Radiation and Local Anti-CD40 Generate an Effective in situ Vaccine in Preclinical Models of Pancreatic Cancer

The Immune Revolution: A Case for Priming, Not Checkpoint

(2018) Robert H. Vonderheide   CANCER CELL

Combined sublethal irradiation and agonist anti-CD40 enhance donor T cell accumulation and control of autochthonous murine pancreatic tumors

(2018) Lindsay K. Ward-Kavanagh et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Radiotherapy and CD40 activation separately augment immunity to checkpoint blockade in cancer

(2018) Andrew J Rech et al.   CANCER RESEARCH

TGFβ drives immune evasion in genetically reconstituted colon cancer metastasis

(2018) Daniele V. F. Tauriello et al.   NATURE

Eradication of spontaneous malignancy by local immunotherapy

(2018) Idit Sagiv-Barfi et al.   Science Translational Medicine

Targeting Cytokine Therapy to the Pancreatic Tumor Microenvironment Using PD-L1–Specific VHHs

(2018) Michael Dougan et al.   Cancer Immunology Research

TGFβ attenuates tumour response to PD-L1 blockade by contributing to exclusion of T cells

(2018) Sanjeev Mariathasan et al.   NATURE

Targeting Immunotherapy to the Tumor Microenvironment

(2017) Michael Dougan et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Vitiligo in a patient with lung adenocarcinoma treated with nivolumab: A case report

(2017) Takeshi Uenami et al.   LUNG CANCER

An immunogenic personal neoantigen vaccine for patients with melanoma

(2017) Patrick A. Ott et al.   NATURE

cGAS Conducts Micronuclei DNA Surveillance

(2017) Carina C. de Oliveira Mann et al.   TRENDS IN CELL BIOLOGY

Radiotherapy and CTLA-4 Blockade Shape the TCR Repertoire of Tumor-Infiltrating T Cells

(2017) Nils-Petter Rudqvist et al.   Cancer Immunology Research

Checkpoint Blockade Toxicity and Immune Homeostasis in the Gastrointestinal Tract

(2017) Michael Dougan   Frontiers in Immunology

Tumor-Derived CCL2 Mediates Resistance to Radiotherapy in Pancreatic Ductal Adenocarcinoma

(2016) Anusha Kalbasi et al.   CLINICAL CANCER RESEARCH

A renewed model of pancreatic cancer evolution based on genomic rearrangement patterns

(2016) Faiyaz Notta et al.   NATURE

IFN  and CCL2 Cooperate to Redirect Tumor-Infiltrating Monocytes to Degrade Fibrosis and Enhance Chemotherapy Efficacy in Pancreatic Carcinoma

(2016) K. B. Long et al.   Cancer Discovery

Transformation of the tumour microenvironment by a CD40 agonist antibody correlates with improved responses to PD-L1 blockade in a mouse orthotopic pancreatic tumour model

(2016) Nadia M. Luheshi et al.   Oncotarget

Imalytics Preclinical: Interactive Analysis of Biomedical Volume Data

(2016) Felix Gremse et al.   Theranostics

CD40 Stimulation Obviates Innate Sensors and Drives T Cell Immunity in Cancer

(2016) Katelyn T. Byrne et al.   Cell Reports

Antitumor Efficacy of Radiation plus Immunotherapy Depends upon Dendritic Cell Activation of Effector CD8+ T Cells

(2016) S. J. Dovedi et al.   Cancer Immunology Research

Trial Watch: Immunotherapy plus radiation therapy for oncological indications

(2016) Erika Vacchelli et al.   OncoImmunology

Optimizing Timing of Immunotherapy Improves Control of Tumors by Hypofractionated Radiation Therapy

(2016) Kristina H. Young et al.   PLoS One

Awakening the immune system with radiation: Optimal dose and fractionation

(2015) Saumil J. Gandhi et al.   CANCER LETTERS

TGFβ Is a Master Regulator of Radiation Therapy-Induced Antitumor Immunity

(2015) Claire Vanpouille-Box et al.   CANCER RESEARCH

Radiotherapy Combined with Novel STING-Targeting Oligonucleotides Results in Regression of Established Tumors

(2015) J. R. Baird et al.   CANCER RESEARCH

Exclusion of T Cells From Pancreatic Carcinomas in Mice Is Regulated by Ly6Clow F4/80+ Extratumoral Macrophages

(2015) Gregory L. Beatty et al.   GASTROENTEROLOGY

Vitiligo-Like Depigmentation in Patients With Stage III-IV Melanoma Receiving Immunotherapy and Its Association With Survival: A Systematic Review and Meta-Analysis

(2015) Hansje-Eva Teulings et al.   JOURNAL OF CLINICAL ONCOLOGY

Radiation and dual checkpoint blockade activate non-redundant immune mechanisms in cancer

(2015) Christina Twyman-Saint Victor et al.   NATURE

Oncolytic viruses: a new class of immunotherapy drugs

(2015) Howard L. Kaufman et al.   NATURE REVIEWS DRUG DISCOVERY

Radiotherapy combined with TLR7/8 activation induces strong immune responses against gastrointestinal tumors

(2015) Sebastian Schölch et al.   Oncotarget

Direct Activation of STING in the Tumor Microenvironment Leads to Potent and Systemic Tumor Regression and Immunity

(2015) Leticia Corrales et al.   Cell Reports

A systematic evaluation of abscopal responses following radiotherapy in patients with metastatic melanoma treated with ipilimumab

(2015) Ravi A Chandra et al.   OncoImmunology

Neutralizing Murine TGF R2 Promotes a Differentiated Tumor Cell Phenotype and Inhibits Pancreatic Cancer Metastasis

(2014) K. T. Ostapoff et al.   CANCER RESEARCH

Contextual regulation of pancreatic cancer stem cell phenotype and radioresistance by pancreatic stellate cells

(2014) Osama Al-Assar et al.   RADIOTHERAPY AND ONCOLOGY

Stereotactic Radiation Therapy Augments Antigen-Specific PD-1-Mediated Antitumor Immune Responses via Cross-Presentation of Tumor Antigen

(2014) A. B. Sharabi et al.   Cancer Immunology Research

TGF  Inhibition Prior to Hypofractionated Radiation Enhances Efficacy in Preclinical Models

(2014) K. H. Young et al.   Cancer Immunology Research

A Phase I Study of an Agonist CD40 Monoclonal Antibody (CP-870,893) in Combination with Gemcitabine in Patients with Advanced Pancreatic Ductal Adenocarcinoma

(2013) G. L. Beatty et al.   CLINICAL CANCER RESEARCH

Getting Personal with Neoantigen-Based Therapeutic Cancer Vaccines

(2013) N. Hacohen et al.   Cancer Immunology Research

Transnuclear TRP1-Specific CD8 T Cells with High or Low Affinity TCRs Show Equivalent Antitumor Activity

(2013) S. K. Dougan et al.   Cancer Immunology Research

Tumor-Derived Granulocyte-Macrophage Colony-Stimulating Factor Regulates Myeloid Inflammation and T Cell Immunity in Pancreatic Cancer

(2012) Lauren J. Bayne et al.   CANCER CELL

Oncogenic Kras-Induced GM-CSF Production Promotes the Development of Pancreatic Neoplasia

(2012) Yuliya Pylayeva-Gupta et al.   CANCER CELL

Synergy of Topical Toll-like Receptor 7 Agonist with Radiation and Low-Dose Cyclophosphamide in a Mouse Model of Cutaneous Breast Cancer

(2012) M. Z. Dewan et al.   CLINICAL CANCER RESEARCH

Toll-like receptor 7 regulates pancreatic carcinogenesis in mice and humans

(2012) Atsuo Ochi et al.   JOURNAL OF CLINICAL INVESTIGATION

Immunologic Correlates of the Abscopal Effect in a Patient with Melanoma

(2012) Michael A. Postow et al.   NEW ENGLAND JOURNAL OF MEDICINE

Safety, Activity, and Immune Correlates of Anti–PD-1 Antibody in Cancer

(2012) Suzanne L. Topalian et al.   NEW ENGLAND JOURNAL OF MEDICINE

TGF 1 Inhibition Increases the Radiosensitivity of Breast Cancer Cells In Vitro and Promotes Tumor Control by Radiation In Vivo

(2011) F. Bouquet et al.   CLINICAL CANCER RESEARCH

CD40 Agonists Alter Tumor Stroma and Show Efficacy Against Pancreatic Carcinoma in Mice and Humans

(2011) G. L. Beatty et al.   SCIENCE

Improved Survival with Ipilimumab in Patients with Metastatic Melanoma

(2010) F. Stephen Hodi et al.   NEW ENGLAND JOURNAL OF MEDICINE

Fractionated but Not Single-Dose Radiotherapy Induces an Immune-Mediated Abscopal Effect when Combined with Anti-CTLA-4 Antibody

(2009) M. Z. Dewan et al.   CLINICAL CANCER RESEARCH