Integrated regulation of PIKK-mediated stress responses by AAA+ proteins RUVBL1 and RUVBL2

The Hsp90 chaperone machinery: from structure to drug development

(2011) Ji-Sook Hahn   BMB Reports

Heat shock protein 90 regulates phosphatidylinositol 3-kinase-related protein kinase family proteins together with the RUVBL1/2 and Tel2-containing co-factor complex

(2011) Natsuko Izumi et al.   CANCER SCIENCE

The nonsense-mediated mRNA decay SMG-1 kinase is regulated by large-scale conformational changes controlled by SMG-8

(2011) E. Arias-Palomo et al.   GENES & DEVELOPMENT

A Novel Role for hSMG-1 in Stress Granule Formation

(2011) J. A. L. Brown et al.   MOLECULAR AND CELLULAR BIOLOGY

N- and C-terminal Upf1 phosphorylations create binding platforms for SMG-6 and SMG-5:SMG-7 during NMD

(2011) Yukiko Okada-Katsuhata et al.   NUCLEIC ACIDS RESEARCH

Tel2 structure and function in the Hsp90-dependent maturation of mTOR and ATR complexes

(2010) H. Takai et al.   GENES & DEVELOPMENT

A genetic screen identifies the Triple T complex required for DNA damage signaling and ATM and ATR stability

(2010) K. E. Hurov et al.   GENES & DEVELOPMENT

The Pih1-Tah1 Cochaperone Complex Inhibits Hsp90 Molecular Chaperone ATPase Activity

(2010) Kelvin Eckert et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tti1 and Tel2 Are Critical Factors in Mammalian Target of Rapamycin Complex Assembly

(2010) Takeshi Kaizuka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CK2 Phospho-Dependent Binding of R2TP Complex to TEL2 Is Essential for mTOR and SMG1 Stability

(2010) Zuzana Hořejší et al.   MOLECULAR CELL

HSP90 and Its R2TP/Prefoldin-like Cochaperone Are Involved in the Cytoplasmic Assembly of RNA Polymerase II

(2010) Séverine Boulon et al.   MOLECULAR CELL

Induction of tumour immunity by targeted inhibition of nonsense-mediated mRNA decay

(2010) Fernando Pastor et al.   NATURE

HSP90 at the hub of protein homeostasis: emerging mechanistic insights

(2010) Mikko Taipale et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Smg1 is required for embryogenesis and regulates diverse genes via alternative splicing coupled to nonsense-mediated mRNA decay

(2010) D. R. McIlwain et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

AAA+ Proteins RUVBL1 and RUVBL2 Coordinate PIKK Activity and Function in Nonsense-Mediated mRNA Decay

(2010) N. Izumi et al.   Science Signaling

Repair of ionizing radiation-induced DNA double-strand breaks by non-homologous end-joining

(2009) Brandi L. Mahaney et al.   BIOCHEMICAL JOURNAL

Nutrient-dependent regulation of autophagy through the target of rapamycin pathway: Figure 1

(2009) Yu-Yun Chang et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

The TOR pathway comes of age

(2009) Monique N. Stanfel et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Phosphorylation of Telomeric Repeat Binding Factor 1 (TRF1) by Akt Causes Telomere Shortening

(2009) Yen-Chung Chen et al.   CANCER INVESTIGATION

RETRACTED: DNA-PKcs-PIDDosome: A Nuclear Caspase-2-Activating Complex with Role in G2/M Checkpoint Maintenance

(2009) Mingan Shi et al.   CELL

Genotoxic Stress Abrogates Renewal of Melanocyte Stem Cells by Triggering Their Differentiation

(2009) Ken Inomata et al.   CELL

Cytoplasmic ATM in Neurons Modulates Synaptic Function

(2009) Jiali Li et al.   CURRENT BIOLOGY

Common mechanisms of PIKK regulation

(2009) Courtney A. Lovejoy et al.   DNA REPAIR

SMG-8 and SMG-9, two novel subunits of the SMG-1 complex, regulate remodeling of the mRNA surveillance complex during nonsense-mediated mRNA decay

(2009) A. Yamashita et al.   GENES & DEVELOPMENT

Translational reprogramming following UVB irradiation is mediated by DNA-PKcs and allows selective recruitment to the polysomes of mRNAs encoding DNA repair enzymes

(2009) I. R. Powley et al.   GENES & DEVELOPMENT

Rictor/TORC2 regulates fat metabolism, feeding, growth, and life span in Caenorhabditis elegans

(2009) A. A. Soukas et al.   GENES & DEVELOPMENT

Kinome Sirna Screen Identifies SMG-1 as a Negative Regulator of Hypoxia-inducible Factor-1α in Hypoxia

(2009) Run-Qiang Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

High-resolution mapping of the protein interaction network for the human transcription machinery and affinity purification of RNA polymerase II-associated complexes

(2009) Philippe Cloutier et al.   METHODS

TOR Complex 2 Controls Gene Silencing, Telomere Length Maintenance, and Survival under DNA-Damaging Conditions

(2009) M. Schonbrun et al.   MOLECULAR AND CELLULAR BIOLOGY

RVB1/RVB2: Running Rings around Molecular Biology

(2009) Sudhakar Jha et al.   MOLECULAR CELL

Gcn5 and SAGA Regulate Shelterin Protein Turnover and Telomere Maintenance

(2009) Boyko S. Atanassov et al.   MOLECULAR CELL

An ATM- and ATR-dependent checkpoint inactivates spindle assembly by targeting CEP63

(2009) Eloise Smith et al.   NATURE CELL BIOLOGY

Molecular mechanisms of mTOR-mediated translational control

(2009) Xiaoju Max Ma et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Specific regulation of mRNA cap methylation by the c-Myc and E2F1 transcription factors

(2009) M D Cole et al.   ONCOGENE

Rictor/TORC2 Regulates Caenorhabditis elegans Fat Storage, Body Size, and Development through sgk-1

(2009) Kevin T Jones et al.   PLOS BIOLOGY

Fission Yeast Tel1ATM and Rad3ATR Promote Telomere Protection and Telomerase Recruitment

(2009) Bettina A. Moser et al.   PLoS Genetics

Chaperone ligand-discrimination by the TPR-domain protein Tah1

(2008) Stefan H. Millson et al.   BIOCHEMICAL JOURNAL

mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1)

(2008) Juan M. García-Martínez et al.   BIOCHEMICAL JOURNAL

Pontin and Reptin, Two Related ATPases with Multiple Roles in Cancer

(2008) O. Huber et al.   CANCER RESEARCH

Identification of ATPases Pontin and Reptin as Telomerase Components Essential for Holoenzyme Assembly

(2008) Andrew S. Venteicher et al.   CELL

Upf1 Phosphorylation Triggers Translational Repression during Nonsense-Mediated mRNA Decay

(2008) Olaf Isken et al.   CELL

SKAR Links Pre-mRNA Splicing to mTOR/S6K1-Mediated Enhanced Translation Efficiency of Spliced mRNAs

(2008) Xiaoju Max Ma et al.   CELL

The Target of Rapamycin Pathway Antagonizes pha-4/FoxA to Control Development and Aging

(2008) Karyn L. Sheaffer et al.   CURRENT BIOLOGY

Targeting Hsp90: small-molecule inhibitors and their clinical development

(2008) Tony Taldone et al.   CURRENT OPINION IN PHARMACOLOGY

Reptin and Pontin function antagonistically with PcG and TrxG complexes to mediate Hox gene control

(2008) Soda Balla Diop et al.   EMBO REPORTS

Molecular cloning of novel Monad binding protein containing tetratricopeptide repeat domains

(2008) Yuki Itsuki et al.   FEBS LETTERS

Tel2 mediates activation and localization of ATM/Tel1 kinase to a double-strand break

(2008) C. M. Anderson et al.   GENES & DEVELOPMENT

HCLK2 Is Required for Activity of the DNA Damage Response Kinase ATR

(2008) Jannie M. Rendtlew Danielsen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Protective Role for the Human SMG-1 Kinase against Tumor Necrosis Factor-α-induced Apoptosis

(2008) Vasco Oliveira et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Hsp90 chaperone controls the biogenesis of L7Ae RNPs through conserved machinery

(2008) Séverine Boulon et al.   JOURNAL OF CELL BIOLOGY

Molecular chaperone Hsp90 stabilizes Pih1/Nop17 to maintain R2TP complex activity that regulates snoRNA accumulation

(2008) Rongmin Zhao et al.   JOURNAL OF CELL BIOLOGY

Human Rvb1/Tip49 Is Required for the Histone Acetyltransferase Activity of Tip60/NuA4 and for the Downregulation of Phosphorylation on H2AX after DNA Damage

(2008) S. Jha et al.   MOLECULAR AND CELLULAR BIOLOGY

Regulation of Microtubule Assembly and Organization in Mitosis by the AAA+ ATPase Pontin

(2008) Daniel Ducat et al.   MOLECULAR BIOLOGY OF THE CELL

PKBα/Akt1 Acts Downstream of DNA-PK in the DNA Double-Strand Break Response and Promotes Survival

(2008) Lana Bozulic et al.   MOLECULAR CELL

Ataxia-telangiectasia: from a rare disorder to a paradigm for cell signalling and cancer

(2008) Martin F. Lavin   NATURE REVIEWS MOLECULAR CELL BIOLOGY

ATR: an essential regulator of genome integrity

(2008) Karlene A. Cimprich et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A Novel Role for the SMG-1 Kinase in Lifespan and Oxidative Stress Resistance in Caenorhabditis elegans

(2008) Ingrid Masse et al.   PLoS One

Architecture of the Pontin/Reptin Complex, Essential in the Assembly of Several Macromolecular Complexes

(2008) Eva Torreira et al.   STRUCTURE