Article
Medicine, General & Internal
Yang Liu, Hai-Wen Lu, Shu-Yi Gu, Wen-Wen Wang, Juan Ge, Zhi-Jun Jie, Jin-Guang Jia, Zhi-Ting Gao, Jun Li, Jing-Yun Shi, Shuo Liang, Ke-Bing Cheng, Jiu-Wu Bai, Jie-Ming Qu, Jin-Fu Xu
Summary: Bronchoscopic airway clearance therapy and bronchoalveolar lavage (B-ACT) significantly prolong the time to first acute exacerbation in non-cystic fibrosis bronchiectasis patients, especially for those with severe disease and more severe symptoms.
Article
Critical Care Medicine
Raul Mendez, Laura Feced, Victoria Alcaraz-Serrano, Paula Gonzalez-Jimenez, Leyre Bouzas, Ricardo Alonso, Luis Martinez-Dolz, David Hervas, Laia Fernandez-Barat, Antoni Torres, Rosario Menendez
Summary: Cardiovascular events (CVE) during and after exacerbations of bronchiectasis are associated with age, arterial hypertension, chronic obstructive pulmonary disease (COPD), and severe exacerbations. The occurrence of CVE worsens long-term prognosis.
Article
Respiratory System
John R. Hurst, Andrew Cumella, Camila Nagoda Niklewicz, Keir E. J. Philip, Victoria Singh, Nicholas S. Hopkinson
Summary: A survey was conducted on 4442 individuals with airways diseases to assess their attitudes and intentions towards continuing preventive measures post-COVID-19 pandemic. Findings indicated that a significant portion planned to continue wearing face masks in indoor public spaces and believed everyone should do so during the influenza season. Women, those with bronchiectasis, and older individuals were generally more cautious about continuing these measures.
Article
Immunology
David T. J. Broderick, Tyler Regtien, Alana Ainsworth, Michael W. Taylor, Naveen Pillarisetti
Summary: This pilot study investigates the changes in upper and lower airway microbiota during exacerbation and treatment of bronchiectasis. It found a reduction in the relative abundance of Haemophilus, which is associated with more severe symptoms, suggesting a positive shift in the patient's microbiota.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Medicine, General & Internal
Alejandro A. Diaz, Wei Wang, Jose L. Orejas, Rim Elalami, Wojciech R. Dolliver, Pietro Nardelli, Ruben San Jose Estepar, Bina Choi, Carrie L. Pistenmaa, James C. Ross, Diego J. Maselli, Andrew Yen, Kendra A. Young, Gregory L. Kinney, Michael H. Cho, Raul San Jose Estepar
Summary: This study found that suspected bronchiectasis is associated with an increased risk of mortality in adults with normal and obstructive spirometry. When using computed tomography (CT) to identify bronchiectasis, the difference in mortality risk was attenuated in participants with normal spirometry.
ANNALS OF INTERNAL MEDICINE
(2023)
Article
Medicine, General & Internal
Victoria Alcaraz-Serrano, Ane Arbillaga-Etxarri, Patricia Oscanoa, Laia Fernandez-Barat, Leticia Bueno, Rosanel Amaro, Elena Gimeno-Santos, Antoni Torres
Summary: Low physical activity and high sedentary behaviour in patients with bronchiectasis are associated with hospitalisation over one year, with exacerbation frequency being the key factor influencing changes in physical activity and sedentary behaviour.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Respiratory System
Leonardo Terranova, Patrizia Rise, Andrea Gramegna, Christian Pinna, Carlo Agostoni, Marie-Louise Syren, Stefano Turolo, Paola Marchisio, Francesco Amati, Stefano Aliberti, Angelo Sala, Francesco Blasi
Summary: The study found that pro-inflammatory mediators derived from arachidonic acid metabolism in sputum of bronchiectasis patients were positively associated with neutrophil elastase, Pseudomonas aeruginosa identifications, and radiological gravity index. On the other hand, pro-resolution mediators derived from docosahexaenoic acid were associated with better health status, showing an inverse correlation with radiological gravity index, bacterial infections, and sputum volume production.
RESPIRATORY RESEARCH
(2022)
Article
Virology
Hung-Yu Huang, Chun-Yu Lo, Fu-Tsai Chung, Yu-Tung Huang, Po-Chuan Ko, Chang-Wei Lin, Yu-Chen Huang, Kian Fan Chung, Chun-Hua Wang
Summary: This study aimed to investigate the clinical outcomes and identify risk factors associated with hospitalization and mortality following influenza infection in adult patients with bronchiectasis. The results showed that patients with bronchiectasis had higher hospitalization rates and mortality rates in influenza-related infection. Influenza infection exacerbated the severity of bronchiectasis, and older patients, those with high bronchiectasis aetiology comorbidity index (BACI), and previous exacerbations were more likely to be hospitalized and have higher mortality rates.
Article
Respiratory System
Stefano Aliberti, Giovanni Sotgiu, Andrea Gramegna, Melissa J. McDonnell, Eva Polverino, Antoni Torres, Pieter C. Goeminne, Katerina Dimakou, Michal Shteinberg, Oriol Sibila, Valentina Conio, Thomas C. Fardon, Robert Rutherford, Simone Dore, Laura Saderi, Paola Faverio, Francesco Amati, Angelo G. Corsico, Francesco Blasi, James D. Chalmers
Summary: Thrombocytosis during stable state in patients with bronchiectasis is associated with disease severity, increased exacerbations, higher hospitalization rates, and elevated mortality rates at 3-year and 5-year follow-up.
ANNALS OF THE AMERICAN THORACIC SOCIETY
(2021)
Article
Multidisciplinary Sciences
Jiachen Li, Lirong Liang, Siyu Cao, Hengmo Rong, Lin Feng, Di Zhang, Shuilian Chu, Hang Jing, Zhaohui Tong
Summary: This study described the secular trend and identified risk factors of COPD-related 30-day readmission in Beijing from 2012 to 2017. The overall readmission rate increased from 11.5% in 2012 to 17.2% in 2017, with a higher rate for men. Comorbidities such as osteoporosis, coronary heart disease, congestive heart failure, and cancer were associated with an increased risk of readmission.
SCIENTIFIC REPORTS
(2022)
Article
Chemistry, Physical
Sherif Abdulkader Tawfik, Mahad Rashid, Sunil Gupta, Salvy P. Russo, Tiffany R. Walsh, Svetha Venkatesh
Summary: A machine learning classifier is trained using a dataset of vibrational stability to accurately distinguish between vibrationally stable and unstable materials, which has the potential to be a crucial filtering tool for online material databases, informing the material science community about the vibrational stability or instability of the materials queried in convex hulls.
NPJ COMPUTATIONAL MATERIALS
(2023)
Article
Medicine, General & Internal
Hung-Yu Huang, Fu-Tsai Chung, Chun-Yu Lin, Chun-Yu Lo, Yu-Tung Huang, Yu-Chen Huang, Yu-Te Lai, Shu-Ting Gan, Po-Chuan Ko, Horng-Chyuan Lin, Kian Fan Chung, Chun-Hua Wang
Summary: This study aimed to investigate the clinical outcomes of patients hospitalized for severe bronchiectasis exacerbations. The results showed that patients with multiple comorbidities had a higher risk of mortality and respiratory failure within one year. Older age, male gender, and previous use of systemic corticosteroids were identified as risk factors for one-year mortality. Airway clearance therapy was associated with a lower mortality risk.
FRONTIERS IN MEDICINE
(2022)
Article
Respiratory System
Dave Singh, Gerard J. Criner, Mark T. Dransfield, David M. G. Halpin, MeiLan K. Han, Peter Lange, Sally Lettis, David A. Lipson, David Mannino, Neil Martin, Fernando J. Martinez, Bruce E. Miller, Robert Wise, Chang-Qing Zhu, David Lomas
Summary: The study using IMPACT trial data found that in patients with COPD, higher levels of fibrinogen were associated with higher rates and risks of exacerbations. Fibrinogen could serve as a predictive biomarker for exacerbations in COPD, and may be utilized as an enrichment strategy in trials examining exacerbation outcomes.
RESPIRATORY RESEARCH
(2021)
Article
Respiratory System
Pallavi Bedi, Manjit K. Cartlidge, Yang Zhang, Kim Turnbull, Samantha Donaldson, Andrea Clarke, Jane Crowe, Kadiga Campbell, Catriona Graham, Ruzanna Franguylan, Adriano G. Rossi, Adam T. Hill
Summary: The study suggests that bacterial load-guided intravenous antibiotic therapy is feasible in bronchiectasis exacerbations, and a 14-day treatment course shows potential clinical improvement compared to bacterial load-guided therapy, although paradoxically leads to a prolonged time to next exacerbation.
EUROPEAN RESPIRATORY JOURNAL
(2021)
Article
Respiratory System
Oriol Sibila, Elena Laserna, Amelia Shoemark, Lidia Perea, Diana Bilton, Megan L. Crichton, Anthony De Soyza, Wim G. Boersma, Josje Altenburg, James D. Chalmers
Summary: Improvements in lung function, symptoms, and exacerbation frequency are not closely correlated in bronchiectasis. FEV1 is not a responsive measure, and clinical parameters are not predictive of treatment response. Biomarkers are needed to identify responders.
EUROPEAN RESPIRATORY JOURNAL
(2022)