Huntington's Disease as Neurodevelopmental Disorder: Altered Chromatin Regulation, Coding, and Non-Coding RNA Transcription

Identification of Genetic Factors that Modify Clinical Onset of Huntington’s Disease

(2015) Jong-Min Lee et al.   CELL

Htt CAG repeat expansion confers pleiotropic gains of mutant huntingtin function in chromatin regulation

(2015) Marta Biagioli et al.   HUMAN MOLECULAR GENETICS

Spatiotemporal expression and transcriptional perturbations by long noncoding RNAs in the mouse brain

(2015) Loyal A. Goff et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MicroRNAs Located in the Hox Gene Clusters Are Implicated in Huntington's Disease Pathogenesis

(2014) Andrew G. Hoss et al.   PLoS Genetics

Epigenetic Mechanisms of Neurodegeneration in Huntington’s Disease

(2013) Junghee Lee et al.   Neurotherapeutics

Extensive changes in DNA methylation are associated with expression of mutant huntingtin

(2013) C. W. Ng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Multiple knockout mouse models reveal lincRNAs are required for life and brain development

(2013) Martin Sauvageau et al.   eLife

Induced Pluripotent Stem Cells from Patients with Huntington's Disease Show CAG-Repeat-Expansion-Associated Phenotypes

(2012) The HD iPSC Consortium   Cell Stem Cell

Emerging roles of non-coding RNAs in brain evolution, development, plasticity and disease

(2012) Irfan A. Qureshi et al.   NATURE REVIEWS NEUROSCIENCE

Lack of huntingtin promotes neural stem cells differentiation into glial cells while neurons expressing huntingtin with expanded polyglutamine tracts undergo cell death

(2012) Paola Conforti et al.   NEUROBIOLOGY OF DISEASE

Measures of growth in children at risk for Huntington disease

(2012) J. K. Lee et al.   NEUROLOGY

Differential effects of the Huntington's disease CAG mutation in striatum and cerebellum are quantitative not qualitative

(2011) Elisa Fossale et al.   HUMAN MOLECULAR GENETICS

HD CAG-correlated gene expression changes support a simple dominant gain of function

(2011) Jessie C. Jacobsen et al.   HUMAN MOLECULAR GENETICS

Long noncoding RNAs: the search for function

(2011) Monya Baker   NATURE METHODS

Non-coding RNAs in human disease

(2011) Manel Esteller   NATURE REVIEWS GENETICS

Long non-coding RNAs in Huntington's disease neurodegeneration

(2011) Rory Johnson   NEUROBIOLOGY OF DISEASE

Striatal and white matter predictors of estimated diagnosis for Huntington disease

(2010) Jane S. Paulsen et al.   BRAIN RESEARCH BULLETIN

Mutant huntingtin-impaired degradation of β-catenin causes neurotoxicity in Huntington's disease

(2010) Juliette D Godin et al.   EMBO JOURNAL

Is Huntington disease a developmental disorder?

(2010) Sandrine Humbert   EMBO REPORTS

Annotating non-coding regions of the genome

(2010) Roger P. Alexander et al.   NATURE REVIEWS GENETICS

Huntingtin facilitates polycomb repressive complex 2

(2009) Ihn Sik Seong et al.   HUMAN MOLECULAR GENETICS

The Bifunctional microRNA miR-9/miR-9* Regulates REST and CoREST and Is Downregulated in Huntington's Disease

(2009) A. N. Packer et al.   JOURNAL OF NEUROSCIENCE

Impairment of developmental stem cell-mediated striatal neurogenesis and pluripotency genes in a knock-in model of Huntington's disease

(2009) A. E. Molero et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA