USP14 as a novel prognostic marker promotes cisplatin resistance via Akt/ERK signaling pathways in gastric cancer

Tumor suppressive microRNA-124a inhibits stemness and enhances gefitinib sensitivity of non-small cell lung cancer cells by targeting ubiquitin-specific protease 14

(2018) Fei Yu et al.   CANCER LETTERS

Inhibition of the CSF-1 receptor sensitizes ovarian cancer cells to cisplatin

(2018) Rong Yu et al.   CELL BIOCHEMISTRY AND FUNCTION

Deubiquitinase inhibitor b-AP15 activates endoplasmic reticulum (ER) stress and inhibits Wnt/Notch1 signaling pathway leading to the reduction of cell survival in hepatocellular carcinoma cells

(2018) Youming Ding et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Ubiquitin-specific protease 14 regulates LPS-induced inflammation by increasing ERK1/2 phosphorylation and NF-κB activation

(2017) Ningning Liu et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Proteasome-associated deubiquitinase ubiquitin-specific protease 14 regulates prostate cancer proliferation by deubiquitinating and stabilizing androgen receptor

(2017) Yuning Liao et al.   Cell Death & Disease

Overexpression of ubiquitin specific peptidase 14 predicts unfavorable prognosis in esophageal squamous cell carcinoma

(2017) Baozhu Zhang et al.   Thoracic Cancer

Cancer statistics in China, 2015

(2016) Wanqing Chen et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Proteasome Addiction Defined in Ewing Sarcoma Is Effectively Targeted by a Novel Class of 19S Proteasome Inhibitors

(2016) N. Shukla et al.   CANCER RESEARCH

USP14 regulates autophagy by suppressing K63 ubiquitination of Beclin 1

(2016) Daichao Xu et al.   GENES & DEVELOPMENT

A novel nickel complex works as a proteasomal deubiquitinase inhibitor for cancer therapy

(2016) C Zhao et al.   ONCOGENE

USP14 is a predictor of recurrence in endometrial cancer and a molecular target for endometrial cancer treatment

(2016) Rachel Isaksson Vogel et al.   Oncotarget

Cross-validation of survival associated biomarkers in gastric cancer using transcriptomic data of 1,065 patients

(2016) A. Marcell Szász et al.   Oncotarget

Global cancer statistics, 2012

(2015) Lindsey A. Torre et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Downregulation of ubiquitin-specific protease 14 (USP14) inhibits breast cancer cell proliferation and metastasis, but promotes apoptosis

(2015) Lianxin Zhu et al.   JOURNAL OF MOLECULAR HISTOLOGY

Deubiquitinating enzymes as oncotargets

(2015) Urszula L. McClurg et al.   Oncotarget

Ubiquitin-specific protease 14 (USP14) regulates cellular proliferation and apoptosis in epithelial ovarian cancer

(2014) Yingying Wang et al.   MEDICAL ONCOLOGY

A novel small molecule inhibitor of deubiquitylating enzyme USP14 and UCHL5 induces apoptosis in multiple myeloma and overcomes bortezomib resistance

(2013) Z. Tian et al.   BLOOD

Deubiquitinase Inhibition of 19S Regulatory Particles by 4-Arylidene Curcumin Analog AC17 Causes NF- B Inhibition and p53 Reactivation in Human Lung Cancer Cells

(2013) B. Zhou et al.   MOLECULAR CANCER THERAPEUTICS

Deubiquitylases From Genes to Organism

(2013) Michael J. Clague et al.   PHYSIOLOGICAL REVIEWS

Akt is negatively regulated by the MULAN E3 ligase

(2012) Seunghee Bae et al.   CELL RESEARCH

Cellular functions of the DUBs

(2012) M. J. Clague et al.   JOURNAL OF CELL SCIENCE

Cigarette Smoke Induces Akt Protein Degradation by the Ubiquitin-Proteasome System

(2011) Sun-Yong Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of proteasome deubiquitinating activity as a new cancer therapy

(2011) Pádraig D'Arcy et al.   NATURE MEDICINE

Deubiquitinase Inhibition by Small-Molecule WP1130 Triggers Aggresome Formation and Tumor Cell Apoptosis

(2010) V. Kapuria et al.   CANCER RESEARCH

Ubiquitinated Proteins Activate the Proteasome by Binding to Usp14/Ubp6, which Causes 20S Gate Opening

(2009) Andreas Peth et al.   MOLECULAR CELL