Identifying Individual T Cell Receptors of Optimal Avidity for Tumor Antigens
Published 2015 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Identifying Individual T Cell Receptors of Optimal Avidity for Tumor Antigens
Authors
Keywords
-
Journal
Frontiers in Immunology
Volume 6, Issue -, Pages -
Publisher
Frontiers Media SA
Online
2015-11-18
DOI
10.3389/fimmu.2015.00582
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- From T cell “exhaustion” to anti-cancer immunity
- (2016) Grégory Verdeil et al. BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
- Identification of Rare High-Avidity, Tumor-Reactive CD8+ T Cells by Monomeric TCR-Ligand Off-Rates Measurements on Living Cells
- (2015) M. Hebeisen et al. CANCER RESEARCH
- T cell receptor binding affinity governs the functional profile of cancer-specific CD8+T cells
- (2015) M. P. Tan et al. CLINICAL AND EXPERIMENTAL IMMUNOLOGY
- TCR affinity for p/MHC formed by tumor antigens that are self-proteins: impact on efficacy and toxicity
- (2015) Jennifer D Stone et al. CURRENT OPINION IN IMMUNOLOGY
- Quantitative TCR:pMHC Dissociation Rate Assessment by NTAmers Reveals Antimelanoma T Cell Repertoires Enriched for High Functional Competence
- (2015) Philippe O. Gannon et al. JOURNAL OF IMMUNOLOGY
- Force-Regulated In Situ TCR–Peptide-Bound MHC Class II Kinetics Determine Functions of CD4+T Cells
- (2015) Jinsung Hong et al. JOURNAL OF IMMUNOLOGY
- Nivolumab and Ipilimumab versus Ipilimumab in Untreated Melanoma
- (2015) Michael A. Postow et al. NEW ENGLAND JOURNAL OF MEDICINE
- Pembrolizumab for the Treatment of Non–Small-Cell Lung Cancer
- (2015) Edward B. Garon et al. NEW ENGLAND JOURNAL OF MEDICINE
- Pembrolizumab versus Ipilimumab in Advanced Melanoma
- (2015) Caroline Robert et al. NEW ENGLAND JOURNAL OF MEDICINE
- Neoantigens in cancer immunotherapy
- (2015) T. N. Schumacher et al. SCIENCE
- Engineered T cells for cancer therapy
- (2014) Carl H. June et al. CANCER IMMUNOLOGY IMMUNOTHERAPY
- Comparison of peptide-major histocompatibility complex tetramers and dextramers for the identification of antigen-specific T cells
- (2014) G. Dolton et al. CLINICAL AND EXPERIMENTAL IMMUNOLOGY
- Clonotype-specific avidity influences the dynamics and hierarchy of virus-specific regulatory and effector CD4+T-cell responses
- (2014) Jie Liu et al. EUROPEAN JOURNAL OF IMMUNOLOGY
- Mechanical regulation of T-cell functions
- (2014) Wei Chen et al. IMMUNOLOGICAL REVIEWS
- Single and Dual Amino Acid Substitutions in TCR CDRs Can Enhance Antigen-Specific T Cell Functions
- (2014) Paul F. Robbins et al. JOURNAL OF IMMUNOLOGY
- Accumulation of Serial Forces on TCR and CD8 Frequently Applied by Agonist Antigenic Peptides Embedded in MHC Molecules Triggers Calcium in T Cells
- (2014) S. Pryshchep et al. JOURNAL OF IMMUNOLOGY
- Specific Increase in Potency via Structure-Based Design of a TCR
- (2014) Karolina Malecek et al. JOURNAL OF IMMUNOLOGY
- High Avidity CD8+ T Cells Efficiently Eliminate Motile HIV-Infected Targets and Execute a Locally Focused Program of Anti-Viral Function
- (2014) Maria Hottelet Foley et al. PLoS One
- A sharp T-cell antigen receptor signaling threshold for T-cell proliferation
- (2014) B. B. Au-Yeung et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Reproducible selection of high avidity CD8+ T-cell clones following secondary acute virus infection
- (2014) T. Cukalac et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- An induced rebinding model of antigen discrimination
- (2014) Omer Dushek et al. TRENDS IN IMMUNOLOGY
- Ligand-engaged TCR is triggered by Lck not associated with CD8 coreceptor
- (2014) Javier Casas et al. Nature Communications
- Apoptosis-Regulated Low-Avidity Cancer-Specific CD8+ T Cells Can Be Rescued to Eliminate HER2/neu-Expressing Tumors by Costimulatory Agonists in Tolerized Mice
- (2014) C. M. Black et al. Cancer Immunology Research
- Cardiovascular toxicity and titin cross-reactivity of affinity-enhanced T cells in myeloma and melanoma
- (2013) G. P. Linette et al. BLOOD
- Enhanced-affinity murine T-cell receptors for tumor/self-antigens can be safe in gene therapy despite surpassing the threshold for thymic selection
- (2013) T. M. Schmitt et al. BLOOD
- Relapse or Eradication of Cancer Is Predicted by Peptide-Major Histocompatibility Complex Affinity
- (2013) Boris Engels et al. CANCER CELL
- Adoptive Transfer of Tumor-Infiltrating Lymphocytes in Patients with Metastatic Melanoma: Intent-to-Treat Analysis and Efficacy after Failure to Prior Immunotherapies
- (2013) M. J. Besser et al. CLINICAL CANCER RESEARCH
- Competition between T cells maintains clonal dominance during memory inflation induced by MCMV
- (2013) Holly Turula et al. EUROPEAN JOURNAL OF IMMUNOLOGY
- 2D TCR-pMHC-CD8 kinetics determines T-cell responses in a self-antigen-specific TCR system
- (2013) Baoyu Liu et al. EUROPEAN JOURNAL OF IMMUNOLOGY
- Mixed functional characteristics correlating with TCR-ligand koff-rate of MHC-tetramer reactive T cells within the naive T-cell repertoire
- (2013) Pleun Hombrink et al. EUROPEAN JOURNAL OF IMMUNOLOGY
- CAR-modified anti-CD19 T cells for the treatment of B-cell malignancies: rules of the road
- (2013) Saar Gill et al. EXPERT OPINION ON BIOLOGICAL THERAPY
- The clinical potential for koff-rate measurement in adoptive immunotherapy
- (2013) Magdalena Nauerth et al. Expert Review of Clinical Immunology
- SHP-1 phosphatase activity counteracts increased T cell receptor affinity
- (2013) Michael Hebeisen et al. JOURNAL OF CLINICAL INVESTIGATION
- Cancer Regression and Neurological Toxicity Following Anti-MAGE-A3 TCR Gene Therapy
- (2013) Richard A. Morgan et al. JOURNAL OF IMMUNOTHERAPY
- Distinct TCR signaling pathways drive proliferation and cytokine production in T cells
- (2013) Clifford S Guy et al. NATURE IMMUNOLOGY
- Mining exomic sequencing data to identify mutated antigens recognized by adoptively transferred tumor-reactive T cells
- (2013) Paul F Robbins et al. NATURE MEDICINE
- T-cell receptor affinity and avidity defines antitumor response and autoimmunity in T-cell immunotherapy
- (2013) S. Zhong et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- TCR-Ligand koff Rate Correlates with the Protective Capacity of Antigen-Specific CD8+ T Cells for Adoptive Transfer
- (2013) M. Nauerth et al. Science Translational Medicine
- Identification of a Titin-Derived HLA-A1-Presented Peptide as a Cross-Reactive Target for Engineered MAGE A3-Directed T Cells
- (2013) B. J. Cameron et al. Science Translational Medicine
- Rapid Perturbation in Viremia Levels Drives Increases in Functional Avidity of HIV-specific CD8 T Cells
- (2013) Selena Viganò et al. PLoS Pathogens
- Molecular Insights for Optimizing T Cell Receptor Specificity Against Cancer
- (2013) Michael Hebeisen et al. Frontiers in Immunology
- Structure-Based, Rational Design of T Cell Receptors
- (2013) V. Zoete et al. Frontiers in Immunology
- TCR-Engineered T Cells Meet New Challenges to Treat Solid Tumors: Choice of Antigen, T Cell Fitness, and Sensitization of Tumor Milieu
- (2013) Andre Kunert et al. Frontiers in Immunology
- Analysis, Isolation, and Activation of Antigen-Specific CD4+ and CD8+ T Cells by Soluble MHC-Peptide Complexes
- (2013) Julien Schmidt et al. Frontiers in Immunology
- High-Avidity T Cells Are Preferentially Tolerized in the Tumor Microenvironment
- (2012) Z. Zhu et al. CANCER RESEARCH
- TCR signaling requirements for activating T cells and for generating memory
- (2012) Dietmar Zehn et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- Functional Avidity: A Measure to Predict the Efficacy of Effector T Cells?
- (2012) Selena Viganò et al. Clinical & Developmental Immunology
- Specific Lymphocyte Subsets Predict Response to Adoptive Cell Therapy Using Expanded Autologous Tumor-Infiltrating Lymphocytes in Metastatic Melanoma Patients
- (2012) L. G. Radvanyi et al. CLINICAL CANCER RESEARCH
- Different affinity windows for virus and cancer-specific T-cell receptors: Implications for therapeutic strategies
- (2012) Milos Aleksic et al. EUROPEAN JOURNAL OF IMMUNOLOGY
- Design of T-cell receptor libraries with diverse binding properties to examine adoptive T-cell responses
- (2012) A S Chervin et al. GENE THERAPY
- Insights fromin situanalysis of TCR-pMHC recognition: response of an interaction network
- (2012) Cheng Zhu et al. IMMUNOLOGICAL REVIEWS
- The molecular determinants of CD8 co-receptor function
- (2012) David K. Cole et al. IMMUNOLOGY
- Interplay between T Cell Receptor Binding Kinetics and the Level of Cognate Peptide Presented by Major Histocompatibility Complexes Governs CD8+T Cell Responsiveness
- (2012) Melita Irving et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Human Antitumor CD8+ T Cells Producing Th1 Polycytokines Show Superior Antigen Sensitivity and Tumor Recognition
- (2012) S. Wilde et al. JOURNAL OF IMMUNOLOGY
- Long-term Persistence of CD4+ but Rapid Disappearance of CD8+ T Cells Expressing an MHC Class I-restricted TCR of Nanomolar Affinity
- (2012) Boris Engels et al. MOLECULAR THERAPY
- Safety and Activity of Anti–PD-L1 Antibody in Patients with Advanced Cancer
- (2012) Julie R. Brahmer et al. NEW ENGLAND JOURNAL OF MEDICINE
- Safety, Activity, and Immune Correlates of Anti–PD-1 Antibody in Cancer
- (2012) Suzanne L. Topalian et al. NEW ENGLAND JOURNAL OF MEDICINE
- Trafficking of High Avidity HER-2/neu-Specific T Cells into HER-2/neu-Expressing Tumors after Depletion of Effector/Memory-Like Regulatory T Cells
- (2012) Vivian L. Weiss et al. PLoS One
- High Avidity Cytotoxic T Lymphocytes Can Be Selected into the Memory Pool but They Are Exquisitely Sensitive to Functional Impairment
- (2012) Victoria A. Brentville et al. PLoS One
- Insights into T Cell Recognition of Antigen: Significance of Two-Dimensional Kinetic Parameters
- (2012) Lindsay J. Edwards et al. Frontiers in Immunology
- Functional differences between low- and high-affinity CD8+T cells in the tumor environment
- (2012) Rinke Bos et al. OncoImmunology
- Enhanced cytotoxicity and decreased CD8 dependence of human cancer-specific cytotoxic T lymphocytes after vaccination with low peptide dose
- (2011) Tanja Lövgren et al. CANCER IMMUNOLOGY IMMUNOTHERAPY
- Prognostic and Predictive Impact of Intra- and Peritumoral Immune Infiltrates
- (2011) W. H. Fridman et al. CANCER RESEARCH
- Determinants of Successful CD8 + T-Cell Adoptive Immunotherapy for Large Established Tumors in Mice
- (2011) Christopher A. Klebanoff et al. CLINICAL CANCER RESEARCH
- Durable Complete Responses in Heavily Pretreated Patients with Metastatic Melanoma Using T-Cell Transfer Immunotherapy
- (2011) S. A. Rosenberg et al. CLINICAL CANCER RESEARCH
- Two-Stage Cooperative T Cell Receptor-Peptide Major Histocompatibility Complex-CD8 Trimolecular Interactions Amplify Antigen Discrimination
- (2011) Ning Jiang et al. IMMUNITY
- Structural and biophysical determinants of αβ T-cell antigen recognition
- (2011) John S. Bridgeman et al. IMMUNOLOGY
- High-avidity, high-IFNγ-producing CD8 T-cell responses following immune selection during HIV-1 infection
- (2011) Niamh M Keane et al. IMMUNOLOGY AND CELL BIOLOGY
- Reversible Major Histocompatibility Complex I-Peptide Multimers Containing Ni2+-Nitrilotriacetic Acid Peptides and Histidine Tags Improve Analysis and Sorting of CD8+T Cells
- (2011) Julien Schmidt et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Tumor Regression in Patients With Metastatic Synovial Cell Sarcoma and Melanoma Using Genetically Engineered Lymphocytes Reactive With NY-ESO-1
- (2011) Paul F. Robbins et al. JOURNAL OF CLINICAL ONCOLOGY
- Strength of TCR-Peptide/MHC Interactions and In Vivo T Cell Responses
- (2011) E. Corse et al. JOURNAL OF IMMUNOLOGY
- TCRs Used in Cancer Gene Therapy Cross-React with MART-1/Melan-A Tumor Antigens via Distinct Mechanisms
- (2011) O. Y. Borbulevych et al. JOURNAL OF IMMUNOLOGY
- Cancer immunotherapy comes of age
- (2011) Ira Mellman et al. NATURE
- Cell transfer immunotherapy for metastatic solid cancer—what clinicians need to know
- (2011) Steven A. Rosenberg Nature Reviews Clinical Oncology
- Ipilimumab plus Dacarbazine for Previously Untreated Metastatic Melanoma
- (2011) Caroline Robert et al. NEW ENGLAND JOURNAL OF MEDICINE
- Single cell analysis reveals similar functional competence of dominant and nondominant CD8 T-cell clonotypes
- (2011) D. E. Speiser et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Dependence of T Cell Antigen Recognition on T Cell Receptor-Peptide MHC Confinement Time
- (2010) Milos Aleksic et al. IMMUNITY
- Molecular immunology lessons from therapeutic T-cell receptor gene transfer
- (2010) Sharyn Thomas et al. IMMUNOLOGY
- Ca 2+ Release from the Endoplasmic Reticulum of NY-ESO-1–Specific T Cells Is Modulated by the Affinity of TCR and by the Use of the CD8 Coreceptor
- (2010) Ji-Li Chen et al. JOURNAL OF IMMUNOLOGY
- Evidence for a TCR Affinity Threshold Delimiting Maximal CD8 T Cell Function
- (2010) D. A. Schmid et al. JOURNAL OF IMMUNOLOGY
- MM-GBSA binding free energy decomposition and T cell receptor engineering
- (2010) V. Zoete et al. JOURNAL OF MOLECULAR RECOGNITION
- The kinetics of two-dimensional TCR and pMHC interactions determine T-cell responsiveness
- (2010) Jun Huang et al. NATURE
- TCR–peptide–MHC interactions in situ show accelerated kinetics and increased affinity
- (2010) Johannes B. Huppa et al. NATURE
- Improved Survival with Ipilimumab in Patients with Metastatic Melanoma
- (2010) F. Stephen Hodi et al. NEW ENGLAND JOURNAL OF MEDICINE
- Fast on-rates allow short dwell time ligands to activate T cells
- (2010) C. C. Govern et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- CD4 and CD8 binding to MHC molecules primarily acts to enhance Lck delivery
- (2010) M. N. Artyomov et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The Goldilocks Model for TCR—Too Much Attraction Might Not Be Best for Vaccine Design
- (2010) Jill E. Slansky et al. PLOS BIOLOGY
- Attenuated T Cell Responses to a High-Potency Ligand In Vivo
- (2010) Emily Corse et al. PLOS BIOLOGY
- Gene therapy with human and mouse T-cell receptors mediates cancer regression and targets normal tissues expressing cognate antigen
- (2009) L. A. Johnson et al. BLOOD
- Immunotherapy of Malignant Disease with Tumor Antigen-Specific Monoclonal Antibodies
- (2009) M. Campoli et al. CLINICAL CANCER RESEARCH
- The duration of TCR/pMHC interactions regulates CTL effector function and tumor-killing capacity
- (2009) Erick Riquelme et al. EUROPEAN JOURNAL OF IMMUNOLOGY
- Allorestricted T lymphocytes with a high avidity T-cell receptor towards NY-ESO-1 have potent anti-tumor activity
- (2009) Holger Krönig et al. INTERNATIONAL JOURNAL OF CANCER
- In Situ Cytotoxic and Memory T Cells Predict Outcome in Patients With Early-Stage Colorectal Cancer
- (2009) Franck Pagès et al. JOURNAL OF CLINICAL ONCOLOGY
- Minimally Cultured or Selected Autologous Tumor-infiltrating Lymphocytes After a Lympho-depleting Chemotherapy Regimen in Metastatic Melanoma Patients
- (2009) Michal J. Besser et al. JOURNAL OF IMMUNOTHERAPY
- Complete but curtailed T-cell response to very low-affinity antigen
- (2009) Dietmar Zehn et al. NATURE
- Ocular and Systemic Autoimmunity after Successful Tumor-Infiltrating Lymphocyte Immunotherapy for Recurrent, Metastatic Melanoma
- (2009) Steven Yeh et al. OPHTHALMOLOGY
- T-cell antagonism by short half-life pMHC ligands can be mediated by an efficient trapping of T-cell polarization toward the APC
- (2009) L. J. Carreno et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Loss of CTL Function among High-Avidity Tumor-Specific CD8+ T Cells following Tumor Infiltration
- (2008) C. N. Janicki et al. CANCER RESEARCH
- T-cell receptor binding affinities and kinetics: impact on T-cell activity and specificity
- (2008) Jennifer D. Stone et al. IMMUNOLOGY
- Adoptive Cell Therapy for Patients With Metastatic Melanoma: Evaluation of Intensive Myeloablative Chemoradiation Preparative Regimens
- (2008) Mark E. Dudley et al. JOURNAL OF CLINICAL ONCOLOGY
- Avidity maturation of memory CD8 T cells is limited by self-antigen expression
- (2008) Michael J. Turner et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Cancer Immunotherapy
- (2008) NEW ENGLAND JOURNAL OF MEDICINE
- Effective tumor treatment targeting a melanoma/melanocyte-associated antigen triggers severe ocular autoimmunity
- (2008) D. C. Palmer et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Structure-based design of a T-cell receptor leads to nearly 100-fold improvement in binding affinity for pepMHC
- (2008) Jaafar N. Haidar et al. PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreDiscover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversation