) Hiroshi Fujita et al.   HEART AND VESSELS

Identification of a Lysosomal Pathway Regulating Degradation of the Bone Morphogenetic Protein Receptor Type II

(2010) Hannah J. Durrington et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Isoform-selective HDAC inhibitors: Closing in on translational medicine for the heart

(2010) Timothy A. McKinsey   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Mesenchymal Stromal Cells Expressing Heme Oxygenase-1 Reverse Pulmonary Hypertension

(2010) Olin D. Liang et al.   STEM CELLS

Apelin decreases myocardial injury and improves right ventricular function in monocrotaline-induced pulmonary hypertension

(2009) Inês Falcão-Pires et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Tie2-mediated loss of peroxisome proliferator-activated receptor-γ in mice causes PDGF receptor-β-dependent pulmonary arterial muscularization

(2009) C. Guignabert et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Animal models of pulmonary arterial hypertension: the hope for etiological discovery and pharmacological cure

(2009) Kurt R. Stenmark et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Role of Epidermal Growth Factor Inhibition in Experimental Pulmonary Hypertension

(2009) Bhola Kumar Dahal et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Antifibroblast antibodies from systemic sclerosis patients bind to  -enolase and are associated with interstitial lung disease

(2009) B Terrier et al.   ANNALS OF THE RHEUMATIC DISEASES

Mesenchymal stem cell-based prostacyclin synthase gene therapy for pulmonary hypertension rats

(2009) Kiyoko Takemiya et al.   BASIC RESEARCH IN CARDIOLOGY

Structure–function studies for the panacea, valproic acid

(2009) Nicole Terbach et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Stress Doppler Echocardiography in Relatives of Patients With Idiopathic and Familial Pulmonary Arterial Hypertension

(2009) Ekkehard Grünig et al.   CIRCULATION

Altered Bone Morphogenetic Protein and Transforming Growth Factor-β Signaling in Rat Models of Pulmonary Hypertension

(2009) Lu Long et al.   CIRCULATION

A Dosing/Cross-Development Study of the Multikinase Inhibitor Sorafenib in Patients With Pulmonary Arterial Hypertension

(2009) M Gomberg-Maitland et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Autologous transplantation of bone marrow–derived endothelial progenitor cells attenuates monocrotaline-induced pulmonary arterial hypertension in rats

(2009) Hon-Kan Yip et al.   CRITICAL CARE MEDICINE

Survival in pulmonary arterial hypertension: a reappraisal of the NIH risk stratification equation

(2009) T. Thenappan et al.   EUROPEAN RESPIRATORY JOURNAL

First acute haemodynamic study of soluble guanylate cyclase stimulator riociguat in pulmonary hypertension

(2009) F. Grimminger et al.   EUROPEAN RESPIRATORY JOURNAL

Dichloroacetate treatment partially regresses established pulmonary hypertension in mice with SM22α-targeted overexpression of the serotonin transporter

(2009) Christophe Guignabert et al.   FASEB JOURNAL

Bone Morphogenetic Protein (BMP) and Activin Type II Receptors Balance BMP9 Signals Mediated by Activin Receptor-like Kinase-1 in Human Pulmonary Artery Endothelial Cells

(2009) Paul D. Upton et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The inhibition of pyruvate dehydrogenase kinase improves impaired cardiac function and electrical remodeling in two models of right ventricular hypertrophy: resuscitating the hibernating right ventricle

(2009) Lin Piao et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Cellular and Molecular Basis of Pulmonary Arterial Hypertension

(2009) Nicholas W. Morrell et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Inflammation, Growth Factors, and Pulmonary Vascular Remodeling

(2009) Paul M. Hassoun et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Pulmonary apelin levels and effects in rats with hypoxic pulmonary hypertension

(2009) C.U. Andersen et al.   RESPIRATORY MEDICINE

Platelet-derived Growth Factor Expression and Function in Idiopathic Pulmonary Arterial Hypertension

(2008) Frédéric Perros et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Phase 2 study of sodium phenylbutyrate in ALS

(2008) Merit E. Cudkowicz et al.   Amyotrophic Lateral Sclerosis

Cicletanine for the Treatment of Pulmonary Arterial Hypertension

(2008) Aaron B. Waxman et al.   ARCHIVES OF INTERNAL MEDICINE

Antifibroblast antibodies in systemic sclerosis induce fibroblasts to produce profibrotic chemokines, with partial exploitation of toll-like receptor 4

(2008) Serena Fineschi et al.   ARTHRITIS AND RHEUMATISM

Mechanisms of Cardiac Dysfunction Associated With Tyrosine Kinase Inhibitor Cancer Therapeutics

(2008) Ming Hui Chen et al.   CIRCULATION

Combined Tyrosine and Serine/Threonine Kinase Inhibition by Sorafenib Prevents Progression of Experimental Pulmonary Hypertension and Myocardial Remodeling

(2008) Martina Klein et al.   CIRCULATION

Emerging Concepts and Translational Priorities in Pulmonary Arterial Hypertension

(2008) Evangelos D. Michelakis et al.   CIRCULATION

Interleukin-6 Overexpression Induces Pulmonary Hypertension

(2008) M. Kathryn Steiner et al.   CIRCULATION RESEARCH

Expression and function of soluble guanylate cyclase in pulmonary arterial hypertension

(2008) R. T. Schermuly et al.   EUROPEAN RESPIRATORY JOURNAL

Failure of bone morphogenetic protein receptor trafficking in pulmonary arterial hypertension: potential for rescue

(2008) A. Sobolewski et al.   HUMAN MOLECULAR GENETICS

Molecular pathogenesis of pulmonary arterial hypertension

(2008) Marlene Rabinovitch   JOURNAL OF CLINICAL INVESTIGATION

An antiproliferative BMP-2/PPARγ/apoE axis in human and murine SMCs and its role in pulmonary hypertension

(2008) Georg Hansmann et al.   JOURNAL OF CLINICAL INVESTIGATION

Pulmonary arterial remodeling induced by a Th2 immune response

(2008) Eleen Daley et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A Long-Acting and Highly Selective Prostacyclin Receptor Agonist Prodrug, 2- -N-(methylsulfonyl)acetamide (NS-304), Ameliorates Rat Pulmonary Hypertension with Unique Relaxant Responses of Its Active Form,  acetic Acid (MRE-269), on Rat Pulmonary Artery

(2008) K. Kuwano et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

A quantitative analysis of kinase inhibitor selectivity

(2008) Mazen W Karaman et al.   NATURE BIOTECHNOLOGY

Therapeutic targets in pulmonary arterial hypertension

(2008) Christopher J. Rhodes et al.   PHARMACOLOGY & THERAPEUTICS

Genomic assessment of a multikinase inhibitor, sorafenib, in a rodent model of pulmonary hypertension

(2008) Liliana Moreno-Vinasco et al.   PHYSIOLOGICAL GENOMICS

Acute vasodilator effects of Rho-kinase inhibitors in neonatal rats with pulmonary hypertension unresponsive to nitric oxide

(2007) Patrick J. McNamara et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY