Article
Cell & Tissue Engineering
Gangqi Wang, Bram Heijs, Sarantos Kostidis, Rosalie G. J. Rietjens, Marije Koning, Lushun Yuan, Gesa L. Tiemeier, Ahmed Mahfouz, Sebastien J. Dumas, Martin Giera, Jesper Kers, Susana M. Chuva de Sousa Lopes, Cathelijne W. van den Berg, Bernard M. van den Berg, Ton J. Rabelink
Summary: Accumulating evidence demonstrates the importance of metabolism in cell fate determination. This study uses a multi-omics platform to study cell-type-specific dynamics in metabolism during nephrogenesis and highlights the relevance of understanding metabolic trajectories for guiding stem cell differentiation.
Article
Cell Biology
Feng Yue, Stephanie N. Oprescu, Jiamin Qiu, Lijie Gu, Lijia Zhang, Jingjuan Chen, Naagarajan Narayanan, Meng Deng, Shihuan Kuang
Summary: In skeletal muscle satellite cells, the dynamic distribution of lipid droplets determines cell fate, with LDLow cells outperforming LDHigh cells in regeneration and self-renewal. Interventions in LD biogenesis and catabolism disrupt cell fate balance and impair the regenerative capacity of SCs.
Review
Medicine, Research & Experimental
Alexander C. Lewis, Lev M. Kats
Summary: The altered capacity for self-renewal and differentiation is a key feature of cancer, particularly in diseases like acute myeloid leukemia. Treatments are shifting towards targeting cancer stem cells and altering cell fate decisions to combat the disease.
EMBO MOLECULAR MEDICINE
(2021)
Article
Cell & Tissue Engineering
Matteo Togninalli, Andrew T. V. Ho, Christopher M. M. Madl, Colin A. A. Holbrook, Yu Xin Wang, Klas E. G. Magnusson, Anna Kirillova, Andrew Chang, Helen M. M. Blau
Summary: We developed a dual fluorescence imaging time lapse (Dual-FLIT) microscopy approach combined with machine learning classification strategies to track the fate decisions of muscle stem cells (MuSCs). We found that prostaglandin E2 (PGE2) accelerates MuSC proliferation and promotes symmetric self-renewal, while Oncostatin M (OSM) decreases proliferation rate and blocks myogenic commitment.
NPJ REGENERATIVE MEDICINE
(2023)
Article
Immunology
Zhenlong Li, Rui Ma, Shoubao Ma, Lei Tian, Ting Lu, Jianying Zhang, Bethany L. Mundy-Bosse, Bin Zhang, Guido Marcucci, Michael A. Caligiuri, Jianhua Yu
Summary: ILC1s can control acute myeloid leukemia by promoting leukemia stem cell apoptosis and favoring their differentiation into non-leukemic cells through the production of interferon-gamma. These findings provide a potential strategy for AML immunotherapy.
Article
Cell & Tissue Engineering
Laura Garcia-Prat, Kerstin B. Kaufmann, Florin Schneiter, Veronique Voisin, Alex Murison, Jocelyn Chen, Michelle Chan-Seng-Yue, Olga Gan, Jessica L. McLeod, Sabrina A. Smith, Michelle C. Shoong, Darrien Parris, Kristele Pan, Andy G. X. Zeng, Gabriela Krivdova, Kinam Gupta, Shin-Ichiro Takayanagi, Elvin Wagenblast, Weijia Wang, Mathieu Lupien, Timm Schroeder, Stephanie Z. Xie, John E. Dick
Summary: This study reveals that transcription factor EB-mediated control of lysosomal activity plays a central role in regulating the fate determination of stem cells. TFEB induces the endolysosomal pathway to limit LT-HSC activation, promoting quiescence and self-renewal, while MYC engages biosynthetic processes to drive stem cell activation.
Article
Multidisciplinary Sciences
Cheng Zeng, Jiwei Chen, Emmalee W. Cooke, Arijita Subuddhi, Eliana T. Roodman, Fei Xavier Chen, Kaixiang Cao
Summary: This study reveals the catalytic-independent role of LSD1 in regulating gene expression and cellular differentiation, demonstrating that the loss of LSD1 protein globally de-represses enhancers and impairs cell fate transition. The researchers found that the increase of H3K27ac catalyzed by P300/CBP, rather than the loss of CoREST complex components from chromatin, contributes to the transcription de-repression of LSD1 targets and differentiation defects caused by LSD1 loss.
NATURE COMMUNICATIONS
(2023)
Article
Cell & Tissue Engineering
Henry De Belly, Aki Stubb, Ayaka Yanagida, Celine Labouesse, Philip H. Jones, Ewa K. Paluch, Kevin J. Chalut
Summary: Cell fate transitions are influenced by changes in cell shape and mechanics, with mechanically triggered endocytosis playing a crucial role in regulating early differentiation. Understanding how cell mechanics regulates biochemical signaling pathways and cell fate is of fundamental importance.
Article
Biology
Runxiang Qiu, Jun Wu, Brian Gudenas, Paul A. Northcott, Robert J. Wechsler-Reya, Qiang Lu
Summary: The study shows that targeting Kif20a can inhibit early cell cycle exit and premature neuronal differentiation of cerebellar granule neuron progenitors, suppressing tumor formation in medulloblastoma models. This suggests a potential novel avenue for developing anti-proliferation treatment for malignant brain tumors.
COMMUNICATIONS BIOLOGY
(2021)
Review
Cell & Tissue Engineering
Ram Prosad Chakrabarty, Navdeep S. Chandel
Summary: Mitochondrial metabolism plays a crucial role in determining stem cell fate and function, beyond its traditional roles in ATP production and support for stem cell survival and growth. This review focuses on key conceptual ideas regarding how mitochondria control mammalian stem cell fate and function through mechanisms such as reactive oxygen species generation and TCA cycle metabolite production.
Article
Multidisciplinary Sciences
Weam S. Shahin, Shima O. Ebed, Scott R. Tyler, Branko Miljkovic, Soon H. Choi, Yulong Zhang, Weihong Zhou, Idil A. Evans, Charles Yeaman, John F. Engelhardt
Summary: This study reveals that reactive oxygen species regulate the behavior of neuronal stem cells by oxidizing cysteine residues on Igfbp2 protein, thus controlling their self-renewal and lineage commitment.
NATURE COMMUNICATIONS
(2023)
Article
Cell Biology
Yingying Han, Alvaro Villarreal-Ponce, Guadalupe Gutierrez, Quy Nguyen, Peng Sun, Ting Wu, Benjamin Sui, Geert Berx, Thomas Brabletz, Kai Kessenbrock, Yi Arial Zeng, Kazuhide Watanabe, Xing Dai
Summary: The study reveals the intrinsic requirement of Zeb1 in mammary epithelial ductal side branching and basal cell regenerative capacity. Zeb1 maintains both basal cell fate and stem cell quiescence partly through suppressing Wnt signaling.
Article
Cell Biology
Meghali Aich, Asgar Hussain Ansari, Li Ding, Vytautas Iesmantavicius, Deepanjan Paul, Chunaram Choudhary, Souvik Maiti, Frank Buchholz, Debojyoti Chakraborty
Summary: This study reveals that the lncRNA-associated protein TOBF1 regulates the alternative splicing of transcripts necessary for maintaining stem cell identity in mouse ESCs. One of the affected genes is serine/arginine splicing factor 1 (SRSF1), whose splicing leads to global changes in splicing and expression of downstream genes involved in the maintenance of ESC pluripotency. The study shows that TOBF1 chromatin occupancy, pluripotency-associated OCT-SOX binding motifs, and transcripts undergoing differential expression and splicing converge in specific nuclear territories, collectively contributing to the maintenance of mouse ESC identity.
Review
Biochemistry & Molecular Biology
Ruoxu Wang, Marc Amoyel
Summary: Stem cells and their progeny maintain tissue homeostasis by replacing lost cells. Besides transcriptional regulation, translational regulation plays a critical role in the fate decisions of stem cells.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Article
Cell & Tissue Engineering
Nicolas Dray, Laure Mancini, Udi Binshtok, Felix Cheysson, Willy Supatto, Pierre Mahou, Sebastien Bedu, Sara Ortica, Emmanuel Than-Trong, Monika Krecsmarik, Sebastien Herbert, Jean-Baptiste Masson, Jean-Yves Tinevez, Gabriel Lang, Emmanuel Beaurepaire, David Sprinzak, Laure Bally-Cuif
Summary: The study shows that neural stem cells coordinate their decision to divide in the adult zebrafish brain using spatiotemporally resolved local feedback signals, including short-range inhibition from transient neural progenitors and a dispersion effect from the dividing NSCs themselves. These signals are linked by lineage progression and control the spatiotemporal distribution of output neurons, generating self-propagating dynamics that maintain NSC population homeostasis.
Editorial Material
Plant Sciences
Laura Serna
Review
Developmental Biology
Diego Gonzalez, Sonia Fuentes, Laura Serna
INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY
(2017)
Review
Biochemistry & Molecular Biology
Laura Serna
Article
Developmental Biology
Laura Serna
INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY
(2011)
Article
Developmental Biology
Sonia Fuentes, Roberto C. Canamero, Laura Serna
INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY
(2012)
Editorial Material
Cell Biology
Laura Serna
NATURE CELL BIOLOGY
(2008)
Article
Plant Sciences
Hernan E. Boccalandro, Matias L. Rugnone, Javier E. Moreno, Edmundo L. Ploschuk, Laura Serna, Marcelo J. Yanovsky, Jorge J. Casal
Article
Plant Sciences
Laura Serna
Article
Plant Sciences
Laura Serna
Review
Biochemistry & Molecular Biology
Laura Serna
Article
Plant Sciences
Laura Serna
FRONTIERS IN PLANT SCIENCE
(2020)
Article
Plant Sciences
Laura Serna
Summary: Stomata development is a shared process among all plant groups, with the last step involving symmetrical cell division of the GMC to produce two GCs flanking a pore. Grass MUTE genes, such as BdMUTE, directly control GMC fate and also regulate GC morphogenesis, ensuring proper stomatal development.
FRONTIERS IN PLANT SCIENCE
(2021)
Review
Plant Sciences
Laura Serna
Summary: Drought and heat are important limiting factors in agricultural areas affected by climate change. Maize, a widely produced crop, is highly vulnerable to climate change, resulting in significant yield losses. Research shows that maize responds to drought stress by adjusting stomatal regulation, and when drought and heat occur together, heat intensifies the stomatal response. Understanding the impact of climate change on maize and its stomatal responses can help predict future maize yield and guide management decisions.
FRONTIERS IN PLANT SCIENCE
(2022)
Review
Biochemistry & Molecular Biology
Laura Serna
PLANT SIGNALING & BEHAVIOR
(2008)
