Expanding the Repertoire of Biomarkers for Alzheimer’s Disease: Targeted and Non-targeted Approaches

Synaptotoxic Amyloid-β Oligomers: A Molecular Basis for the Cause, Diagnosis, and Treatment of Alzheimer's Disease?

(2018) William L. Klein   JOURNAL OF ALZHEIMERS DISEASE

Ventricular and Lumbar Cerebrospinal Fluid Concentrations of Alzheimer's Disease Biomarkers in Patients with Normal Pressure Hydrocephalus and Posttraumatic Hydrocephalus

(2018) Sebastian Brandner et al.   JOURNAL OF ALZHEIMERS DISEASE

A Candidate Plasma Protein Classifier to Identify Alzheimer's Disease

(2018) Xuemei Zhao et al.   JOURNAL OF ALZHEIMERS DISEASE

Identification of miRNA Changes in Alzheimer's Disease Brain and CSF Yields Putative Biomarkers and Insights into Disease Pathways

(2017) John P. Cogswell et al.   JOURNAL OF ALZHEIMERS DISEASE

Round robin test on quantification of amyloid-β 1–42 in cerebrospinal fluid by mass spectrometry

(2016) Josef Pannee et al.   Alzheimers & Dementia

Cerebrospinal fluid levels of the synaptic protein neurogranin correlates with cognitive decline in prodromal Alzheimer's disease

(2015) Hlin Kvartsberg et al.   Alzheimers & Dementia

C-terminal neurogranin is increased in cerebrospinal fluid but unchanged in plasma in Alzheimer's disease

(2015) Ann De Vos et al.   Alzheimers & Dementia

Identification of preclinical Alzheimer's disease by a profile of pathogenic proteins in neurally derived blood exosomes: A case-control study

(2015) Massimo S. Fiandaca et al.   Alzheimers & Dementia

Age and amyloid effects on human central nervous system amyloid-beta kinetics

(2015) Bruce W. Patterson et al.   ANNALS OF NEUROLOGY

Alzheimer’s Disease Risk Genes and Mechanisms of Disease Pathogenesis

(2015) Celeste M. Karch et al.   BIOLOGICAL PSYCHIATRY

Alzheimer’s disease cerebrospinal fluid biomarker in cognitively normal subjects

(2015) Jon B. Toledo et al.   BRAIN

Cerebrospinal fluid tau and amyloid-β1-42in patients with dementia

(2015) Tobias Skillbäck et al.   BRAIN

Consensus statement for diagnosis of subcortical small vessel disease

(2015) Gary A Rosenberg et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

A panel of nine cerebrospinal fluid biomarkers may identify patients with atypical parkinsonian syndromes

(2015) N K Magdalinou et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Stable isotope labelling methods in mass spectrometry-based quantitative proteomics

(2015) Osama Chahrour et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

A comprehensive map and functional annotation of the normal human cerebrospinal fluid proteome

(2015) Yang Zhang et al.   Journal of Proteomics

Novel ageing-biomarker discovery using data-intensive technologies

(2015) H.R. Griffiths et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Fluid markers of traumatic brain injury

(2015) Henrik Zetterberg et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

MicroRNA-29a Is a Candidate Biomarker for Alzheimer’s Disease in Cell-Free Cerebrospinal Fluid

(2015) Mareike Müller et al.   MOLECULAR NEUROBIOLOGY

Three dimensions of the amyloid hypothesis: time, space and 'wingmen'

(2015) Erik S Musiek et al.   NATURE NEUROSCIENCE

Isolation and characterization of antibody fragments selective for toxic oligomeric tau

(2015) Huilai Tian et al.   NEUROBIOLOGY OF AGING

Using data-independent, high-resolution mass spectrometry in protein biomarker research: Perspectives and clinical applications

(2015) Tatjana Sajic et al.   Proteomics Clinical Applications

Peripheral and central effects of γ-secretase inhibition by semagacestat in Alzheimer’s disease

(2015) Rachelle S Doody et al.   Alzheimers Research & Therapy

A highly sensitive novel immunoassay specifically detects low levels of soluble Aβ oligomers in human cerebrospinal fluid

(2015) Ting Yang et al.   Alzheimers Research & Therapy

Nonlinear Association Between Cerebrospinal Fluid and Florbetapir F-18 β-Amyloid Measures Across the Spectrum of Alzheimer Disease

(2015) Jon B. Toledo et al.   JAMA Neurology

Peripheral Total Tau in Military Personnel Who Sustain Traumatic Brain Injuries During Deployment

(2015) Anlys Olivera et al.   JAMA Neurology

Targeting Prodromal Alzheimer Disease With Avagacestat

(2015) Vladimir Coric et al.   JAMA Neurology

Longitudinal Cerebrospinal Fluid Biomarker Changes in Preclinical Alzheimer Disease During Middle Age

(2015) Courtney L. Sutphen et al.   JAMA Neurology

Plasma lipidomics analysis finds long chain cholesteryl esters to be associated with Alzheimer’s disease

(2015) P Proitsi et al.   Translational Psychiatry

microRNA-Based Biomarkers and the Diagnosis of Alzheimer’s Disease

(2015) Yuhai Zhao et al.   Frontiers in Neurology

Emerging Technologies to Increase Ligand Binding Assay Sensitivity

(2014) Saloumeh K. Fischer et al.   AAPS Journal

CSF Apo-E levels associate with cognitive decline and MRI changes

(2014) Jon B. Toledo et al.   ACTA NEUROPATHOLOGICA

Plasma exosomal α-synuclein is likely CNS-derived and increased in Parkinson’s disease

(2014) Min Shi et al.   ACTA NEUROPATHOLOGICA

Plasma proteins predict conversion to dementia from prodromal disease

(2014) Abdul Hye et al.   Alzheimers & Dementia

Alzheimer's disease biomarker discovery using SOMAscan multiplexed protein technology

(2014) Martina Sattlecker et al.   Alzheimers & Dementia

Soluble γ-Secretase Modulators Selectively Inhibit the Production of the 42-Amino Acid Amyloid β Peptide Variant and Augment the Production of Multiple Carboxy-Truncated Amyloid β Species

(2014) Steven L. Wagner et al.   BIOCHEMISTRY

An Integrated Workflow for Multiplex CSF Proteomics and Peptidomics—Identification of Candidate Cerebrospinal Fluid Biomarkers of Alzheimer’s Disease

(2014) Mikko Hölttä et al.   JOURNAL OF PROTEOME RESEARCH

Proteomic analysis of cerebrospinal fluid extracellular vesicles: A comprehensive dataset

(2014) Davide Chiasserini et al.   Journal of Proteomics

Circulating Proteomic Signatures of Chronological Age

(2014) Cristina Menni et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Advancing research diagnostic criteria for Alzheimer's disease: the IWG-2 criteria

(2014) Bruno Dubois et al.   LANCET NEUROLOGY

Body Fluid Cytokine Levels in Mild Cognitive Impairment and Alzheimer’s Disease: a Comparative Overview

(2014) Frederic Brosseron et al.   MOLECULAR NEUROBIOLOGY

Identification of longitudinally dynamic biomarkers in Alzheimer’s disease cerebrospinal fluid by targeted proteomics

(2014) Kristin R Wildsmith et al.   Molecular Neurodegeneration

Plasma phospholipids identify antecedent memory impairment in older adults

(2014) Mark Mapstone et al.   NATURE MEDICINE

Cerebrospinal fluid biomarkers in trials for Alzheimer and Parkinson diseases

(2014) Alberto Lleó et al.   Nature Reviews Neurology

The Intersection of Amyloid Beta and Tau at Synapses in Alzheimer’s Disease

(2014) Tara L. Spires-Jones et al.   NEURON

Variability of CSF Alzheimer’s Disease Biomarkers: Implications for Clinical Practice

(2014) Stephanie J. B. Vos et al.   PLoS One

TREM2 mutations implicated in neurodegeneration impair cell surface transport and phagocytosis

(2014) G. Kleinberger et al.   Science Translational Medicine

Prevalence of mixed pathologies in the aging brain

(2014) Jasmin Rahimi et al.   Alzheimers Research & Therapy

β-site amyloid precursor protein-cleaving enzyme 1(BACE1) inhibitor treatment induces Aβ5-X peptides through alternative amyloid precursor protein cleavage

(2014) Erik Portelius et al.   Alzheimers Research & Therapy

Genome-Wide Association Study of CSF Levels of 59 Alzheimer's Disease Candidate Proteins: Significant Associations with Proteins Involved in Amyloid Processing and Inflammation

(2014) John S. K. Kauwe et al.   PLoS Genetics

Diagnostic Performance of Cerebrospinal Fluid Total Tau and Phosphorylated Tau in Creutzfeldt-Jakob Disease

(2014) Tobias Skillbäck et al.   JAMA Neurology

Effect of Potent γ-Secretase Modulator in Human Neurons Derived From Multiple Presenilin 1–Induced Pluripotent Stem Cell Mutant Carriers

(2014) Qing Liu et al.   JAMA Neurology

Blood Biomarkers for Brain Injury in Concussed Professional Ice Hockey Players

(2014) Pashtun Shahim et al.   JAMA Neurology

Cerebrospinal fluid markers including trefoil factor 3 are associated with neurodegeneration in amyloid-positive individuals

(2014) R W Paterson et al.   Translational Psychiatry

Diagnostic accuracy of CSF Ab42 and florbetapir PET for Alzheimer's disease

(2014) Niklas Mattsson et al.   Annals of Clinical and Translational Neurology

CSF biomarker variability in the Alzheimer's Association quality control program

(2013) Niklas Mattsson et al.   Alzheimers & Dementia

Olympic boxing is associated with elevated levels of the neuronal protein tau in plasma

(2013) Sanna Neselius et al.   BRAIN INJURY

High Tau Levels in Cerebrospinal Fluid Predict Rapid Decline and Increased Dementia Mortality in Alzheimer's Disease

(2013) M. Degerman Gunnarsson et al.   DEMENTIA AND GERIATRIC COGNITIVE DISORDERS

AZ-4217: A High Potency BACE Inhibitor Displaying Acute Central Efficacy in Different In Vivo Models and Reduced Amyloid Deposition in Tg2576 Mice

(2013) S. Eketjall et al.   JOURNAL OF NEUROSCIENCE

Preclinical Alzheimer's disease and its outcome: a longitudinal cohort study

(2013) Stephanie JB Vos et al.   LANCET NEUROLOGY

Tracking pathophysiological processes in Alzheimer's disease: an updated hypothetical model of dynamic biomarkers

(2013) Clifford R Jack et al.   LANCET NEUROLOGY

Self-propagation of pathogenic protein aggregates in neurodegenerative diseases

(2013) Mathias Jucker et al.   NATURE

Cerebrospinal fluid biomarkers in Parkinson disease

(2013) Lucilla Parnetti et al.   Nature Reviews Neurology

Reduced expression of hsa-miR-27a-3p in CSF of patients with Alzheimer disease

(2013) C. Sala Frigerio et al.   NEUROLOGY

Reduced CSF p-Tau181 to Tau ratio is a biomarker for FTLD-TDP

(2013) W. T. Hu et al.   NEUROLOGY

GWAS of Cerebrospinal Fluid Tau Levels Identifies Risk Variants for Alzheimer’s Disease

(2013) Carlos Cruchaga et al.   NEURON

Identification of Altered Metabolic Pathways in Plasma and CSF in Mild Cognitive Impairment and Alzheimer’s Disease Using Metabolomics

(2013) Eugenia Trushina et al.   PLoS One

Characterization of Novel CSF Tau and ptau Biomarkers for Alzheimer’s Disease

(2013) Jere E. Meredith Jr. et al.   PLoS One

Plasma amyloid beta measurements - a desired but elusive Alzheimer's disease biomarker

(2013) Jon B Toledo et al.   Alzheimers Research & Therapy

Plasma tau levels in Alzheimer's disease

(2013) Henrik Zetterberg et al.   Alzheimers Research & Therapy

Biomarkers for Alzheimer's disease in plasma, serum and blood - conceptual and practical problems

(2013) Douglas Galasko et al.   Alzheimers Research & Therapy

Alterations in metabolic pathways and networks in Alzheimer’s disease

(2013) R Kaddurah-Daouk et al.   Translational Psychiatry

Amyloid-beta oligomerization in Alzheimer dementia versus high-pathology controls

(2012) Thomas J. Esparza et al.   ANNALS OF NEUROLOGY

Cerebrospinal Fluid Levels ofβ-Amyloid 1-42, but Not of Tau, Are Fully Changed Already 5 to 10 Years Before the Onset of Alzheimer Dementia

(2012) Peder Buchhave   ARCHIVES OF GENERAL PSYCHIATRY

Proteomic Changes in Cerebrospinal Fluid of Presymptomatic and Affected Persons Carrying Familial Alzheimer Disease Mutations

(2012) John M. Ringman   ARCHIVES OF NEUROLOGY

Effect of Immunotherapy With Bapineuzumab on Cerebrospinal Fluid Biomarker Levels in Patients With Mild to Moderate Alzheimer Disease

(2012) Henrik Zetterberg   ARCHIVES OF NEUROLOGY

Recommendations to standardize preanalytical confounding factors in Alzheimer’s and Parkinson’s disease cerebrospinal fluid biomarkers: an update

(2012) Marta del Campo et al.   Biomarkers in Medicine

Exosomes: vesicular carriers for intercellular communication in neurodegenerative disorders

(2012) Anja Schneider et al.   CELL AND TISSUE RESEARCH

iTRAQ and multiple reaction monitoring as proteomic tools for biomarker search in cerebrospinal fluid of patients with Parkinson's disease dementia

(2012) Stefan Lehnert et al.   EXPERIMENTAL NEUROLOGY

Cerebrospinal fluid APOE levels: an endophenotype for genetic studies for Alzheimer's disease

(2012) Carlos Cruchaga et al.   HUMAN MOLECULAR GENETICS

Discovery of AZD3839, a Potent and Selective BACE1 Inhibitor Clinical Candidate for the Treatment of Alzheimer Disease

(2012) Fredrik Jeppsson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cerebrospinal fluid–based kinetic biomarkers of axonal transport in monitoring neurodegeneration

(2012) Patrizia Fanara et al.   JOURNAL OF CLINICAL INVESTIGATION

Identification and proteomic profiling of exosomes in human cerebrospinal fluid

(2012) Jonathan M Street et al.   Journal of Translational Medicine

Translational biomarker discovery in clinical metabolomics: an introductory tutorial

(2012) Jianguo Xia et al.   Metabolomics

The toxic Aβ oligomer and Alzheimer's disease: an emperor in need of clothes

(2012) Iryna Benilova et al.   NATURE NEUROSCIENCE

Plasma multianalyte profiling in mild cognitive impairment and Alzheimer disease

(2012) W. T. Hu et al.   NEUROLOGY

Clinical and Biomarker Changes in Dominantly Inherited Alzheimer's Disease

(2012) Randall J. Bateman et al.   NEW ENGLAND JOURNAL OF MEDICINE

Variant of TREM2 Associated with the Risk of Alzheimer's Disease

(2012) Thorlakur Jonsson et al.   NEW ENGLAND JOURNAL OF MEDICINE

Phosphorylated  -Synuclein in Parkinson's Disease

(2012) Y. Wang et al.   Science Translational Medicine

Toward defining the preclinical stages of Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease

(2011) Reisa A. Sperling et al.   Alzheimers & Dementia

Standardization of preanalytical aspects of cerebrospinal fluid biomarker testing for Alzheimer's disease diagnosis: A consensus paper from the Alzheimer's Biomarkers Standardization Initiative

(2011) Hugo Vanderstichele et al.   Alzheimers & Dementia

Visinin-like protein-1: Diagnostic and prognostic biomarker in Alzheimer disease

(2011) Rawan Tarawneh et al.   ANNALS OF NEUROLOGY

Identification of Candidate IgG Biomarkers for Alzheimer's Disease via Combinatorial Library Screening

(2011) M. Muralidhar Reddy et al.   CELL

Modeling of Pathological Traits in Alzheimer's Disease Based on Systemic Extracellular Signaling Proteome

(2011) Markus Britschgi et al.   MOLECULAR & CELLULAR PROTEOMICS

A targeted proteomics–based pipeline for verification of biomarkers in plasma

(2011) Jeffrey R Whiteaker et al.   NATURE BIOTECHNOLOGY

Diagnosis of Alzheimer's Disease Based on Disease-Specific Autoantibody Profiles in Human Sera

(2011) Eric Nagele et al.   PLoS One

Hypoxia Due to Cardiac Arrest Induces a Time-Dependent Increase in Serum Amyloid β Levels in Humans

(2011) Henrik Zetterberg et al.   PLoS One

Biomarker-based dissection of neurodegenerative diseases

(2011) Bob Olsson et al.   PROGRESS IN NEUROBIOLOGY

Multi-organ distribution of phosphorylated α-synuclein histopathology in subjects with Lewy body disorders

(2010) Thomas G. Beach et al.   ACTA NEUROPATHOLOGICA

Biomarker discovery for Alzheimer’s disease, frontotemporal lobar degeneration, and Parkinson’s disease

(2010) William T. Hu et al.   ACTA NEUROPATHOLOGICA

YKL-40: A Novel Prognostic Fluid Biomarker for Preclinical Alzheimer's Disease

(2010) Rebecca Craig-Schapiro et al.   BIOLOGICAL PSYCHIATRY

Biomarkers of oxidative damage and inflammation in Alzheimer’s disease

(2010) Douglas Galasko et al.   Biomarkers in Medicine

High-content affinity-based proteomics: unlocking protein biomarker discovery

(2010) Edward N Brody et al.   EXPERT REVIEW OF MOLECULAR DIAGNOSTICS

Establishing the Proteome of Normal Human Cerebrospinal Fluid

(2010) Steven E. Schutzer et al.   PLoS One

Cerebrospinal fluid biomarker signature in Alzheimer's disease neuroimaging initiative subjects

(2009) Leslie M. Shaw et al.   ANNALS OF NEUROLOGY

Plasma progranulin levels predict progranulin mutation status in frontotemporal dementia patients and asymptomatic family members

(2009) N. Finch et al.   BRAIN

CSF Biomarkers and Incipient Alzheimer Disease in Patients With Mild Cognitive Impairment

(2009) Niklas Mattsson   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

The amyloid hypothesis for Alzheimer’s disease: a critical reappraisal

(2009) John Hardy   JOURNAL OF NEUROCHEMISTRY

τ Proteins in Serum Predict Outcome After Severe Traumatic Brain Injury

(2009) Po-Chou Liliang et al.   JOURNAL OF SURGICAL RESEARCH

CSF biomarkers predict rate of cognitive decline in Alzheimer disease

(2009) M. I. Kester et al.   NEUROLOGY

Phase 2 Safety Trial Targeting Amyloid β Production With a γ-Secretase Inhibitor in Alzheimer Disease

(2008) Adam S. Fleisher et al.   ARCHIVES OF NEUROLOGY

Low plasma progranulin levels predict progranulin mutations in frontotemporal lobar degeneration

(2008) R. Ghidoni et al.   NEUROLOGY