Regulation of macrophage motility by Irgm1

On the level: IRGM gene function is all about expression

(2009) Alan Huett et al.   Autophagy

Balance of Irgm protein activities determines IFN-γ-induced host defense

(2009) Stanley C. Henry et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Targeting of the GTPase Irgm1 to the phagosomal membrane via PtdIns(3,4)P2 and PtdIns(3,4,5)P3 promotes immunity to mycobacteria

(2009) Sangeeta Tiwari et al.   NATURE IMMUNOLOGY

Disruption of the Toxoplasma gondii Parasitophorous Vacuole by IFNγ-Inducible Immunity-Related GTPases (IRG Proteins) Triggers Necrotic Cell Death

(2009) Yang O. Zhao et al.   PLoS Pathogens

Polymorphism of the IRGM Gene Might Predispose to Fistulizing Behavior in Crohn's Disease

(2008) A Latiano et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Abnormalities in the handling of intracellular bacteria in Crohn’s disease: a link between infectious etiology and host genetic susceptibility

(2008) Anne-Lise Glasser et al.   ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS

The p47 GTPase Lrg-47 (Irgm1) Links Host Defense and Hematopoietic Stem Cell Proliferation

(2008) Carl G. Feng et al.   Cell Stem Cell

Autophagy Gives a Nod and a Wink to the Inflammasome and Paneth Cells in Crohn's Disease

(2008) Vojo Deretic et al.   DEVELOPMENTAL CELL

Regulatory interactions between IRG resistance GTPases in the cellular response to Toxoplasma gondii

(2008) Julia P Hunn et al.   EMBO JOURNAL

Confirmation of association of IRGM and NCF4 with ileal Crohn's disease in a population-based cohort

(2008) R L Roberts et al.   GENES AND IMMUNITY

Positive association of genetic variants in the upstream region of NKX2-3 with Crohn's disease in Japanese patients

(2008) K Yamazaki et al.   GUT

Autophagy as an important process in gut homeostasis and Crohn's disease pathogenesis

(2008) R. J Xavier et al.   GUT

The Gamma Interferon (IFN- )-Inducible GTP-Binding Protein IGTP Is Necessary for Toxoplasma Vacuolar Disruption and Induces Parasite Egression in IFN- -Stimulated Astrocytes

(2008) T. Melzer et al.   INFECTION AND IMMUNITY

Genetic determinants of ulcerative colitis include the ECM1 locus and five loci implicated in Crohn's disease

(2008) Sheila A Fisher et al.   NATURE GENETICS

Deletion polymorphism upstream of IRGM associated with altered IRGM expression and Crohn's disease

(2008) Steven A McCarroll et al.   NATURE GENETICS

Mammalian Rho GTPases: new insights into their functions from in vivo studies

(2008) Sarah J. Heasman et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Emerging themes in IFN-γ-induced macrophage immunity by the p47 and p65 GTPase families

(2007) Avinash R. Shenoy et al.   IMMUNOBIOLOGY