Divergent tissue and sex effects of rapamycin on the proteasome-chaperone network of old mice

A cytosolic protein factor from the naked mole-rat activates proteasomes of other species and protects these from inhibition

(2014) Karl A. Rodriguez et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Liver Damage, Inflammation, and Enhanced Tumorigenesis after Persistent mTORC1 Inhibition

(2014) Atsushi Umemura et al.   Cell Metabolism

Rapamycin and Dietary Restriction Induce Metabolically Distinctive Changes in Mouse Liver

(2014) Zhen Yu et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Coordinated regulation of protein synthesis and degradation by mTORC1

(2014) Yinan Zhang et al.   NATURE

Mice Fed Rapamycin Have an Increase in Lifespan Associated with Major Changes in the Liver Transcriptome

(2014) Wilson C. Fok et al.   PLoS One

Young and old genetically heterogeneous HET3 mice on a rapamycin diet are glucose intolerant but insulin sensitive

(2013) Dudley W. Lamming et al.   AGING CELL

Rapamycin-mediated lifespan increase in mice is dose and sex dependent and metabolically distinct from dietary restriction

(2013) Richard A. Miller et al.   AGING CELL

eRapa Restores a Normal Life Span in a FAP Mouse Model

(2013) P. Hasty et al.   Cancer Prevention Research

The pros and the cons of mTOR inhibitors in kidney transplantation

(2013) Claudio Ponticelli   Expert Review of Clinical Immunology

Hepatic signaling by the mechanistic target of rapamycin complex 2 (mTORC2)

(2013) Dudley W. Lamming et al.   FASEB JOURNAL

Oxidative damage and amyloid-β metabolism in brain regions of the longest-lived rodents

(2013) Yael H. Edrey et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Rapamycin Extends Life and Health in C57BL/6 Mice

(2013) Yiqiang Zhang et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Mammalian target of rapamycin hyperactivity mediates the detrimental effects of a high sucrose diet on Alzheimer's disease pathology

(2013) Miranda E. Orr et al.   NEUROBIOLOGY OF AGING

Rapamycin slows aging in mice

(2012) John E. Wilkinson et al.   AGING CELL

Proteasome inhibitor MG132 induces selective apoptosis in glioblastoma cells through inhibition of PI3K/Akt and NFkappaB pathways, mitochondrial dysfunction, and activation of p38-JNK1/2 signaling

(2012) Alfeu Zanotto-Filho et al.   INVESTIGATIONAL NEW DRUGS

A Proteasome Inhibitor-stimulated Nrf1 Protein-dependent Compensatory Increase in Proteasome Subunit Gene Expression Reduces Polycomb Group Protein Level

(2012) Sivaprakasam Balasubramanian et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Over-expression of heat shock factor 1 phenocopies the effect of chronic inhibition of TOR by rapamycin and is sufficient to ameliorate Alzheimer's-like deficits in mice modeling the disease

(2012) Anson Pierce et al.   JOURNAL OF NEUROCHEMISTRY

A unifying model for mTORC1-mediated regulation of mRNA translation

(2012) Carson C. Thoreen et al.   NATURE

mTOR Is Essential for the Proteotoxic Stress Response, HSF1 Activation and Heat Shock Protein Synthesis

(2012) Shiuh-Dih Chou et al.   PLoS One

Altered Composition of Liver Proteasome Assemblies Contributes to Enhanced Proteasome Activity in the Exceptionally Long-Lived Naked Mole-Rat

(2012) Karl A. Rodriguez et al.   PLoS One

ATP Binds to Proteasomal ATPases in Pairs with Distinct Functional Effects, Implying an Ordered Reaction Cycle

(2011) David M. Smith et al.   CELL

Proteasome alterations during adipose differentiation and aging: links to impaired adipocyte differentiation and development of oxidative stress

(2011) Kalavathi Dasuri et al.   FREE RADICAL BIOLOGY AND MEDICINE

HSP70 mediates dissociation and reassociation of the 26S proteasome during adaptation to oxidative stress

(2011) Tilman Grune et al.   FREE RADICAL BIOLOGY AND MEDICINE

CHIP E3 ligase regulates mammalian senescence by modulating the levels of oxidized proteins

(2011) Christina Sisoula et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Elevated Proteasome Capacity Extends Replicative Lifespan in Saccharomyces cerevisiae

(2011) Undine Kruegel et al.   PLoS Genetics

Oxidative protein damage and the proteasome

(2010) S. Grimm et al.   AMINO ACIDS

A Novel mouse model of enhanced proteostasis: Full-length human heat shock factor 1 transgenic mice

(2010) Anson Pierce et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Rapamycin, But Not Resveratrol or Simvastatin, Extends Life Span of Genetically Heterogeneous Mice

(2010) Richard A. Miller et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Molecular mechanisms of proteasome plasticity in aging

(2010) Karl A. Rodriguez et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Transcription Factor Nrf1 Mediates the Proteasome Recovery Pathway after Proteasome Inhibition in Mammalian Cells

(2010) Senthil K. Radhakrishnan et al.   MOLECULAR CELL

Inhibition of mTOR by Rapamycin Abolishes Cognitive Deficits and Reduces Amyloid-β Levels in a Mouse Model of Alzheimer's Disease

(2010) Patricia Spilman et al.   PLoS One

Widespread Protein Aggregation as an Inherent Part of Aging in C. elegans

(2010) Della C. David et al.   PLOS BIOLOGY

Characterization of the brain 26S proteasome and its interacting proteins

(2010) Hwan-Ching Tai   Frontiers in Molecular Neuroscience

The small heat shock protein HSP25 protects astrocytes against stress induced by proteasomal inhibition

(2009) Olaf Goldbaum et al.   GLIA

The roles of ubiquitin and 26S proteasome in human obesity

(2009) Tsui-Ling Chang et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

(2009) David E. Harrison et al.   NATURE