Highlight report: towards the replacement of in vivo repeated dose systemic toxicity testing

The mechanistic basis for the induction of hepatic steatosis by xenobiotics

(2011) David E Amacher   Expert Opinion on Drug Metabolism & Toxicology

Chronic oral LOAEL prediction by using a commercially available computational QSAR tool

(2010) Bernd Rupp et al.   ARCHIVES OF TOXICOLOGY

A physiologically based toxicokinetic modelling approach to predict relevant concentrations for in vitro testing

(2010) Hans Mielke et al.   ARCHIVES OF TOXICOLOGY

Deoxynivalenol: mechanisms of action, human exposure, and toxicological relevance

(2010) James J. Pestka   ARCHIVES OF TOXICOLOGY

Augmenter of liver regeneration causes different kinetics of ERK1/2 and Akt/PKB phosphorylation than EGF and induces hepatocyte proliferation in an EGF receptor independent and liver specific manner

(2010) Maren Ilowski et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Augmenter of liver regeneration (ALR) protects human hepatocytes against apoptosis

(2010) Maren Ilowski et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Prediction and validation of cell alignment along microvessels as order principle to restore tissue architecture in liver regeneration

(2010) S. Hoehme et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Simultaneous induction of non-neoplastic and neoplastic lesions with highly proliferative hepatocytes following dietary exposure of rats to tocotrienol for 2 years

(2009) Masako Tasaki et al.   ARCHIVES OF TOXICOLOGY

Gene expression profiling in the lung tissue of cynomolgus monkeys in response to repeated exposure to welding fumes

(2009) Jeong-Doo Heo et al.   ARCHIVES OF TOXICOLOGY

Alcohol-induced liver injury: how a small molecule overwhelms one of the cell types with the best regeneration capacity of the human body

(2009) Jan G. Hengstler et al.   ARCHIVES OF TOXICOLOGY

Low level and sub-chronic exposure to methylmercury induces hypertension in rats: nitric oxide depletion and oxidative damage as possible mechanisms

(2009) Denise Grotto et al.   ARCHIVES OF TOXICOLOGY

Effects of chronic 4-n-nonylphenol treatment on aortic vasoconstriction and vasorelaxation in rats

(2009) Chi-Ying Hsieh et al.   ARCHIVES OF TOXICOLOGY

Aluminium neurotoxicity: neurobehavioural and oxidative aspects

(2009) Vijay Kumar et al.   ARCHIVES OF TOXICOLOGY

Toxicity of penta- and decabromodiphenyl ethers after repeated administration to rats: a comparative study

(2009) Elżbieta Bruchajzer et al.   ARCHIVES OF TOXICOLOGY

Chronic effects of perfluorooctanesulfonate exposure on immunotoxicity in adult male C57BL/6 mice

(2009) Guang-Hui Dong et al.   ARCHIVES OF TOXICOLOGY

Role of oxidative stress in alcohol-induced liver injury

(2009) Arthur I. Cederbaum et al.   ARCHIVES OF TOXICOLOGY

Evaluation of carbon tetrachloride-induced stress on rat hepatocytes by 31P NMR and MALDI-TOF mass spectrometry: lysophosphatidylcholine generation from unsaturated phosphatidylcholines

(2009) Alexander Bauer et al.   CHEMISTRY AND PHYSICS OF LIPIDS

A Zone Classification System for Risk Assessment of Idiosyncratic Drug Toxicity Using Daily Dose and Covalent Binding

(2009) S. Nakayama et al.   DRUG METABOLISM AND DISPOSITION

Evaluation of the Potential for Drug-Induced Liver Injury Based on in Vitro Covalent Binding to Human Liver Proteins

(2009) T. Usui et al.   DRUG METABOLISM AND DISPOSITION

Renal dysfunction induced by long-term exposure to depleted uranium in rats

(2008) Guoying Zhu et al.   ARCHIVES OF TOXICOLOGY