Journal
JOURNAL OF VIROLOGY
Volume 87, Issue 9, Pages 5287-5290Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.00278-13
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Funding
- National Institutes of Health [HL59725]
- Center for HIV/AIDS Vaccine Immunology (CHAVI)
- Bill and Melinda Gates Foundation's Collaboration for AIDS Vaccine Discovery
- Duke Center for AIDS Research
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We previously showed that expression of human Fc gamma RI on TZM-bl cells potentiates neutralization by gp41 membrane-proximal external region (MPER)-specific antibodies. Here we show that lysosomotropic reagents known to block phagocytosis do not diminish this effect. We also show that Fc gamma RI occasionally potentiates neutralization by antibodies against the V3 loop of gp120 and cluster I of gp41. We conclude that Fc gamma RI provides a kinetic advantage for neutralizing antibodies against partially cryptic epitopes independent of phagocytosis.
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