Inflammation-mediated changes in drug transporter expression/activity: implications for therapeutic drug response

Increased expression of the multidrug resistance-associated protein 1 (MRP1) in kidney glomeruli of streptozotocin-induced diabetic rats

(2011) Claudia Quezada et al.   BIOLOGICAL CHEMISTRY

Extrahepatic Cancer Suppresses Nuclear Receptor-Regulated Drug Metabolism

(2011) M. Kacevska et al.   CLINICAL CANCER RESEARCH

Organic Anion Transporting Polypeptides (OATPs): Regulation of Expression and Function

(2011) Martin Svoboda et al.   CURRENT DRUG METABOLISM

Mechanisms of Reduced Maternal and Fetal Lopinavir Exposure in a Rat Model of Gestational Diabetes

(2011) G. J. Anger et al.   DRUG METABOLISM AND DISPOSITION

Alteration of Hepatic but Not Renal Transporter Expression in Diet-Induced Obese Mice

(2011) V. R. More et al.   DRUG METABOLISM AND DISPOSITION

ATP-Binding Cassette Transporter Expression in Human Placenta as a Function of Pregnancy Condition

(2011) C. W. Mason et al.   DRUG METABOLISM AND DISPOSITION

Effects of Chronic Renal Failure on Kidney Drug Transporters and Cytochrome P450 in Rats

(2011) J. Naud et al.   DRUG METABOLISM AND DISPOSITION

Role of organic cation transporters in drug-induced toxicity

(2011) Giuliano Ciarimboli   Expert Opinion on Drug Metabolism & Toxicology

Epidemiology and Natural History of Inflammatory Bowel Diseases

(2011) Jacques Cosnes et al.   GASTROENTEROLOGY

Epidemiology of IBS

(2011) Rok Seon Choung et al.   GASTROENTEROLOGY CLINICS OF NORTH AMERICA

Inflammatory links between obesity and metabolic disease

(2011) Carey N. Lumeng et al.   JOURNAL OF CLINICAL INVESTIGATION

Changes in expression of hepatic cytochrome P450 subfamily enzymes during development of adjuvant-induced arthritis in rats

(2011) Hisakazu Sanada et al.   JOURNAL OF TOXICOLOGICAL SCIENCES

Role of high-fat diet in regulation of gene expression of drug metabolizing enzymes and transporters

(2011) Romi Ghose et al.   LIFE SCIENCES

Epidemiology of CVD in rheumatic disease, with a focus on RA and SLE

(2011) Deborah P. M. Symmons et al.   Nature Reviews Rheumatology

LPS-induced dissociation of multidrug resistance-associated protein 2 (Mrp2) and radixin is associated with Mrp2 selective internalization in rats

(2010) Junjiro Saeki et al.   BIOCHEMICAL PHARMACOLOGY

The Disposition of Pravastatin in a Rat Model of Streptozotocin-Induced Diabetes and Organic Anion Transporting Polypeptide 2 and Multidrug Resistance-Associated Protein 2 Expression in the Liver

(2010) Yoshitaka Hasegawa et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

P-glycoprotein and breast cancer resistance protein expression and function at the blood–brain barrier and blood–cerebrospinal fluid barrier (choroid plexus) in streptozotocin-induced diabetes in rats

(2010) Valeska Reichel et al.   BRAIN RESEARCH

The Role of Cerebral Vascular NFĸB in LPS-induced Inflammation: Differential Regulation of Efflux Transporter and Transporting Cytokine Receptors

(2010) Weihong Pan et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Effect of Obesity on the Pharmacokinetics of Drugs in Humans

(2010) Michael J. Hanley et al.   CLINICAL PHARMACOKINETICS

Inflammation: Planning for a Source of Pharmacokinetic/Pharmacodynamic Variability in Translational Studies

(2010) V D Schmith et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Inflammation and Cancer: Causes and Consequences

(2010) M M Moore et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Cancer and Inflammation: Implications for Pharmacology and Therapeutics

(2010) F Balkwill et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Impact of Polyinosinic/Polycytidylic Acid on Placental and Hepatobiliary Drug Transporters in Pregnant Rats

(2010) V. Petrovic et al.   DRUG METABOLISM AND DISPOSITION

Hepatic OATP and OCT uptake transporters: their role for drug-drug interactions and pharmacogenetic aspects

(2010) Christina Fahrmayr et al.   DRUG METABOLISM REVIEWS

Regulation of drug transporter mRNA expression by interferon-γ in primary human hepatocytes

(2010) Marc Le Vee et al.   FUNDAMENTAL & CLINICAL PHARMACOLOGY

Regulation of MRP2/ABCC2 and BSEP/ABCB11 Expression in Sandwich Cultured Human and Rat Hepatocytes Exposed to Inflammatory Cytokines TNF-α, IL-6, and IL-1β

(2010) Lei Diao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pharmacokinetics of drugs in rats with diabetes mellitus induced by alloxan or streptozocin: comparison with those in patients with type I diabetes mellitus

(2010) Joo H. Lee et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

The pharmacokinetics of morphine and its glucuronide conjugate in a rat model of streptozotocin-induced diabetes and the expression of MRP2, MRP3 and UGT2B1 in the liver

(2010) Yoshitaka Hasegawa et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Inducible nitric oxide synthase-mediated decrease of intestinal P-glycoprotein expression under streptozotocin-induced diabetic conditions

(2010) Ayaka Nawa et al.   LIFE SCIENCES

Membrane transporters in drug development

(2010)   NATURE REVIEWS DRUG DISCOVERY

Xenobiotic, Bile Acid, and Cholesterol Transporters: Function and Regulation

(2010) C. D. Klaassen et al.   PHARMACOLOGICAL REVIEWS

Increased Plasma Exposures of Five Protoberberine Alkaloids from Coptidis Rhizoma in Streptozotocin-Induced Diabetic Rats: Is P‐GP Involved?

(2010) Sen Yu et al.   PLANTA MEDICA

Nuclear Receptor Regulation of the Adaptive Response of Bile Acid Transporters in Cholestasis

(2010) Martin Wagner et al.   SEMINARS IN LIVER DISEASE

The Role of Inflammation in Cholestasis: Clinical and Basic Aspects

(2010) Astrid Kosters et al.   SEMINARS IN LIVER DISEASE

Pharmacokinetics of fexofenadine following LPS administration to rats

(2010) S. Jaisue et al.   XENOBIOTICA

Mechanisms of pH-gradient driven transport mediated by organic anion polypeptide transporters

(2009) Simone Leuthold et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Effects of obesity induced by high-fat diet on the pharmacokinetics of nelfinavir, a HIV protease inhibitor, in laboratory rats

(2009) Nobuyuki Sugioka et al.   BIOPHARMACEUTICS & DRUG DISPOSITION

Changes in mRNA expression of ABC and SLC transporters in liver and intestines of the adjuvant-induced arthritis rat

(2009) Satoshi Uno et al.   BIOPHARMACEUTICS & DRUG DISPOSITION

Experimental rat models to study the metabolic syndrome

(2009) Amaya Aleixandre de Artiñano et al.   BRITISH JOURNAL OF NUTRITION

Impact of OATP transporters on pharmacokinetics

(2009) A Kalliokoski et al.   BRITISH JOURNAL OF PHARMACOLOGY

Regulation of BCRP (ABCG2) and P-Glycoprotein (ABCB1) by Cytokines in a Model of the Human Blood–Brain Barrier

(2009) Birk Poller et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

ABC Efflux Pump-Based Resistance to Chemotherapy Drugs

(2009) Paul D. W. Eckford et al.   CHEMICAL REVIEWS

Impact of Acute Streptozotocin-Induced Diabetes on ABC Transporter Expression in Rats

(2009) Gregory J. Anger et al.   CHEMISTRY & BIODIVERSITY

Impact of Infectious and Inflammatory Disease on Cytochrome P450–Mediated Drug Metabolism and Pharmacokinetics

(2009) ET Morgan   CLINICAL PHARMACOLOGY & THERAPEUTICS

Changes in mRNA Expression Levels of Solute Carrier Transporters in Inflammatory Bowel Disease Patients

(2009) K. A. Wojtal et al.   DRUG METABOLISM AND DISPOSITION

Regulation of human hepatic drug transporter expression by pro-inflammatory cytokines

(2009) Olivier Fardel et al.   Expert Opinion on Drug Metabolism & Toxicology

Nuclear receptors: mediators and modifiers of inflammation-induced cholestasis

(2009) Jaap Mulder   Frontiers in Bioscience-Landmark

Cellular and molecular pathways linking inflammation and cancer

(2009) Chiara Porta et al.   IMMUNOBIOLOGY

Redundant roles for cJun-N-terminal kinase 1 and 2 in interleukin-1β-mediated reduction and modification of murine hepatic nuclear retinoid X receptor α

(2009) Astrid Kosters et al.   JOURNAL OF HEPATOLOGY

Liver disease associated with canalicular transport defects: Current and future therapies

(2009) Janneke M. Stapelbroek et al.   JOURNAL OF HEPATOLOGY

Regulation of major efflux transporters under inflammatory conditions at the blood-brain barrierin vitro

(2009) Magdalena von Wedel-Parlow et al.   JOURNAL OF NEUROCHEMISTRY

Change in P-glycoprotein and caveolin protein expression in brain striatum capillaries in New Zealand Obese mice with type 2 diabetes

(2009) Kuo-Chen Wu et al.   LIFE SCIENCES

Impact of experimental colitis on hepatobiliary transporter expression and bile duct injury in mice

(2009) Jörg Jahnel et al.   LIVER INTERNATIONAL

Thioredoxin-interacting protein links oxidative stress to inflammasome activation

(2009) Rongbin Zhou et al.   NATURE IMMUNOLOGY

Inflammatory Bowel Disease

(2009) Clara Abraham et al.   NEW ENGLAND JOURNAL OF MEDICINE

Psoriasis

(2009) Frank O. Nestle et al.   NEW ENGLAND JOURNAL OF MEDICINE

Inflammation Mediated Down-Regulation of Hepatobiliary Transporters Contributes to Intrahepatic Cholestasis and Liver Damage in Murine Biliary Atresia

(2009) Huiqi Yang et al.   PEDIATRIC RESEARCH

Temporal and Spatial Analysis of Clinical and Molecular Parameters in Dextran Sodium Sulfate Induced Colitis

(2009) Yutao Yan et al.   PLoS One

Insulin therapy restores impaired function and expression of P-glycoprotein in blood–brain barrier of experimental diabetes

(2008) Haiyan Liu et al.   BIOCHEMICAL PHARMACOLOGY

Increase in P-glycoprotein accompanied by activation of protein kinase Cα and NF-κB p65 in the livers of rats with streptozotocin-induced diabetes

(2008) Natsumi Kameyama et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Neuroinflammation Activates Mdr1b Efflux Transport Through NFκB: Promoter Analysis in BBB Endothelia

(2008) Chuanhui Yu et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Inflammation and Altered Drug Clearance in Cancer: Transcriptional Repression of a Human CYP3A4 Transgene in Tumor-bearing Mice

(2008) GR Robertson et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Emerging Evidence of the Impact of Kidney Disease on Drug Metabolism and Transport

(2008) TD Nolin et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Closing the Gaps: A Full Scan of the Intestinal Expression of P-Glycoprotein, Breast Cancer Resistance Protein, and Multidrug Resistance-Associated Protein 2 in Male and Female Rats

(2008) C. MacLean et al.   DRUG METABOLISM AND DISPOSITION

Effect of Endotoxin on the Expression of Placental Drug Transporters and Glyburide Disposition in Pregnant Rats

(2008) V. Petrovic et al.   DRUG METABOLISM AND DISPOSITION

Regulation of Drug Transporter Expression in Human Hepatocytes Exposed to the Proinflammatory Cytokines Tumor Necrosis Factor-  or Interleukin-6

(2008) M. L. Vee et al.   DRUG METABOLISM AND DISPOSITION

Regulation of Drug-Metabolizing Enzymes and Transporters in Infection, Inflammation, and Cancer

(2008) E. T. Morgan et al.   DRUG METABOLISM AND DISPOSITION

Inflammation and CYP3A4-mediated drug metabolism in advanced cancer: impact and implications for chemotherapeutic drug dosing

(2008) Marina Kacevska et al.   Expert Opinion on Drug Metabolism & Toxicology

Up-regulation and Cytoprotective Role of Epithelial Multidrug Resistance-associated Protein 1 in Inflammatory Bowel Disease

(2008) Hans Blokzijl et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Expression levels of MDR1, MRP1, MRP4, and MRP5 in peripheral blood mononuclear cells from HIV infected patients failing antiretroviral therapy

(2008) Ombretta Turriziani et al.   JOURNAL OF MEDICAL VIROLOGY

Effect of Hemodialysis on Hepatic Cytochrome P450 Functional Expression

(2008) Josée Michaud et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Drug-Metabolizing Enzyme and Transporter Expression in a Mouse Model of Diabetes and Obesity

(2008) Qiuqiong Cheng et al.   MOLECULAR PHARMACEUTICS

Increased amyloid β-peptide (1–40) level in brain of streptozotocin-induced diabetic rats

(2008) Y. Liu et al.   NEUROSCIENCE

Hepatitis B Virus Infection

(2008) Jules L. Dienstag   NEW ENGLAND JOURNAL OF MEDICINE

Xenobiotic transporters of the human organic anion transporting polypeptides (OATP) family

(2008) B. Hagenbuch et al.   XENOBIOTICA

Organic cation transporters

(2008) G. Ciarimboli   XENOBIOTICA

P-glycoprotein-mediated efflux of phenobarbital at the blood-brain barrier evidence from transport experiments in vitro

(2007) Zhi-Hong Yang et al.   EPILEPSY RESEARCH

Regulation of Transporters by Nuclear Hormone Receptors: Implications during Inflammation

(2007) Shirley Teng et al.   MOLECULAR PHARMACEUTICS

Decreased dromotropic response to verapamil despite pronounced increased drug concentration in rheumatoid arthritis

(2003) Patrick R. Mayo et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY