Using a Non-Image-Based Medium-Throughput Assay for Screening Compounds Targeting N-myristoylation in Intracellular Leishmania Amastigotes

Structure-Based Design of Potent and Selective Leishmania N-Myristoyltransferase Inhibitors

(2014) Jennie A. Hutton et al.   JOURNAL OF MEDICINAL CHEMISTRY

Induction of a Stringent Metabolic Response in Intracellular Stages of Leishmania mexicana Leads to Increased Dependence on Mitochondrial Metabolism

(2014) Eleanor C. Saunders et al.   PLoS Pathogens

Diverse modes of binding in structures ofLeishmania majorN-myristoyltransferase with selective inhibitors

(2014) James A. Brannigan et al.   IUCrJ

Management of trypanosomiasis and leishmaniasis

(2012) M. P. Barrett et al.   BRITISH MEDICAL BULLETIN

New oxidovanadium(IV) N -acylhydrazone complexes: Promising antileishmanial and antitrypanosomal agents

(2012) Julio Benítez et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Different susceptibilities of Leishmania spp. promastigotes to the Annona muricata acetogenins annonacinone and corossolone, and the Platymiscium floribundum coumarin scoparone

(2012) Nadja Soares Vila-Nova et al.   EXPERIMENTAL PARASITOLOGY

The Anti-Trypanosome Drug Fexinidazole Shows Potential for Treating Visceral Leishmaniasis

(2012) S. Wyllie et al.   Science Translational Medicine

Fexinidazole: A Potential New Drug Candidate for Chagas Disease

(2012) Maria Terezinha Bahia et al.   PLoS Neglected Tropical Diseases

Selective Inhibitors of Protozoan Protein N-myristoyltransferases as Starting Points for Tropical Disease Medicinal Chemistry Programs

(2012) Andrew S. Bell et al.   PLoS Neglected Tropical Diseases

A fluorescence-based assay for N-myristoyltransferase activity

(2011) Victor Goncalves et al.   ANALYTICAL BIOCHEMISTRY

Identification of Inhibitors of the Leishmania cdc2-Related Protein Kinase CRK3

(2011) Laura A. T. Cleghorn et al.   ChemMedChem

Discovery of a Novel Class of Orally Active Trypanocidal N-Myristoyltransferase Inhibitors

(2011) Stephen Brand et al.   JOURNAL OF MEDICINAL CHEMISTRY

Evaluation of antileishmanial, cytotoxic and antioxidant activities of essential oils extracted from plants issued from the leishmaniasis-endemic region of Sned (Tunisia)

(2011) S. Ben Hadj Ahmed et al.   NATURAL PRODUCT RESEARCH

A Screen against Leishmania Intracellular Amastigotes: Comparison to a Promastigote Screen and Identification of a Host Cell-Specific Hit

(2011) Geraldine De Muylder et al.   PLoS Neglected Tropical Diseases

High Throughput Screens Yield Small Molecule Inhibitors of Leishmania CRK3:CYC6 Cyclin-Dependent Kinase

(2011) Roderick G. Walker et al.   PLoS Neglected Tropical Diseases

Successful Treatment with Posaconazole of a Patient with Chronic Chagas Disease and Systemic Lupus Erythematosus

(2010) María-Jesús Pinazo et al.   AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE

Effects of Ravuconazole Treatment on Parasite Load and Immune Response in Dogs Experimentally Infected with Trypanosoma cruzi

(2010) L. d. F. Diniz et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

In vitro activity of anti-leishmanial drugs against Leishmania donovani is host cell dependent

(2010) K. Seifert et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

N-myristoyltransferase inhibitors as new leads to treat sleeping sickness

(2010) Julie A. Frearson et al.   NATURE

The potential of metabolomics for Leishmania research in the post-genomics era

(2010) RICHARD A. SCHELTEMA et al.   PARASITOLOGY

Antileishmanial High-Throughput Drug Screening Reveals Drug Candidates with New Scaffolds

(2010) Jair L. Siqueira-Neto et al.   PLoS Neglected Tropical Diseases

Whole-genome comparative RNA expression profiling of axenic and intracellular amastigote forms of Leishmania infantum

(2009) Annie Rochette et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

TriTrypDB: a functional genomic resource for the Trypanosomatidae

(2009) Martin Aslett et al.   NUCLEIC ACIDS RESEARCH

Genome-wide gene expression profiling analysis of Leishmania major and Leishmania infantum developmental stages reveals substantial differences between the two species

(2008) Annie Rochette et al.   BMC GENOMICS

Kinetoplastids: related protozoan pathogens, different diseases

(2008) Ken Stuart et al.   JOURNAL OF CLINICAL INVESTIGATION

Transgenic, FluorescentLeishmania mexicanaAllow Direct Analysis of the Proteome of Intracellular Amastigotes

(2008) Daniel Paape et al.   MOLECULAR & CELLULAR PROTEOMICS