Article
Medicine, General & Internal
Xiaoyu Xie, Huanran Lv, Chenxi Liu, Xiaonan Su, Zhen Yu, Shouyang Song, Hongjun Bian, Miaomiao Tian, Chengyong Qin, Jianni Qi, Qiang Zhu
Summary: HBeAg activates macrophages via the TLR-2/NF-kappa B signal pathway and further exacerbates hepatic fibrosis by facilitating motility, proliferation, and contraction of HSCs with the help of macrophages.
Article
Biochemistry & Molecular Biology
Yang Zheng, Yunqi Li, Xianwen Ran, Di Wang, Xianghui Zheng, Maomao Zhang, Bo Yu, Yong Sun, Jian Wu
Summary: The study reveals that the m(6)A modification writer Mettl14 plays a critical role in macrophage inflammation in atherosclerosis through the NF-kappa B/IL-6 signaling pathway. Mettl14 regulates the stability of Myd88 mRNA and affects the distribution of p65 in nuclei, which in turn influences the expression of IL-6. Moreover, Mettl14 gene knockout reduces the inflammatory response of macrophages and the development of atherosclerotic plaques.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Multidisciplinary Sciences
Alice Coillard, Lea Guyonnet, Alba De Juan, Adeline Cros, Elodie Segura
Summary: Monocytes are recruited to inflamed tissues where they encounter a broad range of microbial motifs, leading to differentiation into mo-mac or mo-DC. Viruses promote mo-mac differentiation via TLR signaling, while Mycobacteria favor mo-DC differentiation through NOD signaling.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Chemistry, Multidisciplinary
Naibo Feng, Li Liang, Mengtian Fan, Yu Du, Cheng Chen, Rong Jiang, Dongsheng Yu, Yuyou Yang, Mengying Zhang, Lin Deng, Xingyue Li, Nana Geng, Menglin Xian, Qizhong Qin, Xiaoli Li, Qiaoyan Tan, Fengtao Luo, Fangzhou Song, Huabing Qi, Yangli Xie, Fengjin Guo
Summary: The study investigates the use of siRNA drugs targeting the ERN1 gene for the treatment of autoimmune inflammatory diseases. The developed nanodrug delivery system demonstrates efficient targeting and therapeutic effects in mouse models of arthritis and inflammatory bowel disease.
Article
Multidisciplinary Sciences
Zhipeng Meng, Fu-Long Li, Cao Fang, Benjamin Yeoman, Yunjiang Qiu, Ying Wang, Xiaomin Cai, Kimberly C. Lin, Di Yang, Min Luo, Vivian Fu, Xiaoxiao Ma, Yarui Diao, Filippo G. Giancotti, Bing Ren, Adam J. Engler, Kun-Liang Guan
Summary: This study reveals that class 3 Semaphorins (SEMA3s) activate the Hippo pathway to regulate tissue growth, angiogenesis, and tumorigenesis, highlighting the critical role of Hippo signaling in SEMA3 physiological function.
Article
Gastroenterology & Hepatology
Michael A. Schumacher, Isabella C. Dennis, Cambrian Y. Liu, Cache Robinson, Judie Shang, Jessica K. Bernard, M. Kay Washington, D. Brent Polk, Mark R. Frey
Summary: Research has shown that NRG4/ErbB4 signaling can limit the production of proinflammatory cytokines in macrophages, thus restraining the severity of chronic inflammatory diseases.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
(2021)
Article
Neurosciences
Xiaoqin Liu, Xiaojuan Zhang, Xiaojie Niu, Peijun Zhang, Qing Wang, Xiuhua Xue, Guobin Song, Jiezhong Yu, Guoping Xi, Lijuan Song, Yanhua Li, Cungen Ma
Summary: The research demonstrates that Mdivi-1 significantly alleviates inflammation in mice with EAE by promoting M2 polarization, inhibiting TLR2/4 and GSK3β-mediated NF-κB activation.
MOLECULAR NEUROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Haein Lee, Eunha Kim, Seyun Kim
Summary: In response to LPS stimulation, the levels of IPMK in macrophages decrease due to the binding of miR-181c to the 3'UTR of IPMK mRNA, which leads to the suppression of TLR4 signaling and inflammation. Deletion of the miR-181c-binding site prevents the downregulation of IPMK levels and reduces the activation of TRAF6 and the expression of proinflammatory cytokines.
Article
Biochemistry & Molecular Biology
Zhaokun Xu, Xiujing Hao, Min Li, Haixia Luo
Summary: This study examines the properties of R. equi-derived extracellular vesicles (EVs) and their role in mediating inflammatory responses in macrophages. The results show that R. equi-EVs can induce macrophage cytotoxicity and increase the expression of inflammatory factors through the TLR2-NF-κB/MAPK pathway. The study also compares the differences in macrophage inflammatory responses mediated by EVs derived from virulent and avirulent strains of R. equi.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, Research & Experimental
Dongyin Guan, Hosung Bae, Dishu Zhou, Ying Chen, Chunjie Jiang, Cam Mong La, Yang Xiao, Kun Zhu, Wenxiang Hu, Trang Minh Trinh, Panpan Liu, Ying Xiong, Bishuang Cai, Cholsoon Jang, Mitchell A. Lazar
Summary: Hepatocyte-specific deletion of Rev-erb alpha and -beta affects cholesterol and lipid metabolism, as well as rhythmic gene expression in liver nonparenchymal cells. In diet-induced obesity-induced fatty liver, SCAP in hepatocytes is required for diurnal remodeling and epigenomic reprogramming in liver macrophages. Loss of REV-ERB alpha and beta attenuates the rhythmicity of liver macrophages and alters polypeptide secretion.
JOURNAL OF CLINICAL INVESTIGATION
(2023)
Article
Biochemistry & Molecular Biology
Kriti Sharma, Shiv Kumar, Ravi Prakash, Sonu Khanka, Tripti Mishra, Rajat Rathur, Arpon Biswas, Sarvesh Kumar Verma, R. S. Bhatta, T. Narender, Divya Singh
Summary: Chebulinic acid (CA), derived from Triphala, has been found to have anti-inflammatory, antioxidant, and anti-tumor effects. In an inflammatory bone loss condition, CA can prevent bone loss, improve bone micro-architectures, enhance bone regeneration, and maintain bone serum markers. CA also reduces the production of pro-inflammatory cytokines and attenuates inflammatory impairment to osteoblast cells through the suppression of the NFkB signaling pathway. These findings suggest that CA may be a potential novel therapeutic strategy for inflammatory diseases in bones.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Article
Medicine, Research & Experimental
Ming Zhao, Jing Hou, Sichun Zheng, Xiaodan Ma, Xinyu Fu, Songhua Hu, Kai Zhao, Wei Xu
Summary: The present study investigated the molecular mechanisms of macrophage inflammatory response to polysaccharides from Peucedanum praeruptorum Dunn (PPDs). The study identified that PPDs modulated macrophage activation mainly through TLR2/TLR4-dependent MAPK and NF-KB pathways, affecting cell phagocytic activity and expression and secretion of inflammatory factors and chemokines.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Engineering, Biomedical
Derek Avery, Lais Morandini, Luke S. Sheakley, Arth H. Shah, Loc Bui, Jefferson O. Abaricia, Rene Olivares-Navarrete
Summary: This study investigates the role of canonical Wnt signaling in the response of macrophages to titanium surface properties. The results show that activating canonical Wnt signaling promotes a pro-inflammatory phenotype, while inhibiting it enhances an anti-inflammatory response.
Article
Dentistry, Oral Surgery & Medicine
Thayana S. S. Lea, Gustavo H. Tomasi, Lucas P. Conzatti, Luiz C. P. Marrone, Mark A. Reynolds, Maximiliano S. Gomes
Summary: This study found that a higher oral inflammatory burden (sum of endodontic and periodontal diseases) was independently associated with higher levels of carotid atherosclerotic burden among hospital patients with ischemic stroke. Oral inflammatory diseases may boost the vascular risk in this specific population.
JOURNAL OF ENDODONTICS
(2022)
Article
Pharmacology & Pharmacy
Haijiao Long, Haiyue Lin, Pan Zheng, Lianjie Hou, Ming Zhang, Shuyun Lin, Kai Yin, Guojun Zhao
Summary: This study reveals the mechanism by which Astragalus mongholicus polysaccharides (APS) regulate inflammation in THP-1 macrophages through N6-methyladenosine (m(6)A) modification. APS reduces m(6)A modification levels and Wilms' tumor 1-associating protein (WTAP) gene expression, leading to the inhibition of IL-6 expression. Further investigation shows that APS regulates IL-6 expression through WTAP-mediated p65 nuclear translocation.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Allergy
O. T. Burton, J. Medina Tamayo, A. J. Stranks, S. Miller, K. J. Koleoglou, E. O. Weinberg, H. C. Oettgen
CLINICAL AND EXPERIMENTAL ALLERGY
(2018)
Article
Dentistry, Oral Surgery & Medicine
Nasi Huang, Elyse Shimomura, Gang Yin, Cuong Tran, Aaron Sato, Alex Steiner, Tyler Heibeck, Michelle Tam, Jeffery Fairman, Frank C. Gibson
JOURNAL OF CLINICAL PERIODONTOLOGY
(2019)
Article
Dentistry, Oral Surgery & Medicine
Susan Yost, Philip Stashenko, Yoonhee Choi, Maria Kukuruzinska, Caroline A. Genco, Andrew Salama, Ellen O. Weinberg, Carolyn D. Kramer, Jorge Frias-Lopez
INTERNATIONAL JOURNAL OF ORAL SCIENCE
(2018)
Article
Multidisciplinary Sciences
Ellen O. Weinberg, Beatriz Ferran, Yuko Tsukahara, Michaela M. S. Hatch, Jingyan Han, Colin E. Murdoch, Reiko Matsui
Article
Immunology
Tianmou Zhu, Ryan McClure, Odile B. Harrison, Caroline Genco, Paola Massari
Article
Microbiology
Wenjing Le, Xiaohong Su, Xiangdi Lou, Xuechun Li, Xiangdong Gong, Baoxi Wang, Caroline A. Genco, John P. Mueller, Peter A. Rice
Summary: The study found that zoliflodacin maintains strong in vitro activity against clinical gonococcal isolates, even those with high-level resistance to ciprofloxacin, azithromycin, and extended-spectrum cephalosporins.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2021)
Article
Immunology
Fernanda G. Rocha, Gregory Ottenberg, Zavier G. Eure, Mary E. Davey, Frank C. Gibson
Summary: The study reveals that P. gingivalis delivers sphingolipids to host cells via OMVs, which can limit host inflammatory response. A mutant lacking sphingolipids induces a stronger inflammatory immune response compared to the wild-type strain.
INFECTION AND IMMUNITY
(2021)
Article
Immunology
George Papadopoulos, Robert Berland, Ashwini Sunkavalli, Stephen R. Coats, Richard P. Darveau, Caroline A. Genco
Summary: Most Gram-negative bacteria trigger a strong immune response through recognition of lipid A by Toll-like receptor 4, but some bacteria like Porphyromonas gingivalis alter their lipid A structure to evade detection and influence host adaptive immunity, leading to chronic infections associated with systemic inflammatory disorders.
INFECTION AND IMMUNITY
(2021)
Article
Immunology
Ana Paula R. Costa-Lourenco, Xiaohong Su, Wenjing Le, Zhaoyan Yang, Gregory J. Patts, Paola Massari, Caroline A. Genco
Summary: This study examined epidemiological and clinical factors associated with gonorrhea in women exposed to men with gonococcal urethritis in China. The findings showed high prevalence of N. gonorrhoeae infections in women, with many experiencing symptoms and inflammatory responses. The study highlights the importance of determining target populations for gonococcal vaccine strategies.
Article
Microbiology
Xuechun Li, Wenjing Le, Xiangdi Lou, Biwei Wang, Caroline A. Genco, Peter A. Rice, Xiaohong Su
Summary: The study demonstrated that gentamicin showed excellent in vitro susceptibility against clinical gonococcal isolates, including multidrug-resistant strains. Combinations of gentamicin with ertapenem, ceftriaxone, and azithromycin exhibited synergistic effects against certain multidrug-resistant isolates, with no antagonism observed in any of the antimicrobial combinations, showing potential for guiding clinical testing of combination therapies.
MICROBIOLOGY SPECTRUM
(2021)
Article
Microbiology
Xuechun Li, Wenjing Le, Xiangdi Lou, Caroline A. Genco, Peter A. Rice, Xiaohong Su
Summary: Neisseria gonorrhoeae isolates collected in Nanjing, China that showed decreased susceptibility or resistance to extended-spectrum cephalosporins (ESCs) were found to have varying susceptibility to ertapenem. The study also identified genetic determinants of ESC resistance and analyzed associations with ertapenem susceptibility. The findings suggest that ertapenem may be an effective therapy for ESC-resistant isolates with identifiable resistance determinants.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2022)
Article
Microbiology
Dev K. Ranjit, Zachary D. Moye, Fernanda G. Rocha, Gregory Ottenberg, Frank C. Nichols, Hey-Min Kim, Alejandro R. Walker, Frank C. Gibson, Mary E. Davey
Summary: This study reports a novel kinase in Porphyromonas gingivalis that phosphorylates dihydrosphingosine to form dhS1P, and regulates the lipid profile of P. gingivalis. This finding is of great importance for studying immune modulation mechanisms.
MICROBIOLOGY SPECTRUM
(2022)
Article
Microbiology
Alison K. Criss, Caroline A. Genco, Scott D. Gray-Owen, Ann E. Jerse, H. Steven Seifert
Summary: Neisseria gonorrhoeae (Ngo) is the main cause of gonorrhea, a sexually transmitted infection, with 87 million new infections reported globally each year. Rising infection rates and antibiotic-resistant strains have raised concerns about untreatable infections. Neutrophils play a central role in symptomatic disease, impacting both Ngo infection and damage to host tissues.
Article
Immunology
Guillermo Madico, Olga Gursky, Jeff Fairman, Paola Massari
Article
Allergy
Anne Chetty, Azeem Sharda, Rod Warburton, Ellen O. Weinberg, Jinghui Dong, Min Fang, G. Gary Sahagian, Tiangmeng Chen, Chang Xue, John J. Castellot, Philip G. Haydon, Heber C. Nielsen
JOURNAL OF ASTHMA AND ALLERGY
(2018)