Cellular N-myristoyltransferases play a crucial picornavirus genus-specific role in viral assembly, virion maturation, and infectivity

Genomic RNA folding mediates assembly of human parechovirus

(2017) Shabih Shakeel et al.   Nature Communications

Direct-acting antivirals and host-targeting strategies to combat enterovirus infections

(2017) Lisa Bauer et al.   Current Opinion in Virology

Picornavirus RNA is protected from cleavage by ribonuclease during virion uncoating and transfer across cellular and model membranes

(2017) Elisabetta Groppelli et al.   PLoS Pathogens

A highly conserved amino acid in VP1 regulates maturation of enterovirus 71

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N-Myristoyltransferase Inhibition Induces ER-Stress, Cell Cycle Arrest, and Apoptosis in Cancer Cells

(2016) Emmanuelle Thinon et al.   ACS Chemical Biology

Inhibition of enterovirus VP4 myristoylation is a potential antiviral strategy for hand, foot and mouth disease

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Multiple capsid-stabilizing interactions revealed in a high-resolution structure of an emerging picornavirus causing neonatal sepsis

(2016) Shabih Shakeel et al.   Nature Communications

The novel asymmetric entry intermediate of a picornavirus captured with nanodiscs

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N-myristoyltransferase 1 interacts with calnexin at the endoplasmic reticulum

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Systems Analysis of Protein Fatty Acylation in Herpes Simplex Virus-Infected Cells Using Chemical Proteomics

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Association of NMT2 with the acyl-CoA carrier ACBD6 protects theN-myristoyltransferase reaction from palmitoyl-CoA

(2015) Eric Soupene et al.   JOURNAL OF LIPID RESEARCH

The Structure of Human Parechovirus 1 Reveals an Association of the RNA Genome with the Capsid

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The anti-obesity drug orlistat reveals anti-viral activity

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Cadherin-related family member 3, a childhood asthma susceptibility gene product, mediates rhinovirus C binding and replication

(2015) Yury A. Bochkov et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of Ljungan virus provides insight into genome packaging of this picornavirus

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Coxsackievirus B3 VLPs purified by ion exchange chromatography elicit strong immune responses in mice

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Virus-induced double-membrane vesicles

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Coxsackievirus B3 induces crosstalk between autophagy and apoptosis to benefit its release after replicating in autophagosomes through a mechanism involving caspase cleavage of autophagy-related proteins

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The VP4 Peptide of Hepatitis A Virus Ruptures Membranes through Formation of Discrete Pores

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Picornavirus Morphogenesis

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Global profiling of co- and post-translationally N-myristoylated proteomes in human cells

(2014) Emmanuelle Thinon et al.   Nature Communications

Capsid Protein VP4 of Human Rhinovirus Induces Membrane Permeability by the Formation of a Size-Selective Multimeric Pore

(2014) Anusha Panjwani et al.   PLoS Pathogens

An Interaction between Glutathione and the Capsid Is Required for the Morphogenesis of C-Cluster Enteroviruses

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Binding of Glutathione to Enterovirus Capsids Is Essential for Virion Morphogenesis

(2014) Hendrik Jan Thibaut et al.   PLoS Pathogens

The Enterovirus 71 A-particle Forms a Gateway to Allow Genome Release: A CryoEM Study of Picornavirus Uncoating

(2013) Kristin L. Shingler et al.   PLoS Pathogens

Alanine Scanning of Poliovirus 2CATPaseReveals New Genetic Evidence that Capsid Protein/2CATPaseInteractions Are Essential for Morphogenesis

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The 3A Protein from Multiple Picornaviruses Utilizes the Golgi Adaptor Protein ACBD3 To Recruit PI4KIII 

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A fluorescence-based assay for N-myristoyltransferase activity

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Picornavirus non-structural proteins as targets for new anti-virals with broad activity

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Destabilization of Coxsackievirus B3 Genome Integrated with Enhanced Green Fluorescent Protein Gene

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Discovery of a Novel Class of Orally Active Trypanocidal N-Myristoyltransferase Inhibitors

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Ebola virus entry requires the cholesterol transporter Niemann–Pick C1

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Molecular modeling, organ culture and reverse genetics for a newly identified human rhinovirus C

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The Transformation of Enterovirus Replication Structures: a Three-Dimensional Study of Single- and Double-Membrane Compartments

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Type B coxsackieviruses and their interactions with the innate and adaptive immune systems

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N-myristoyltransferase inhibitors as new leads to treat sleeping sickness

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Quasispecies Theory and the Behavior of RNA Viruses

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Direct Interaction between Two Viral Proteins, the Nonstructural Protein 2CATPase and the Capsid Protein VP3, Is Required for Enterovirus Morphogenesis

(2010) Ying Liu et al.   PLoS Pathogens

Dynamin- and Lipid Raft-Dependent Entry of Decay-Accelerating Factor (DAF)-Binding and Non-DAF-Binding Coxsackieviruses into Nonpolarized Cells

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Foot-and-Mouth Disease Virus Assembly: Processing of Recombinant Capsid Precursor by Exogenous Protease Induces Self-Assembly of Pentamers In Vitro in a Myristoylation-Dependent Manner

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GBF1, a Guanine Nucleotide Exchange Factor for Arf, Is Crucial for Coxsackievirus B3 RNA Replication

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A genome-wide genetic screen for host factors required for hepatitis C virus propagation

(2009) Q. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Autophagosome Supports Coxsackievirus B3 Replication in Host Cells

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Identification of Host Proteins Required for HIV Infection Through a Functional Genomic Screen

(2008) Abraham L. Brass et al.   SCIENCE

N-Myristoyltransferase isozymes exhibit differential specificity for human immunodeficiency virus type 1 Gag and Nef

(2007) K. E. Seaton et al.   JOURNAL OF GENERAL VIROLOGY

HIV-1 production is specifically associated with human NMT1 long form in human NMT isozymes

(2007) Nobutoki Takamune et al.   MICROBES AND INFECTION