Insulin-like growth factor binding protein-3 (IGFBP-3): Novel ligands mediate unexpected functions

IGFBP-3 sensitizes antiestrogen-resistant breast cancer cells through interaction with GRP78

(2012) Chao Li et al.   CANCER LETTERS

Interaction Between IGF Binding Protein-3 and TGFβ in the Regulation of Adipocyte Differentiation

(2012) Hasanthi C. de Silva et al.   ENDOCRINOLOGY

Metabolic Actions of Insulin-Like Growth Factor-I in Normal Physiology and Diabetes

(2012) David R. Clemmons   ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA

Engulfment Protein GULP Is Regulator of Transforming Growth Factor-β Response in Ovarian Cells

(2012) Cheng-I J. Ma et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

IGF binding protein-3 mediates stress-induced apoptosis in non-transformed mammary epithelial cells

(2012) Brian J. Leibowitz et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Sphingolipids: regulators of crosstalk between apoptosis and autophagy

(2012) Megan M. Young et al.   JOURNAL OF LIPID RESEARCH

Upregulation of hepatic LRP1 by rosiglitazone: a possible novel mechanism of the beneficial effect of thiazolidinediones on atherogenic dyslipidemia

(2012) Jae Hoon Moon et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

IGFBP-3 binds GRP78, stimulates autophagy and promotes the survival of breast cancer cells exposed to adverse microenvironments

(2012) S Grkovic et al.   ONCOGENE

The critical roles of endoplasmic reticulum chaperones and unfolded protein response in tumorigenesis and anticancer therapies

(2012) B Luo et al.   ONCOGENE

Lessons from C. elegans: signaling pathways for longevity

(2012) Louis R. Lapierre et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Radiotherapy and Erlotinib Combined: Review of the Preclinical and Clinical Evidence

(2012) Vivek K. Mehta   Frontiers in Oncology

Structural analyses of death domains and their interactions

(2011) Hyun Ho Park   APOPTOSIS

The retinoid X receptors and their ligands

(2011) Marcia I. Dawson et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012

(2011) L Galluzzi et al.   CELL DEATH AND DIFFERENTIATION

Signalling pathways of insulin-like growth factors (IGFs) and IGF binding protein-3

(2011) Janet L. Martin et al.   GROWTH FACTORS

Analysis of the cellular uptake and nuclear delivery of insulin-like growth factor binding protein-3 in human osteosarcoma cells

(2011) Lucia Micutkova et al.   INTERNATIONAL JOURNAL OF CANCER

Insulin-like Growth Factor-binding Protein-3 (IGFBP-3) Blocks the Effects of Asthma by Negatively Regulating NF-κB Signaling through IGFBP-3R-mediated Activation of Caspases

(2011) Yong-Chul Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Rosiglitazone Inhibits Transforming Growth Factor-β1 Mediated Fibrogenesis in ADPKD Cyst-Lining Epithelial Cells

(2011) Yawei Liu et al.   PLoS One

Loss of sphingosine kinase-1 in carcinoma cells increases formation of reactive oxygen species and sensitivity to doxorubicin-induced DNA damage

(2010) Andrea Huwiler et al.   BRITISH JOURNAL OF PHARMACOLOGY

Epidermal Growth Factor Receptor in Triple-Negative and Basal-Like Breast Cancer

(2010) Monika L. Burness et al.   CANCER JOURNAL

The epidermal growth factor receptor modulates DNA double-strand break repair by regulating non-homologous end-joining

(2010) Malte Kriegs et al.   DNA REPAIR

Transforming Growth Factor-β (TGFβ) Receptors I/II Differentially Regulate TGFβ1 and IGF-Binding Protein-3 Mitogenic Effects in the Human Placenta

(2010) Karen Forbes et al.   ENDOCRINOLOGY

Identification of a Novel Cell Death Receptor Mediating IGFBP-3-induced Anti-tumor Effects in Breast and Prostate Cancer

(2010) Angela R. Ingermann et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

IGFBP-3 Can Either Inhibit or Enhance EGF-mediated Growth of Breast Epithelial Cells Dependent upon the Presence of Fibronectin

(2010) Jamie McIntosh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of adipocyte differentiation by insulin-like growth factor-binding protein-3

(2009) Sophie S. Y. Chan et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

An online survival analysis tool to rapidly assess the effect of 22,277 genes on breast cancer prognosis using microarray data of 1,809 patients

(2009) Balazs Györffy et al.   BREAST CANCER RESEARCH AND TREATMENT

Crosstalk Between Epidermal Growth Factor Receptor- and Insulin-Like Growth Factor-1 Receptor Signaling: Implications for Cancer Therapy

(2009) J. Veeken et al.   CURRENT CANCER DRUG TARGETS

Potentiation of Growth Factor Signaling by Insulin-like Growth Factor-binding Protein-3 in Breast Epithelial Cells Requires Sphingosine Kinase Activity

(2009) Janet L. Martin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Interaction of Insulin-like Growth Factor-binding Protein-3 and BAX in Mitochondria Promotes Male Germ Cell Apoptosis

(2009) Yue Jia et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Insulin-like Growth Factor-1 Binding Protein Acid-labile Subunit Alters Mesenchymal Stromal Cell Fate

(2009) J. Christopher Fritton et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The DNA-damage response in human biology and disease

(2009) Stephen P. Jackson et al.   NATURE

Prognostic Significance of Growth Factors and the Urokinase-Type Plasminogen Activator System in Pancreatic Ductal Adenocarcinoma

(2009) Aiqun Xue et al.   PANCREAS

Constitutive Smad signaling and Smad-dependent collagen gene expression in mouse embryonic fibroblasts lacking peroxisome proliferator-activated receptor-γ

(2008) Asish K Ghosh et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The unfolded protein response regulator GRP78/BiP is required for endoplasmic reticulum integrity and stress-induced autophagy in mammalian cells

(2008) J Li et al.   CELL DEATH AND DIFFERENTIATION

Serum complexes of insulin-like growth factor-1 modulate skeletal integrity and carbohydrate metabolism

(2008) Shoshana Yakar et al.   FASEB JOURNAL

Over Expression of Insulin-Like Growth Factor Binding Protein 3 in Clear Cell Renal Cell Carcinoma

(2008) Shang-Tian Chuang et al.   JOURNAL OF UROLOGY

Lipid signalling in disease

(2008) Matthias P. Wymann et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A Functional Nuclear Localization Signal in Insulin-Like Growth Factor Binding Protein-6 Mediates Its Nuclear Import

(2007) Cristiana Iosef et al.   ENDOCRINOLOGY