Azacytidine prevents experimental xenogeneic graft-versus-host disease without abrogating graft-versus-leukemia effects

Targeting Aurora kinase A and JAK2 prevents GVHD while maintaining Tregand antitumor CTL function

(2017) Brian C. Betts et al.   Science Translational Medicine

Acute Graft-versus-Host Disease: Novel Biological Insights

(2016) Takanori Teshima et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

Tolerability and Clinical Activity of Post-Transplantation Azacitidine in Patients Allografted for Acute Myeloid Leukemia Treated on the RICAZA Trial

(2016) Charles Craddock et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

Novel approaches for preventing acute graft-versus-host disease after allogeneic hematopoietic stem cell transplantation

(2016) Sophie Servais et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Poor Repair of Skeletal Muscle in Aging Mice Reflects a Defect in Local, Interleukin-33-Dependent Accumulation of Regulatory T Cells

(2016) Wilson Kuswanto et al.   IMMUNITY

IL-2 consumption by highly activated CD8 T cells induces regulatory T-cell dysfunction in patients with hemophagocytic lymphohistiocytosis

(2016) Stéphanie Humblet-Baron et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Azacytidine mitigates experimental sclerodermic chronic graft-versus-host disease

(2016) Gilles Fransolet et al.   Journal of Hematology & Oncology

Prophylactic use of low-dose interleukin-2 and the clinical outcomes of hematopoietic stem cell transplantation: A randomized study

(2016) Xiang-Yu Zhao et al.   OncoImmunology

Human monocyte-derived suppressor cells control graft-versus-host disease by inducing regulatory forkhead box protein 3–positive CD8+ T lymphocytes

(2015) Nona Janikashvili et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Monoclonal antibodies against GARP/TGF-β1 complexes inhibit the immunosuppressive activity of human regulatory T cells in vivo

(2015) Julia Cuende et al.   Science Translational Medicine

Validation of a multicolor staining to monitor phosphoSTAT5 levels in regulatory T-cell subsets

(2015) Grégory Ehx et al.   Oncotarget

Identification and characterization of the specific murine NK cell subset supporting graft-versus-leukemia- and reducing graft-versus-host-effects

(2015) Kathrin Meinhardt et al.   OncoImmunology

HLA-haploidentical transplantation with regulatory and conventional T-cell adoptive immunotherapy prevents acute leukemia relapse

(2014) M. F. Martelli et al.   BLOOD

Current issues in chronic graft-versus-host disease

(2014) G. Socie et al.   BLOOD

Impact of in vivo T-cell depletion on outcome of AML patients in first CR given peripheral blood stem cells and reduced-intensity conditioning allo-SCT from a HLA-identical sibling donor: a report from the Acute Leukemia Working Party of the European group for Blood and Marrow Transplantation

(2014) F Baron et al.   BONE MARROW TRANSPLANTATION

Clinical development of demethylating agents in hematology

(2014) Shyamala C. Navada et al.   JOURNAL OF CLINICAL INVESTIGATION

The mechanistic role of DNA methylation in myeloid leukemogenesis

(2014) J Jasielec et al.   LEUKEMIA

5-Azacytidine Promotes an Inhibitory T-Cell Phenotype and Impairs Immune Mediated Antileukemic Activity

(2014) Thomas Stübig et al.   MEDIATORS OF INFLAMMATION

TREG-cell therapies for autoimmune rheumatic diseases

(2014) Makoto Miyara et al.   Nature Reviews Rheumatology

“Do you catch my drift?”

(2014) Timothy Hannon   TRANSFUSION

Multiparameter single-cell profiling of human CD4+FOXP3+ regulatory T-cell populations in homeostatic conditions and during graft-versus-host disease

(2013) S. Dong et al.   BLOOD

Impact of bone marrow-derived mesenchymal stromal cells on experimental xenogeneic graft-versus-host disease

(2013) France Bruck et al.   CYTOTHERAPY

Mechanisms of resistance to azacitidine in human leukemia cell lines

(2013) Piyanuch Sripayap et al.   EXPERIMENTAL HEMATOLOGY

Development and Maintenance of Regulatory T cells

(2013) Naganari Ohkura et al.   IMMUNITY

IL-2 therapy promotes suppressive ICOS+ Treg expansion in melanoma patients

(2013) Geok Choo Sim et al.   JOURNAL OF CLINICAL INVESTIGATION

Graft-Versus-Host Disease and Graft-Versus-Tumor Effects After Allogeneic Hematopoietic Cell Transplantation

(2013) Rainer Storb et al.   JOURNAL OF CLINICAL ONCOLOGY

Salvage therapy with azacitidine increases regulatory T cells in peripheral blood of patients with AML or MDS and early relapse after allogeneic blood stem cell transplantation

(2013) T Schroeder et al.   LEUKEMIA

Antiapoptotic Mcl-1 is critical for the survival and niche-filling capacity of Foxp3+ regulatory T cells

(2013) Wim Pierson et al.   NATURE IMMUNOLOGY

Aldehyde Dehydrogenase Expression Drives Human Regulatory T Cell Resistance to Posttransplantation Cyclophosphamide

(2013) C. G. Kanakry et al.   Science Translational Medicine

Azacitidine augments expansion of regulatory T cells after allogeneic stem cell transplantation in patients with acute myeloid leukemia (AML)

(2012) O. C. Goodyear et al.   BLOOD

Human T cells depend on functional calcineurin, tumour necrosis factor-α and CD80/CD86 for expansion and activation in mice

(2012) H. Søndergaard et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

The effects of 5-azacytidine on the function and number of regulatory T cells and T-effectors in myelodysplastic syndrome

(2012) B. Costantini et al.   HAEMATOLOGICA

Granzyme B-Mediated Damage of CD8+ T Cells Impairs Graft-versus-Tumor Effect

(2012) G. Bian et al.   JOURNAL OF IMMUNOLOGY

Impact of graft-versus-host disease after reduced-intensity conditioning allogeneic stem cell transplantation for acute myeloid leukemia: a report from the Acute Leukemia Working Party of the European group for blood and marrow transplantation

(2012) F Baron et al.   LEUKEMIA

Azacitidine differentially affects CD4pos T-cell polarization in vitro and in vivo in high risk myelodysplastic syndromes

(2012) Hetty J. Bontkes et al.   LEUKEMIA RESEARCH

Blocking IL-21 signaling ameliorates xenogeneic GVHD induced by human lymphocytes

(2011) K. L. Hippen et al.   BLOOD

Impact of the hypomethylating agent 5-azacytidine on dendritic cells function

(2011) Jihane Frikeche et al.   EXPERIMENTAL HEMATOLOGY

Massive ex Vivo Expansion of Human Natural Regulatory T Cells (Tregs) with Minimal Loss of in Vivo Functional Activity

(2011) K. L. Hippen et al.   Science Translational Medicine

Myelodysplastic Syndromes

(2010) Bart L. Scott et al.   Annual Review of Medicine

In vivo administration of hypomethylating agents mitigate graft-versus-host disease without sacrificing graft-versus-leukemia

(2010) J. Choi et al.   BLOOD

Infusion of ex vivo expanded T regulatory cells in adults transplanted with umbilical cord blood: safety profile and detection kinetics

(2010) C. G. Brunstein et al.   BLOOD

Th17/Treg ratio in human graft-versus-host disease

(2010) P. Ratajczak et al.   BLOOD

Cutting Edge: Mechanisms of IL-2-Dependent Maintenance of Functional Regulatory T Cells

(2010) L. Barron et al.   JOURNAL OF IMMUNOLOGY

Role of conserved non-coding DNA elements in the Foxp3 gene in regulatory T-cell fate

(2010) Ye Zheng et al.   NATURE

Generation of functional human T-cell subsets with HLA-restricted immune responses in HLA class I expressing NOD/SCID/IL2r null humanized mice

(2010) L. D. Shultz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

What Is the Role for Donor Natural Killer Cells after Nonmyeloablative Conditioning?

(2009) Frédéric Baron et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

Immunomodulatory effect of 5-azacytidine (5-azaC): potential role in the transplantation setting

(2009) L. I. Sanchez-Abarca et al.   BLOOD

Human peripheral blood leucocyte non-obese diabetic-severe combined immunodeficiency interleukin-2 receptor gamma chain gene mouse model of xenogeneic graft-versus-host-like disease and the role of host major histocompatibility complex

(2009) M. A. King et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Comparison of stable human Treg and Th clones by transcriptional profiling

(2009) Julie Stockis et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

DNA methylation controls Foxp3 gene expression

(2008) Julia K. Polansky et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Azacytidine causes complex DNA methylation responses in myeloid leukemia

(2008) C. Stresemann et al.   MOLECULAR CANCER THERAPEUTICS