Predicting Harms and Benefits in Translational Trials: Ethics, Evidence, and Uncertainty

What Can Be Inferred from the Interruption of the Semagacestat Trial for Treatment of Alzheimer's Disease?

(2010) Jeffrey Cummings   BIOLOGICAL PSYCHIATRY

Rosiglitazone Monotherapy in Mild-to-Moderate Alzheimer’s Disease: Results from a Randomized, Double-Blind, Placebo-Controlled Phase III Study

(2010) Michael Gold et al.   DEMENTIA AND GERIATRIC COGNITIVE DISORDERS

Stem cells in human neurodegenerative disorders — time for clinical translation?

(2010) Olle Lindvall et al.   JOURNAL OF CLINICAL INVESTIGATION

Alzheimer's disease: clinical trials and drug development

(2010) Francesca Mangialasche et al.   LANCET NEUROLOGY

Gene delivery of AAV2-neurturin for Parkinson's disease: a double-blind, randomised, controlled trial

(2010) William J Marks et al.   LANCET NEUROLOGY

Alzheimer's failure raises questions about disease-modifying strategies

(2010) Andy Extance   NATURE REVIEWS DRUG DISCOVERY

Randomized controlled trial of atorvastatin in mild to moderate Alzheimer disease: LEADe

(2010) H. H. Feldman et al.   NEUROLOGY

Beyond Access vs. Protection in Trials of Innovative Therapies

(2010) A. J. London et al.   SCIENCE

Publication Bias in Reports of Animal Stroke Studies Leads to Major Overstatement of Efficacy

(2010) Emily S. Sena et al.   PLOS BIOLOGY

Improving Bioscience Research Reporting: The ARRIVE Guidelines for Reporting Animal Research

(2010) Carol Kilkenny et al.   PLOS BIOLOGY

Can Animal Models of Disease Reliably Inform Human Studies?

(2010) H. Bart van der Worp et al.   PLOS MEDICINE

Effects of NXY-059 in experimental stroke: an individual animal meta-analysis

(2009) PMW Bath et al.   BRITISH JOURNAL OF PHARMACOLOGY

Development of semagacestat (LY450139), a functional γ-secretase inhibitor, for the treatment of Alzheimer's disease

(2009) David B Henley et al.   EXPERT OPINION ON PHARMACOTHERAPY

Effect of Tarenflurbil on Cognitive Decline and Activities of Daily Living in Patients With Mild Alzheimer DiseaseA Randomized Controlled Trial

(2009) Robert C. Green   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Launching invasive, first-in-human trials against Parkinson's disease: Ethical considerations

(2009) Jonathan Kimmelman et al.   MOVEMENT DISORDERS

The scientific and clinical basis for the treatment of Parkinson disease (2009)

(2009) C. W. Olanow et al.   NEUROLOGY

A phase 2 multiple ascending dose trial of bapineuzumab in mild to moderate Alzheimer disease

(2009) S. Salloway et al.   NEUROLOGY

Survey of the Quality of Experimental Design, Statistical Analysis and Reporting of Research Using Animals

(2009) Carol Kilkenny et al.   PLoS One

Fetal Cells Again?

(2009) C. Holden   SCIENCE

Treatment Success in CancerNew Cancer Treatment Successes Identified in Phase 3 Randomized Controlled Trials Conducted by the National Cancer Institute–Sponsored Cooperative Oncology Groups, 1955 to 2006

(2008) Benjamin Djulbegovic   ARCHIVES OF INTERNAL MEDICINE

A Call for Physiopathological Ethics

(2008) Pedro R Lowenstein   MOLECULAR THERAPY

Good Laboratory Practice

(2008) Malcolm R. Macleod et al.   STROKE

Methodological Quality of Animal Studies of Neuroprotective Agents Currently in Phase II/III Acute Ischemic Stroke Trials

(2008) Maria Philip et al.   STROKE