Allosteric and Biased G Protein-Coupled Receptor Signaling Regulation: Potentials for New Therapeutics
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Title
Allosteric and Biased G Protein-Coupled Receptor Signaling Regulation: Potentials for New Therapeutics
Authors
Keywords
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Journal
Frontiers in Endocrinology
Volume 5, Issue -, Pages -
Publisher
Frontiers Media SA
Online
2014-05-08
DOI
10.3389/fendo.2014.00068
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- (2013) Denise Wootten et al. NATURE REVIEWS DRUG DISCOVERY
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- (2013) J. Quoyer et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
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- (2013) Honoo Satake et al. Frontiers in Endocrinology
- GPCR heterodimers: asymmetries in ligand binding and signalling output offer new targets for drug discovery
- (2012) Eugénie Goupil et al. BRITISH JOURNAL OF PHARMACOLOGY
- TRV120027, a Novel β-Arrestin Biased Ligand at the Angiotensin II Type I Receptor, Unloads the Heart and Maintains Renal Function When Added to Furosemide in Experimental Heart Failure
- (2012) Guido Boerrigter et al. Circulation-Heart Failure
- Allosteric Modulator ORG27569 Induces CB1 Cannabinoid Receptor High Affinity Agonist Binding State, Receptor Internalization, and GiProtein-independent ERK1/2 Kinase Activation
- (2012) Kwang H. Ahn et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Peptides from Second Extracellular Loop of C-C Chemokine Receptor Type 5 (CCR5) Inhibit Diverse Strains of HIV-1
- (2012) Cajetan Dogo-Isonagie et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Functional Selectivity in GPCR Signaling: Understanding the Full Spectrum of Receptor Conformations
- (2012) E. Goupil et al. MINI-REVIEWS IN MEDICINAL CHEMISTRY
- β-arrestin 2 regulates Aβ generation and γ-secretase activity in Alzheimer's disease
- (2012) Amantha Thathiah et al. NATURE MEDICINE
- Randomised clinical trial: effects of monotherapy with ADX10059, a mGluR5 inhibitor, on symptoms and reflux events in patients with gastro-oesophageal reflux disease
- (2011) F. Zerbib et al. ALIMENTARY PHARMACOLOGY & THERAPEUTICS
- CXCR7/CXCR4 Heterodimer Constitutively Recruits β-Arrestin to Enhance Cell Migration
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- (2011) N. J. Smith et al. MOLECULAR PHARMACOLOGY
- AFQ056 treatment of levodopa-induced dyskinesias: Results of 2 randomized controlled trials
- (2011) Daniela Berg et al. MOVEMENT DISORDERS
- Epigenetic Modification of the FMR1 Gene in Fragile X Syndrome Is Associated with Differential Response to the mGluR5 Antagonist AFQ056
- (2011) S. Jacquemont et al. Science Translational Medicine
- GPCR structure and activation: an essential role for the first extracellular loop in activating the adenosine A2B receptor
- (2010) Miriam C. Peeters et al. FASEB JOURNAL
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- CXCR1 blockade selectively targets human breast cancer stem cells in vitro and in xenografts
- (2010) Christophe Ginestier et al. JOURNAL OF CLINICAL INVESTIGATION
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- Teaching old receptors new tricks: biasing seven-transmembrane receptors
- (2010) Sudarshan Rajagopal et al. NATURE REVIEWS DRUG DISCOVERY
- Efficacy, tolerability and pharmacokinetics of a modified release formulation of ADX10059, a negative allosteric modulator of metabotropic glutamate receptor 5: an esophageal pH-impedance study in healthy subjects
- (2010) F. Zerbib et al. NEUROGASTROENTEROLOGY AND MOTILITY
- GPCR Somatostatin Receptor Extracellular Loop 2 Is a Key Ectodomain for Making Subtype-Selective Antibodies With Agonist-Like Activities in the Pancreatic Neuroendocrine Tumor BON Cell Line
- (2010) Frank P. Leu et al. PANCREAS
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- VRQ397 (CRAVKY): a novel noncompetitive V2 receptor antagonist
- (2009) L. Rihakova et al. AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
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- (2009) E Berry-Kravis et al. JOURNAL OF MEDICAL GENETICS
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- (2009) Shivani Ahuja et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
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- (2008) A Zarbock et al. BRITISH JOURNAL OF PHARMACOLOGY
- Identification and Functional Characterization of Allosteric Agonists for the G Protein-Coupled Receptor FFA2
- (2008) T. Lee et al. MOLECULAR PHARMACOLOGY
- Structural diversity of G protein-coupled receptors and significance for drug discovery
- (2008) Malin C. Lagerström et al. NATURE REVIEWS DRUG DISCOVERY
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