Article
Multidisciplinary Sciences
Annette B. Vogel, Isis Kanevsky, Ye Che, Kena A. Swanson, Alexander Muik, Mathias Vormehr, Lena M. Kranz, Kerstin C. Walzer, Stephanie Hein, Alptekin Gueler, Jakob Loschko, Mohan S. Maddur, Ayuko Ota-Setlik, Kristin Tompkins, Journey Cole, Bonny G. Lui, Thomas Ziegenhals, Arianne Plaschke, David Eisel, Sarah C. Dany, Stephanie Fesser, Stephanie Erbar, Ferdia Bates, Diana Schneider, Bernadette Jesionek, Bianca Saenger, Ann-Kathrin Wallisch, Yvonne Feuchter, Hanna Junginger, Stefanie A. Krumm, Andre P. Heinen, Petra Adams-Quack, Julia Schlereth, Stefan Schille, Christoph Kroener, Ramon de la Caridad Guimil Garcia, Thomas Hiller, Leyla Fischer, Rani S. Sellers, Shambhunath Choudhary, Olga Gonzalez, Fulvia Vascotto, Matthew R. Gutman, Jane A. Fontenot, Shannan Hall-Ursone, Kathleen Brasky, Matthew C. Griffor, Seungil Han, Andreas A. H. Su, Joshua A. Lees, Nicole L. Nedoma, Ellene H. Mashalidis, Parag Sahasrabudhe, Charles Y. Tan, Danka Pavliakova, Guy Singh, Camila Fontes-Garfias, Michael Pride, Ingrid L. Scully, Tara Ciolino, Jennifer Obregon, Michal Gazi, Ricardo Carrion, Kendra J. Alfson, Warren Kalina, Deepak Kaushal, Pei-Yong Shi, Thorsten Klamp, Corinna Rosenbaum, Andreas N. Kuhn, Ozlem Tureci, Philip R. Dormitzer, Kathrin U. Jansen, Ugur Sahin
Summary: The two vaccine candidates, BNT162b1 and BNT162b2, developed contain modified messenger RNA encoding immunogens derived from the spike glycoprotein of SARS-CoV-2. They have shown promising immune responses in mice and rhesus macaques, with ongoing phase I trials in Germany and the USA and a global phase II/III trial for BNT162b2.
Article
Multidisciplinary Sciences
Pragya D. Yadav, Raches Ella, Sanjay Kumar, Dilip R. Patil, Sreelekshmy Mohandas, Anita M. Shete, Krishna M. Vadrevu, Gaurav Bhati, Gajanan Sapkal, Himanshu Kaushal, Savita Patil, Rajlaxmi Jain, Gururaj Deshpande, Nivedita Gupta, Kshitij Agarwal, Mangesh Gokhale, Basavaraj Mathapati, Siddhanath Metkari, Chandrashekhar Mote, Dimpal Nyayanit, Deepak Y. Patil, B. S. Sai Prasad, Annasaheb Suryawanshi, Manoj Kadam, Abhimanyu Kumar, Sachin Daigude, Sanjay Gopale, Triparna Majumdar, Deepak Mali, Prasad Sarkale, Shreekant Baradkar, Pranita Gawande, Yash Joshi, Sidharam Fulari, Hitesh Dighe, Sharda Sharma, Rashmi Gunjikar, Abhinendra Kumar, Kaumudi Kalele, Vellimedu K. Srinivas, Raman R. Gangakhedkar, Krishna M. Ella, Priya Abraham, Samiran Panda, Balram Bhargava
Summary: This study demonstrates the protective efficacy and immunogenicity of the inactivated SARS-CoV-2 vaccine BBV152 in rhesus macaques, indicating that the vaccine candidate is in clinical development.
NATURE COMMUNICATIONS
(2021)
Article
Immunology
Carolina Garrido, Alan D. Curtis, Maria Dennis, Sachi H. Pathak, Hongmei Gao, David Montefiori, Mark Tomai, Christopher B. Fox, Pamela A. Kozlowski, Trevor Scobey, Jennifer E. Munt, Michael L. Mallory, Pooja T. Saha, Michael G. Hudgens, Lisa C. Lindesmith, Ralph S. Baric, Olubukola M. Abiona, Barney Graham, Kizzmekia S. Corbett, Darin Edwards, Andrea Carfi, Genevieve Fouda, Koen K. A. Van Rompay, Kristina De Paris, Sallie R. Permar
Summary: The study evaluated the safety and immunogenicity of two SARS-CoV-2 vaccines in infant Rhesus macaques, showing that both vaccines were well-tolerated and highly immunogenic. The vaccines elicited high levels of antibodies and cellular immune responses that persisted up to week 22, indicating the potential for a pediatric SARS-CoV-2 vaccine with durable immunity.
SCIENCE IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Stella J. Berendam, Papa K. Morgan-Asiedu, Riley J. Mangan, Shuk Hang Li, Holly Heimsath, Kan Luo, Alan D. Curtis, Joshua A. Eudailey, Christopher B. Fox, Mark A. Tomai, Bonnie Phillips, Hannah L. Itell, Erika Kunz, Michael Hudgens, Kenneth Cronin, Kevin Wiehe, S. Munir Alam, Koen K. A. Van Rompay, Kristina De Paris, Sallie R. Permar, M. Anthony Moody, Genevieve G. Fouda
Summary: This study evaluated the impact of different adjuvants in pediatric HIV vaccine regimens on the developing infant B cell receptor repertoire. Results showed that while different adjuvants in vaccine regimens may induce higher magnitude and quality of plasma antibody responses, they do not lead to distinct antigen-specific memory BCR repertoires.
Article
Cell Biology
Xuan He, Malika Aid, Abishek Chandrashekar, Jingyou Yu, Katherine McMahan, Frank Wegmann, Catherine Jacob-Dolan, Jenny S. Maron, Caroline Atyeo, Huahua Wan, Daniel Sellers, Jinyan Liu, Michelle Lifton, Sarah Gardner, Esther A. Bondzie, Julia Barrett, Kunza Ahmad, Tochi Anioke, Jake Yalley-Ogunro, Jeanne Muench, Adrienne Goode, Hanne Andersen, Mark G. Lewis, Galit Alter, Hanneke Schuitemaker, Roland Zahn, Dan H. Barouch
Summary: This study found that single-shot Ad26.COV2.S immunization in rhesus macaques resulted in durable immune responses, including binding and neutralizing antibodies, memory B cells, and long-lasting plasma cells. Boosting with Ad26.COV2.S or Ad26.COV2.S.351 significantly increased the humoral and cellular immune responses, which were highly cross-reactive against multiple SARS-CoV-2 variants. The modified Ad26.COV2.S.351 vaccine showed slightly higher immune responses against specific variants.
SCIENCE TRANSLATIONAL MEDICINE
(2022)
Article
Immunology
Arundhathi Venkatasubramaniam, Grant Liao, Eunice Cho, Rajan P. Adhikari, Tom Kort, Frederick W. Holtsberg, Karen E. Elsass, Dean J. Kobs, Thomas L. Rudge, Keith D. Kauffman, Nickiana E. Lora, Daniel L. Barber, M. Javad Aman, Hatice Karauzum
Summary: The 4-component staphylococcal vaccine targeting secreted toxins shows good safety and immunogenicity in non-human primates, generating both humoral and cellular immune responses. Targeting secreted toxins could be a potential next-generation approach for staphylococcal vaccines in humans.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Microbiology
Margherita Rosati, Mahesh Agarwal, Xintao Hu, Santhi Devasundaram, Dimitris Stellas, Bhabadeb Chowdhury, Jenifer Bear, Robert Burns, Duncan Donohue, Laurent Pessaint, Hanne Andersen, Mark G. Lewis, Evangelos Terpos, Meletios Athanasios Dimopoulos, Alexander Wlodawer, James I. Mullins, David J. Venzon, George N. Pavlakis, Barbara K. Felber
Summary: Both DNA and mRNA vaccines have shown promise in animal models, with DNA vaccines demonstrating protective efficacy and immunogenicity against SARS-CoV-2 in rhesus macaques. DNA vaccine regimens can induce potent antibody and T cell responses, with the co-immunization of protein showing superior effectiveness.
Article
Immunology
Michael K. McCracken, Caitlin H. Kuklis, Chandrika B. Kannadka, David A. Barvir, Mark A. Sanborn, Adam T. Waickman, Hayden C. Siegfried, Kaitlin A. Victor, Kristin L. Hatch, Rafael De la Barrera, Shannon D. Walls, Wiriya Rutvisuttinunt, Jeffrey R. Currier, Heather Friberg, Richard G. Jarman, Gregory D. Gromowski
Summary: In a study on rhesus macaques, priming with purified inactivated vaccines followed by administration of a tetravalent live attenuated vaccine led to higher peak viremias and in vitro ADE activity. Additionally, the primed groups displayed more balanced and higher neutralizing antibody seroconversion and titers post live attenuated vaccine administration compared to the control group.
Article
Immunology
Petra Mooij, Juan Garcia-Arriaza, Patricia Perez, Adrian Lazaro-Frias, Babs E. Verstrepen, Kinga P. Boszormenyi, Daniella Mortier, Zahra Fagrouch, Gwendoline Kiemenyi-Kayere, Henk Niphuis, Roja Fidel Acar, Lisette Meijer, Marieke A. Stammes, Ivanela Kondova, Ernst J. Verschoor, Corine H. GeurtsvanKessel, Erwin de Bruin, Reina S. Sikkema, Joanna Luczkowiak, Rafael Delgado, Dolores Montenegro, Eugenia Puentes, Esteban Rodriguez, Willy M. J. M. Bogers, Gerrit Koopman, Mariano Esteban
Summary: This study demonstrates that a modified vaccinia virus Ankara (MVA) vector expressing a full-length SARS-CoV-2 spike (S) protein (MVA-S) vaccine has good safety and high immunogenicity in rhesus macaques. Vaccination with MVA-S can induce neutralizing antibodies against SARS-CoV-2 and its variants, reduce viral loads, and alleviate lung pathology caused by the disease. The findings support the potential use of MVA-S as a vaccine for SARS-CoV-2 in clinical trials.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Ginger Young, Melissa Zahralban-Steele, Hansi J. Dean
Summary: This study evaluated the immunogenicity and efficacy of Takeda's purified inactivated Zika vaccine (PIZV) candidate in macaques previously vaccinated with several commercially available heterologous flavivirus vaccines. Heterologous flavivirus vaccination did not induce Zika virus neutralizing antibodies and did not affect neutralizing antibody titers after one dose of PIZV. After a second PIZV dose, previous vaccination with flavivirus vaccines had a variable impact on Zika virus neutralizing antibody titers. However, all macaques were protected against viremia after Zika virus challenge 8-12 months post-PIZV vaccination. Therefore, vaccine-induced immunity against heterologous flavivirus vaccines does not affect PIZV efficacy in macaques.
Article
Cell Biology
Marco Mandolesi, Daniel J. Sheward, Leo Hanke, Junjie Ma, Pradeepa Pushparaj, Laura Perez Vidakovics, Changil Kim, Monika Adori, Klara Lenart, Karin Lore, Xaquin Castro Dopico, Jonathan M. Coquet, Gerald M. McInerney, Gunilla B. Karlsson Hedestam, Ben Murrell
Summary: The study demonstrates that protein immunization with adjuvanted SARS-CoV-2 spike trimers can induce potent neutralizing antibody responses in mice and rhesus macaques, with exceptionally high titers lasting at least 4 months.
CELL REPORTS MEDICINE
(2021)
Article
Microbiology
Brendon Y. Chua, Toshiki Sekiya, Marios Koutsakos, Naoki Nomura, Louise C. Rowntree, Thi H. O. Nguyen, Hayley A. McQuilten, Marumi Ohno, Yuki Ohara, Tomohiro Nishimura, Masafumi Endo, Yasushi Itoh, Jennifer R. Habel, Kevin J. Selva, Adam K. Wheatley, Bruce D. Wines, P. Mark Hogarth, Stephen J. Kent, Amy W. Chung, David C. Jackson, Lorena E. Brown, Masashi Shingai, Katherine Kedzierska, Hiroshi Kida
Summary: Compared to split virus vaccines, inactivated whole influenza virus particle vaccines induce stronger humoral responses, higher frequencies of influenza-specific B-cell and CD4(+) T-cell responses, and enhanced hemagglutination inhibition titers. These findings provide key insights into the immune responses induced by inactivated whole influenza virus particle vaccines in immunologically-naive individuals.
Article
Immunology
Puthupparampil V. Scaria, Charles Anderson, Olga Muratova, Nada Alani, Hung V. Trinh, Steven T. Nadakal, Irfan Zaidi, Lynn Lambert, Zoltan Beck, Emma K. Barnafo, Kelly M. Rausch, Chris Rowe, Beth Chen, Gary R. Matyas, Mangala Rao, Carl R. Alving, David L. Narum, Patrick E. Duffy
Summary: Studies showed that using ALFQ liposomal adjuvant can enhance the immunogenicity of malaria transmission-blocking vaccine candidates Pfs25-EPA and Pfs230D1-EPA in Rhesus macaques. Both conjugates generated strong antibody responses and functional activity after two vaccinations, although the activity declined.
Article
Virology
Jingyou Yu, Natalie D. Collins, Noe B. Mercado, Katherine McMahan, Abishek Chandrashekar, Jinyan Liu, Tochi Anioke, Aiquan Chang, Victoria M. Giffin, David L. Hope, Daniel Sellers, Felix Nampanya, Sarah Gardner, Julia Barrett, Huahua Wan, Jason Velasco, Elyse Teow, Anthony Cook, Alex Van Ry, Laurent Pessaint, Hanne Andersen, Mark G. Lewis, Christian Hofer, Donald S. Burke, Erica K. Barkei, Hannah A. D. King, Caroline Subra, Diane Bolton, Kayvon Modjarrad, Nelson L. Michael, Dan H. Barouch
Summary: This study examined the immunogenicity and protective efficacy of an oral live vaccine against SARS-CoV-2 in rhesus macaques. The results showed that the oral vaccine provided partial protection against respiratory SARS-CoV-2 challenge, but further optimization of the vaccine formulation and administration route is needed.
JOURNAL OF VIROLOGY
(2022)
Article
Infectious Diseases
Lo Vang, Christopher S. Morello, Jason Mendy, Danielle Thompson, Darly Manayani, Ben Guenther, Justin Julander, Daniel Sanford, Amit Jain, Amish Patel, Paul Shabram, Jonathan Smith, Jeff Alexander
Summary: A Zika virus-like particle (VLP) vaccine was developed using genetically engineered VLPs, which induced protective neutralizing antibodies in both mice and nonhuman primates, supporting further evaluation in human clinical trials.
PLOS NEGLECTED TROPICAL DISEASES
(2021)
Article
Immunology
Kwadwo Asamoah Kusi, Ebenezer Addo Ofori, Kwadwo Akyea-Mensah, Eric Kyei-Baafour, Augustina Frimpong, Nana Aba Ennuson, Maria Belmonte, Harini Ganeshan, Jun Huang, Linda Eva Amoah, Eileen Villasante, Martha Sedegah
Summary: This study aimed to identify immunodominant portions of four malaria vaccine candidate antigens, and found that circumsporozoite protein (CSP) and apical membrane antigen 1 (AMA1) have relatively higher numbers of epitopes that trigger IFN-gamma and granzyme B-secreting T cells in adults with life-long exposure to malaria parasites.
Article
Medicine, General & Internal
Godfrey Bwire, Alex Riolexus Ario, Patricia Eyu, Felix Ocom, Joseph F. Wamala, Kwadwo A. Kusi, Latif Ndeketa, Kondwani C. Jambo, Rhoda K. Wanyenze, Ambrose O. Talisuna
Summary: This passage introduces the discovery of a new coronavirus and the associated COVID-19 disease in China in December 2019. It explains that scientists initially predicted a severe situation in Africa, but the reality did not match the predictions. Therefore, the purpose of this forum is to bring together experts to discuss the current situation of COVID-19 in Africa, analyze why Africa's situation differs from the predictions, and propose measures to support Africa in overcoming the negative effects of COVID-19 and accelerate the achievement of sustainable development goals.
Article
Infectious Diseases
Atikatou Mama, Charity Ahiabor, Bernard Tornyigah, Naa Adjeley Frempong, Kwadwo A. Kusi, Bright Adu, David Courtin, Sandrine Houze, Philippe Deloron, Michael F. Ofori, Abraham K. Anang, Frederic Ariey, Nicaise Tuikue Ndam
Summary: Despite the positive impact of the new IPTp-SP policy in Ghana on birth weight of newborns, the selective pressure from the use of 3 or more IPTp-SP doses results in the emergence of parasites carrying non-synonymous mutations.
Article
Medicine, Research & Experimental
Didac Macia, Joseph J. Campo, Gemma Moncunill, Chenjerai Jairoce, Augusto J. Nhabomba, Maximilian Mpina, Hermann Sorgho, David Dosoo, Ousmane Traore, Kwadwo Asamoah Kusi, Nana Aba Williams, Amit Oberai, Arlo Randall, Hector Sanz, Clarissa Valim, Kwaku Poku Asante, Seth Owusu-Agyei, Halidou Tinto, Selidji Todagbe Agnandji, Simon Kariuki, Ben Gyan, Claudia Daubenberger, Benjamin Mordmuller, Paula Petrone, Carlota Dobano
Summary: The RTS,S/AS01E vaccine can induce strong off-target antibody responses, which may decrease the incidence of clinical malaria.
Article
Chemistry, Multidisciplinary
Yuxiang Dong, Yogesh Sonawane, Steven P. Maher, Anne-Marie Zeeman, Victor Chaumeau, Amelie Vantaux, Caitlin A. Cooper, Francis C. K. Chiu, Eileen Ryan, Jenna McLaren, Gong Chen, Sergio Wittlin, Benoit Witkowski, Francois Nosten, Kamaraj Sriraghavan, Dennis E. Kyle, Clemens H. M. Kocken, Susan A. Charman, Jonathan L. Vennerstrom
Summary: This study investigates the metabolism and activity of the catechol derivative RC-12 (WR 27653). The results suggest that the metabolites of RC-12 may contribute to its superior efficacy against liver-stage malaria parasites in rhesus monkeys compared to humans. However, none of the identified metabolites showed activity against Plasmodium vivax or Plasmodium cynomolgi liver-stage parasites.
Article
Infectious Diseases
Cecilia Elorm Lekpor, Felix Botchway, Kwadwo Asamoah Kusi, Andrew A. Adjei, Michael D. Wilson, Jonathan K. Stiles, Nana O. Wilson
Summary: This study conducted in Ghana assessed the saliva levels of CXCL10, Ang-1, and Ang-2 in malaria patients. The results showed elevated levels of CXCL10 and Ang-2 in the saliva of malaria patients. This suggests that detection of these biomarkers in saliva may have potential applications for non-invasive malaria diagnosis.
Article
Multidisciplinary Sciences
Jennifer Suurbaar, Azizath Moussiliou, Rachida Tahar, Rebecca W. Olsen, Yvonne Adams, Nanna Dalgaard, Eric K. Baafour, Selorme Adukpo, Lars Hviid, Kwadwo A. Kusi, Jules Alao, Michael F. Ofori, Nicaise T. Ndam, Anja R. Jensen
Summary: The highly polymorphic Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) family is expressed on the surface of infected erythrocytes and is crucial for the virulence of malaria. This study found that different clinically relevant subgroups of PfEMP1 exhibit varying levels of binding to ICAM-1, with higher levels of specific IgG against ICAM-1-binding DBL beta domains in uncomplicated malaria (UM) children. Additionally, plasma from UM children elicited a stronger antibody-dependent cellular phagocytosis (ADCP) response compared to plasma from severe malaria (SM) children.
SCIENTIFIC REPORTS
(2022)
Article
Immunology
Augustina Frimpong, Ewurama D. A. Owusu, Jones Amo Amponsah, Elizabeth Obeng-Aboagye, William van der Puije, Abena Fremaah Frempong, Kwadwo Asamoah Kusi, Michael Fokuo Ofori
Summary: Sepsis is a major complication in children and often misdiagnosed due to overlapping clinical features with other infections. This study identified seven potential biomarkers that can differentiate sepsis from malaria and other febrile conditions, providing a diagnostic tool for areas burdened with infectious diseases.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Immunology
Seth A. Domfeh, Patrick W. Narkwa, Osbourne Quaye, Kwadwo A. Kusi, Bright S. Addy, Sian Lant, Rebecca P. Sumner, Carlos Maluquer De Motes, Gordon A. Awandare, Charles Ansah, Mohamed Mutocheluh
Summary: It is discovered in this study that cryptolepine, a pharmacologically active alkaloid in the medicinal plant Cryptolepis sanguinolenta, is a strong inducer of the IFN-1 response, with potential anticancer and antiviral effects. The effects of cryptolepine are not mediated by nucleic acids released upon damage. This finding suggests that cryptolepine-based medications could be tested for the management of chronic viral infections and cancers in resource-limited regions of the world.
JOURNAL OF IMMUNOLOGY RESEARCH
(2022)
Article
Immunology
Erica M. Pasini, Annemarie Voorberg van der Wel, Nicole Heijmans, Onny Klop, Anne-Marie Zeeman, Herman Oostermeijer, Ivonne Nieuwenhuis, Roberto Rodriguez Garcia, Nicole Onur van der Werff, Sam O. Hofman, Frank A. W. Verreck, Edmond J. Remarque, Bart W. Faber, Clemens H. M. Kocken
Summary: Vaccine development for Plasmodium vivax is lagging behind other types of malaria. A study on a macaque model with relapsing malaria showed that limited blood-stage parasite exposure may enhance protection.
Article
Infectious Diseases
Gabriel Mitchell, Guglielmo Roma, Annemarie van der Wel, Martin Beibel, Anne-Marie Zeeman, Sven Schuierer, Laura Torres, Erika L. L. Flannery, Clemens H. M. Kocken, Sebastian A. A. Mikolajczak, Thierry T. T. Diagana
Summary: This study characterized the host gene expression in rhesus macaque hepatocytes infected with Plasmodium cynomolgi, identifying specific host pathways modulated during the exo-erythrocytic stage of the parasite. It provides valuable insights into the interaction between hepatocytes and the parasite during relapsing malaria infection.
Article
Immunology
Maria Belmonte, Harini Ganeshan, Jun Huang, Arnel Belmonte, Sandra Inoue, Rachel Velasco, Neda Acheampong, Ebenezer Addo Ofori, Kwadwo Akyea-Mensah, Augustina Frimpong, Nana Aba Ennuson, Abena Fremaah Frempong, Eric Kyei-Baafour, Linda Eva Amoah, Kimberly Edgel, Bjoern Peters, Eileen Villasante, Kwadwo Asamoah Kusi, Martha Sedegah
Summary: A malaria vaccine that can effectively induce sterilizing immunity against malaria in genetically diverse populations is urgently needed. This study identifies parasite-specific immune responses and conservatively conserved epitopes that could be effective against multiple strains of P. falciparum in genetically diverse populations. These findings provide valuable insights for the development of a simpler and cost-effective intervention.
Article
Chemistry, Medicinal
Ilaria D'Agostino, Susi Zara, Simone Carradori, Viviana De Luca, Clemente Capasso, Clemens H. M. Kocken, Anne-Marie Zeeman, Andrea Angeli, Fabrizio Carta, Claudiu T. Supuran
Summary: The hybrid compounds synthesized in this study, which combine the Artesunate core with a sulfonamide moiety, showed high inhibition potency against the protozoan PfCA, while exhibiting low cytotoxic effects on human cells, indicating a wide therapeutic window.
Article
Parasitology
Naa Adjeley Frempong, Charity Ahiabor, William K. Anyan, Atikatou Mama, Kwadwo Asamoah Kusi, Michael F. Ofori, Bright Adu, Alex Yaw Debrah, Abraham K. Anang, Nicaise T. Ndam, David Courtin
Summary: Anaemia is prevalent during pregnancy in sub-Saharan Africa, and parasitic infections, particularly Plasmodium falciparum, are associated with increased risk of anaemia. However, Schistosoma haematobium infection did not show a significant correlation with haemoglobin levels. It is recommended to initiate routine diagnosis and treatment of S. haematobium infections in endemic areas to reduce schistosomiasis during pregnancy.
JOURNAL OF PARASITOLOGY RESEARCH
(2023)
Article
Immunology
Augustina Frimpong, Michael Fokuo Ofori, Abdoelnaser M. Degoot, Kwadwo Asamoah Kusi, Buri Gershom, Jacob Quartey, Eric Kyei-Baafour, Nhi Nguyen, Wilfred Ndifon
Summary: This study conducted a detailed comparative analysis of the T cell repertoire in African children with and without clinical malaria, revealing that children with symptomatic malaria have lower TCR diversity and frequency of shared TCR sequences. Exposure to P. falciparum antigens during malaria disrupts the adaptive immune response.
FRONTIERS IN IMMUNOLOGY
(2022)