Targeting agr- and agr-Like Quorum Sensing Systems for Development of Common Therapeutics to Treat Multiple Gram-Positive Bacterial Infections

Development of a Peptide Antagonist against fsr Quorum Sensing of Enterococcus faecalis

(2013) Jiro Nakayama et al.   ACS Chemical Biology

Effects of the Peptide Pheromone Plantaricin A and Cocultivation with Lactobacillus sanfranciscensis DPPMA174 on the Exoproteome and the Adhesion Capacity of Lactobacillus plantarum DC400

(2013) Maria Calasso et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Attenuating Staphylococcus aureus Virulence Gene Regulation: A Medicinal Chemistry Perspective

(2013) Christopher P. Gordon et al.   JOURNAL OF MEDICINAL CHEMISTRY

Bacterial Quorum Sensing: Its Role in Virulence and Possibilities for Its Control

(2013) S. T. Rutherford et al.   Cold Spring Harbor Perspectives in Medicine

Daptomycin and Tigecycline Have Broader Effective Dose Ranges than Vancomycin as Prophylaxis against a Staphylococcus aureus Surgical Implant Infection in Mice

(2012) Jared A. Niska et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Identification of a Hydrophobic Cleft in the LytTR Domain of AgrA as a Locus for Small Molecule Interactions That Inhibit DNA Binding

(2012) Paul G. Leonard et al.   BIOCHEMISTRY

Staphylococcus epidermidis recovered from indwelling catheters exhibit enhanced biofilm dispersal and “self-renewal” through downregulation of agr

(2012) Lu Dai et al.   BMC MICROBIOLOGY

A novel function for the competence inducing peptide, XIP, as a cell death effector ofStreptococcus mutans

(2012) Iwona B. Wenderska et al.   FEMS MICROBIOLOGY LETTERS

Role of the Agr-Like Quorum-Sensing System in Regulating Toxin Production by Clostridium perfringens Type B Strains CN1793 and CN1795

(2012) Jianming Chen et al.   INFECTION AND IMMUNITY

Development of Competence for Genetic Transformation of Streptococcus mutans in a Chemically Defined Medium

(2012) K. Desai et al.   JOURNAL OF BACTERIOLOGY

The Cryptic Competence Pathway in Streptococcus pyogenes Is Controlled by a Peptide Pheromone

(2012) L. Mashburn-Warren et al.   JOURNAL OF BACTERIOLOGY

Allele-Dependent Differences in Quorum-Sensing Dynamics Result in Variant Expression of Virulence Genes in Staphylococcus aureus

(2012) E. Geisinger et al.   JOURNAL OF BACTERIOLOGY

Nasal Carriage as a Source of agr-Defective Staphylococcus aureus Bacteremia

(2012) Davida S. Smyth et al.   JOURNAL OF INFECTIOUS DISEASES

Methicillin Resistance Reduces the Virulence of Healthcare-Associated Methicillin-Resistant Staphylococcus aureus by Interfering With the agr Quorum Sensing System

(2012) Justine K. Rudkin et al.   JOURNAL OF INFECTIOUS DISEASES

Random mutagenesis and topology analysis of the autoinducing peptide biosynthesis proteins inStaphylococcus aureus

(2012) Matthew Thoendel et al.   MOLECULAR MICROBIOLOGY

Quorumpeps database: chemical space, microbial origin and functionality of quorum sensing peptides

(2012) Evelien Wynendaele et al.   NUCLEIC ACIDS RESEARCH

The Enterococcus faecalis Exoproteome: Identification and Temporal Regulation by Fsr

(2012) Jayendra Shankar et al.   PLoS One

Detection of Staphylococcus aureus Delta-Toxin Production by Whole-Cell MALDI-TOF Mass Spectrometry

(2012) Julie Gagnaire et al.   PLoS One

PlcRa, a New Quorum-Sensing Regulator from Bacillus cereus, Plays a Role in Oxidative Stress Responses and Cysteine Metabolism in Stationary Phase

(2012) Eugénie Huillet et al.   PLoS One

Quorum-sensing agr mediates bacterial oxidation response via an intramolecular disulfide redox switch in the response regulator AgrA

(2012) F. Sun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

How Staphylococcus aureus biofilms develop their characteristic structure

(2012) S. Periasamy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Shared Antibiotic Resistome of Soil Bacteria and Human Pathogens

(2012) K. J. Forsberg et al.   SCIENCE

Bacterial Quorum Sensing and Metabolic Incentives to Cooperate

(2012) A. A. Dandekar et al.   SCIENCE

Disrupting theluxSquorum sensing gene does not significantly affectBacillus anthracisvirulence in mice or guinea pigs

(2012) Joel Bozue et al.   Virulence

Necrotrophism Is a Quorum-Sensing-Regulated Lifestyle in Bacillus thuringiensis

(2012) Thomas Dubois et al.   PLoS Pathogens

Evidence of Autoinduction Heterogeneity via Expression of the Agr System of Listeria monocytogenes at the Single-Cell Level

(2011) Dominique Garmyn et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Evolution and some functions of the NprR–NprRB quorum-sensing system in the Bacillus cereus group

(2011) Jorge Rocha et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

The Antibiotic Crisis: Can We Reverse 65 Years of Failed Stewardship?

(2011) Brad Spellberg   ARCHIVES OF INTERNAL MEDICINE

Progress Toward a Staphylococcus aureus Vaccine

(2011) R. S. Daum et al.   CLINICAL INFECTIOUS DISEASES

Targeting FKBP isoforms with small-molecule ligands

(2011) Elizabeth A Blackburn et al.   CURRENT OPINION IN PHARMACOLOGY

Are Bacteriocins Underexploited? NOVEL Applications for OLD Antimicrobials

(2011) Manuel Montalban-Lopez et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Anti-HIV siamycin I directly inhibits autophosphorylation activity of the bacterial FsrC quorum sensor and other ATP-dependent enzyme activities

(2011) Pikyee Ma et al.   FEBS LETTERS

Genome sequence of Staphylococcus lugdunensis N920143 allows identification of putative colonization and virulence factors

(2011) Simon Heilbronner et al.   FEMS MICROBIOLOGY LETTERS

The Agr-Like Quorum-Sensing System Regulates Sporulation and Production of Enterotoxin and Beta2 Toxin by Clostridium perfringens Type A Non-Food-Borne Human Gastrointestinal Disease Strain F5603

(2011) Jihong Li et al.   INFECTION AND IMMUNITY

Role of the Accessory Gene Regulatoragrin Community-Associated Methicillin-Resistant Staphylococcus aureus Pathogenesis

(2011) Gordon Y. C. Cheung et al.   INFECTION AND IMMUNITY

Antimicrobial Stewardship

(2011) Pranita D. Tamma et al.   INFECTIOUS DISEASE CLINICS OF NORTH AMERICA

The Fsr Quorum-Sensing System of Enterococcus faecalisModulates Surface Display of the Collagen-Binding MSCRAMM Ace through Regulation of gelE

(2011) K. L. Pinkston et al.   JOURNAL OF BACTERIOLOGY

Coordinated Regulation by AgrA, SarA, and SarR To Control agr Expression in Staphylococcus aureus

(2011) D. Reyes et al.   JOURNAL OF BACTERIOLOGY

Complete Genome Sequence of the Canine Pathogen Staphylococcus pseudintermedius

(2011) N. L. B. Zakour et al.   JOURNAL OF BACTERIOLOGY

Staphylococcus aureus Evades the Extracellular Antimicrobial Activity of Mast Cells by Promoting Its Own Uptake

(2011) Jens Abel et al.   Journal of Innate Immunity

Reannotation of the genome sequence of Clostridium difficile strain 630

(2011) M. Monot et al.   JOURNAL OF MEDICAL MICROBIOLOGY

Molecular Insights into the Control of Transcription Initiation at the Staphylococcus aureus agr operon

(2011) Jonathan Reynolds et al.   JOURNAL OF MOLECULAR BIOLOGY

The incongruent gelatinase genotype and phenotype in Enterococcus faecalis are due to shutting off the ability to respond to the gelatinase biosynthesis-activating pheromone (GBAP) quorum-sensing signal

(2011) N. Teixeira et al.   MICROBIOLOGY-SGM

A novel role for SarX in Staphylococcus epidermidis biofilm regulation

(2011) S. E. Rowe et al.   MICROBIOLOGY-SGM

A cell-cell communication system regulates protease production during sporulation in bacteria of the Bacillus cereus group

(2011) Stéphane Perchat et al.   MOLECULAR MICROBIOLOGY

Evidence that the Agr-like quorum sensing system regulates the toxin production, cytotoxicity and pathogenicity of Clostridium perfringens type C isolate CN3685

(2011) Jorge E. Vidal et al.   MOLECULAR MICROBIOLOGY

Rapamycin passes the torch: a new generation of mTOR inhibitors

(2011) Don Benjamin et al.   NATURE REVIEWS DRUG DISCOVERY

Lactobacillus reuteri-produced cyclic dipeptides quench agr-mediated expression of toxic shock syndrome toxin-1 in staphylococci

(2011) J. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Colonization, pathogenicity, host susceptibility, and therapeutics for Staphylococcus aureus: what is the clinical relevance?

(2011) Steven Y. C. Tong et al.   Seminars in Immunopathology

Epsilon-Toxin Production by Clostridium perfringens Type D Strain CN3718 Is Dependent upon the agr Operon but Not the VirS/VirR Two-Component Regulatory System

(2011) J. Chen et al.   mBio

Antibodies to Streptococcus pneumoniae Capsular Polysaccharide Enhance Pneumococcal Quorum Sensing

(2011) M. Yano et al.   mBio

The Sociomicrobiology of Antivirulence Drug Resistance: a Proof of Concept

(2011) B. Mellbye et al.   mBio

Hemoglobin Promotes Staphylococcus aureus Nasal Colonization

(2011) Melissa Pynnonen et al.   PLoS Pathogens

The Staphylococcus aureus RNome and Its Commitment to Virulence

(2011) Brice Felden et al.   PLoS Pathogens

Small Molecule Inhibitors of Staphylococcus aureus RnpA Alter Cellular mRNA Turnover, Exhibit Antimicrobial Activity, and Attenuate Pathogenesis

(2011) Patrick D. Olson et al.   PLoS Pathogens

Regulation of Neurotoxin Production and Sporulation by a Putative agrBD Signaling System in Proteolytic Clostridium botulinum

(2010) C. M. Cooksley et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

The RNPP family of quorum-sensing proteins in Gram-positive bacteria

(2010) Jorge Rocha-Estrada et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Staphylococcus aureus sigma B-dependent emergence of small-colony variants and biofilm production following exposure to Pseudomonas aeruginosa 4-hydroxy-2-heptylquinoline-N-oxide

(2010) Gabriel Mitchell et al.   BMC MICROBIOLOGY

Bicarbonate enhances expression of the endocarditis and biofilm associated pilus locus, ebpR-ebpABC, in Enterococcus faecalis

(2010) Agathe Bourgogne et al.   BMC MICROBIOLOGY

Peptide Signaling in the Staphylococci

(2010) Matthew Thoendel et al.   CHEMICAL REVIEWS

Reduced Vancomycin Susceptibility in Staphylococcus aureus, Including Vancomycin-Intermediate and Heterogeneous Vancomycin-Intermediate Strains: Resistance Mechanisms, Laboratory Detection, and Clinical Implications

(2010) B. P. Howden et al.   CLINICAL MICROBIOLOGY REVIEWS

Immunotherapeutic strategies to combat staphylococcal infections

(2010) Knut Ohlsen et al.   INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY

Staphylococcus epidermidis surfactant peptides promote biofilm maturation and dissemination of biofilm-associated infection in mice

(2010) Rong Wang et al.   JOURNAL OF CLINICAL INVESTIGATION

Mutations inagrDo Not Persist in Natural Populations of Methicillin‐ResistantStaphylococcus aureus

(2010) Bo Shopsin et al.   JOURNAL OF INFECTIOUS DISEASES

Targeting of Alpha‐Hemolysin by Active or Passive Immunization Decreases Severity of USA300 Skin Infection in a Mouse Model

(2010) Adam D. Kennedy et al.   JOURNAL OF INFECTIOUS DISEASES

The group A Streptococcus small regulatory RNA FasX enhances streptokinase activity by increasing the stability of the ska mRNA transcript

(2010) Esmeralda Ramirez-Peña et al.   MOLECULAR MICROBIOLOGY

A novel double-tryptophan peptide pheromone controls competence in Streptococcus spp. via an Rgg regulator

(2010) Lauren Mashburn-Warren et al.   MOLECULAR MICROBIOLOGY

Anti-virulence strategies to combat bacteria-mediated disease

(2010) David A. Rasko et al.   NATURE REVIEWS DRUG DISCOVERY

Epistatic Relationships between sarA and agr in Staphylococcus aureus Biofilm Formation

(2010) Karen E. Beenken et al.   PLoS One

Importance of the Global Regulators Agr and SaeRS in the Pathogenesis of CA-MRSA USA300 Infection

(2010) Christopher P. Montgomery et al.   PLoS One

Inhibiting effects of Streptococcus salivarius on competence-stimulating peptide-dependent biofilm formation by Streptococcus mutans

(2010) S. Tamura et al.   Oral microbiology and immunology

Role ofluxSinBacillus anthracisgrowth and virulence factor expression

(2010) Marcus B. Jones et al.   Virulence

Membrane Damage Elicits an Immunomodulatory Program in Staphylococcus aureus

(2010) Ahmed S. Attia et al.   PLoS Pathogens

Identification of a two-component VirR/VirS regulon in Clostridium perfringens

(2009) Kaori Ohtani et al.   ANAEROBE

Computer-Aided Identification of Recognized Drugs as Pseudomonas aeruginosa Quorum-Sensing Inhibitors

(2009) L. Yang et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

PapR peptide maturation: role of the NprB protease inBacillus cereus569 PlcR/PapR global gene regulation

(2009) Andrei P. Pomerantsev et al.   FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY

Interconnections between Sigma B, agr, and Proteolytic Activity in Staphylococcus aureus Biofilm Maturation

(2009) K. J. Lauderdale et al.   INFECTION AND IMMUNITY

Staphylococcal Vaccines and Immunotherapies

(2009) Adam C. Schaffer et al.   INFECTIOUS DISEASE CLINICS OF NORTH AMERICA

Virulence Gene Regulation by the agr System in Clostridium perfringens

(2009) K. Ohtani et al.   JOURNAL OF BACTERIOLOGY

CodY in Staphylococcus aureus: a Regulatory Link between Metabolism and Virulence Gene Expression

(2009) K. Pohl et al.   JOURNAL OF BACTERIOLOGY

Symmetric signalling within asymmetric dimers of theStaphylococcus aureusreceptor histidine kinase AgrC

(2009) Elizabeth A. George Cisar et al.   MOLECULAR MICROBIOLOGY

AgrD-dependent quorum sensing affects biofilm formation, invasion, virulence and global gene expression profiles inListeria monocytogenes

(2009) Christian U. Riedel et al.   MOLECULAR MICROBIOLOGY

Confinement-induced quorum sensing of individual Staphylococcus aureus bacteria

(2009) Eric C Carnes et al.   Nature Chemical Biology

Functional Characterization of the Antibiotic Resistance Reservoir in the Human Microflora

(2009) M. O. A. Sommer et al.   SCIENCE

The Staphylococcus intermedius group of bacterial pathogens: species re-classification, pathogenesis and the emergence of meticillin resistance

(2009) J. Ross Fitzgerald   VETERINARY DERMATOLOGY

Functional Analysis of the Quorum-Sensing Streptococcal Invasion Locus (sil)

(2009) Ilia Belotserkovsky et al.   PLoS Pathogens

Comparative genome and phenotypic analysis of Clostridium difficile 027 strains provides insight into the evolution of a hypervirulent bacterium

(2009) Richard A Stabler et al.   GENOME BIOLOGY

Quorum Sensing in Staphylococci

(2008) Richard P. Novick et al.   Annual Review of Genetics

Linezolid Alone or Combined with Rifampin against Methicillin-Resistant Staphylococcus aureus in Experimental Foreign-Body Infection

(2008) D. Baldoni et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Ambuic Acid Inhibits the Biosynthesis of Cyclic Peptide Quormones in Gram-Positive Bacteria

(2008) J. Nakayama et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Approaches to the discovery of new antibacterial agents based on bacteriocinsThis paper is one of a selection of papers published in this Special Issue, entitled CSBMCB — Systems and Chemical Biology, and has undergone the Journal's usual peer review process.

(2008) Clarissa S. Sit et al.   Biochemistry and Cell Biology

Apolipoprotein B Is an Innate Barrier against Invasive Staphylococcus aureus Infection

(2008) M. Michal Peterson et al.   Cell Host & Microbe

Skin and Soft‐Tissue Infections Caused by Community‐Acquired Methicillin‐ResistantStaphylococcus aureus

(2008) Martin E. Stryjewski et al.   CLINICAL INFECTIOUS DISEASES

Regulation ofsagA, siaAandscpCby SilCR, a putative signaling peptide ofStreptococcus pyogenes

(2008) Kowthar Y. Salim et al.   FEMS MICROBIOLOGY LETTERS

Bacillus cereus Induces Permeability of an In Vitro Blood-Retina Barrier

(2008) A. L. Moyer et al.   INFECTION AND IMMUNITY

Co-evolutionary aspects of human colonisation and infection by Staphylococcus aureus

(2008) A VANBELKUM et al.   INFECTION GENETICS AND EVOLUTION

A comparison of moxifloxacin and levofloxacin topical prophylaxis in a fluoroquinolone-resistant Staphylococcus aureus rabbit model

(2008) Regis P. Kowalski et al.   JAPANESE JOURNAL OF OPHTHALMOLOGY

Prevalence ofagrDysfunction among ColonizingStaphylococcus aureusStrains

(2008) Bo Shopsin et al.   JOURNAL OF INFECTIOUS DISEASES

Virulence Gene Expression in Human Community‐AcquiredStaphylococcus aureusInfection

(2008) Jennifer A. Loughman et al.   JOURNAL OF INFECTIOUS DISEASES

agr function in clinical Staphylococcus aureus isolates

(2008) K. E. Traber et al.   MICROBIOLOGY-SGM

RNAIII-Independent Target Gene Control by the agr Quorum-Sensing System: Insight into the Evolution of Virulence Regulation in Staphylococcus aureus

(2008) Shu Y. Queck et al.   MOLECULAR CELL

Molecular basis for group-specific activation of the virulence regulator PlcR by PapR heptapeptides

(2008) L. Bouillaut et al.   NUCLEIC ACIDS RESEARCH

Targeting QseC Signaling and Virulence for Antibiotic Development

(2008) D. A. Rasko et al.   SCIENCE

agr-Mediated Dispersal of Staphylococcus aureus Biofilms

(2008) Blaise R. Boles et al.   PLoS Pathogens

The biology and future prospects of antivirulence therapies

(2007) Lynette Cegelski et al.   NATURE REVIEWS MICROBIOLOGY