Thrombin cleaves IL‐33 and modulates IL‐33‐activated allergic lung inflammation

The Coagulation and Immune Systems Are Directly Linked through the Activation of Interleukin-1α by Thrombin

(2019) Laura C. Burzynski et al.   IMMUNITY

NFATc1-E2F1-LMCD1–Mediated IL-33 Expression by Thrombin Is Required for Injury-Induced Neointima Formation

(2019) Suresh Govatati et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Environmental allergens induce allergic inflammation through proteolytic maturation of IL-33

(2018) Corinne Cayrol et al.   NATURE IMMUNOLOGY

Chromatin regulates IL-33 release and extracellular cytokine activity

(2018) Jared Travers et al.   Nature Communications

Interleukin-33 (IL-33): A nuclear cytokine from the IL-1 family

(2017) Corinne Cayrol et al.   IMMUNOLOGICAL REVIEWS

Prothrombotic State in Asthma Is Related to Increased Levels of Inflammatory Cytokines, IL-6 and TNFα, in Peripheral Blood

(2017) Stanislawa Bazan-Socha et al.   INFLAMMATION

Heparin Protects BALB/c Mice from Mite-Induced Airway Allergic Inflammation

(2017) L.S. Fu et al.   INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY

Impaired fibrinolysis and lower levels of plasma α2-macroglobulin are associated with an increased risk of severe asthma exacerbations

(2017) Stanislawa Bazan-Socha et al.   Scientific Reports

Asthma is associated with enhanced thrombin formation and impaired fibrinolysis

(2016) S. Bazan-Socha et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Programming of Intestinal Epithelial Differentiation by IL-33 Derived from Pericryptal Fibroblasts in Response to Systemic Infection

(2016) Mousumi Mahapatro et al.   Cell Reports

Effect of the oral thrombin inhibitor dabigatran on allergic lung inflammation induced by repeated house dust mite administration in mice

(2015) Johannes D. de Boer et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Environmental Microbial Exposure and Protection against Asthma

(2015) Patrick G. Holt et al.   NEW ENGLAND JOURNAL OF MEDICINE

Oxidation of the alarmin IL-33 regulates ST2-dependent inflammation

(2015) E. Suzanne Cohen et al.   Nature Communications

Low-Molecular-Weight Heparin and Unfractionated Heparin Decrease Th-1, 2, and 17 Expressions

(2014) Jing-Ning Huang et al.   PLoS One

Central domain of IL-33 is cleaved by mast cell proteases for potent activation of group-2 innate lymphoid cells

(2014) E. Lefrancais et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanisms of Airway Remodeling

(2013) Nobuaki Hirota et al.   CHEST

Asthma

(2013) Fernando D Martinez et al.   LANCET

Asthma and coagulation

(2012) J. D. de Boer et al.   BLOOD

Risk of deep vein thrombosis and pulmonary embolism in asthma

(2012) Christof J. Majoor et al.   EUROPEAN RESPIRATORY JOURNAL

Lung Natural Helper Cells Are a Critical Source of Th2 Cell-Type Cytokines in Protease Allergen-Induced Airway Inflammation

(2012) Timotheus Y.F. Halim et al.   IMMUNITY

Endogenous IL-33 Is Highly Expressed in Mouse Epithelial Barrier Tissues, Lymphoid Organs, Brain, Embryos, and Inflamed Tissues: In Situ Analysis Using a Novel Il-33-LacZ Gene Trap Reporter Strain

(2012) M. Pichery et al.   JOURNAL OF IMMUNOLOGY

The Extended Cleavage Specificity of Human Thrombin

(2012) Maike Gallwitz et al.   PLoS One

IL-33 is processed into mature bioactive forms by neutrophil elastase and cathepsin G

(2012) E. Lefrancais et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Innate IL-13–producing nuocytes arise during allergic lung inflammation and contribute to airways hyperreactivity

(2011) Jillian L. Barlow et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Human IL-25- and IL-33-responsive type 2 innate lymphoid cells are defined by expression of CRTH2 and CD161

(2011) Jenny M Mjösberg et al.   NATURE IMMUNOLOGY

Nuocytes represent a new innate effector leukocyte that mediates type-2 immunity

(2010) Daniel R. Neill et al.   NATURE

A Large-Scale, Consortium-Based Genomewide Association Study of Asthma

(2010) Miriam F. Moffatt et al.   NEW ENGLAND JOURNAL OF MEDICINE

Systemically dispersed innate IL-13-expressing cells in type 2 immunity

(2010) A. E. Price et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Immunological and Inflammatory Functions of the Interleukin-1 Family

(2009) Charles A. Dinarello   Annual Review of Immunology

Coagulation and innate immune responses: can we view them separately?

(2009) M. Delvaeye et al.   BLOOD

Suppression of Interleukin-33 Bioactivity through Proteolysis by Apoptotic Caspases

(2009) Alexander U. Lüthi et al.   IMMUNITY

Innate production of TH2 cytokines by adipose tissue-associated c-Kit+Sca-1+ lymphoid cells

(2009) Kazuyo Moro et al.   NATURE

Sequence variants affecting eosinophil numbers associate with asthma and myocardial infarction

(2009) Daniel F Gudbjartsson et al.   NATURE GENETICS

The IL-1-like cytokine IL-33 is inactivated after maturation by caspase-1

(2009) C. Cayrol et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Coagulation factors in the airways in moderate and severe asthma and the effect of inhaled steroids

(2009) F J H Brims et al.   THORAX

Molecular mimicry between IL-33 and KSHV for attachment to chromatin through the H2A–H2B acidic pocket

(2008) Lucie Roussel et al.   EMBO REPORTS

Thrombin induced secretion of macrophage migration inhibitory factor (MIF) and its effect on nuclear signaling in endothelium

(2008) Raj Wadgaonkar et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Thrombin enhances the production of monocyte chemoattractant protein-1 and macrophage inflammatory protein-2 in cultured rat glomerular epithelial cells

(2008) T. Fujita et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

The IL-1-Like Cytokine IL-33 Is Constitutively Expressed in the Nucleus of Endothelial Cells and Epithelial Cells In Vivo: A Novel ‘Alarmin’?

(2008) Christine Moussion et al.   PLoS One