Stem cells in human neurodegenerative disorders — time for clinical translation?

Delayed post-ischaemic neuroprotection following systemic neural stem cell transplantation involves multiple mechanisms

(2009) Marco Bacigaluppi et al.   BRAIN

Parkinson's Disease Patient-Derived Induced Pluripotent Stem Cells Free of Viral Reprogramming Factors

(2009) Frank Soldner et al.   CELL

Intrathecal transplantation of human neural stem cells overexpressing VEGF provide behavioral improvement, disease onset delay and survival extension in transgenic ALS mice

(2009) D H Hwang et al.   GENE THERAPY

Neuroprotective Effects of Mesenchymal Stem Cells Derived from Human Embryonic Stem Cells in Transient Focal Cerebral Ischemia in Rats

(2009) Yi-Ping Liu et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Human neural stem cell grafts in the spinal cord of SOD1 transgenic rats: Differentiation and structural integration into the segmental motor circuitry

(2009) Leyan Xu et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Microglia in ALS: The Good, The Bad, and The Resting

(2009) Jenny S. Henkel et al.   Journal of Neuroimmune Pharmacology

A  Immunotherapy Protects Morphology and Survival of Adult-Born Neurons in Doubly Transgenic APP/PS1 Mice

(2009) B. Biscaro et al.   JOURNAL OF NEUROSCIENCE

Neprilysin Overexpression Inhibits Plaque Formation But Fails to Reduce Pathogenic A  Oligomers and Associated Cognitive Deficits in Human Amyloid Precursor Protein Transgenic Mice

(2009) W. J. Meilandt et al.   JOURNAL OF NEUROSCIENCE

Stem cell-based cell therapy in neurological diseases: A review

(2009) Seung U. Kim et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Neurorestorative therapies for stroke: underlying mechanisms and translation to the clinic

(2009) Zheng Gang Zhang et al.   LANCET NEUROLOGY

Cell Therapy for CNS Trauma

(2009) K. K. Jain   MOLECULAR BIOTECHNOLOGY

Molecular and Magnetic Resonance Imaging of Human Embryonic Stem Cell–Derived Neural Stem Cell Grafts in Ischemic Rat Brain

(2009) Marcel M Daadi et al.   MOLECULAR THERAPY

Neuroprotective effects of brain-derived neurotrophic factor in rodent and primate models of Alzheimer's disease

(2009) Alan H Nagahara et al.   NATURE MEDICINE

Forebrain ependymal cells are Notch-dependent and generate neuroblasts and astrocytes after stroke

(2009) Marie Carlén et al.   NATURE NEUROSCIENCE

VEGF enhance cortical newborn neurons and their neurite development in adult rat brain after cerebral ischemia

(2009) Yong-Quan Wang et al.   NEUROCHEMISTRY INTERNATIONAL

Effects of human neural stem cell transplantation in canine spinal cord hemisection

(2009) Seung-Hoon Lee et al.   NEUROLOGICAL RESEARCH

Ex Vivo VEGF Delivery by Neural Stem Cells Enhances Proliferation of Glial Progenitors, Angiogenesis, and Tissue Sparing after Spinal Cord Injury

(2009) Hyuk Min Kim et al.   PLoS One

Analysis of Host-Mediated Repair Mechanisms after Human CNS-Stem Cell Transplantation for Spinal Cord Injury: Correlation of Engraftment with Recovery

(2009) Mitra J. Hooshmand et al.   PLoS One

Human Neural Stem Cells Genetically Modified to Overexpress Akt1 Provide Neuroprotection and Functional Improvement in Mouse Stroke Model

(2009) Hong J. Lee et al.   PLoS One

Efficient production of mesencephalic dopamine neurons by Lmx1a expression in embryonic stem cells

(2009) S. Friling et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stem cells in the treatment of chronic spinal cord injury: evaluation of somatosensitive evoked potentials in 39 patients

(2009) A F Cristante et al.   SPINAL CORD

Case report on the clinical results of a combined cellular therapy for chronic spinal cord injured patients

(2009) G A Moviglia et al.   SPINAL CORD

Directed Differentiation of Human-Induced Pluripotent Stem Cells Generates Active Motor Neurons

(2009) Saravanan Karumbayaram et al.   STEM CELLS

Is it too soon for Mesenchymal Stem Cell trials in people with ALS?

(2008) Irina Badayan et al.   Amyotrophic Lateral Sclerosis

Impact of grafted serotonin and dopamine neurons on development of L-DOPA-induced dyskinesias in parkinsonian rats is determined by the extent of dopamine neuron degeneration

(2008) T. Carlsson et al.   BRAIN

Parthenogenetic dopamine neurons from primate embryonic stem cells restore function in experimental Parkinson's disease

(2008) Rosario Sanchez-Pernaute et al.   BRAIN

Induction of A9 dopaminergic neurons from neural stem cells improves motor function in an animal model of Parkinson's disease

(2008) Fiona E. O’Keeffe et al.   BRAIN

Disease-Specific Induced Pluripotent Stem Cells

(2008) In-Hyun Park et al.   CELL

Mechanisms and Functional Implications of Adult Neurogenesis

(2008) Chunmei Zhao et al.   CELL

Stem Cell Clinics Online: The Direct-to-Consumer Portrayal of Stem Cell Medicine

(2008) Darren Lau et al.   Cell Stem Cell

Non-Cell-Autonomous Effect of Human SOD1G37R Astrocytes on Motor Neurons Derived from Human Embryonic Stem Cells

(2008) Maria C.N. Marchetto et al.   Cell Stem Cell

Stem Cells for Spinal Cord Repair

(2008) Fanie Barnabé-Heider et al.   Cell Stem Cell

Stem cell therapy in stroke

(2008) F. Locatelli et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Treatment of amyotrophic lateral sclerosis patients by autologous bone marrow-derived hematopoietic stem cell transplantation: a 1-year follow-up

(2008) H. Deda et al.   CYTOTHERAPY

Long-term accumulation of microglia with proneurogenic phenotype concomitant with persistent neurogenesis in adult subventricular zone after stroke

(2008) Pär Thored et al.   GLIA

Wnt5a-treated midbrain neural stem cells improve dopamine cell replacement therapy in parkinsonian mice

(2008) Clare L. Parish et al.   JOURNAL OF CLINICAL INVESTIGATION

Failure of Neuronal Maturation in Alzheimer Disease Dentate Gyrus

(2008) Bin Li et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Transplanted Mouse Embryonic Stem-Cell-Derived Motoneurons Form Functional Motor Units and Reduce Muscle Atrophy

(2008) D. C. Yohn et al.   JOURNAL OF NEUROSCIENCE

Generation of spinal motor neurons from human fetal brain-derived neural stem cells: Role of basic fibroblast growth factor

(2008) Paivi M. Jordan et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Direct Muscle Delivery of GDNF With Human Mesenchymal Stem Cells Improves Motor Neuron Survival and Function in a Rat Model of Familial ALS

(2008) Masatoshi Suzuki et al.   MOLECULAR THERAPY

Therapeutic cloning in individual parkinsonian mice

(2008) Viviane Tabar et al.   NATURE MEDICINE

Lewy bodies in grafted neurons in subjects with Parkinson's disease suggest host-to-graft disease propagation

(2008) Jia-Yi Li et al.   NATURE MEDICINE

Lewy body–like pathology in long-term embryonic nigral transplants in Parkinson's disease

(2008) Jeffrey H Kordower et al.   NATURE MEDICINE

Focal transplantation–based astrocyte replacement is neuroprotective in a model of motor neuron disease

(2008) Angelo C Lepore et al.   NATURE NEUROSCIENCE

Human mesenchymal stem cell transplantation extends survival, improves motor performance and decreases neuroinflammation in mouse model of amyotrophic lateral sclerosis

(2008) A. Vercelli et al.   NEUROBIOLOGY OF DISEASE

Stem and progenitor cell therapies: recent progress for spinal cord injury repair

(2008) J. Louro et al.   NEUROLOGICAL RESEARCH

Hematopoietic stem cell transplantation in patients with sporadic amyotrophic lateral sclerosis

(2008) S. H. Appel et al.   NEUROLOGY

Adherent Self-Renewable Human Embryonic Stem Cell-Derived Neural Stem Cell Line: Functional Engraftment in Experimental Stroke Model

(2008) Marcel M. Daadi et al.   PLoS One

Highly efficient and large-scale generation of functional dopamine neurons from human embryonic stem cells

(2008) M. S. Cho et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neurons derived from reprogrammed fibroblasts functionally integrate into the fetal brain and improve symptoms of rats with Parkinson's disease

(2008) M. Wernig et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Induced Pluripotent Stem Cells Generated from Patients with ALS Can Be Differentiated into Motor Neurons

(2008) J. T. Dimos et al.   SCIENCE

Directed Evolution of Motor Neurons from Genetically Engineered Neural Precursors

(2008) Delphine Bohl et al.   STEM CELLS

Directed Differentiation of Ventral Spinal Progenitors and Motor Neurons from Human Embryonic Stem Cells by Small Molecules

(2008) Xue-Jun Li et al.   STEM CELLS

Embryonic Stem Cell-Derived Pitx3-Enhanced Green Fluorescent Protein Midbrain Dopamine Neurons Survive Enrichment by Fluorescence-Activated Cell Sorting and Function in an Animal Model of Parkinson's Disease

(2008) Eva Hedlund et al.   STEM CELLS

Functional Integration of Newly Generated Neurons Into Striatum After Cerebral Ischemia in the Adult Rat Brain

(2008) Shang-Wei Hou et al.   STROKE

S tem Cell T herapies as an E merging P aradigm in S troke (STEPS)

(2008)   STROKE

Spinal Cord Injury Reveals Multilineage Differentiation of Ependymal Cells

(2008) Konstantinos Meletis et al.   PLOS BIOLOGY

Neural stem/precursor cells for the treatment of ischemic stroke

(2007) Marco Bacigaluppi et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Stem cell treatment in Amyotrophic Lateral Sclerosis

(2007) Letizia Mazzini et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Neurogenic responses to amyloid-beta plaques in the brain of Alzheimer’s disease-like transgenic (pPDGF-APPSw,Ind) mice

(2007) Li Gan et al.   NEUROBIOLOGY OF DISEASE