Article
Allergy
Alexandra Schroeder, Lars P. Lunding, Ulrich M. Zissler, Christina Vock, Sina Webering, Johanna C. Ehlers, Zane Orinska, Adam Chaker, Carsten B. Schmidt-Weber, Niklas J. Lang, Herbert B. Schiller, Marcus A. Mall, Heinz Fehrenbach, Charles A. Dinarello, Michael Wegmann
Summary: The study found that IL-37 downregulates allergic airway inflammation by counterbalancing the disease-amplifying effects of IL-1 beta and IL-33.
Article
Allergy
Yuying Huang, Xuezhen Li, Lin Zhu, Chunrong Huang, Wen Chen, Zhiyang Ling, SongLing Zhu, Xintong Feng, Chunyan Yi, Wangpeng Gu, Chenghua Yan, Jing Wang, Liyan Ma, Xiao Su, Ranran Dai, Guochao Shi, Bing Sun, Yaguang Zhang
Summary: The study discovered that by inhibiting thrombin, the maturation of IL-33 can be regulated, thus impacting ILC2s cells and treating lung inflammation.
Article
Critical Care Medicine
Daniel P. Cook, Christopher M. Thomas, Ashley Y. Wu, Mark Rusznak, Jian Zhang, Weisong Zhou, Jacqueline-Yvonne Cephus, Katherine N. Gibson-Corley, Vasiliy V. Polosukhin, Allison E. Norlander, Dawn C. Newcomb, David A. Stoltz, R. Stokes Peebles
Summary: Type 2 inflammation is observed in cystic fibrosis patients. This study reveals that CFTR deficiency leads to increased expression and release of IL-33, and deletion of IL-33 reduces allergen-induced inflammation in the CF lung.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Review
Medicine, General & Internal
Yuanji Dong, Jixin Zhong, Lingli Dong
Summary: IL-33 plays a crucial role in activating various immune cells, while the IL-33/ST2 axis has a dual effect in rheumatic diseases, showing both detrimental and protective roles.
FRONTIERS IN MEDICINE
(2021)
Editorial Material
Immunology
Hirohito Kita
Summary: This passage describes the transfer of IL-33 from the nucleus to the cytoplasm and its extracellular release through gasdermin D pores in airway epithelial cells exposed to allergen proteases.
Article
Immunology
ChunYan Yuan
Summary: IL-33 is a cytokine that modulates inflammation and immune responses, primarily associated with the development of Th2 immunological responses. It has been shown to be elevated in various autoimmune disorders, suggesting a role in inducing autoimmunity and inflammatory damage. The IL-33/ST2 axis holds promising potential as a therapeutic target for autoimmune disease treatment.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Pio Conti, Fabrizio E. Pregliasco, Rosa G. Bellomo, Carla E. Gallenga, Alessandro Caraffa, Spyros K. Kritas, Dorina Lauritano, Gianpaolo Ronconi
Summary: Psoriasis is a skin disease characterized by autoimmune features and inflammatory symptoms, often accompanied by various comorbidities. Immune cells like MCs and cytokines such as IL-36 play significant roles in the inflammation process of psoriasis, while IL-38 and IL-37 may serve as potential therapeutic tools for inhibiting inflammation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Editorial Material
Immunology
Elizabeth A. Kennedy, Kellie Ann Jurado
Summary: This article investigates the unclear mechanisms of labor initiation and highlights the significance of timely labor for infant and maternal health. Siewiera et al. demonstrate the crucial role of innate type 2 immune responses in controlling uterus-intrinsic onset of labor in mice.
Editorial Material
Immunology
Lewis W. Yu, Elaine Y. Hsiao
Summary: This study reveals how immune signals can indirectly modulate enteric function through neurotransmitter regulation, promoting gut motility by inducing intestinal serotonin.
Review
Immunology
Eric Jou, Noe Rodriguez-Rodriguez, Andrew N. J. McKenzie
Summary: Colorectal cancer (CRC) is the second leading cause of cancer-related death worldwide, and current immunotherapeutic interventions have limited effectiveness. Cytokines interleukin-25 (IL-25) and IL-33, expressed by barrier epithelial cells, play important roles in the intestinal immune responses and can influence tumorigenesis in CRC. IL-25 and IL-33 have different effects on different subtypes of CRC and can modulate various immune cell types and pathways, including angiogenesis, tumor stemness, invasion, and metastasis.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Amiko M. Uchida, Gabrielle Ro, Li Qiang, Kathryn A. Peterson, June Round, Michael Dougan, Stephanie K. Dougan
Summary: This study describes a method for differentiating eosinophils from hematopoietic stem cells and investigates their response to IL-33. The differentiated eosinophils displayed similar morphology and phenotype to peripheral eosinophils and showed increased expression of IL-33 receptors and cytokines in response to IL-33 stimulation. These findings suggest that eosinophils differentiated from CD34 cells can be used as a model to study type 2 inflammation in vitro.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Mourad Azzout, Celine Dietrich, Francois Machavoine, Pauline Gastineau, Alix Bottier, Guillaume Lezmi, Maria Leite-de-Moraes
Summary: IL-33 combined with IL-12 can directly target MAIT cells to induce their activation and cytokine production. This novel mechanism of IL-33 activation provides insight into the mode of action by which human MAIT cells can promote inflammatory responses in a TCR-independent manner.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Allergy
Aurora Holgado, Zhuangzhuang Liu, Aigerim Aidarova, Christina Mueller, Mira Haegman, Yasmine Driege, Marja Kreike, Charlotte L. Scott, Inna S. Afonina, Rudi Beyaert
Summary: IL-33 plays a crucial role in allergic diseases, and A20 is involved in regulating IL-33 signaling. In the absence of A20 in macrophages, IL-33-induced lung immune responses are altered, with reduced type 2 immune response and increased production of IFN-gamma. This study reveals a novel role for A20 in regulating IL-33-induced STAT1 signaling in macrophages.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2023)
Article
Medicine, Research & Experimental
Yu-Wen Liu, Shin-Huei Fu, Ming-Wei Chien, Chao-Yuan Hsu, Ming-Hong Lin, Jia-Ling Dong, Rita Jui-Hsien Lu, Yi-Jing Lee, Pao-Yang Chen, Chih-Hung Wang, Huey-Kang Sytwu
Summary: This study revealed that BLIMP1 represses IL-21 expression to regulate autoimmune response, while IL-21 can activate a feedback loop to induce BLIMP1 expression. These findings have important implications for the development of personalized treatment approaches for autoimmune diseases.
Review
Oncology
Mingyue Cai, Na Chen
Summary: This article provides a systematic review of the roles of IL-9, IRF-8, and AP-1 in tumor development, particularly in DLBCL. Studies have found a correlation between IL-9 and DLBCL prognosis. The article also discusses future research prospects.
FRONTIERS IN ONCOLOGY
(2022)
Article
Dentistry, Oral Surgery & Medicine
K. H. Yeom, W. Ariyoshi, T. Okinaga, A. Washio, T. Morotomi, C. Kitamura, T. Nishihara
INTERNATIONAL ENDODONTIC JOURNAL
(2016)
Article
Chemistry, Analytical
Satoshi Fujii, Shinobu Sato, Keisuke Fukuda, Toshinori Okinaga, Wataru Ariyoshi, Michihiko Usui, Keisuke Nakashima, Tatsuji Nishihara, Shigeori Takenaka
ANALYTICAL SCIENCES
(2016)
Article
Biochemistry & Molecular Biology
Shirou Tabe, Hisako Hikiji, Wataru Ariyoshi, Tomomi Hashidate-Yoshida, Hideo Shindou, Toshinori Okinaga, Takao Shimizu, Kazuhiro Tominaga, Tatsuji Nishihara
Article
Orthopedics
Junya Furuta, Wataru Ariyoshi, Toshinori Okinaga, Jun Takeuchi, Sho Mitsugi, Kazuhiro Tominaga, Tatsuji Nishihara
JOURNAL OF ORTHOPAEDIC RESEARCH
(2017)
Article
Biochemistry & Molecular Biology
Mai Otsuka, Toshinori Okinaga, Wataru Ariyoshi, Chiaki Kitamura, Tatsuji Nishihara
JOURNAL OF CELLULAR BIOCHEMISTRY
(2017)
Article
Biochemistry & Molecular Biology
Tomonari Kajita, Wataru Ariyoshi, Toshinori Okinaga, Sho Mitsugi, Kazuhiro Tominaga, Tatsuji Nishihara
JOURNAL OF CELLULAR BIOCHEMISTRY
(2018)
Article
Agriculture, Dairy & Animal Science
N. Jaffar, T. Okinaga, T. Nishihara, T. Maeda
JOURNAL OF DAIRY SCIENCE
(2018)
Article
Dentistry, Oral Surgery & Medicine
Y. Moritani, M. Usui, K. Sano, K. Nakazawa, T. Hanatani, M. Nakatomi, T. Iwata, T. Sato, W. Ariyoshi, T. Nishihara, K. Nakashima
JOURNAL OF PERIODONTAL RESEARCH
(2018)
Article
Cell Biology
Junya Kaneko, Toshinori Okinaga, Wataru Ariyoshi, Hisako Hikiji, Seiko Fujii, Kenjiro Iwanaga, Kazuhiro Tominaga, Tatsuji Nishihara
CELL BIOLOGY INTERNATIONAL
(2018)
Article
Cell Biology
Wichida Chaweewannakorn, Wataru Ariyoshi, Toshinori Okinaga, Yuko Fujita, Kenshi Maki, Tatsuji Nishihara
JOURNAL OF CELLULAR PHYSIOLOGY
(2019)
Article
Multidisciplinary Sciences
Fumika Hirabayashi, Kenjiro Iwanaga, Toshinori Okinaga, Osamu Takahashi, Wataru Ariyoshi, Ryo Suzuki, Mutsumi Sugii, Kazuo Maruyama, Kazuhiro Tominaga, Tatsuji Nishihara
Article
Multidisciplinary Sciences
Shirou Tabe, Hisako Hikiji, Wataru Ariyoshi, Tomomi Hashidate-Yoshida, Hideo Shindou, Takao Shimizu, Toshinori Okinaga, Yuji Seta, Kazuhiro Tominaga, Tatsuji Nishihara
SCIENTIFIC REPORTS
(2017)
Correction
Anesthesiology
Sakiko Kitamura, Kenichi Takechi, Tasuku Nishihara, Amane Konishi, Yasushi Takasaki, Toshihiro Yorozuya
JOURNAL OF CLINICAL ANESTHESIA
(2019)
Article
Immunology
Junya Kaneko, Toshinori Okinaga, Hisako Hikiji, Wataru Ariyoshi, Daigo Yoshiga, Manabu Habu, Kazuhiro Tominaga, Tatsuji Nishihara
INFLAMMATION AND REGENERATION
(2018)
Article
Biochemistry & Molecular Biology
Wichida Chaweewannakorn, Wataru Ariyoshi, Toshinori Okinaga, Kazumasa Morikawa, Katsura Saeki, Kenshi Maki, Tatsuji Nishihara
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2017)
Article
Biochemistry & Molecular Biology
Soojung Hahn, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim
Summary: This study utilized three-dimensional intestinal organoids to investigate the effects of metformin on inflammatory bowel disease (IBD) and found that metformin can enhance intestinal barrier function and reduce levels of inflammatory cytokines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
V. V. Sudarev, M. S. Gette, S. V. Bazhenov, O. M. Tilinova, E. V. Zinovev, I. V. Manukhov, A. I. Kuklin, Yu. L. Ryzhykau, A. V. Vlasov
Summary: This study investigated the self-assembly processes of ferritin-based protein complexes and obtained structurally characterized oligomeric states. These results provide new potential and opportunities for the application of ferritin in various fields.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Yalda Sabaghi, Farnaz Pourfarzad, Leila Zolghadr, Azita Bahrami, Tahereh Shojazadeh, Alireza Farasat, Nematollah Gheibi
Summary: p-Coumaric acid (p-CA) is a plant compound with anti-cancer activities. This study designed a nano-liposomal carrier containing p-CA to enhance its effectiveness against melanoma cells. The findings showed that the liposomal form of p-CA had a greater impact on the cells. Kinetic modeling indicated that the best fitting model was zero-order.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
M. D. Nazmul Hasan, Md Mahfuzur Rahman, Al Asmaul Husna, Nobuhiro Nozaki, Osamu Yamato, Naoki Miura
Summary: This study investigated the expression of ncRNAs other than miRNAs in different histologic subtypes of canine mammary gland tumors (MGT). Three aberrantly expressed ncRNAs were identified as potential biomarkers for differentiating MGT subtypes. YRNA and tRFs expression levels were found to be decreased in metastatic compared to primary MGT cell lines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Seine A. Shintani
Summary: In this study, the researchers used signal analysis to study the instantaneous amplitude and phase of sarcomeric oscillations in skeletal muscle. They identified two types of oscillations, sarcomeric oscillations and sarcosynced oscillations, and visualized their behavior during propagating waves. The researchers discovered the presence of sarcomeric defect holes and sarcomeric collision holes, which are important indicators for understanding the oscillation properties of sarcomeres. This finding has important implications for improving our understanding of muscle function and its regulatory mechanisms.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuanglin Zhang, Yuzhong Jia, Guolan Ma, Yanyan Yang, Zhenzhen Cao, Antao Luo, Zefu Zhang, Shihan Li, Jie Wen, Hanfeng Liu, Jihua Ma
Summary: Bupleurum is an antiarrhythmic agent that may exert its effects by inhibiting L-type calcium channels.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Tomotaka Ohkubo, Yasuhiko Matsumoto, Hiroaki Sasaki, Kaoru Kinoshita, Yuki Ogasawara, Takashi Sugita
Summary: This study found that Citrobacter koseri inhibits the growth of Staphylococcus epidermidis, disrupting the balance between S. epidermidis and Staphylococcus aureus, and exacerbating inflammation in atopic dermatitis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Toshifumi Asano, Philipp Sasse, Takao Nakata
Summary: A Cre recombination-based fluorescent reporter system was developed to monitor cell-cell fusion. The system successfully detected the formation of multinuclear myotubes and placental syncytiotrophoblast. This tool could facilitate the study of cell-to-cell fusion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Ke Shi, Yunlong Shan, Xiao Sun, Kuida Chen, Qiong Luo, Qiang Xu
Summary: This study found that low expression of TP53INP2 is associated with poor survival in colorectal cancer (CRC) patients. As the malignancy of CRC progresses, TP53INP2 expression gradually decreases. Knockdown of TP53INP2 promotes CRC cell proliferation and tumor growth. Mechanistically, TP53INP2 deficiency decreases phosphorylation of beta-catenin, leading to increased accumulation and enhanced nuclear translocation and transcriptional activity. Additionally, TP53INP2 sequesters TIM50, inhibiting its activation of beta-catenin. In conclusion, downregulation of TP53INP2 promotes CRC progression by activating beta-catenin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Martina Rossi, Fabio Tomaselli, Alejandro Hochkoeppler
Summary: Oligomeric enzymes are known for their higher catalytic rates compared to monomeric enzymes, but the extent of additivity in their activity is still not well understood. This study used tetrameric rabbit lactate dehydrogenase as a model to examine the kinetics of its catalytic action. Surprisingly, when the concentration of the limiting reactant exceeded that of a single subunit, there was a significant slowdown in the enzyme's conformational rearrangements.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Amin Sahraei, Mohammad Javad Shamsoddini, Fakhrossadat Mohammadi, Leila Hassani
Summary: This study explored the inhibitory effects of gallium curcumin, indium curcumin, and vanadyl curcumin on the amyloid fibrillation of hen egg white lysozyme, as well as the binding interactions of these metal complexes with the enzyme. The results showed that indium curcumin and vanadyl curcumin exhibited higher binding affinities and stronger inhibitory effects on amyloid fibrillation compared to gallium curcumin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Takahiro Sasaki, Yoshiki Kuse, Shinsuke Nakamura, Masamitsu Shimazawa
Summary: PGRN deficiency plays a significant role in cardiac remodeling and arrhythmias post-myocardial infarction (MI), potentially by promoting metabolic abnormalities in macrophages.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Hongwei Zhao, Yiqiang Li, Yibo Zhang, Chi Zhang
Summary: Electrical brain stimulation technology is commonly used to treat brain neurological disorders, but it can cause side effects. This study investigated the impact of electric fields on nerve fibers and revealed the possible origin of side effects. The findings provide guidance for selecting electrical parameters in clinical stimulation therapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Julia S. Scott, Lake-Ee Quek, Andrew J. Hoy, Johannes V. Swinnen, Zeyad D. Nassar, Lisa M. Butler
Summary: The fatty acid elongation enzyme ELOVL5 plays a critical role in promoting metastasis in prostate cancer. Knocking down ELOVL5 leads to the accumulation of malonyl-CoA, which inhibits fatty acid oxidation in mitochondria. This study highlights the importance of fatty acid elongation in regulating cell viability and provides a potential target for prostate cancer treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Zan Zhou, Wen-jun Jiang, Li Li, Jun-qiang Si
Summary: This study investigates the effect of noise exposure on cognitive function in mice and explores the underlying molecular mechanisms. The findings suggest that noise exposure leads to increased inflammation, increased phosphorylation of Tau protein, and decreased levels of postsynaptic density protein, resulting in cognitive impairment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)