Review
Nutrition & Dietetics
Zhijuan Miao, Marianne Schultzberg, Xiuzhe Wang, Yuwu Zhao
Summary: Polyunsaturated fatty acids (PUFAs) have shown potential benefits in the prevention and treatment of ischemic stroke, with specialized pro-resolving mediators (SPMs) as promising new anti-stroke therapy.
CLINICAL NUTRITION
(2021)
Review
Pharmacology & Pharmacy
Nils Helge Schebb, Hartmut Kuehn, Astrid S. Kahnt, Katharina M. Rund, Valerie B. O'Donnell, Nicolas Flamand, Marc Peters-Golden, Per-Johan Jakobsson, Karsten H. Weylandt, Nadine Rohwer, Robert C. Murphy, Gerd Geisslinger, Garret A. FitzGerald, Julien Hanson, Claes Dahlgren, Mohamad Wessam Alnouri, Stefan Offermanns, Dieter Steinhilber
Summary: This paper critically evaluates the biosynthetic pathways of specialized pro-resolving lipid mediators (SPMs), their receptors and signaling cascades, and the analytical methods used to quantify these mediators. It concludes that there is limited biosynthetic capacity for SPMs in human leukocytes, the identity and signaling of proposed SPM receptors need further validation, SPM levels are not related to dietary supplementation or resolution of inflammation, and the commonly reported methodology for quantification of SPMs is unreliable.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Immunology
Maria Belen Sanchez-Rodriguez, Erica Tellez, Mireia Casulleras, Francesc E. Borras, Vicente Arroyo, Joan Claria, Maria-Rosa Sarrias
Summary: This study analyzed the macrophage anti-inflammatory protein CD5L in the plasma extracellular vesicles (EVs) of patients with acute-on chronic liver failure (ACLF) and its relationship with lipid mediators. The circulating EV contents in ACLF were significantly altered, leading to a loss of anti-inflammatory and pro-resolving molecules involved in the control of acute inflammation.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Jamie D. Kraft, Robert Blomgran, Iben Lundgaard, Marianne Quiding-Jarbrink, Jonathan S. Bromberg, Emma Borgeson
Summary: Recent studies are investigating the possibility of targeting chronic inflammation by promoting resolution of inflammation to enhance lymphatic function and mitigate disease, focusing on how specialized pro-resolving mediators regulate this process.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Wheeler Torres, Jose Luis Perez, Maria P. Diaz, Luis D'Marco, Ana Checa-Ros, Ruben Carrasquero, Lisse Angarita, Yosselin Gomez, Maricarmen Chacin, Paola Ramirez, Nelson Villasmil, Samuel Duran-Aguero, Climaco Cano, Valmore Bermudez
Summary: Cancer is a major global health issue characterized by cell mutation, proliferation, invasion, and metastasis. The increasing incidence of cancer highlights the need for new approaches to understand the molecular changes involved in its development, including chronic inflammation. Specialized pro-resolving mediators (SPMs), bioactive lipids derived from polyunsaturated fatty acids (PUFAs), have shown potential as novel anti-inflammatory molecules that could improve anti-tumor immunity. This review aims to explore the effects of SPMs on carcinogenesis and their therapeutic potential.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Fernanda S. S. Rasquel-Oliveira, Matheus Deroco Veloso da Silva, Geovana Martelossi-Cebinelli, Victor Fattori, Rubia Casagrande, Waldiceu A. A. Verri Jr
Summary: During infection, inflammation can be harmful when it becomes excessive or chronic. Specialized pro-resolving lipid mediators (SPMs), derived from omega-3 and -6 polyunsaturated fatty acids, play a crucial role in resolving inflammation and promoting a coordinated immune response against pathogens. SPMs regulate leukocyte influx, reduce cytokine and chemokine levels, enhance bacterial clearance, inhibit viral replication, stimulate tissue healing, and decrease antibiotic requirements. Understanding the biosynthesis and effects of SPMs in different infections could have important implications for developing new therapeutic strategies.
Review
Biochemistry & Molecular Biology
Mervin Chavez-Castillo, Angel Ortega, Lorena Cudris-Torres, Pablo Duran, Milagros Rojas, Alexander Manzano, Bermary Garrido, Juan Salazar, Aljadis Silva, Diana Marcela Rojas-Gomez, Juan B. De Sanctis, Valmore Bermudez
Summary: Specialized pro-resolving lipid mediators (SPMs) have emerged as a promising alternative for chronic pain management, playing a central role in regulating inflammation and neuroinflammation. Studies have shown that SPMs can inhibit central and peripheral sensitizations associated with chronic pain disorders, providing a potential therapeutic tool for patients with CP.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Chemistry, Multidisciplinary
Jiulong Li, Xiao Liu, Qian Xiang, Tian Xia, Huan Meng
Summary: Inflammation is a defense mechanism used by the body to fight against infection and tissue damage. Specialized pro-resolving mediators (SPMs) generated from fatty acids can effectively moderate inflammation and reduce tissue damage, chronic conditions, and COVID-19. However, the molecular processes underlying SPM actions are not fully understood.
Article
Biochemistry & Molecular Biology
Abrar E. Al-Shaer, Nicole Buddenbaum, Saame Raza Shaikh
Summary: Chronic inflammation plays a significant role in the pathogenesis of various diseases, with specialized pro-resolving mediators (SPMs) being crucial for resolving inflammation. Increasing dietary intake of EPA/DHA may be a viable strategy for promoting inflammation resolution, although research on the effectiveness of EPA/DHA supplementation in improving inflammatory status has shown inconsistencies.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2021)
Review
Pharmacology & Pharmacy
Alessandro Leuti, Marina Fava, Niccolo Pellegrini, Mauro Maccarrone
Summary: Inflammation and neuroinflammation play critical roles in generating neuropathic pain in chronic diseases, with specialized pro-resolving mediators emerging as crucial in regulating the inflammatory cascade and onset of chronic inflammation and pain. Accumulating evidence suggests a synergy between these mediators and other signaling pathways, implying a more intricate relationship between inflammation and pain perception than initially anticipated.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Paul M. Jordan, Oliver Werz
Summary: Acute inflammation caused by bacterial infections is a necessary biological defense mechanism, but if it becomes persistent and uncontrolled, it may lead to chronic diseases and tissue destruction. Specialized pro-resolving mediators (SPMs) can effectively resolve bacteria-initiated inflammation, promoting bacterial clearance, tissue repair, and regeneration.
Article
Immunology
Evangelos Papathanasiou, Andrew R. Scott, Carroll Ann Trotman, Corinna Beale, Lori Lyn Price, Gordon S. Huggins, Yang Zhang, Irene Georgakoudi, Thomas E. Van Dyke
Summary: This preclinical experimental study evaluated the impact of the methyl-ester of pro-resolving lipid mediator lipoxin A(4) (LXA(4)-ME) on scarring in a novel rabbit model of cleft lip repair. The results showed that LXA(4)-ME can reduce inflammation, decrease scar formation, and improve wound healing outcomes.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Dentistry, Oral Surgery & Medicine
Davy Aubeux, Ove A. Peters, Sepanta Hosseinpour, Solene Tessier, Valerie Geoffroy, Fabienne Perez, Alexis Gaudin
Summary: Endodontics focuses on the study of dental pulp and periradicular tissues, aiming to prevent chronic inflammation and promote repair or regeneration. Specialized Pro-resolving lipid Mediators have shown potential in managing inflammatory diseases, including in endodontic therapy, by enhancing immune responses and reducing inflammatory processes.
Review
Immunology
Maria G. Balta, Evangelos Papathanasiou, Panagiotis F. Christopoulos
Summary: This review highlights the importance of specialized pro-resolving mediators (SPMs) in the treatment of COVID-19, emphasizing their role in regulating macrophages and promoting resolution of inflammation. It also discusses the molecular events linking lipid mediators with COVID-19 severity and the clinical potentials of SPMs in COVID-19 immunotherapeutics.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Allergy
Insha Zahoor, Shailendra Giri
Summary: Multiple sclerosis (MS) is a neuroinflammatory disease where the role of specialized pro-resolving lipid mediators (SPMs) is contentious due to variable outcomes in biological matrices across studies, possibly attributed to differences in population characteristics.
CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY
(2021)