Therapeutic opportunities for targeting the ubiquitous cell surface receptor CD47

Thrombospondin 1 and Vasoactive Agents Indirectly Alter Tumor Blood Flow

(2015) Jeff S. Isenberg et al.   NEOPLASIA

CD47 Expression on T Cell Is a Self-Control Negative Regulator of Type 1 Immune Response

(2014) S. Bouguermouh et al.   JOURNAL OF IMMUNOLOGY

Diminished adhesion and activation of platelets and neutrophils with CD47 functionalized blood contacting surfaces

(2012) Matthew J. Finley et al.   BIOMATERIALS

Is targeting of CD47-SIRP  enough for treating hematopoietic malignancy?

(2012) X. W. Zhao et al.   BLOOD

CD47 functions as a molecular switch for erythrocyte phagocytosis

(2012) P. Burger et al.   BLOOD

Activated CD47 promotes pulmonary arterial hypertension through targeting caveolin-1

(2012) Philip M. Bauer et al.   CARDIOVASCULAR RESEARCH

Janus-like opposing roles of CD47 in autoimmune brain inflammation in humans and mice

(2012) May H. Han et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Endothelial CD47 Promotes Vascular Endothelial-Cadherin Tyrosine Phosphorylation and Participates in T Cell Recruitment at Sites of Inflammation In Vivo

(2012) V. Azcutia et al.   JOURNAL OF IMMUNOLOGY

The matricellular protein thrombospondin-1 globally regulates cardiovascular function and responses to stress via CD47

(2012) David D. Roberts et al.   MATRIX BIOLOGY

The CD47-signal regulatory protein alpha (SIRPa) interaction is a therapeutic target for human solid tumors

(2012) S. B. Willingham et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Thrombospondin-1 and Angiotensin II Inhibit Soluble Guanylyl Cyclase through an Increase in Intracellular Calcium Concentration

(2011) Saumya Ramanathan et al.   BIOCHEMISTRY

Extranodal dissemination of non-Hodgkin lymphoma requires CD47 and is inhibited by anti-CD47 antibody therapy

(2011) M. P. Chao et al.   BLOOD

A new disulfide-linked dimer of a single-chain antibody fragment against human CD47 induces apoptosis in lymphoid malignant cells via the hypoxia inducible factor-1α pathway

(2011) Morihiko Sagawa et al.   CANCER SCIENCE

CD47 applies the brakes to angiogenesis via vascular endothelial growth factor receptor-2

(2011) Sukhbir Kaur et al.   CELL CYCLE

The Beclin 1 network regulates autophagy and apoptosis

(2011) R Kang et al.   CELL DEATH AND DIFFERENTIATION

Sympathetic Neural Mechanisms in Human Blood Pressure Regulation

(2011) Emma C. Hart et al.   CURRENT HYPERTENSION REPORTS

Nitric oxide synthases: regulation and function

(2011) U. Forstermann et al.   EUROPEAN HEART JOURNAL

Therapies using anti-angiogenic peptide mimetics of thrombospondin-1

(2011) Jack Henkin et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Heparan Sulfate Modification of the Transmembrane Receptor CD47 Is Necessary for Inhibition of T Cell Receptor Signaling by Thrombospondin-1

(2011) Sukhbir Kaur et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Exon skipping and dystrophin restoration in patients with Duchenne muscular dystrophy after systemic phosphorodiamidate morpholino oligomer treatment: an open-label, phase 2, dose-escalation study

(2011) Sebahattin Cirak et al.   LANCET

CD47-signal regulatory protein-  (SIRP ) interactions form a barrier for antibody-mediated tumor cell destruction

(2011) X. W. Zhao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Self inhibition of phagocytosis: The affinity of ‘marker of self’ CD47 for SIRPα dictates potency of inhibition but only at low expression levels

(2010) Richard K. Tsai et al.   BLOOD CELLS MOLECULES AND DISEASES

Thrombospondin-1 is an inhibitor of pharmacological activation of soluble guanylate cyclase

(2010) Thomas W Miller et al.   BRITISH JOURNAL OF PHARMACOLOGY

Therapeutic Antibody Targeting of CD47 Eliminates Human Acute Lymphoblastic Leukemia

(2010) Mark P. Chao et al.   CANCER RESEARCH

Pathogenesis and Clinical Physiology of Hypertension

(2010) Mukesh Singh et al.   CARDIOLOGY CLINICS

Thrombospondin-1 supports blood pressure by limiting eNOS activation and endothelial-dependent vasorelaxation

(2010) Eileen M. Bauer et al.   CARDIOVASCULAR RESEARCH

Anti-CD47 Antibody Synergizes with Rituximab to Promote Phagocytosis and Eradicate Non-Hodgkin Lymphoma

(2010) Mark P. Chao et al.   CELL

Correlated Expression of CD47 and SIRPA in Bone Marrow and in Peripheral Blood Predicts Recurrence in Breast Cancer Patients

(2010) M. Nagahara et al.   CLINICAL CANCER RESEARCH

Targeting SIRP-α protects from type 2-driven allergic airway inflammation

(2010) Marianne Raymond et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Glucose Regulation of Thrombospondin and Its Role in the Modulation of Smooth Muscle Cell Proliferation

(2010) Laura A. Maile et al.   Experimental Diabetes Research

Thrombospondin-1 Inhibits VEGF Receptor-2 Signaling by Disrupting Its Association with CD47

(2010) Sukhbir Kaur et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Thrombospondin-1 null mice are resistant to hypoxia-induced pulmonary hypertension

(2010) Cristhiaan D Ochoa et al.   Journal of Cardiothoracic Surgery

Thrombospondin-1 inhibition of vascular smooth muscle cell responses occurs via modulation of both cAMP and cGMP

(2010) Mingyi Yao et al.   PHARMACOLOGICAL RESEARCH

Mechanisms Underlying Lineage Commitment and Plasticity of Helper CD4+ T Cells

(2010) J. J. O'Shea et al.   SCIENCE

Calreticulin Is the Dominant Pro-Phagocytic Signal on Multiple Human Cancers and Is Counterbalanced by CD47

(2010) M. P. Chao et al.   Science Translational Medicine

Macrophages as mediators of tumor immunosurveillance

(2010) Siddhartha Jaiswal et al.   TRENDS IN IMMUNOLOGY

Blockade of Thrombospondin-1-CD47 Interactions Prevents Necrosis of Full Thickness Skin Grafts

(2009) Jeff S. Isenberg et al.   ANNALS OF SURGERY

Molecular Mechanisms Responsible for the Atheroprotective Effects of Laminar Shear Stress

(2009) Shi Pan   ANTIOXIDANTS & REDOX SIGNALING

Dominant role of CD47-thrombospondin-1 interactions in myeloma-induced fusion of human dendritic cells: implications for bone disease

(2009) A. Kukreja et al.   BLOOD

CD47 Regulates Bone Mass and Tumor Metastasis to Bone

(2009) O. Uluckan et al.   CANCER RESEARCH

CD47 Is Upregulated on Circulating Hematopoietic Stem Cells and Leukemia Cells to Avoid Phagocytosis

(2009) Siddhartha Jaiswal et al.   CELL

CD47 Is an Adverse Prognostic Factor and Therapeutic Antibody Target on Human Acute Myeloid Leukemia Stem Cells

(2009) Ravindra Majeti et al.   CELL

Role of BNIP3 and NIX in cell death, autophagy and mitophagy

(2009) J Zhang et al.   CELL DEATH AND DIFFERENTIATION

Activation of CD47 receptors causes histamine secretion from mast cells

(2009) E. Sick et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

A role for CD47 in the development of experimental colitis mediated by SIRPα+CD103−dendritic cells

(2009) Genevieve Fortin et al.   JOURNAL OF EXPERIMENTAL MEDICINE

CD47 and TLR-2 Cross-Talk Regulates Neutrophil Transmigration

(2009) A. C. Chin et al.   JOURNAL OF IMMUNOLOGY

Neurovascular effects of CD47 signaling: Promotion of cell death, inflammation, and suppression of angiogenesis in brain endothelial cells in vitro

(2009) Changhong Xing et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Thrombospondin-1 and CD47 regulate blood pressure and cardiac responses to vasoactive stress

(2009) Jeff S. Isenberg et al.   MATRIX BIOLOGY

Thrombospondin-1–CD47 blockade and exogenous nitrite enhance ischemic tissue survival, blood flow and angiogenesis via coupled NO–cGMP pathway activation

(2009) Jeff S. Isenberg et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

Thrombospondin-1/CD47 Blockade following Ischemia-Reperfusion Injury Is Tissue Protective

(2009) Justin B. Maxhimer et al.   PLASTIC AND RECONSTRUCTIVE SURGERY

Down-Regulation of Platelet Surface CD47 Expression in Escherichia coli O157:H7 Infection-Induced Thrombocytopenia

(2009) Ya-Lan Guo et al.   PLoS One

Identification, molecular characterization, clinical prognosis, and therapeutic targeting of human bladder tumor-initiating cells

(2009) K. S. Chan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Radioprotection in Normal Tissue and Delayed Tumor Growth by Blockade of CD47 Signaling

(2009) J. B. Maxhimer et al.   Science Translational Medicine

Functions and molecular mechanisms of the CD47–SIRPα signalling pathway

(2009) Takashi Matozaki et al.   TRENDS IN CELL BIOLOGY

Thrombospondin-1 and CD47 Limit Cell and Tissue Survival of Radiation Injury

(2008) Jeff S. Isenberg et al.   AMERICAN JOURNAL OF PATHOLOGY

Gene Silencing of CD47 and Antibody Ligation of Thrombospondin-1 Enhance Ischemic Tissue Survival in a Porcine Model

(2008) Jeff S. Isenberg et al.   ANNALS OF SURGERY

CD47 on experimentally senescent murine RBCs inhibits phagocytosis following Fc  receptor-mediated but not scavenger receptor-mediated recognition by macrophages

(2008) M. Olsson et al.   BLOOD

Thrombospondin 1 Promotes Tumor Macrophage Recruitment and Enhances Tumor Cell Cytotoxicity of Differentiated U937 Cells

(2008) G. Martin-Manso et al.   CANCER RESEARCH

Inhibition of Vascular Endothelial Growth Factor-A Signaling Induces Hypertension: Examining the Effect of Cediranib (Recentin; AZD2171) Treatment on Blood Pressure in Rat and the Use of Concomitant Antihypertensive Therapy

(2008) J. O. Curwen et al.   CLINICAL CANCER RESEARCH

CD47 in the Immune Response: Role of Thrombospondin and SIRP-α Reverse Signaling

(2008) Marika Sarfati et al.   CURRENT DRUG TARGETS

Glucose-Oxidized Low-Density Lipoproteins Enhance Insulin-Like Growth Factor I-Stimulated Smooth Muscle Cell Proliferation by Inhibiting Integrin-Associated Protein Cleavage

(2008) Lee B. Allen et al.   ENDOCRINOLOGY

Modulation of erythroid adhesion receptor expression by hydroxyurea in children with sickle cell disease

(2008) M.-H. Odievre et al.   HAEMATOLOGICA

Differential Interactions of Thrombospondin-1, -2, and -4 with CD47 and Effects on cGMP Signaling and Ischemic Injury Responses

(2008) Jeff S. Isenberg et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Glucose Regulation of Integrin-Associated Protein Cleavage Controls the Response of Vascular Smooth Muscle Cells to Insulin-Like Growth Factor-I

(2008) Laura A. Maile et al.   MOLECULAR ENDOCRINOLOGY

Treatment of liver ischemia–reperfusion injury by limiting thrombospondin-1/CD47 signaling

(2008) Jeff S. Isenberg et al.   SURGERY

Markers of platelet activation and apoptosis during storage of apheresis- and buffy coat-derived platelet concentrates for 7 days

(2008) Abdul-Majeed Albanyan et al.   TRANSFUSION

Association of CD47 with Natural Killer Cell-Mediated Cytotoxicity of Head-and-Neck Squamous Cell Carcinoma Lines

(2008) Min Jung Kim et al.   TUMOR BIOLOGY

Thrombospondin-1 stimulates platelet aggregation by blocking the antithrombotic activity of nitric oxide/cGMP signaling

(2007) J. S. Isenberg et al.   BLOOD