ULK1 and JNK are involved in mitophagy incurred by LRRK2 G2019S expression

Interplay of LRRK2 with chaperone-mediated autophagy

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LRRK2 and autophagy: a common pathway for disease

(2012) Claudia Manzoni   BIOCHEMICAL SOCIETY TRANSACTIONS

Genetic analysis of Parkinson's disease-linked leucine-rich repeat kinase 2

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(G2019S) LRRK2 activates MKK4-JNK pathway and causes degeneration of SN dopaminergic neurons in a transgenic mouse model of PD

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The LRRK2 G2019S mutant exacerbates basal autophagy through activation of the MEK/ERK pathway

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Mitochondrial dysfunction in Parkinson's disease: molecular mechanisms and pathophysiological consequences

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LRRK2 regulates mitochondrial dynamics and function through direct interaction with DLP1

(2012) X. Wang et al.   HUMAN MOLECULAR GENETICS

Structures containing Atg9A and the ULK1 complex independently target depolarized mitochondria at initial stages of Parkin-mediated mitophagy

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Leucine-rich repeat kinase 2 disturbs mitochondrial dynamics via Dynamin-like protein

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Disrupted Autophagy Leads to Dopaminergic Axon and Dendrite Degeneration and Promotes Presynaptic Accumulation of  -Synuclein and LRRK2 in the Brain

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Mitochondrial dynamics and neuronal fate in Parkinson's disease

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Mitochondrial dynamics in neurodegeneration

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Regulation of PINK1-Parkin-mediated mitophagy

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Synthesis and SAR of novel quinazolines as potent and brain-penetrant c-jun N-terminal kinase (JNK) Inhibitors

(2011) Yuanjun He et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

SnapShot: Mitochondrial Dynamics

(2011) Yasushi Tamura et al.   CELL

Control of autophagy as a therapy for neurodegenerative disease

(2011) Harry Harris et al.   Nature Reviews Neurology

Dopaminergic Neuronal Loss, Reduced Neurite Complexity and Autophagic Abnormalities in Transgenic Mice Expressing G2019S Mutant LRRK2

(2011) David Ramonet et al.   PLoS One

LRRK2 signaling pathways: the key to unlocking neurodegeneration?

(2011) Daniel C. Berwick et al.   TRENDS IN CELL BIOLOGY

The role of the Atg1/ULK1 complex in autophagy regulation

(2010) Noboru Mizushima   CURRENT OPINION IN CELL BIOLOGY

Enhanced Striatal Dopamine Transmission and Motor Performance with LRRK2 Overexpression in Mice Is Eliminated by Familial Parkinson's Disease Mutation G2019S

(2010) X. Li et al.   JOURNAL OF NEUROSCIENCE

The role of leucine-rich repeat kinase 2 (LRRK2) in Parkinson's disease

(2010) Mark R. Cookson   NATURE REVIEWS NEUROSCIENCE

LRRK2 and the Stress Response: Interaction with MKKs and JNK-Interacting Proteins

(2010) C.H. Hsu et al.   Neurodegenerative Diseases

Phosphorylation of ULK1 (hATG1) by AMP-Activated Protein Kinase Connects Energy Sensing to Mitophagy

(2010) D. F. Egan et al.   SCIENCE

Parkinson disease, LRRK2 and the endocytic-autophagic pathway

(2009) Javier Alegre-Abarrategui et al.   Autophagy

Roles of mitophagy and the mitochondrial permeability transition in remodeling of cultured rat hepatocytes

(2009) Sara Rodriguez-Enriquez et al.   Autophagy

LRRK2 in Parkinson’s disease: genetic and clinical studies from patients

(2009) Udhaya Kumari et al.   FEBS Journal

Mitochondrial dynamics-fusion, fission, movement, and mitophagy-in neurodegenerative diseases

(2009) H. Chen et al.   HUMAN MOLECULAR GENETICS

The Parkinson disease-associated protein kinase LRRK2 exhibits MAPKKK activity and phosphorylates MKK3/6 and MKK4/7,in vitro

(2009) Christian Johannes Gloeckner et al.   JOURNAL OF NEUROCHEMISTRY

LRRK2 Modulates Vulnerability to Mitochondrial Dysfunction in Caenorhabditis elegans

(2009) S. Saha et al.   JOURNAL OF NEUROSCIENCE

Mitochondrial kinases in Parkinson’s disease: Converging insights from neurotoxin and genetic models

(2009) Ruben K. Dagda et al.   MITOCHONDRION

Ulk1 plays a critical role in the autophagic clearance of mitochondria and ribosomes during reticulocyte maturation

(2008) M. Kundu et al.   BLOOD

Autophagy in the Pathogenesis of Disease

(2008) Beth Levine et al.   CELL