Topical rather than intradermal application of the TLR7 ligand imiquimod leads to human dermal dendritic cell maturation and CD8+T-cell cross-priming

Inducing Antitumor T Cell Immunity: Comparative Functional Analysis of Interstitial Versus Langerhans Dendritic Cells in a Human Cell Line Model

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Immunization of Malignant Melanoma Patients with Full-Length NY-ESO-1 Protein Using TLR7 Agonist Imiquimod as Vaccine Adjuvant

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Human CD1c+ dendritic cells secrete high levels of IL-12 and potently prime cytotoxic T-cell responses

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IRF4 Transcription Factor-Dependent CD11b+ Dendritic Cells in Human and Mouse Control Mucosal IL-17 Cytokine Responses

(2013) Andreas Schlitzer et al.   IMMUNITY

Intradermal Delivery of TLR Agonists in a Human Explant Skin Model: Preferential Activation of Migratory Dendritic Cells by Polyribosinic-Polyribocytidylic Acid and Peptidoglycans

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TLR7 Triggering with Polyuridylic Acid Promotes Cross-Presentation in CD8 + Conventional Dendritic Cells by Enhancing Antigen Preservation and MHC Class I Antigen Permanence on the Dendritic Cell Surface

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IL-10 Conditioning of Human Skin Affects the Distribution of Migratory Dendritic Cell Subsets and Functional T Cell Differentiation

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Aldara activates TLR7-independent immune defence

(2013) Anne Walter et al.   Nature Communications

The differential production of cytokines by human Langerhans cells and dermal CD14+ DCs controls CTL priming

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Adjuvants for human vaccines

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Human Tissues Contain CD141hi Cross-Presenting Dendritic Cells with Functional Homology to Mouse CD103+ Nonlymphoid Dendritic Cells

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Characterization of resident and migratory dendritic cells in human lymph nodes

(2012) Elodie Segura et al.   JOURNAL OF EXPERIMENTAL MEDICINE

IL-17 and IL-22 enhance skin inflammation by stimulating the secretion of IL-1β by keratinocytes via the ROS-NLRP3-caspase-1 pathway

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Topical Imiquimod has Therapeutic and Immunomodulatory Effects Against Intracranial Tumors

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The ophthalmic side-effects of imiquimod therapy in the management of periocular skin lesions

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Use of defined TLR ligands as adjuvants within human vaccines

(2010) Malcolm S. Duthie et al.   IMMUNOLOGICAL REVIEWS

The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors

(2010) Taro Kawai et al.   NATURE IMMUNOLOGY

Understanding human myeloid dendritic cell subsets for the rational design of novel vaccines

(2009) Eynav Klechevsky et al.   HUMAN IMMUNOLOGY

Molecular mechanism and function of CD40/CD40L engagement in the immune system

(2009) Raul Elgueta et al.   IMMUNOLOGICAL REVIEWS

Modulation of adaptive immunity with Toll-like receptors

(2009) Santhakumar Manicassamy et al.   SEMINARS IN IMMUNOLOGY

Triggering TLR7 in mice induces immune activation and lymphoid system disruption, resembling HIV-mediated pathology

(2008) S. Baenziger et al.   BLOOD

Functional Specializations of Human Epidermal Langerhans Cells and CD14+ Dermal Dendritic Cells

(2008) Eynav Klechevsky et al.   IMMUNITY

The Use of TLR7 and TLR8 Ligands for the Enhancement of Cancer Immunotherapy

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