Impact of High Glucose and Proteasome Inhibitor MG132 on Histone H2A and H2B Ubiquitination in Rat Glomerular Mesangial Cells

Proteasome inhibition-induced p38 MAPK/ERK signaling regulates autophagy and apoptosis through the dual phosphorylation of glycogen synthase kinase 3β

(2012) Cheol-Hee Choi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Apoptosis inducer NGFI-B is degraded by the proteasome and stabilized by treatment with EGF

(2012) Bjørn O. Strøm et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Metabolic Memory and Chronic Diabetes Complications: Potential Role for Epigenetic Mechanisms

(2012) Robert V. Intine et al.   Current Diabetes Reports

Proteasome inhibitor MG132 induces selective apoptosis in glioblastoma cells through inhibition of PI3K/Akt and NFkappaB pathways, mitochondrial dysfunction, and activation of p38-JNK1/2 signaling

(2012) Alfeu Zanotto-Filho et al.   INVESTIGATIONAL NEW DRUGS

Acetylation of Retinal Histones in Diabetes Increases Inflammatory Proteins

(2012) Chandra Sekhar Rao Kadiyala et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Chromatin Modifications Associated with Diabetes

(2012) Samuel T. Keating et al.   Journal of Cardiovascular Translational Research

Diabetes-induced Epigenetic Signature in Vascular Cells

(2012) Tijana Mitic et al.   Endocrine Metabolic & Immune Disorders-Drug Targets

Proteasome inhibitors induce apoptosis and reduce viral replication in primary effusion lymphoma cells

(2011) Chiaki Saji et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

MG132 treatment attenuates cardiac remodeling and dysfunction following aortic banding in rats via the NF-κB/TGFβ1 pathway

(2011) Yuedong Ma et al.   BIOCHEMICAL PHARMACOLOGY

Epigenetics: deciphering its role in diabetes and its chronic complications

(2011) Louisa M Villeneuve et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

CPVL/CHN2 Genetic Variant Is Associated With Diabetic Retinopathy in Chinese Type 2 Diabetic Patients

(2011) Cheng Hu et al.   DIABETES

Tubular Injury in a Rat Model of Type 2 Diabetes Is Prevented by Metformin

(2011) Yumi Takiyama et al.   DIABETES

Early intensive insulin therapy attenuates the p38 pathway in the renal cortex and indices of nephropathy in diabetic rats

(2011) Donghong Fang et al.   ENDOCRINE JOURNAL

Epigenetics in Diabetic Kidney Disease

(2011) M. A. Reddy et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Histone deacetylase inhibition attenuates diabetes-associated kidney growth: potential role for epigenetic modification of the epidermal growth factor receptor

(2011) Richard E. Gilbert et al.   KIDNEY INTERNATIONAL

Optimizing Allocation of Kidneys from Older Donors

(2010) P. Ruggenenti et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Glycemic memory associated epigenetic changes

(2010) Andrew L. Siebel et al.   BIOCHEMICAL PHARMACOLOGY

Enhanced Levels of microRNA-125b in Vascular Smooth Muscle Cells of Diabetic db/db Mice Lead to Increased Inflammatory Gene Expression by Targeting the Histone Methyltransferase Suv39h1

(2010) L. M. Villeneuve et al.   DIABETES

Core histone H2A ubiquitylation and transcriptional regulation

(2010) Miki Higashi et al.   EXPERIMENTAL CELL RESEARCH

Epigenetic Histone Methylation Modulates Fibrotic Gene Expression

(2010) G. Sun et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

New pharmacological treatments for improving renal outcomes in diabetes

(2010) Anne-Emilie Declèves et al.   Nature Reviews Nephrology

Metabolic memory and diabetic nephropathy: potential role for epigenetic mechanisms

(2010) Stephen Tonna et al.   Nature Reviews Nephrology

RAGE and the pathogenesis of chronic kidney disease

(2010) Vivette D'Agati et al.   Nature Reviews Nephrology

Effects of proteasome inhibitors on rat renal fibrosis in vitro and in vivo

(2010) TORU SAKAIRI et al.   NEPHROLOGY

Hyperglycemia Induces a Dynamic Cooperativity of Histone Methylase and Demethylase Enzymes Associated With Gene-Activating Epigenetic Marks That Coexist on the Lysine Tail

(2009) D. Brasacchio et al.   DIABETES

Therapies for hyperglycaemia-induced diabetic complications: from animal models to clinical trials

(2009) Nigel A. Calcutt et al.   NATURE REVIEWS DRUG DISCOVERY

Epigenetic mechanisms that underpin metabolic and cardiovascular diseases

(2009) Peter D. Gluckman et al.   Nature Reviews Endocrinology

Transient high glucose causes persistent epigenetic changes and altered gene expression during subsequent normoglycemia

(2008) Assam El-Osta et al.   JOURNAL OF EXPERIMENTAL MEDICINE