Deep Brain Stimulation and L-DOPA Therapy: Concepts of Action and Clinical Applications in Parkinson's Disease

Cerebello-cortical network fingerprints differ between essential, Parkinson’s and mimicked tremors

(2018) Muthuraman Muthuraman et al.   BRAIN

Postoperative rehabilitation after deep brain stimulation surgery for movement disorders

(2018) Niels Allert et al.   CLINICAL NEUROPHYSIOLOGY

Primary Sensorimotor Cortex Drives the Common Cortical Network for Gamma Synchronization in Voluntary Hand Movements

(2018) Gertrúd Tamás et al.   Frontiers in Human Neuroscience

Subthalamic deep brain stimulation and levodopa in Parkinson’s disease: a meta-analysis of combined effects

(2018) Joaquin A. Vizcarra et al.   JOURNAL OF NEUROLOGY

Levodopa response differs in Parkinson's motor subtypes: A task-based effective connectivity study

(2017) Brianne Mohl et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Parkinson’s disease as a multisystem disorder

(2017) Lisa Klingelhoefer et al.   JOURNAL OF NEURAL TRANSMISSION

Probabilistic versus deterministic tractography for delineation of the cortico-subthalamic hyperdirect pathway in patients with Parkinson disease selected for deep brain stimulation

(2017) Mikkel V. Petersen et al.   JOURNAL OF NEUROSURGERY

A diffusion-based connectivity map of the GPi for optimised stereotactic targeting in DBS

(2017) Nadia Moreira da Silva et al.   NEUROIMAGE

Shifting from constant-voltage to constant-current in Parkinson’s disease patients with chronic stimulation

(2017) P. Amami et al.   NEUROLOGICAL SCIENCES

Intraoperative Microstimulation Predicts Outcome of Postoperative Macrostimulation in Subthalamic Nucleus Deep Brain Stimulation for Parkinson's Disease

(2017) Raja Mehanna et al.   NEUROMODULATION

Current Concepts on the Physiopathological Relevance of Dopaminergic Receptors

(2017) Ada Ledonne et al.   Frontiers in Cellular Neuroscience

Opicapone as Adjunct to Levodopa Therapy in Patients With Parkinson Disease and Motor Fluctuations

(2017) Andrew J. Lees et al.   JAMA Neurology

An Analysis of the Use of Multichannel Microelectrode Recording During Deep Brain Stimulation Surgeries at a Single Center

(2017) Steven Falowski et al.   Operative Neurosurgery

Effects of DBS in parkinsonian patients depend on the structural integrity of frontal cortex

(2017) Muthuraman Muthuraman et al.   Scientific Reports

Tractography patterns of subthalamic nucleus deep brain stimulation

(2016) Nora Vanegas-Arroyave et al.   BRAIN

Are studies of motor cortex plasticity relevant in human patients with Parkinson’s disease?

(2016) Matteo Bologna et al.   CLINICAL NEUROPHYSIOLOGY

Levodopa Effect on Basal Ganglia Motor Circuit in Parkinson's Disease

(2016) Lin-Lin Gao et al.   CNS Neuroscience & Therapeutics

How close are we to individualized medicine for Parkinson’s disease?

(2016) Hee Jin Kim et al.   Expert Review of Neurotherapeutics

The effect of L-dopa in Parkinson’s disease as revealed by neurophysiological studies of motor and sensory functions

(2016) Antonio Suppa et al.   Expert Review of Neurotherapeutics

Parkinson’s: a syndrome rather than a disease?

(2016) Nataliya Titova et al.   JOURNAL OF NEURAL TRANSMISSION

Current and experimental treatments of Parkinson disease: A guide for neuroscientists

(2016) Wolfgang Oertel et al.   JOURNAL OF NEUROCHEMISTRY

Gamma Oscillations in the Hyperkinetic State Detected with Chronic Human Brain Recordings in Parkinson's Disease

(2016) Nicole C. Swann et al.   JOURNAL OF NEUROSCIENCE

Cortical Plasticity Induction by Pairing Subthalamic Nucleus Deep-Brain Stimulation and Primary Motor Cortical Transcranial Magnetic Stimulation in Parkinson's Disease

(2016) K. Udupa et al.   JOURNAL OF NEUROSCIENCE

A brain network model explaining tremor in Parkinson's disease

(2016) Christian Duval et al.   NEUROBIOLOGY OF DISEASE

135 A Comparison of Outcomes Between Deep Brain Stimulation Under General Anesthesia Versus Conscious Sedation With Awake Evaluation

(2016) François Alesch et al.   NEUROSURGERY

Adaptive deep brain stimulation in Parkinson's disease

(2016) M. Beudel et al.   PARKINSONISM & RELATED DISORDERS

Adjuvant therapies for Parkinson’s disease: critical evaluation of safinamide

(2016) Fabrizio Stocchi et al.   Drug Design Development and Therapy

How close are we to individualized medicine for Parkinson’s disease?

(2016) Hee Jin Kim et al.   Expert Review of Neurotherapeutics

The effect of L-dopa in Parkinson’s disease as revealed by neurophysiological studies of motor and sensory functions

(2016) Antonio Suppa et al.   Expert Review of Neurotherapeutics

Dopaminergic modulation of motor network dynamics in Parkinson's disease

(2015) J. Michely et al.   BRAIN

Rotigotine is a potent agonist at dopamine D1receptors as well as at dopamine D2and D3receptors

(2015) Martyn Wood et al.   BRITISH JOURNAL OF PHARMACOLOGY

Deep brain stimulation for movement disorders

(2015) Alfonso Fasano et al.   CURRENT OPINION IN NEUROLOGY

Task-related activity in sensorimotor cortex in Parkinson's disease and essential tremor: changes in beta and gamma bands

(2015) Nathan C. Rowland et al.   Frontiers in Human Neuroscience

Subthalamic nucleus stimulation improves Parkinsonian gait via brainstem locomotor centers

(2015) Peter H. Weiss et al.   MOVEMENT DISORDERS

Microstructural changes in white matter associated with freezing of gait in Parkinson's disease

(2015) Sarah Vercruysse et al.   MOVEMENT DISORDERS

MDS clinical diagnostic criteria for Parkinson's disease

(2015) Ronald B. Postuma et al.   MOVEMENT DISORDERS

Amantadine extended release for levodopa-induced dyskinesia in Parkinson's disease (EASED Study)

(2015) Rajesh Pahwa et al.   MOVEMENT DISORDERS

Therapeutic deep brain stimulation reduces cortical phase-amplitude coupling in Parkinson's disease

(2015) Coralie de Hemptinne et al.   NATURE NEUROSCIENCE

The medical treatment of patients with Parkinson's disease receiving subthalamic neurostimulation

(2015) Athanasia Alexoudi et al.   PARKINSONISM & RELATED DISORDERS

Pathophysiology of L-dopa-induced motor and non-motor complications in Parkinson's disease

(2015) Matthieu F. Bastide et al.   PROGRESS IN NEUROBIOLOGY

The modern pre-levodopa era of Parkinson's disease: insights into motor complications from sub-Saharan Africa

(2014) R. Cilia et al.   BRAIN

Subthalamic Nucleus Deep Brain Stimulation Induces Motor Network BOLD Activation: Use of a High Precision MRI Guided Stereotactic System for Nonhuman Primates

(2014) Hoon-Ki Min et al.   Brain Stimulation

Fiber tractography of the axonal pathways linking the basal ganglia and cerebellum in Parkinson disease: implications for targeting in deep brain stimulation

(2014) Jennifer A. Sweet et al.   JOURNAL OF NEUROSURGERY

Pallidal neurostimulation in patients with medication-refractory cervical dystonia: a randomised, sham-controlled trial

(2014) Jens Volkmann et al.   LANCET NEUROLOGY

Levodopa therapy for Parkinson's disease: Pharmacokinetics and pharmacodynamics

(2014) Peter A. LeWitt   MOVEMENT DISORDERS

Levodopa: Effect on cell death and the natural history of Parkinson's disease

(2014) C. Warren Olanow   MOVEMENT DISORDERS

The place of dopamine in the cortico-basal ganglia circuit

(2014) S.N. Haber   NEUROSCIENCE

Deep-Brain Stimulation — Entering the Era of Human Neural-Network Modulation

(2014) Michael S. Okun   NEW ENGLAND JOURNAL OF MEDICINE

Subthalamic Nucleus High-Frequency Stimulation Restores Altered Electrophysiological Properties of Cortical Neurons in Parkinsonian Rat

(2014) Bertrand Degos et al.   PLoS One

A direct relationship between oscillatory subthalamic nucleus–cortex coupling and rest tremor in Parkinson’s disease

(2013) Jan Hirschmann et al.   BRAIN

Rhythm-specific modulation of the sensorimotor network in drug-naïve patients with Parkinson’s disease by levodopa

(2013) Fabrizio Esposito et al.   BRAIN

Parkinsonian apathy responds to dopaminergic stimulation of D2/D3 receptors with piribedil

(2013) Stéphane Thobois et al.   BRAIN

Synchronized neural oscillations and the pathophysiology of Parkinsonʼs disease

(2013) Ashwini Oswal et al.   CURRENT OPINION IN NEUROLOGY

Non-dopaminergic Treatments for Motor Control in Parkinson’s Disease

(2013) Susan H. Fox   DRUGS

Modulation of human corticospinal excitability by paired associative stimulation

(2013) Richard G. Carson et al.   Frontiers in Human Neuroscience

Subthalamic Nucleus Neurons Are Synchronized to Primary Motor Cortex Local Field Potentials in Parkinson's Disease

(2013) S. A. Shimamoto et al.   JOURNAL OF NEUROSCIENCE

Extended-release carbidopa-levodopa (IPX066) compared with immediate-release carbidopa-levodopa in patients with Parkinson's disease and motor fluctuations: a phase 3 randomised, double-blind trial

(2013) Robert A Hauser et al.   LANCET NEUROLOGY

Continuous intrajejunal infusion of levodopa-carbidopa intestinal gel for patients with advanced Parkinson's disease: a randomised, controlled, double-blind, double-dummy study

(2013) C Warren Olanow et al.   LANCET NEUROLOGY

Future of brain stimulation: New targets, new indications, new technology

(2013) Marwan Hariz et al.   MOVEMENT DISORDERS

Axonal and synaptic failure suppress the transfer of firing rate oscillations, synchrony and information during high frequency deep brain stimulation

(2013) Robert Rosenbaum et al.   NEUROBIOLOGY OF DISEASE

Functional MRI reveals frequency-dependent responses during deep brain stimulation at the subthalamic nucleus or internal globus pallidus

(2013) Hsin-Yi Lai et al.   NEUROIMAGE

Levodopa reinstates connectivity from prefrontal to premotor cortex during externally paced movement in Parkinson's disease

(2013) Damian M. Herz et al.   NEUROIMAGE

White matter microstructure deteriorates across cognitive stages in Parkinson disease

(2013) T. R. Melzer et al.   NEUROLOGY

Neurostimulation for Parkinson's Disease with Early Motor Complications

(2013) W.M.M. Schuepbach et al.   NEW ENGLAND JOURNAL OF MEDICINE

Differences in Dopaminergic Modulation to Motor Cortical Plasticity between Parkinson's Disease and Multiple System Atrophy

(2013) Shoji Kawashima et al.   PLoS One

The Heterogeneity of Early Parkinson’s Disease: A Cluster Analysis on Newly Diagnosed Untreated Patients

(2013) Roberto Erro et al.   PLoS One

Advances in the pharmacological treatment of Parkinson's disease: targeting neurotransmitter systems

(2013) Lars Brichta et al.   TRENDS IN NEUROSCIENCES

Motor Cortical Plasticity in Parkinson’s Disease

(2013) Kaviraja Udupa et al.   Frontiers in Neurology

A practical guide to diagnostic transcranial magnetic stimulation: Report of an IFCN committee

(2012) S. Groppa et al.   CLINICAL NEUROPHYSIOLOGY

Essential tremor and tremor in Parkinson's disease are associated with distinct ‘tremor clusters’ in the ventral thalamus

(2012) David J. Pedrosa et al.   EXPERIMENTAL NEUROLOGY

Imaging gait disorders in parkinsonism: a review

(2012) Audrey Maillet et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Movement-Related Changes in Local and Long-Range Synchronization in Parkinson's Disease Revealed by Simultaneous Magnetoencephalography and Intracranial Recordings

(2012) V. Litvak et al.   JOURNAL OF NEUROSCIENCE

The subthalamic nucleus at 3.0 Tesla: choice of optimal sequence and orientation for deep brain stimulation using a standard installation protocol

(2012) Hans U. Kerl et al.   JOURNAL OF NEUROSURGERY

Treatment of motor and non-motor features of Parkinson's disease with deep brain stimulation

(2012) Alfonso Fasano et al.   LANCET NEUROLOGY

Oscillating central motor networks in pathological tremors and voluntary movements. What makes the difference?

(2012) M. Muthuraman et al.   NEUROIMAGE

Deep brain stimulation induces BOLD activation in motor and non-motor networks: An fMRI comparison study of STN and EN/GPi DBS in large animals

(2012) Hoon-Ki Min et al.   NEUROIMAGE

Movement related dynamics of subthalmo-cortical alpha connectivity in Parkinson's disease

(2012) Ashwini Oswal et al.   NEUROIMAGE

Turning tables: Should GPi become the preferred DBS target for Parkinson disease?

(2012) M. Tagliati   NEUROLOGY

Functional reorganization of sensorimotor cortex in early Parkinson disease

(2012) M. Kojovic et al.   NEUROLOGY

Therapeutic Deep Brain Stimulation in Parkinsonian Rats Directly Influences Motor Cortex

(2012) Qian Li et al.   NEURON

Resting-state brain connectivity in patients with Parkinson's disease and freezing of gait

(2012) Alessandro Tessitore et al.   PARKINSONISM & RELATED DISORDERS

Feasibility of Using Ultra-High Field (7 T) MRI for Clinical Surgical Targeting

(2012) Yuval Duchin et al.   PLoS One

Alpha-band oscillations, attention, and controlled access to stored information

(2012) Wolfgang Klimesch   TRENDS IN COGNITIVE SCIENCES

History, Applications, and Mechanisms of Deep Brain Stimulation

(2012) Svjetlana Miocinovic et al.   JAMA Neurology

Treatment of patients with essential tremor

(2011) Günther Deuschl et al.   LANCET NEUROLOGY

Functional imaging of subthalamic nucleus deep brain stimulation in Parkinson's disease

(2011) Tessel Boertien et al.   MOVEMENT DISORDERS

The interplay of cholinergic function, attention, and falls in Parkinson's disease

(2011) Alison Yarnall et al.   MOVEMENT DISORDERS

The Movement Disorder Society Evidence-Based Medicine Review Update: Treatments for the motor symptoms of Parkinson's disease

(2011) Susan H. Fox et al.   MOVEMENT DISORDERS

Parkinson's Disease Therapeutics: New Developments and Challenges Since the Introduction of Levodopa

(2011) Yoland Smith et al.   NEUROPSYCHOPHARMACOLOGY

A basis for the pathological oscillations in basal ganglia

(2011) Moran Weinberger et al.   NEUROREPORT

Resting oscillatory cortico-subthalamic connectivity in patients with Parkinson’s disease

(2010) Vladimir Litvak et al.   BRAIN

Neural oscillator based control for pathological tremor suppression via functional electrical stimulation

(2010) Dingguo Zhang et al.   CONTROL ENGINEERING PRACTICE

Deep brain stimulation mechanisms: beyond the concept of local functional inhibition

(2010) Jean-Michel Deniau et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Complexity of subthalamic 13–35Hz oscillatory activity directly correlates with clinical impairment in patients with Parkinson's disease

(2010) Chiung Chu Chen et al.   EXPERIMENTAL NEUROLOGY

Lack of LTP-like plasticity in primary motor cortex in Parkinson's disease

(2010) A. Suppa et al.   EXPERIMENTAL NEUROLOGY

Theta burst stimulation over the primary motor cortex does not induce cortical plasticity in Parkinson’s disease

(2010) Carsten Eggers et al.   JOURNAL OF NEUROLOGY

Neuropsychiatric effects of subthalamic neurostimulation in Parkinson disease

(2010) Jens Volkmann et al.   Nature Reviews Neurology

Imaging dopamine receptors in humans with [11C]-(+)-PHNO: Dissection of D3 signal and anatomy

(2010) Andri C. Tziortzi et al.   NEUROIMAGE

Parkinson's disease tremor-related metabolic network: Characterization, progression, and treatment effects

(2010) Hideo Mure et al.   NEUROIMAGE

Distinct oscillatory STN-cortical loops revealed by simultaneous MEG and local field potential recordings in patients with Parkinson's disease

(2010) J. Hirschmann et al.   NEUROIMAGE

Pallidal versus Subthalamic Deep-Brain Stimulation for Parkinson's Disease

(2010) Kenneth A. Follett et al.   NEW ENGLAND JOURNAL OF MEDICINE

White Matter Involvement in Idiopathic Parkinson Disease: A Diffusion Tensor Imaging Study

(2009) G. Gattellaro et al.   AMERICAN JOURNAL OF NEURORADIOLOGY

The Nature and Time Course of Cortical Activation Following Subthalamic Stimulation in Parkinson's Disease

(2009) R. Kuriakose et al.   CEREBRAL CORTEX

Characterisation of tremor-associated local field potentials in the subthalamic nucleus in Parkinson’s disease

(2009) Christiane Reck et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

PET Functional Imaging of Deep Brain Stimulation in Movement Disorders and Psychiatry

(2009) Benedicte Ballanger et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

SPECT and PET analysis of subthalamic stimulation in Parkinson’s disease: analysis using a manual segmentation

(2009) Claire Haegelen et al.   JOURNAL OF NEUROLOGY

L-Dopa Modulates Functional Connectivity in Striatal Cognitive and Motor Networks: A Double-Blind Placebo-Controlled Study

(2009) C. Kelly et al.   JOURNAL OF NEUROSCIENCE

Tiefe Hirnstimulation bei idiopathischem Parkinson-Syndrom

(2009) R. Hilker et al.   NERVENARZT

Safety of MRI in patients with implanted deep brain stimulation devices

(2009) Michele Tagliati et al.   NEUROIMAGE

L-Dopa Medication in Parkinson's Disease Restores Activity in the Motor Cortico-Striatal Loop but Does Not Modify the Cognitive Network

(2009) Thomas Jubault et al.   PLoS One

Optical Deconstruction of Parkinsonian Neural Circuitry

(2009) V. Gradinaru et al.   SCIENCE

Subthalamic nucleus stimulation-induced regional blood flow responses correlate with improvement of motor signs in Parkinson disease

(2008) M. Karimi et al.   BRAIN

Consensus paper on short-interval intracortical inhibition and other transcranial magnetic stimulation intracortical paradigms in movement disorders

(2008) Alfredo Berardelli et al.   Brain Stimulation

Clinical and cerebral activity changes induced by subthalamic nucleus stimulation in advanced Parkinson's disease: A prospective case-control study

(2008) Roberto Cilia et al.   CLINICAL NEUROLOGY AND NEUROSURGERY

Local field potential beta activity in the subthalamic nucleus of patients with Parkinson's disease is associated with improvements in bradykinesia after dopamine and deep brain stimulation

(2008) N.J. Ray et al.   EXPERIMENTAL NEUROLOGY

Patterns of Bidirectional Communication between Cortex and Basal Ganglia during Movement in Patients with Parkinson Disease

(2008) E. Lalo et al.   JOURNAL OF NEUROSCIENCE

Functional organization of the basal ganglia: Therapeutic implications for Parkinson's disease

(2008) Jose A. Obeso et al.   MOVEMENT DISORDERS

Latest view on the mechanism of action of deep brain stimulation

(2008) Constance Hammond et al.   MOVEMENT DISORDERS

The history of dopamine and levodopa in the treatment of Parkinson's disease

(2008) Stanley Fahn   MOVEMENT DISORDERS

Levodopa-sensitive, dynamic changes in effective connectivity during simultaneous movements in Parkinson's disease

(2008) S.J. Palmer et al.   NEUROSCIENCE

STN-stimulation in Parkinson's disease restores striatal inhibition of thalamocortical projection

(2007) Jacob Geday et al.   HUMAN BRAIN MAPPING