Genetic and Genomic Architecture of the Evolution of Resistance to Antifungal Drug Combinations

JointSNVMix: a probabilistic model for accurate detection of somatic mutations in normal/tumour paired next-generation sequencing data

(2012) Andrew Roth et al.   BIOINFORMATICS

Hsp90 Molecular Chaperone Inhibitors: Are We There Yet?

(2012) L. Neckers et al.   CLINICAL CANCER RESEARCH

The 2012 Garrod Lecture: Discovery of antibacterial drugs in the 21st century

(2012) I. Chopra   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Evolutionary insight from whole-genome sequencing of experimentally evolved microbes

(2012) JEREMY R. DETTMAN et al.   MOLECULAR ECOLOGY

The stepwise acquisition of fluconazole resistance mutations causes a gradual loss of fitness inCandida albicans

(2012) Christoph Sasse et al.   MOLECULAR MICROBIOLOGY

Heat shock protein 90 in neurodegenerative diseases

(2012) Wenjie Luo et al.   Molecular Neurodegeneration

Fast gapped-read alignment with Bowtie 2

(2012) Ben Langmead et al.   NATURE METHODS

Tackling Human Fungal Infections

(2012) G. D. Brown et al.   SCIENCE

Projected life expectancy of people with HIV according to timing of diagnosis

(2011) Fumiyo Nakagawa et al.   AIDS

Antifungal Drug Resistance: Mechanisms, Epidemiology, and Consequences for Treatment

(2011) Michael A. Pfaller   AMERICAN JOURNAL OF MEDICINE

The Chemical Biology of Immunophilin Ligands

(2011) S. Gaali et al.   CURRENT MEDICINAL CHEMISTRY

Population biological principles of drug-resistance evolution in infectious diseases

(2011) Pia Abel zur Wiesch et al.   LANCET INFECTIOUS DISEASES

Regulatory Circuitry Governing Fungal Development, Drug Resistance, and Disease

(2011) R. S. Shapiro et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Cross-species discovery of syncretic drug combinations that potentiate the antifungal fluconazole

(2011) M. Spitzer et al.   Molecular Systems Biology

A framework for variation discovery and genotyping using next-generation DNA sequencing data

(2011) Mark A DePristo et al.   NATURE GENETICS

Heat shock and awe

(2011) Elie Dolgin et al.   NATURE MEDICINE

Tackling antibiotic resistance

(2011) Karen Bush et al.   NATURE REVIEWS MICROBIOLOGY

Hsp90 Governs Dispersion and Drug Resistance of Fungal Biofilms

(2011) Nicole Robbins et al.   PLoS Pathogens

A simple yeast-based system for analyzing inhibitor resistance in the human cancer drug targets Hsp90α/β

(2010) Stefan H. Millson et al.   BIOCHEMICAL PHARMACOLOGY

Savant: genome browser for high-throughput sequencing data

(2010) M. Fiume et al.   BIOINFORMATICS

A survey of sequence alignment algorithms for next-generation sequencing

(2010) H. Li et al.   BRIEFINGS IN BIOINFORMATICS

Epidemiology of Invasive Mycoses in North America

(2010) Michael A. Pfaller et al.   CRITICAL REVIEWS IN MICROBIOLOGY

Determinants of Divergent Adaptation and Dobzhansky-Muller Interaction in Experimental Yeast Populations

(2010) James B. Anderson et al.   CURRENT BIOLOGY

Fungal infections in oncology patients: update on epidemiology, prevention, and treatment

(2010) Kieren A Marr   CURRENT OPINION IN ONCOLOGY

Genomic Plasticity of the Human Fungal Pathogen Candida albicans

(2010) Anna Selmecki et al.   EUKARYOTIC CELL

The Genome Analysis Toolkit: A MapReduce framework for analyzing next-generation DNA sequencing data

(2010) A. McKenna et al.   GENOME RESEARCH

HSP90 at the hub of protein homeostasis: emerging mechanistic insights

(2010) Mikko Taipale et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Highly-multiplexed barcode sequencing: an efficient method for parallel analysis of pooled samples

(2010) A. M. Smith et al.   NUCLEIC ACIDS RESEARCH

Optimal Drug Synergy in Antimicrobial Treatments

(2010) Joseph Peter Torella et al.   PLoS Computational Biology

PKC Signaling Regulates Drug Resistance of the Fungal Pathogen Candida albicans via Circuitry Comprised of Mkc1, Calcineurin, and Hsp90

(2010) Shantelle L. LaFayette et al.   PLoS Pathogens

Structural Basis of the Radicicol Resistance Displayed by a Fungal Hsp90

(2009) Chrisostomos Prodromou et al.   ACS Chemical Biology

The Sequence Alignment/Map format and SAMtools

(2009) H. Li et al.   BIOINFORMATICS

Fast and accurate short read alignment with Burrows-Wheeler transform

(2009) H. Li et al.   BIOINFORMATICS

CNV-seq, a new method to detect copy number variation using high-throughput sequencing

(2009) Chao Xie et al.   BMC BIOINFORMATICS

A Systematic Survey Identifies Prions and Illuminates Sequence Features of Prionogenic Proteins

(2009) Simon Alberti et al.   CELL

Epidemiology and Outcomes of Candidemia in 2019 Patients: Data from the Prospective Antifungal Therapy Alliance Registry

(2009) David L. Horn et al.   CLINICAL INFECTIOUS DISEASES

Population genomics of domestic and wild yeasts

(2009) Gianni Liti et al.   NATURE

Drug interactions and the evolution of antibiotic resistance

(2009) Pamela J. Yeh et al.   NATURE REVIEWS MICROBIOLOGY

Saccharomyces Genome Database provides mutant phenotype data

(2009) S. R. Engel et al.   NUCLEIC ACIDS RESEARCH

New tools at the Candida Genome Database: biochemical pathways and full-text literature search

(2009) Marek S. Skrzypek et al.   NUCLEIC ACIDS RESEARCH

Harnessing Hsp90 function as a powerful, broadly effective therapeutic strategy for fungal infectious disease

(2009) Leah E. Cowen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Acquisition of Aneuploidy Provides Increased Fitness during the Evolution of Antifungal Drug Resistance

(2009) Anna M. Selmecki et al.   PLoS Genetics

Hsp90 Governs Echinocandin Resistance in the Pathogenic Yeast Candida albicans via Calcineurin

(2009) Sheena D. Singh et al.   PLoS Pathogens

Ultrafast and memory-efficient alignment of short DNA sequences to the human genome

(2009) Ben Langmead et al.   GENOME BIOLOGY

Synergistic Effect of Calcineurin Inhibitors and Fluconazole against Candida albicans Biofilms

(2008) P. Uppuluri et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Characterization of the kinetics and mechanisms of inhibition of drugs interacting with the S. cerevisiae multidrug resistance pumps Pdr5p and Snq2p

(2008) Tomáš Hendrych et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

SOAP: short oligonucleotide alignment program

(2008) R. Li et al.   BIOINFORMATICS

Stress, Drugs, and Evolution: the Role of Cellular Signaling in Fungal Drug Resistance

(2008) Leah E. Cowen et al.   EUKARYOTIC CELL

Mapping short DNA sequencing reads and calling variants using mapping quality scores

(2008) H. Li et al.   GENOME RESEARCH

An isochromosome confers drug resistance in vivo by amplification of two genes, ERG11 and TAC1

(2008) Anna Selmecki et al.   MOLECULAR MICROBIOLOGY

The evolution of fungal drug resistance: modulating the trajectory from genotype to phenotype

(2008) Leah E. Cowen   NATURE REVIEWS MICROBIOLOGY

Accelerated evolution of resistance in multidrug environments

(2008) M. Hegreness et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Drug interactions modulate the potential for evolution of resistance

(2008) J.-B. Michel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA